Patent application number | Description | Published |
20110066623 | Methods and Systems for Compressing Indices - Systems and methods for compressing indices are described. In one aspect, a plurality of items are selected where each item has an entry in an inverted index and each item entry comprises a listing of articles that the item appears in. At least a first item entry and a second item entry are determined for compression and the second item entry is compressed into the first item entry resulting in a compressed first item entry. | 03-17-2011 |
20110191175 | Determining a Meaning of a Knowledge Item Using Document Based Information - Systems and methods that determine a meaning of a knowledge item using related information are described. In one aspect, a knowledge item is received, related information associated with the knowledge item is received, at least one related meaning based on the related information is determined, and a knowledge item meaning for the knowledge item based at least in part on the related meaning is determined. Several algorithms and types of related information useful in carrying out such systems and methods are described. | 08-04-2011 |
20120041959 | EDITING A NETWORK OF INTERCONNECTED CONCEPTS - Systems and methods that create and edit a network of interconnected concepts are disclosed. In one embodiment, a semantic engine implements a method comprising receiving a primary term representing a first concept to be added to a network of interrelated concepts, receiving at least one related term related to the primary term, receiving at least one relationship between the first concept and a second concept, receiving a strength value associated with the relationship, and adding the first concept to the network. | 02-16-2012 |
20120059828 | Methods and Systems for Compressing Indices - Systems and methods for compressing indices are described. In one aspect, a plurality of items are selected where each item has an entry in an inverted index and each item entry comprises a listing of articles that the item appears in. At least a first item entry and a second item entry are determined for compression and the second item entry is compressed into the first item entry resulting in a compressed first item entry. | 03-08-2012 |
20130232099 | Determining a Meaning of a Knowledge Item Using Document-Based Information - Systems and methods that determine a meaning of a knowledge item using related information are described. In one aspect, a knowledge item is received, related information associated with the knowledge item is received, at least one related meaning based on the related information is determined, and a knowledge item meaning for the knowledge item based at least in part on the related meaning is determined. Several algorithms and types of related information useful in carrying out such systems and methods are described. | 09-05-2013 |
20130232145 | METHODS AND SYSTEMS FOR EDITING A NETWORK OF INTERCONNECTED CONCEPTS - Systems and methods that create and edit a network of interconnected concepts are disclosed. In one embodiment, a semantic engine implements a method comprising receiving a primary term representing a first concept to be added to a network of interrelated concepts, receiving at least one related term related to the primary term, receiving at least one relationship between the first concept and a second concept, receiving a strength value associated with the relationship, and adding the first concept to the network. | 09-05-2013 |
Patent application number | Description | Published |
20080306130 | Inhibitors of ubiquitin E1 - The present invention features pyrazolidinyl compounds, pharmaceutical compositions of substituted pyrazolidinyl compounds and methods of treating a patient suffering from cancer or viral infection, the method comprising administering to a patient one or more pyrazolidinyl compounds of the invention. | 12-11-2008 |
20100048593 | DEAZAFLAVIN COMPOUNDS AND METHODS OF USE THEREOF - The present invention features 5-deazaflavin compounds, pharmaceutical compositions of 5-deazaflavin compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more 5-deazaflavin compounds of the invention. | 02-25-2010 |
20100305180 | INHIBITORS OF UBIQUITIN E1 - The present invention features pyrazolidinyl compounds, pharmaceutical compositions of substituted pyrazolidinyl compounds and methods of treating a patient suffering from cancer or viral infection, the method comprising administering to a patient one or more pyrazolidinyl compounds of the invention. | 12-02-2010 |
