Siu, US
Alec Siu, Seattle, WA US
Patent application number | Description | Published |
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20130166640 | REAL-TIME MARKUP OF MAPS WITH USER-GENERATED CONTENT - User-generated content that is associated with a geographic location is uploaded to existing networked services or directly to a digital map updating service. Distinct digital map updating services can be assigned to defined geographic areas, such that they are only notified of, or poll for, new user-generated content within their defined geographic areas. Utilizing the geographic location associated with such user-generated content, the digital map updating service identifies one or more digital map “tiles”, which are updated to include new user-generated content and capable applications on client devices can be notified directly of such new user-generated content if they are accessing the relevant tiles. Additionally, data mining can be performed and deductions of events from data mining can be indicated in the digital map in the same manner. | 06-27-2013 |
Chun Hin Nelson Siu, Kirkland, WA US
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20130242708 | MODERN CALENDAR SYSTEM INCLUDING FREE FORM INPUT ELECTRONIC CALENDAR SURFACE - Embodiments provide electronic calendar application features and functionality that includes a free form calendar input surface, but the embodiments are not so limited. In an embodiment, a computer-based method can be configured to provide electronic calendar features including a free form calendar surface that enables users to personalize the calendar surface using a variety of input types and methods. Other embodiments are included. | 09-19-2013 |
20130246912 | ELECTRONIC NOTE TAKING FEATURES INCLUDING BLANK NOTE TRIGGERS - Embodiments provide electronic note-taking and application features and functionality, but the embodiments are not so limited. In an embodiment, a computer-based method can be configured to provide note-taking features, including using blank notes as focus placeholders and resurfacing triggers. Other embodiments are included. | 09-19-2013 |
20130246963 | PERSONAL NOTES ON A CALENDAR ITEM - Embodiments provide functionality to provide electronic calendar features and functionalities including personal note-taking features on calendar items, but the embodiments are not so limited. In an embodiment, a computer-based method can be configured to provide a personal note-taking space that enables users to take personal notes on appointment or meeting items with or without sharing the personal notes. Other embodiments are included. | 09-19-2013 |
Cynthia O. Siu, Ringoes, NJ US
Patent application number | Description | Published |
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20110073425 | EXPANDABLE CARRYING CASE - This invention relates to a carrying case used to transport objects or documents, such as posters, drawings, or blueprints for presentation at conventions, exhibitions, meetings or similar functions. The expandable carrying case is made of leather or similarly sturdy, durable synthetic material such as nylon. It has flexible tubes that constitute a protective container for objects or rolled-up documents when deployed, and can be coiled up and stored in the said cylindrical case when not in use. The benefits of the present invention include its versatility in transporting objects or documents of different sizes or lengths. The flexible extensions are interconnected to each other, and to the cover and elongated tubular member through zippers, or similarly durable, sturdy fasteners to form one enclosed, protective carrier. This makes the current invention a uniquely versatile, flexible and reusable (hence “green”) transport/storage device. | 03-31-2011 |
Daniel K. Siu, Westford, MA US
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20100208588 | SHARED SHAPING OF NETWORK TRAFFIC - A method for sharing an aggregate bandwidth among a group of traffic classes may include allocating a portion of the aggregate bandwidth to one of the group of traffic classes having a first priority associated therewith, where the allocated portion is referred to as a first bandwidth. The method may include allocating an unused portion of the aggregate bandwidth to a second one of the group of traffic classes having a second priority associated therewith in conjunction with a parameter associated with a downstream device. | 08-19-2010 |
20110019544 | SYSTEMS FOR SCHEDULING THE TRANSMISSION OF DATA IN A NETWORK DEVICE - In a network device, a line card includes a first scheduler configured to perform scheduling for data units of a first type and a second scheduler that is connected in series to the first scheduler and configured to perform scheduling for data units of a second type. The schedulers may be configured in a variety of ways to achieve certain data unit flow characteristics. | 01-27-2011 |
Jessica Siu, Austin, TX US
