Patent application number | Description | Published |
20080228151 | Transdermal drug delivery with controlled heat for treating musculoskeletal pain and/or inflammation - Systems and methods for transdermal drug delivery with controlled heat are provided. Such systems can comprise a heating apparatus that includes an exothermic chemical composition, typically in the form of individual heating elements. The heating apparatus can be exposed to ambient oxygen through a cover. The cover can reduce the amount of ambient oxygen capable of contacting the chemical composition compared to when the cover is not present. In some embodiments, the heating apparatus can include more than one heating element. The systems can further include a drug-containing layer that includes a drug. The drug-containing layer can have a surface area of about 50 cm | 09-18-2008 |
20090005745 | Transdermal drug delivery systems for delivering anti-inflammatory drugs - Systems for delivering an anti-inflammatory drug and methods for treating osteoarthritis are provided. Such systems can comprise, in one embodiment, a transdermal patch with a sufficient amount of anti-inflammatory drug in a formulation for sustained transdermal delivery at a human skin site. The system can further include a permeation composition or device, such as a heating device. The heating device can be configured for application over the transdermal patch and the human skin site. Further, the heating device can be configured for heating the human skin site to a specific temperature range from 36° C. to 42° C., and for maintaining the human skin site within that temperature range for a period of at least 4 or 5 hours. | 01-01-2009 |
20090175945 | Systems, Methods, and Formulations for Topically Treating Nail Fungal Infections and Nail Psoriasis - The present invention is drawn to systems, methods, and formulations for treating nail disorders. The system comprises an active agent formulation and a first barrier film. The active agent formulation includes an active agent and an aqueous liquid component. The first barrier film is configured to form a sheath over at least a portion of a finger or toe on which the nail is located. An optional second barrier film, with lower moisture vapor transmission rate than the first barrier film, is placed between the first barrier film and the active agent formulation (or between the active agent formulation and the external environment) to reduce the water evaporation from the active agent formulation. The sheath is configured to be capable of securing and retaining the active agent formulation within the sheath on a finger nail or toe nail while reducing evaporation of the liquid component of the aqueous liquid component of the active agent formulation. The active agent formulation can be a “slow-molding” hydrogel formulation that can slowly flow into the exact shape of the diseased nail to assure intimate contact and continuous delivery of the drug, while cannot be squeezed out of the position during the application. | 07-09-2009 |
20100267678 | FLUX-ENABLING COMPOSITIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS - The present invention is drawn to adhesive solidifying formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein at least one non-volatile solvent is a flux-enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated. | 10-21-2010 |
20120294907 | TWO OR MORE SOLIDIFYING AGENT-CONTAINING COMPOSITIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS - The present invention is drawn to adhesive solidifying formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and at least two solidifying agents. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent, wherein at least one non-volatile solvent is flux-enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated. | 11-22-2012 |
20120294926 | TWO OR MORE VOLATILE SOLVENT-CONTAINING COMPOSITIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS - The present invention is drawn to adhesive formulations and methods of drug delivery. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least two volatile solvents, and a non-volatile solvent system including at least one non-volatile solvent, wherein at least one non-volatile solvent is capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated. | 11-22-2012 |
20120301517 | TWO OR MORE NON-VOLATILE SOLVENT-CONTAINING COMPOSITIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS - The present invention is drawn to adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can have a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least two non-volatile solvents. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated. | 11-29-2012 |
20130022564 | COMPOSITIONS AND METHODS FOR DERMALLY TREATING INFECTIONS - The present invention is drawn to solidifying adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug for treating various skin infections, such as fungal, bacterial, and/or viral skin infections. The formulation can include anti-infective drug, solvent vehicle, and solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The non-volatile solvent system can facilitate the delivery of the drug at therapeutically effective rates for sustained periods of time. The non-volatile solvent system can also act to plasticize the solidifying agent. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated. | 01-24-2013 |
20140314815 | ADHESIVE SOLID GEL-FORMING FORMULATIONS FOR DERMAL DRUG DELIVERY - The present invention is drawn to adhesive solid gel-forming formulations, methods of drug delivery, and solidified gel layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a gelling agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein at least one non-volatile solvent is flux-enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified gel layer after at least a portion of the volatile solvent system is evaporated. The solidified gel layer is can be removed by peeling or washing. | 10-23-2014 |