20120289569 | INHIBITORS OF UBIQUITIN E1 - The present invention features pyrazolidinyl compounds, pharmaceutical compositions of substituted pyrazolidinyl compounds and methods of treating a patient suffering from cancer or viral infection, the method comprising administering to a patient one or more pyrazolidinyl compounds of the invention. | 11-15-2012 |
Patent application number | Description | Published |
20090029319 | COMPONENTS FOR PERMANENT REMOVABLE AND ADJUSTABLE DENTURES AND BRIDGES - A locking cap for dental implants embedded in hard dental tissue, such as tooth stubs or bones. The locking caps are ovoidal in plan view and may be formed of materials, such as non-adherent polymers, that are rigid, but softer than the material of the dental implant. | 01-29-2009 |
20110053112 | DRILL WITH BANDED MARKINGS - A dental drill is used for preparing an osteotomy and includes a socket operably received in a hand piece; a shaft for cutting the osteotomy. The shaft has a tip end and bands that have a first and second edge. The second edge is further from the tip end than the first edge. The edges mark an osteotomy depth from a bone or a surgical length from a gingivus. | 03-03-2011 |
20110104637 | VARIABLY MOUNTABLE IMPLANT WITH STEPPED SOCKET - An implant for supporting a prosthetic tooth in an anatomically correct shape of a maxillary and/or mandibular central or lateral incisor includes a post for securing to a mandible of a patient; an abutment; and a socket having a bifurcated stepped shape. The bifurcated stepped shape defines a schematic-anatomical analog to the maxillary and/or mandibular central or lateral incisor. | 05-05-2011 |
20110281235 | COMPONENTS FOR PERMANENT REMOVABLE AND ADJUSTABLE DENTURES AND BRIDGES - A locking cap for dental implants embedded in hard dental tissue, such as tooth stubs or bones. The locking caps are ovoidal in plan view and may be formed of materials, such as non-adherent polymers, that are rigid, but softer than the material of the dental implant. | 11-17-2011 |
20130266911 | CROSS-RIDGE IMPLANT, DRILL, AND METHOD FOR IMPLANTATION - An implant system includes an implant and a stabilizer, which includes a manipulation portion for handling and locating the stabilizer, a main body comprising a manipulation channel, and a transverse channel for connecting the stabilizer and an implant, the transverse channel having an axis perpendicular to an axis of the manipulation channel. The implant includes a thread and the transverse channel includes threads for engaging the threads. The system further includes a jig fixture having a first arm and a second arm responsive to a manipulator; the first arm engages the manipulation portion, the second arm for engages the manipulation channel. | 10-10-2013 |
20130316303 | NARROWED IMPLANT BODY - A dental implant includes a crown socket; an abutment; and an implant body having a shank that includes a threaded portion and a narrowing portion for increasing an offset distance to a tooth root adjacent to the implant body, the narrowing portion having an absence of threads. In another embodiment, a dental implant includes an implant body having a threaded tip portion distal from the abutment, a shank portion between the tip and the abutment, the shank portion having an unthreaded portion and a threaded portion in one cross-section through the shank portion. | 11-28-2013 |
20150140510 | COMPONENTS FOR PERMANENT REMOVABLE AND ADJUSTABLE DENTURES AND BRIDGES - A locking cap for dental implants embedded in hard dental tissue, such as tooth stubs or bones. The locking caps are ovoidal in plan view and may be formed of materials, such as non-adherent polymers, that are rigid, but softer than the material of the dental implant. | 05-21-2015 |
20150351881 | COMPONENTS FOR PERMANENT REMOVABLE AND ADJUSTABLE DENTURES AND BRIDGES - A locking cap for dental implants embedded in hard dental tissue, such as tooth stubs or bones. The locking caps are ovoidal in plan view and may be formed of materials, such as non-adherent polymers, that are rigid, but softer than the material of the dental implant. | 12-10-2015 |
Patent application number | Description | Published |
20090286852 | RNA containing modified nucleosides and methods of use thereof - This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules. | 11-19-2009 |
20110086028 | PREVENTION OF HIV INFECTION - This invention relates to methods compositions and devices for inhibiting infection of a subject's host cell by HIV. Specifically, the invention relates to methods and compositions capable of inhibiting the binding and subsequent infection by HIV of a host cell through the inhibition of the interaction between gp-340 expressed on the cell surface and V3 loop on the HIV envelope and devices comprising these compositions. | 04-14-2011 |