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20150095788 | SYSTEMS AND METHODS FOR AUTOMATED COMMISSIONING OF VIRTUALIZED DISTRIBUTED CONTROL SYSTEMS - Systems and methods for automated commissioning of virtualized distributed control systems are disclosed. An example method includes accessing a data structure including a list of configuration names for network cards associated with first and second host servers of a virtual process control environment. The first and second host servers implement virtual machines corresponding to workstations for a process control system. The example method also includes when configuring the first host server, assigning a first name to a first one of the network cards associated with the first host server. The example method further includes when configuring the second host server, assigning the first name to a second one of the network cards associated with the second host server based on a user selection of the first name from the list of configuration names. The second host server is configured after the first host server. | 04-02-2015 |
Kam Siu, Milford, CT US
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20150291562 | IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE - The description relates to imide-based compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type. | 10-15-2015 |
Kam W. Siu, Farmingdale, NY US
Patent application number | Description | Published |
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20090163468 | Fused Bicyclic mTor Inhibitors - Compounds represented by Formula (I) | 06-25-2009 |
20110190496 | FUSED BICYCLIC mTOR INHIBITORS - Compounds represented by Formula (I) | 08-04-2011 |
20120046267 | 7-AMINOFUROPYRIDINE DERIVATIVES - Compounds of Formula 1, as shown below and defined herein: | 02-23-2012 |
20130165651 | FUSED BICYCLIC mTOR INHIBITORS - Compounds represented by Formula (I) | 06-27-2013 |
20130261086 | MACROCYCLIC KINASE INHIBITORS - Compounds of Formula (I): wherein variables are defined herein, and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers for which FAK inhibition is beneficial. | 10-03-2013 |
20140315911 | DIHYDROPTERIDINONES - Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven or mediated at least in part by RSK. This Abstract is not limiting of the invention. | 10-23-2014 |
Kam W. Siu, Famingdale, NY US
Patent application number | Description | Published |
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20100099679 | FUSED BICYCLIC mTOR INHIBITORS - Compounds represented by Formula (I) | 04-22-2010 |
Kem W. Siu, Farmingdale, NY US
Patent application number | Description | Published |
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20110218183 | Fused Bicyclic mTOR Inhibitors - Compounds represented by Formula (I) | 09-08-2011 |
Kit Yan Siu, Rhinebeck, NY US
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20110146232 | CONTROL SYSTEM FOR A PULSE DETONATION TURBINE ENGINE - A pulse detonation turbine engine (PDTE) includes at least one controllable multi-tube pulse detonation combustor (PDC) configured to initiate firing of one or more pulse detonation tubes in response to operation of a plurality of controllable peripheral PDC components to regulate PDTE output characteristics. A control system including a programmable controller directed by algorithmic software operates to generate control inputs for the plurality of controllable peripheral PDC components in response to PDTE input conditions, such that one or more PD tube controllable inputs can be different for at least one PD tube relative to another PD tube within the multi-tube PDC, and further such that detonation timing can be different for at least one PD tube relative to another PD tube within the multi-tube PDC. | 06-23-2011 |
Louis Siu, Brooklyn, NY US
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20110113333 | CREATION AND DELIVERY OF RINGTONES OVER A COMMUNICATIONS NETWORK - A method on a server for providing a ringtone based on a video can be provided. The method can include providing a graphical user interface to a user over a communications network and receiving, via the graphical user interface, identifying information for a video file on a third party server. The method can further include sending to the third party server a request for the video file, wherein the request is based on the identifying information and receiving the video file from the third party server. The method can further include streaming the video file to the user via the graphical user interface and receiving, via the graphical user interface, segment data identifying a segment of the video file. The method can further include generating a ringtone from the video file based on the segment data and transmitting the ringtone to the user. | 05-12-2011 |
Man-Hung Siu, Lexington, MA US
