Patent application number | Description | Published |
20090238876 | BISPHOSPHONATES FOR TREATING ENDOMETRIOSIS - A novel method of treating endometriosis is disclosed. The method comprises administering to a female subject in need thereof a therapeutically effective amount of particles comprising an agent capable of inhibiting phagocytic cells of the female subject. | 09-24-2009 |
20110082483 | Cutting balloon assembly and method of manufacturing thereof - A cutting balloon assembly and a method for fabrication of the assembly is described. The cutting balloon assembly comprises a delivery catheter, an expandable balloon mounted on the catheter distal end, and a scoring mesh disposed around the expandable balloon. The scoring mesh comprises interlacing filaments that extend from a mesh proximal end towards a mesh distal end, form distal filament loops at said mesh distal end, and then return to the mesh proximal end. At least a part of the interlacing filaments forms one or more permanent links with neighboring filaments between the mesh proximal end and the mesh distal end. | 04-07-2011 |
20110293519 | MOLECULAR IMAGING AGENTS - Provided is radiolabeled ammonium salts and uses thereof as myocardial perfusion agents in molecular imaging. | 12-01-2011 |
20120232638 | CUTTING BALLOON ASSEMBLY AND METHOD OF MANUFACTURING THEREOF - A method for fabrication of a cutting balloon assembly is described. The method includes providing a predetermined number of filaments having predetermined properties, diameter and length and fabricating a scoring mesh on a weaving jig having a plurality of pins disposed circumferentially about the jig's surface. The fabrication of the scoring mesh includes placing the filaments between the pins and interlacing the filaments to form a scoring mesh by interweaving and intertwining at least a part of filament to form one or more permanent links with neighboring filaments. The fabrication of the scoring mesh also includes forming distal and proximal filament loops that protrude from the mesh distal and proximal ends, respectfully. The scoring mesh is mounted on an expandable balloon mounted on a distal end of a delivery catheter. | 09-13-2012 |
Patent application number | Description | Published |
20090311708 | METHOD OF DETERMINING A CHEMOTHERAPEUTIC REGIMEN BASED ON ERCC1 AND TS EXPRESSION - The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing TS and/or ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and prognosticate the probable resistance of a patient's tumor to treatment with 5-FU and oxaliplatin-based therapies by examination of the amount of TS and/or ERCC1 mRNA in a patient's tumor cells and comparing it to a predetermined threshold expression level for those genes. More specifically, the invention provides to oligonucleotide primer pairs ERCC1 and TS and methods comprising their use for detecting levels of ERCC1 and TS mRNA, respectively. | 12-17-2009 |
20100009365 | PROCESS FOR HIGH-THROUGHPUT DNA METHYLATION ANALYSIS - There is disclosed an improved high-throughput and quantitative process for determining methylation patterns in genomic DNA samples based on amplifying modified nucleic acid, and detecting methylated nucleic acid based on amplification-dependent displacement of specifically annealed hybridization probes. Specifically, the inventive process provides for treating genomic DNA samples with sodium bisulfite to create methylation-dependent sequence differences, followed by detection with fluorescence-based quantitative PCR techniques. The process is particularly well suited for the rapid analysis of a large number of nucleic acid samples, such as those from collections of tumor tissues | 01-14-2010 |
20110212981 | Method of Determining a Chemotherapeutic Regimen Based on ERCC1 and TS Expression - The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing TS and/or ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and prognosticate the Probable resistance of a patient's tumor to treatment with 5-FU and oxaliplatin-based therapies by examination of the amount of TS and/or ERCC1 mRNA in a Patient's tumor cells and comparing it to a predetermined threshold expression level for those genes. More specifically, the invention provides to oligonucleotide prither pairs ERCC1 and TS and methods comprising their use for detecting levels of ERCC1 and TS mRNA, respectively. | 09-01-2011 |
20120040346 | Method of Determining Chemotherapy of Metastatic Tumor by Assaying DPD Gene Expression in Primary Tumors - The invention relates to a method for determining a chemotherapeutic regimen for an individual, comprising obtaining a mRNA sample from a primary tumor specimen; determining a gene expression level for a tumor gene determinant in the specimen; comparing the gene expression level for the tumor gene determinant with a predetermined threshold value for that gene; and providing a chemotherapeutic regimen comprising a chemotherapeutic agent appropriate for the tumor gene determinant to treat the tumor metastases. | 02-16-2012 |