20110143397 | RNA PREPARATIONS COMPRISING PURIFIED MODIFIED RNA FOR REPROGRAMMING CELLS - The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs. | 06-16-2011 |
20130111615 | RNA Containing Modified Nucleosides and Methods of Use Thereof | 05-02-2013 |
20130197068 | RNA Containing Modified Nucleosides and Methods of Use Thereof - This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules. | 08-01-2013 |
20130261172 | RNA Containing Modified Nucleosides and Methods of Use Thereof - This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules. | 10-03-2013 |
20140349320 | Using Adaptive Immunity to Detect Drug Resistance - The present invention relates to a method of using adaptive immunity to detect drug resistance in infectious diseases. The invention provides novel antigens associated with drug resistant MTB infection. | 11-27-2014 |
20150038558 | RNA Containing Modified Nucleosides and Methods of Use Thereof - This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules. | 02-05-2015 |
20150203540 | Cytoplasmic Tail Modifications to Boost Surface Expression and Immunogenicity of Envelope Glycoproteins - The invention provides compositions and methods for enhanced expression of a viral envelope protein. The invention provides a composition comprising a cytoplasmic tail modification to enhance surface expression of both HIV and non-HIV viral envelope proteins as wells as other membrane associated proteins resulting in increased immunogenicity. | 07-23-2015 |
20150315572 | RNA PREPARATIONS COMPRISING PURIFIED MODIFIED RNA FOR REPROGRAMMING CELLS - The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs. | 11-05-2015 |
20160030527 | Compositions and Methods for Treatment of Stroke - The present invention provides compositions and methods for treating stroke. The invention relates to inhibiting the level and/or activity of cell debris after the onset of stroke. In certain embodiments, the invention provides for the catabolism or inhibition of at least one of extracellular RNA, extracellular DNA, and extracellular ATP. | 02-04-2016 |
20160032316 | Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides - This invention provides purified preparations of an RNA, oligoribonucleotide, or polyribonucleotide comprising a modified nucleoside, and methods of assessing purity of purified preparations of an RNA, oligoribonucleotide, or polyribonucleotide comprising a modified nucleoside. | 02-04-2016 |
Patent application number | Description | Published |
20100062212 | Hydrocarbon reformer substrate having a graded structure for thermal control - A reformer substrate for supporting a catalyst in a hydrocarbon reformer, comprising a graded structure that is inhomogeneous either radially, longitudinally, or both. The inhomogeous graded structure components are selected and arranged to maintain the catalyst operating temperature during extended periods of catalytic inactivity. Selection is based primarily on heat capacity and/or thermal loss properties. Generally, the perimeter of the substrate, radially and/or longitudinally comprises a thick wall of high thermal mass materials to reduce conductive and radiated heat loss, and a high thermal capacity material within the substrate to reduce radiated heat loss. Preferred materials are open-cell rigid foams such as zirconia-toughened alumina reticulated foam, for negative thermal loads in endothermic reaction regimes, and zirconia-mullite honeycomb monolith, for positive or neutral thermal loads in exothermic or autothermic reaction regimes. | 03-11-2010 |
20110269033 | System for Adding Sulfur to a Fuel Cell Stack System for Improved Fuel Cell Stability - A system for adding sulfur to a fuel cell stack, having a reformer adapted to reform a hydrocarbon fuel stream containing sulfur contaminants, thereby providing a reformate stream having sulfur; a sulfur trap fluidly coupled downstream of the reformer for removing sulfur from the reformate stream, thereby providing a desulfurized reformate stream; and a metering device in fluid communication with the reformate stream upstream of the sulfur trap and with the desulfurized reformate stream downstream of the sulfur trap. The metering device is adapted to bypass a portion of the reformate stream to mix with the desulfurized reformate stream, thereby producing a conditioned reformate stream having a predetermined sulfur concentration that gives an acceptable balance of minimal drop in initial power with the desired maximum stability of operation over prolonged periods for the fuel cell stack. | 11-03-2011 |