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20140142925 | SELF-ORGANIZING UNIT RECOGNITION FOR SPEECH AND OTHER DATA SERIES - An approach automated processing for audio or other data series or signals, which is applicable where little or no transcribed training data is available, makes uses identification of self-organizing units (SOUs) in conjunction with automated creation of, or augmentation of an existing dictionary, with “pseudo-words” or tokens represented in terms of the SOUs. In some examples, the dictionary is iteratively updated (e.g., augmented) during training, optionally with updating of models of the SOUs during the iteration. | 05-22-2014 |
Michael Yiu-Kwan Siu, Bellevue, WA US
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20150258447 | METHOD AND SYSTEM FOR DYNAMICALLY INCORPORATING ADVERTISING CONTENT INTO MULTIMEDIA ENVIRONMENTS - Methods and systems for dynamically incorporating advertising content into multimedia environments, such as games, are provided. Example embodiments include a dynamic inserter, which selects content, based upon a set of criteria, to deliver to a receiving client system, such as a game client. The game client typically dynamically determines locations with the game where advertisements may be inserted. Associated with these locations are ad tags that specify criteria for the ads. For example, the criteria may include ad type, ad genre, and scheduling information. The game client then sends indications of these ad tags to the dynamic inserter to be used to select appropriate ads. The dynamic inserter selects ads based upon the criteria and sends them to the game client, which selects them for ad tags with conforming criteria. The game client then renders the selected ad in the appropriate location. In one embodiment, the dynamic inserter comprises a game client, game server, ad server, a communications channel, and, optionally, an ad client. | 09-17-2015 |
Nelson Siu, Kirkland, WA US
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20130212252 | REPRESENTING REMOTELY AVAILABLE USERS THROUGH WORKING ELSEWHERE STATUS - An application provides a “working elsewhere” status for users working at a location other than their regular work location and still available for meetings, communication sessions, etc. The application determines a user location being other than regular work location and the user still being available through user selection, information from user associated application(s), and/or from a presence notification. The application adjusts the user status to a working elsewhere status and makes the new status available to other applications such as calendaring, communication applications, presence service(s), and comparable ones. Meetings may be scheduled, communication sessions facilitated if the working elsewhere status is sufficient/acceptable for other users. | 08-15-2013 |
20140365951 | NAVIGATING A CALENDAR - A calendar view smoothly and progressively transitions between different calendar views. Instead of snapping to a week view in response to changing from a month view to the week view, the month view progressively transitions to the week view while receiving an interaction. For example, the week view may smoothly expand while the view of the other weeks in the month smoothly decrease in size while the interaction is being received. A user may navigate between different calendar views such as year to month, month to week, week to multiple days, days to single days, and the like. When navigating month to month, week to week, day to day, and the like, the transitions between each time element are progressively and smoothly transitioned. Task information or other information that is displayed in the calendar progressively transitions to show more or less information depending on the interaction being received. | 12-11-2014 |
20140372898 | DISPLAYING LIFE EVENTS WHILE NAVIGATING A CALENDAR - Life events relating to a user are displayed on a calendar. A user may navigate to different time periods in the calendar and see past life events relating to the user displayed on the calendar. The life events that are displayed on the calendar may include different types of content and be determined from different sources. For example, the life events for the time period may be: pictures, events, social media posts, messages, and the like. Different content sources may be used to locate the life events relating to the user. The life events that are selected for display on the calendar may be shown differently from other content that is included on the calendar. The life events may be processed to adjust an appearance of the life event before it is displayed. A user may also share a life experience with other users. | 12-18-2014 |
Nelson Chun Hin Siu, Kirkland, WA US
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20090299807 | SCHEDULING OPPORTUNITY PREVIEWER - Various technologies and techniques are disclosed for previewing and managing scheduling opportunities. A scheduling opportunity is received. A context of one or more surrounding appointments to the scheduling opportunity is retrieved. The scheduling opportunity is displayed with the context of the surrounding appointments, such as in a mini-calendar format. When the appointment is a recurrent appointment, the scheduling opportunity for the recurrent appointment is displayed with a context of the surrounding appointments. | 12-03-2009 |