Patent application number | Description | Published |
20080221548 | Eradication of Pigmentation and Scar Tissue - The invention is a non-surgical method for the eradication of pigmentation and scar tissue from an area of skin. The method comprises repeatedly puncturing the area of skin with an array of needles. As the needles are inserted into the skin, the needles and surface of the skin are washed with a clean solution. As the needles are withdrawn from the skin, the flow of clean solution ceases and the dirty solution, which contains cellular fluids and pigments released by the action of the needles, is removed from the surface. The invention is also a solution, which is used to clean the needles and to aid in destroying the pigment containing cells, and an apparatus, which is especially designed to move the needles into and out of the surface of the skin and to provide synchronization of the motion of the needles and flow of the solution such as to maximize the effectiveness of the method. | 09-11-2008 |
20100286951 | FOOT MEASURING DEVICE - The invention presents an apparatus for measuring the dimensions of human feet. The apparatus is comprised of a base ( | 11-11-2010 |
20110100406 | SPLIT THERMO-ELECTRIC STRUCTURE AND DEVICES AND SYSTEMS THAT UTILIZE SAID STRUCTURE - The invention is a Split-Thermo-Electric Structure (STES) and devices and systems that utilize said structure. The STES comprises a first thermo-electric element at an elevated temperature and a second thermo-electric element at a low (cold) temperature. The first thermo-electric element and the second thermo-electric element are connected by either an intermediate connection that conducts both electric current and heat or by a thermo-electric chain comprised of one or more thermo-electric elements. Each pair of the thermo-electric elements in the chain are connected by an intermediate connection that conducts both electric current and heat. Each of the thermo-electric elements and each of the intermediate connections in the STES exhibit a temperature-gradient. The STESs can be utilized in Seebeck or Peltier devices. The STESs can be utilized to construct devices comprised a plurality of n-type and p-type pairs of STESs, wherein each of the STESs in the device are connected at each end to a support layer. One of the support layers can be thermally connected to a heat source and the second support layer thermally connected to a heat sink in order to create a thermo-electric system. The heat source or the heat sink or both can be located at a distance from their respective support layer. | 05-05-2011 |
20120042661 | SPLIT THERMO-ELECTRIC CYCLES FOR SIMULTANEOUS COOLING, HEATING, AND TEMPERATURE CONTROL - The invention is new types of split-thermo-electric structures for cooling, heating, or stabilizing the temperature of an object or for electric power generation. In a first type of structure the transport of the electric current between the heat absorbing and the heat dispersing sides of the structure is disengaged from the flow of heat between the sides of the thermo-electric structure. In a second type of structure a layer of thermo-electric material on the heat absorbing side of the structure is connected by connection layers to two or more layers of thermo-electric material on the heat dispersing side of the structure. In a third type of structure the elements of which the structure is comprised are arranged to cause different values of electric current to flow at the heat absorbing and the heat dispersing sides of the structure and through different elements in the interior of the structure. | 02-23-2012 |
20120067064 | THERMO-ELECTRIC STRUCTURE - The invention is a split-thermo-electric structure for cooling, heating, or stabilizing the temperature of an object or for electric power generation. The structure of the invention is comprised of one or more legs comprised of two or more layers of thermo-electric material and a connection layer ( | 03-22-2012 |
20140094837 | SKIN PUNCTURING APPARATUS FOR USE IN A NON-SURGICAL METHOD FOR ERADICATION OF TATTOOS - The invention is a skin puncturing apparatus for use in a non-surgical method for eradication of a tattoo from an area of skin. The apparatus comprises: (a) a handle section comprising a motor and gear assembly for causing a reciprocating motion to a shaft connected to the gear assembly; (b) a barrel section surrounding the shaft, the first end of the barrel section attached to the handle and the second end of the barrel section having a tip adapted to be placed in contact with the area of skin; (c) a bundle of needles attached by means of a needles holder to the distal end of the shaft; and (d) an inlet body comprising an inlet port through which cleaning solution is introduced into the tip located at the lower edge of the barrel section. | 04-03-2014 |