20120251906 | System for Adding Sulfur to a Fuel Cell Stack System for Improved Fuel Cell Stability - A system for adding sulfur to a reformate stream feeding a fuel cell stack, having a sulfur source for providing sulfur to the reformate stream and a metering device in fluid connection with the sulfur source and the reformate stream. The metering device injects sulfur from the sulfur source to the reformate stream at a predetermined rate, thereby providing a conditioned reformate stream to the fuel cell stack. The system provides a conditioned reformate stream having a predetermined sulfur concentration that gives an acceptable balance of minimal drop in initial power with the desired maximum stability of operation over prolonged periods for the fuel cell stack. | 10-04-2012 |
Patent application number | Description | Published |
20080301016 | Method, System, and Computer Program Product for Customer Linking and Identification Capability for Institutions - In an enterprise where a database maintains multiple accounts for one or more business customers, a method, system, and computer program product correctly links accounts which are associated with a single location of a common business. Further hierarchical linkages are established between accounts associated with multiple locations of the common business. The linkages are established via matching rules, the matching rules including provisions for optimizing the quality of the account data, integrating account-related data from external sources, and assigning quality-of-matching factors to different kinds of account data. Both internal and external account data are utilized to create an integrated view, or “business demographics”, of the business structure of the single common business shared by the linked, hierarchically-related accounts. Separate accounts of separate businesses which are nonetheless related accounts may be associated with each other. Feedback loops may be used to correct both erroneous data and the linking rules. | 12-04-2008 |
20090070289 | Methods, Systems, and Computer Program Products for Estimating Accuracy of Linking of Customer Relationships - The disclosed methods, systems, and computer-program products allow a business to estimate linking errors in customer relationships in a database and to identify metrics that improve the linking accuracy. In an embodiment, a plurality of sample customer relationships are selected from a database to form a sample data set that is statistically representative of the database. Potential linking errors are then identified within the sample data set. The identified potential linking errors are then validated to identify actual linking errors in the sample data set. Once validated, the actual linking errors within the sample data set are used to estimate linking errors within the database. Further, the estimated linking errors in the database may be analyzed to identify one or more factors that contribute to the linking errors. | 03-12-2009 |
20090094237 | Methods, Systems, and Computer Program Products for Generating Data Quality Indicators for Relationships in a Database - The disclosed methods, systems, and computer-program products allow a business to generate data quality indicators for relationships in a database. In an embodiment, one or more relationships linked to a customer are retrieved from a database to form a set of relationships. A match confidence code is generated for each relationship based on a score generated by the comparison of customer data associated with the respective relationship and corresponding customer data obtained from an external industry database. A link confidence code is subsequently determined for the customer based on a score generated by the scores used to define the match confidence code for each relationship in the set of relationships and on internal data associated with each relationship in the set of relationships. The link confidence code for the customer and the match confidence codes and the respective scores for the set of relationships may be provided to an end user of the database in order to improve decisions made by the end user at the customer level. | 04-09-2009 |
20120030216 | Methods, Systems, and Computer Program Products for Generating Data Quality Indicators for Relationships in a Database - The disclosed methods, systems, and computer-program products allow a business to generate data quality indicators for relationships in a database. In an embodiment, one or more relationships linked to a customer are retrieved from a database to form a set of relationships. A match confidence code is generated for each relationship based on a score generated by the comparison of customer data associated with the respective relationship and corresponding customer data obtained from an external industry database. A link confidence code is subsequently determined for the customer based on a score generated by the scores used to define the match confidence code for each relationship in the set of relationships and on internal data associated with each relationship in the set of relationships. | 02-02-2012 |