Patrick Siu, Tyngsborough, MA US
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20130342688 | Security System and Method using Wireless Adapters and PoE Cameras - A wireless adapter and method for providing a wireless connection to at least one wired security device includes at least one combined data/power physical port to which the wired security device connects. A power supply module receives power from an external power source and a power injector provides power to the combined data/power physical port to thereby power the wired security device. In this way, the wireless adapter supplies both power and data connection at the same physical port/jack of the wired security devices, such as IP security cameras, via an interface cable from the wireless adapter. This configuration has advantages in lowering the manufacturing costs of the cameras and reducing installation costs. Furthermore, the same standard camera can be used for both standard wired connections and wireless connections. | 12-26-2013 |
Paul Wai-Man Siu, Evanston, IL US
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20150034500 | METAL ORGANIC FRAMEWORKS FOR ELECTRONIC GAS STORAGE - A metal organic framework (MOF) includes a coordination product of a metal ion and an at least bidentate organic ligand, where the metal ion and the organic ligand are selected to provide a deliverable adsorption capacity of at least 70 g/l for an electronic gas. A porous organic polymer (POP) includes polymerization product from at least a plurality of organic monomers, where the organic monomers are selected to provide a deliverable adsorption capacity of at least 70 g/l for an electronic gas. | 02-05-2015 |
Raymond Siu US
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20140032659 | FACILITATING COMMUNICATIONS BETWEEN USERS OF MULTIPLE SOCIAL NETWORKS - A system and method facilitates communications between users of multiple social networks by combining social graphs from the social networks. During operation, a user requests the system to search for particular parameters. The system determines a set of matching user profiles and provides profile information and connection options for each of the matching user profiles. The profile information provided to the user varies depending on the degree of connection to the profile and the type of connection. Similarly, the system varies the connection options provided based on the degree of connection and the network membership of the profile. Available connection options may include sending a direct message, requesting an introduction, saving the profile for later viewing, and sending a limited message. | 01-30-2014 |
Roberto Siu, Providence, RI US
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20110107933 | POLYESTER FILM WITH ADHESIVE PROPERTIES - A multilayer composite film for sublimation type dye transfer imaging includes a polyester base layer and an adhesive layer onto which an ink layer of the sublimation dye can be placed. The adhesive layer includes an acrylic resin, an epoxy resin monomer and a crosslinking agent. The components of the adhesive layer preferably are water soluble or water dispersible. | 05-12-2011 |
20110305913 | OPTICALLY CLEAR UV AND HYDROLYSIS RESISTANT POLYESTER FILM - Biaxially oriented polyester films including polyester polymer, a carbodiimide hydrolysis stabilizer, and a UV absorber are described. The polyester films have a carboxyl end group concentration of 5-20 equivalents per ton, and a haze value of 2% or less. The films exhibit superior transparency and possess stable light transmission characteristics. Methods of making the films and articles produced from the films are also described. | 12-15-2011 |
20130068768 | BARRIER LIDDING STRUCTURE BASED ON POLYPROPYLENE FILM - Multi-layer films suitable as sealable or peelable sheet that can be used for closing foodstuff containers are described. These multi-layer films includes a polymeric substrate layer and a seal or a peel-seal layer. The multilayer composite film preferably includes four component layers, namely in order, a polymeric base layer for mechanical strength, a thin organic barrier layer, an ethylene polymer-based adhesive layer, and a heat seal layer including an ethylene copolymer, such as ethylene vinyl acetate copolymer. The film is useful as a peelable heat sealable lid for containers of diverse polymer compositions storing various products such as foodstuffs and pharmaceuticals. | 03-21-2013 |