20150025051 | FORMULATIONS FOR TREATING SKIN DISORDERS - The present invention is drawn to adhesive solidifying formulations for treating skin disorders, such as dermatitis or psoriasis. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent, wherein the non-volatile solvent system is capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated. | 01-22-2015 |
20150126481 | ADHESIVE PEEL-FORMING FORMULATIONS FOR DERMAL DELIVERY OF DRUGS AND METHODS OF USING THE SAME - The present disclosure is drawn to an adhesive peel-forming formulation for dermal delivery of a drug, comprising a drug, a solvent vehicle, and a polymer peel-forming agent. The solvent vehicle can comprise a volatile solvent system comprising one or more volatile solvent, and a non-volatile solvent system comprising two or more non-volatile solvents. The non-volatile solvent system can have a solubility with respect to the drug that is within a window of operable solubility such that the drug is deliverable at therapeutically effective rates over a sustained period of time. | 05-07-2015 |
Patent application number | Description | Published |
20150220073 | PROGRESSIVE PROFILING IN AN AUTOMATION SYSTEM - A computer-implemented method for progressive profiling in a home automation system is described. Data related to a premises and an occupant of the premises may be analyzed and one or more observations may be made based on the analysis of the data. Upon detecting one or more conditions associated with the one or more observations made, an offer to perform one or more actions may be communicated to the occupant. | 08-06-2015 |
20150220513 | SYSTEMS AND METHODS FOR PERSONIFYING COMMUNICATIONS - Systems and methods are described for personifying communications. According to at least one embodiment, the computer-implemented method for personifying a natural-language communication includes observing a linguistic pattern of a user. The method may also include analyzing the linguistic pattern of the user and adapting the natural-language communication based at least in part on the analyzed linguistic pattern of the user. In some embodiments, observing the linguistic pattern of the user may include receiving data indicative of the linguistic pattern of the user. The data may be one of verbal data or written data. Written data may include at least one of a text message, email, social media post, or computer-readable note. Verbal data may include at least one of a recorded telephone conversation, voice command, or voice message. | 08-06-2015 |
20150222578 | USER MANAGEMENT METHODS AND SYSTEMS - Methods and systems are described for managing and adding user profiles to access an automation system. According to at least one embodiment, the computer-implemented method includes receiving a request to add a user to an automation system. The request is generated from one of a mobile computing device or an automation controller of the automation system. The method further includes receiving contact information for the user and generating a message to send to the user. The message includes an invitation to the automation system. The method also includes sending the message to the user. | 08-06-2015 |
Patent application number | Description | Published |
20090099165 | Protein Kinase Inhibitors - Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: | 04-16-2009 |
20110212929 | Protein Kinase Inhibitors - Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: | 09-01-2011 |
20120277229 | SUBSTITUTED 3-(1H-BENZO[D]IMIDAZOL-2-YL)-1H-INDAZOLE ANALOGS AS INHIBITORS OF THE PDK1 KINASE - In one aspect, the invention relates to substituted 3-(1H-benzo[d]imidazol-2-yl)-1H-indazole analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the PDK1 kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions for treating disorders associated with dysfunction of the PDK1 kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 11-01-2012 |
20120283261 | SUBSTITUTED N-PHENYLPYRIMIDIN-2-AMINE ANALOGS AS INHIBITORS OF THE AXL KINASE - In one aspect, the invention relates to substituted N-phenylpyrimidin-2-amine analogs, derivatives thereof, and related compounds, which are useful as inhibitors of Axl kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions for treating disorders associated with dysfunction of the Axl kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 11-08-2012 |
20130059847 | SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS - In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 03-07-2013 |
20130302303 | PROTEIN KINASE INHIBITORS - Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: | 11-14-2013 |
20140094445 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS - In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 04-03-2014 |
20140163017 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS - In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 06-12-2014 |
20150018349 | SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS - In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 01-15-2015 |
20150150864 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS - In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 06-04-2015 |
Patent application number | Description | Published |