20130031109 | METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR LINKING CUSTOMER INFORMATION - In a business where a database tracks customers and manages customer accounts, a method and system correctly link accounts with customers. The method entails reading customer information for a first customer and for a second customer, and then utilizing personal identification information obtained from other sources to determine if the first customer is the same as the second customer. If the first customer and the second customer are the same person, the first customer and the second customer are identified as being the same unique person. Accounts associated with the two customers are identified as belonging to the same unique person. Viewed another way, the method and system of the present invention takes an existing database of personal identification information, and cross-references that database against other sources of personal identification information to identify persons who appear to be separate persons, but who are actually one and the same individual. | 01-31-2013 |
20130325880 | Methods, Systems, and Computer Program Products for Generating Data Quality Indicators for Relationships in a Database - The disclosed methods, systems, and computer-program products allow a business to generate data quality indicators for relationships in a database. In an embodiment, one or more relationships linked to a customer are retrieved from a database to form a set of relationships. A match confidence code is generated for each relationship based on a score generated by the comparison of customer data associated with the respective relationship and corresponding customer data obtained from an external industry database. A link confidence code is subsequently determined for the customer based on a score generated by the scores used to define the match confidence code for each relationship in the set of relationships and on internal data associated with each relationship in the set of relationships. | 12-05-2013 |
20140188555 | IDENTIFYING AND MANAGING STRATEGIC PARTNER RELATIONSHIPS - Systems and methods that identify and manage partner relationships are disclosed. A third-party trustee collects and processes confidential customer information from more than one interested parties. The third-party trustee acts as a neutral intermediary between the parties. The third-party trustee processes and analyzes the information received from the various parties to identify mutual and/or prospective customers between the interested parties. The processing results may then be used for further analysis to help at least one of the interested parties to improve their marketing efforts, risk management, and servicing of their customers. | 07-03-2014 |
20160034467 | METHODS, SYSTEMS, AND COMPUTER PROGRAM PRODUCTS FOR GENERATING DATA QUALITY INDICATORS FOR RELATIONSHIPS IN A DATABASE - The disclosed methods, systems, and computer-program products allow a business to generate data quality indicators for relationships in a database. In an embodiment, one or more relationships linked to a customer are retrieved from a database to form a set of relationships. A match confidence code is generated for each relationship based on a score generated by the comparison of customer data associated with the respective relationship and corresponding customer data obtained from an external industry database. A link confidence code is subsequently determined for the customer based on a score generated by the scores used to define the match confidence code for each relationship in the set of relationships and on internal data associated with each relationship in the set of relationships. | 02-04-2016 |
Patent application number | Description | Published |
20110165133 | METHOD OF DE-DIFFERENTIATING AND RE-DIFFERENTIATING SOMATIC CELLS USING RNA - RNA prepared by in vitro transcription using a polymerase chain reaction (PCR)-generated template can be introduced into a cell to modulate cell activity. This method is useful in de-differentiating somatic cells to pluripotent, multipotent, or unipotent cells; re-differentiating stem cells into differentiated cells; or reprogramming of somatic cells to modulate cell activities such as metabolism. Cells can also be transfected with inhibitory RNAs, such as small interfering RNA (siRNA) or micro RNA (miRNA), or combinations thereof to induce reprogramming of somatic cells. For example, target cells are isolated from a donor, contacted with one or more RNA's causing the cells to be de-differentiated, re-differentiated, or reprogrammed in vitro, and administered to a patient in need thereof. The resulting cells are useful for treating one or more symptoms of a variety of diseases and disorders, for organ regeneration, and for restoration of the immune system. | 07-07-2011 |