20130068769 | LIDDING STRUCTURE BASED ON POLYLACTIC ACID FILM - Described is a multi-layer film suitable as sealable or peelable sheet specially used for closing foodstuff containers. This multi-layer sheet includes a polymeric substrate layer and a seal or a peel-seal layer. Preferably, the film includes at least three main component layers, namely in order, a polymeric base layer for mechanical strength, an ethylene polymer-based adhesive layer, and a heat seal layer comprising an ethylene copolymer, such as ethylene vinyl acetate copolymer. | 03-21-2013 |
20130224411 | PEELABLE ANTIFOG COATED FILM FOR AMORPHOUS POLYESTER TRAYS - Described are antifog films useful for packaging food, and more particularly to antifog films that can be used as lidding films in trays made of amorphous polyester. The films may include at least one base layer or film, such as a polyester film, and a heat seal layer. The antifog layer is coated on the heat seal layer. The heat seal layer allows the antifog coating to more strongly adhere to the antifog film. The heat seal layer may be an amorphous polyester layer. | 08-29-2013 |
20130260122 | LOW SEAL INITIATION LID FOR RIGID SUBSTRATES - A polyolefin-based heat sealable and peelable lidding film. The peelable seal films comprise from 5 to 95 percent by weight of a polyolefin based plastomer or elastomer and from 5 to 95 percent by weight of a second plastomer or elastomer. The invention also relates to methods of making and using the heat sealable, peelable seal films, having improved low seal initiation temperature. | 10-03-2013 |
20130309430 | POLYESTER CEREAL LINER WITH ZERO MIGRATION - Peelable extrusion coated barrier films including a polyester containing layer, and methods of making and using peelable extrusion coated plastic films having a polyester containing layer. One embodiment is a barrier film including a base film layer including polyester, and an extrusion coated peelable heat seal layer including polyethylene. | 11-21-2013 |
20140017474 | FILM STRUCTURES CONTAINING A BIAXIALLY ORIENTED FILM WITH TWO EXTRUDED POLYOLEFIN LAYERS - Film structures containing a biaxially oriented film with an extruded polyolefin layer on each side of the biaxially oriented film are obtained. One polyolefin layer may, for example, be fin sealed to exhibit a peelable heat sealable performance. The other polyolefin layer may exhibit a paper like appearance and may be lap sealable. | 01-16-2014 |
20140065315 | BIAXIALLY ORIENTED BIO-BASED POLYOLEFIN FILM THAT HAS BEEN EXTRUSION COATED WITH BIO-BASED SEALANT FOR LIDDING APPLICATIONS - A lidding film including a polyester film including a bio-based polyester, and an extrusion coated heat seal layer including a bio-based polymer. The polyester film may include a biaxially oriented core layer including bio-based polyester and an amorphous copolyester skin layer. The heat seal layer may include a low density polyethylene. | 03-06-2014 |
20140065398 | BIAXIALLY ORIENTED BIO-BASED POLYOLEFIN FILM THAT HAS BEEN EXTRUSION COATED WITH BIO-BASED SEALANT FOR LIDDING APPLICATIONS - A lidding film including a polyester film including a bio-based polyester, and an extrusion coated heat seal layer including a bio-based polymer. The polyester film may include a biaxially oriented core layer including bio-based polyester and an amorphous copolyester skin layer. The heat seal layer may include a low density polyethylene. | 03-06-2014 |
20140252001 | BARRIER LIDDING STRUCTURE BASED ON POLYPROPYLENE FILM - Multi-layer films suitable as sealable or peelable sheet that can be used for closing foodstuff containers are described. These multi-layer films includes a polymeric substrate layer and a seal or a peel-seal layer. The multilayer composite film preferably includes four component layers, namely in order, a polymeric base layer for mechanical strength, a thin organic barrier layer, an ethylene polymer-based adhesive layer, and a heat seal layer including an ethylene copolymer, such as ethylene vinyl acetate copolymer. The film is useful as a peelable heat sealable lid for containers of diverse polymer compositions storing various products such as foodstuffs and pharmaceuticals. | 09-11-2014 |
20140295076 | LOW SEAL INITIATION LID FOR RIGID SUBSTRATES - A polyolefin-based heat sealable and peelable lidding film. The peelable seal films comprise from 5 to 95 percent by weight of a polyolefin based plastomer or elastomer and from 5 to 95 percent by weight of a second plastomer or elastomer. The invention also relates to methods of making and using the heat sealable, peelable seal films, having improved low seal initiation temperature. | 10-02-2014 |
20140329015 | PEELABLE ANTIFOG COATED FILM FOR AMORPHOUS POLYESTER TRAYS - Described are antifog films useful for packaging food, and more particularly to antifog films that can be used as lidding films in trays made of amorphous polyester. The films may include at least one base layer or film, such as a polyester film, and a heat seal layer. The antifog layer is coated on the heat seal layer. The heat seal layer allows the antifog coating to more strongly adhere to the antifog film. The heat seal layer may be an amorphous polyester layer. | 11-06-2014 |