20080225474 | APPARATUS, SYSTEM, AND METHOD FOR SCALABLE, COMPOSITE, RECONFIGURABLE BACKPLANE - An apparatus, system, and method are disclosed for a scalable, composite, reconfigurable backplane. The backplane is made up of one or more blade aggregation modules which provide switching for attached devices. The blade aggregation module connects to transition cards that then connect with blade modules. The blade aggregation module provides connectivity to the connected modules, which may connect to a second blade aggregation module through the transition cards. The transition cards may additionally connect with unit aggregation modules to connect rows of blade modules together. Transition cards can also provide outside connectivity. The backplane, made up of blade aggregation modules, transition cards, and unit aggregation modules, is highly scalable and versatile, and also provides an unblocked airflow path to facilitate cooling the blades. | 09-18-2008 |
20100113992 | Vibrating Massage Roller Utilizing a Plurality of Supports and Eccentric Weights - The present invention is a vibrational roller utilizing a motorized vibrational drive using a plurality of eccentric weights and associated supports. The weights are positioned along the axis of rotation in a manner to synchronize them and minimize vibrational dissipation throughout the roller. Each weight has at least one associated support. The supports then transmit vibrational forces to the surface of the roller in an evenly distributed manner. A second co-operational motor may be used to extend motor life and aid in initiating vibrations. A control panel and associated circuitry are utilized to alter vibrational characteristics. The roller may be battery powered or powered through a standard wall outlet. The roller itself is manufactured of a durable yet deformable material, such as foam rubber, and may be inserted into selectable sleeves of varying physical properties for desired effect. | 05-06-2010 |
Patent application number | Description | Published |
20110240005 | Thermally Actuated Turntable for Conventional/Convection Cooking Ovens - The present invention is a thermally actuated turntable suitable for conventional and convection cooking ovens, which posses uneven temperature/cooking characteristics. By means of coupling dissimilar materials, each having a wide variance in their respective coefficients of thermal expansion, the relative linear expansion of these materials caused by the ambient heat found in the cooking chamber of an oven can be utilized in such a way as to create a thermo-linear motor and thus produce relatively small linear displacements of the actuator with relatively high force capabilities. This linear displacement can then be magnified by means of the mechanical advantage of levers to produce sufficient linear displacement of a rack and pinion gear set which is capable of producing multiple rotations of an attached platter during a typical short duration cooking cycle. This slow speed rotational motion is very advantageous for cooking short duration food items. | 10-06-2011 |
20110314743 | Locking Jack for a Window Well Cover - A window well cover jack that is disclosed. The window well cover jack has three arms: a base arm, a support arm and an actuator handle, all connected to aid in the lifting of a window well cover and allow egress. In one embodiment, the jack is lockable in a stowed position. It is also possible to add a spring assist to aid in the lifting of a window well cover. Ideally, the window well cover jack is also lockable in a deployed position to aid in holding an ajar window well cover so as to facilitate escape. A simple link, which is easily broken by emergency crews with the proper tools but secure against intruders without said tools, connects the window well cover jack to a window well cover. | 12-29-2011 |
20130180873 | Field Optic Maintenance Kit - A portable field optics maintenance kit fit into the form of a cloth wallet. An easily portable compact wallet accessory to properly maintain and clean optics that are used in the field away from where most optics cleaning kits are stored. | 07-18-2013 |
20130181024 | Optical Support Device - Disclosed herein are embodiments of a device for transferring the weight of an optical device to the body of the person using that optical device. In some devices, a support harness with shoulder straps is used to bear the weight of the optical device transferred by a support frame. The support frame may be temporarily attached to the optical device and/or support harness for easy assembly and disassembly. In some embodiments, the support harness is collapsible into a compact size. | 07-18-2013 |
20130256475 | Article Supports and Adapters Therefor - Disclosed herein are embodiments of an adapter for affixing useful articles upon a support system. A first article adapter is provided. In some devices, binoculars are outfitted with a connecting rod that the adapter can snap into. Other article adapters include a camera mount and a gun mount. A second support adapter can then be attached to a stand, such as a tripod, bipod, or monopod, or other support structure using known means. | 10-03-2013 |
20150121737 | Firearm Handgrip with Tool Component - A handgrip for a firearm is disclosed. The handgrip features a tool, in particular a melee component, stowed within a portion of the handgrip, the remaining portion of the melee component forming a finger guard. A latch is provided to hold the melee component in the stowed position. The interface of the melee component with the handgrip component may be either a rotatable interface, utilizing a lower pivot point and a latch such that the melee component may be rotated out of the handgrip or may be a sliding interface, with the melee component sliding within a provided trench. Two latching mechanisms for a rotating interface are disclosed. Other tools, such as bipods and flashlights, may be adapted to also fit the provided trench. | 05-07-2015 |