20140213485 | Methods For Preparing cDNA From Low Quantities of Cells - Methods for preparing cDNA libraries from single and low quantities of cells are disclosed. The methods are based on the principles of multi-strand displacement amplification or semi-random primed polymerase chain reaction. The methods typically include a step of reverse transcription and subsequent amplification of cDNA. The methods can be adapted for preparation of cDNA libraries that are representative of mRNA or whole RNA expressed by the cell or cells. The cDNA is suitable for sequencing or microarray analysis. | 07-31-2014 |
20140249212 | Compositions and Methods for Transient Expression of Recombinant RNA - Compositions for transient but prolonged exogenous mRNA expression through the use of the transcription system of negative strand RNA viruses, and methods of use thereof are disclosed. In some embodiments, the system contains only RNAs and does not include any DNA molecules. The compositions typically include an RNA template unit (rTeUn) that includes a virus regulatory sequences operably linked to a coding sequence of interest. The rTeUn is typically transfected to a host cell's cytoplasm in the presence of virus expression system proteins that mediate replication of the rTeUn and transcription of the transgene. The rTeUn RNA bonded to viral proteins exhibits high resistance to degradation, prolonged duration of expression, and is free of viral genes. The compositions can be used to reprogram cell. For example, the compositions and methods can be used to redirected lymphocytes to target cancer cells, or to dedifferentiate somatic cells into induce pluripotent stem cells. | 09-04-2014 |
20150368694 | METHODS FOR CLOSED CHROMATIN MAPPING AND DNA METHYLATION ANALYSIS FOR SINGLE CELLS - Methods of identifying DNase I Hyper-Resistant Sites (DHRS), or in board sense, highly compact chromatin and characterizing the DNA methylation status of DMRs such as CpG islands and CpG island shores are provided. The methods are particularly useful for analysis of genomic DNA from low quantities of cells, for example, less than 1,000 cells, less than 100 cells, less than 10 cells, or even one cell, and can be used to generate chromatin and methylation profiles. The downstream analyses include in parallel massive sequencing, microarray, PCR and Sanger sequencing, hybridization and other platforms. These methods can be used to generate chromatin and DNA methylation profiles in drug development, diagnostics, and therapeutic applications are also provided. | 12-24-2015 |
Patent application number | Description | Published |
20150099753 | FORM 5 POLYMORPH OF 7-(TERT-BUTYL-D9)-3-(2,5-DIFLUOROPHENYL)-6-((1-METHYL-1H-1,2,4-TRIAZOL-5-- YL)METHOXY)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE - The present invention provides individual crystalline polymorphs of 7-(tert-Butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine designated Form 5. The Form 5 polymorph disclosed herein is characterized according to one or more of (a) powder X-ray diffraction data (“XRPD”); (b) differential scanning calorimetry (“DSC”); (c) FT-Raman spectroscopy; (d) FT-IR spectroscopy; and (e) thermogravimetric analysis (TGA). | 04-09-2015 |
20150119398 | FORM 2 POLYMORPH OF 7-(TERT-BUTYL-D9)-3-(2,5-DIFLUOROPHENYL)-6-((1-METHYL-1H-1,2,4-TRIAZOL-5-- YL)METHOXY)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE - The present invention provides the Form 2 crystalline polymorph of 7-(ieri-Butyl-d9)-3-(2,5-difluorophenyl)-6((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine. The polymorph disclosed herein is characterized according to one or more of (a) powder X-ray diffraction data (“XRPD”); (b) differential scanning calorimetry (“DSC”); (c) FT-Raman spectrum; (d) FT-IT spectrum; and (e) thermogravimetric analysis (TGA). | 04-30-2015 |
20150158870 | POLYMORPHS OF 7-(TERT-BUTYL-D9)-3-(2,5-DIFLUOROPHENYL)-6-((1-METHYL-1H-1,2,4-TRIAZOL-5-- YL)METHOXY)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE - The present invention provides individual crystalline polymorphs of 7-(tert-Butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine designated Form 1, Form 3 and Form 4. Each polymorph disclosed herein is characterized according to one or more of (a) powder X-ray diffraction data (“XRPD”); (b) differential scanning calorimetry (“DSC”); and (e) thermogravimetric analysis (TGA). | 06-11-2015 |