Simon Siu, Quincy, MA US
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20110196431 | CONSTRAINED MOTION BONE SCREW ASSEMBLY - A bone screw assembly includes an anchor portion and a head portion, such as a rod-receiving portion, movably mounted to the anchor portion to allow for controlled angulation between the anchor portion and the head portion. The anchor portion is pivotable in one or more selected directions about an axis relative to the head portion. A restriction member, which may be a rod seat, prevents the anchor portion from pivoting in one or more different directions about another axis relative to the head portion and/or a spinal fixation element received in the head portion. The restriction member may be inserted in the head portion to control direction that the anchor portion pivots relative to the head portion. The restriction member may also serve as a compression member and/or rod seat for seating a spinal rod coupled to the bone screw assembly. | 08-11-2011 |
20110282402 | INSTRUMENTS AND METHODS FOR MANIPULATING VERTEBRA - A method for manipulating a vertebra includes connecting a first bone anchor to a first vertebra, connecting a second bone anchor to a second bone anchor, positioning a spinal rod in a receiving member of the first bone anchor and in a receiving member of the second bone anchor, connecting a first instrument to the receiving member of the first bone anchor, and manipulating the first instrument to rotate first bone anchor and the first vertebra relative to the second vertebra. | 11-17-2011 |
20140188182 | INSTRUMENTS AND METHODS FOR MANIPULATING VERTEBRA - A method for manipulating a vertebra includes connecting a first bone anchor to a first vertebra, connecting a second bone anchor to a second bone anchor, positioning a spinal rod in a receiving member of the first bone anchor and in a receiving member of the second bone anchor, connecting a first instrument to the receiving member of the first bone anchor, and manipulating the first instrument to rotate first bone anchor and the first vertebra relative to the second vertebra. | 07-03-2014 |
Stephen W. Siu, Bloomfield, MI US
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20130161105 | Modular Battery Assembly Support and Seals - A battery assembly, or module, for a vehicle having a battery compartment that defines an opening in the floor. The battery module is disposed partially within the battery compartment and extends through an opening in the floor of a battery compartment to be partially disposed below the floor of the vehicle. A method of installing a battery module into a vehicle is also disclosed. The battery module is inserted partially into an opening in a floor of a battery compartment with a lower portion of the battery module being retained below the floor and an upper portion of the battery module being retained above the floor. A seal is attached between the battery module and the opening in the floor. | 06-27-2013 |
Stephen Wai-Fun Siu, Bloomfield, MI US
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20130249243 | CRASH BRACE FOR ENERGY MANAGEMENT - A crash brace is incorporated into a body structure of an automotive vehicle as an energy absorption and management device to assist in managing the energy during rear and side impact collisions, thereby protecting internal structures within the rear end of the vehicle. | 09-26-2013 |
Steve Siu, Bloomfield, MI US
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20120175177 | Vehicle Battery Pack Frame - The present disclosure relates to a battery assembly for a vehicle, including a battery module having a plurality of battery cells, and a frame configured to reinforce the battery module, the frame having an upper section and a lower section of different size or shape. | 07-12-2012 |
Tony Siu, Brookline, MA US
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20080287457 | Inhibitors of Akt Activity - The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention. These substituted naphthyridines have unexpected advantageous properties when compared to other naphthyridines reported in PCT publication WO2003/086394, such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on. | 11-20-2008 |
20100160309 | INHIBITORS OF JANUS KINASES AND/OR 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 - The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDK1 kinase inhibitory activity by administering the compound to a patient in need of treatment or prevention of myeloproliferative disorders or cancer. | 06-24-2010 |
20100197634 | INHIBITORS OF JANUS KINASES - The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer. | 08-05-2010 |
20100267707 | Tyrosine Kinase Inhibitors - The present invention relates to 4-indol-3-yl-N-phenylpyrimidin-2-amine derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals. | 10-21-2010 |
20110082136 | INHIBITORS OF JANUS KINASES - The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer. | 04-07-2011 |
20110245205 | AMINOPYRIMIDINES AS SYK INHIBITORS - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 10-06-2011 |
20120004240 | INHIBITORS OF AKT ACTIVITY - The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer. | 01-05-2012 |
20120220624 | PYRAZOLO [3,4-B] PYRIDIN-4-ONE KINASE INHIBITORS - The present invention is directed to novel kinase inhibitors of general formula (I) and pharmaceutically acceptable salts thereof, and to the use of the kinase inhibitors of general formula (I) for treating diseases or disorders in which tau phosphorylation and cell cycle regulation is implicated, such as Alzheimer's Disease and cancer. | 08-30-2012 |
20120277192 | AMINOPYRIMIDINES AS SYK INHIBITORS - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 11-01-2012 |
20130040933 | AZAINDOLES AS JANUS KINASE INHIBITORS - The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof. Compounds of formula I are inhibitors of Janus kinases and as such are useful for the treatment of various diseases and conditions mediated by said enzymes, such as rheumatoid arthritis, asthma, COPD, ALS, and the like. | 02-14-2013 |
20130225591 | IMIDOTHIAZOLE KINASE INHIBITORS - The present invention is directed to novel kinase inhibitors of general formula (I) and pharmaceutically acceptable salts thereof, and to the use of the kinase inhibitors of general formula (I) for treating diseases or disorders in which tau phosphorylation and cell cycle regulation is implicated, such as Alzheimer's Disease and cancer. | 08-29-2013 |
20140235641 | PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS - The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. | 08-21-2014 |
20140243290 | Aminopyrimidines as SYK Inhibitors - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 08-28-2014 |
20140243309 | CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS - The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. | 08-28-2014 |
20150191461 | PYRAZOLYL DERIVATIVES AS SYK INHIBITORS - The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer. | 07-09-2015 |
Tze L. Siu, Seattle, WA US
Patent application number | Description | Published |
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20090157239 | Vertical Gust Suppression System for Transport Aircraft - A method for vertical gust suppression due to turbulence for an aircraft having at least one of direct lift control surfaces or pitch control surfaces. The method includes sensing atmospheric turbulence, measuring the sensed atmospheric turbulence to generate turbulence data, generating a command based on the turbulence data, and applying the command to aircraft controls to actuate the direct lift control surfaces or the pitch control surfaces based on the turbulence data. Therefore, an aircraft response to the actuation of the direct lift control surfaces or the pitch control surfaces reduces a vertical acceleration, a pitch acceleration, a pitch rate, a pitch attitude or a structural load of the aircraft due to the turbulence. Thus, the method reduces the effects of vertical gusts of wind on the aircraft, improves the comfort level for aircraft passengers and crew, and reduces diversions the aircraft may take to avoid the turbulence. | 06-18-2009 |
Vince Siu, Providence, RI US
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20120183988 | INTEIN-BASED FLUORESCENT BIO-CIRCUIT FOR VITAMIN D DETECTION - This invention is directed to an intein-based vitamin D fluorescent biosensor that accurately and rapidly measures 1α,25-hydroxyvitamin D3. Measurement at picomolar quantities is noted. Particular reference is made to the use of | 07-19-2012 |
Yin-Fai Siu, Research Triangle Park, NC US
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20120276569 | METHODS FOR DETECTING LP-PLA2 ACTIVITY AND INHIBITION OF LP-PLA2 ACTIVITY - This invention relates to methods for determining the activity of Lp-PLA2 in at least one sample from an animal. The invention also relates to methods for determining the inhibition of Lp-PLA2 activity in samples from animals that are administered an Lp-PLA2 inhibitor. | 11-01-2012 |
20150017671 | METHODS FOR DETECTING LP-PLA2 ACTIVITY AND INHIBITION OF LP-PLA2 ACTIVITY - This invention relates to methods for determining the activity of Lp-PLA2 in at least one sample from an animal. The invention also relates to methods for determining the inhibition of Lp-PLA2 activity in samples from animals that are administered an Lp-PLA2 inhibitor. | 01-15-2015 |
Yin Fai Amy Siu, Research Triangle Park, NC US
Patent application number | Description | Published |
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20150247858 | METHODS FOR DETECTING LP-PLA2 ACTIVITY AND INHIBITION OF LP-PLA2 ACTIVITY - This invention relates to methods for determining the activity of Lp-PLA2 in at least one sample from an animal. The invention also relates to methods for determining the inhibition of Lp-PLA2 activity in samples from animals that are administered an Lp-PLA2 inhibitor. | 09-03-2015 |