Michael Adler
Michael Adler, Riehen CH
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20110044977 | Subcutaneous anti-HER2 antibody formulations and uses thereof - The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g. Trastuzumab (HERCEPTIN™), Pertuzumab or T-DM1, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-HER2 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided. | 02-24-2011 |
20110076273 | Highly Concentrated Pharmaceutical Formulations - The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-CD20 antibody, such as e.g. Rituximab, Ocrelizumab, or HuMab | 03-31-2011 |
20110158987 | NOVEL ANTIBODY FORMULATION - This invention relates to a pharmaceutical formulation of an antibody against Epidermal Growth Factor Receptor (EGFR), a process for the preparation and uses of the formulation. | 06-30-2011 |
20120128687 | NOVEL ANTIBODY FORMULATION - Pharmaceutical liquid formulation of an antibody against human OX40L, a process for the preparation and uses of the formulation. | 05-24-2012 |
20130216532 | Subcutaneous anti-HER2 Antibody Formulations and Uses Thereof - The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g. Trastuzumab (HERCEPTIN™), Pertuzumab or T-DM1, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-HER2 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided. | 08-22-2013 |
20130251725 | Anti-P-Selectin Antibody Formulation - The present invention relates to a stable liquid pharmaceutical formulation comprising 40 mg/ml to 200 mg/ml of an antibody against P-selectin; 0.01% to 0.1% of a poloxamer; 5 mM to 100 mM of a buffer; and 100 mM to 500 mM of at least one stabilizer; at a pH in the range from 4.5 to 7.0. | 09-26-2013 |
20150086537 | HIGHLY CONCENTRATED PHARMACEUTICAL FORMULATIONS - The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-CD20 antibody, such as e.g. Rituximab, Ocrelizumab, or HuMab | 03-26-2015 |
Michael Adler, Langen-Debstedt DE
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20100143925 | CONJUGATE COMPLEXES FOR ANALYTE DETECTION - The present invention relates to novel conjugate complexes for immunoassays as well as kits comprising these conjugate complexes, methods of producing these complexes, and methods of detecting an analyte by use of these complexes. The conjugate complexes of the invention comprise one or more non-nucleic acid receptors capable of specifically binding an analyte, one or more nucleic acid markers comprising a predetermined nucleotide sequence, one or more first linker molecules capable of specifically binding the non-nucleic acid receptor and the nucleic acid marker, and one or more second linker molecules capable of specifically binding the first linker molecules. | 06-10-2010 |
20100291562 | METHOD FOR THE DETECTION OF AN ANALYTE IN BIOLOGICAL MATRIX - The present invention relates to a method for the highly sensitive Immuno-PCR detection of an analyte in a sample comprising the use of a nucleic acids containing sample dilution buffer for diluting the sample as well as methods for the preparation of the sample dilution buffer and the use thereof. | 11-18-2010 |
Michael Adler, Holzweissig DE
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20100239392 | BOOK BINDING MACHINE AND METHOD FOR OPERATING A BOOK BINDING MACHINE - A book binding machine includes a collating machine, a perfect binder and a transfer device disposed between the collating machine and the perfect binder. The collating machine and the perfect binder are actuated by a common control device. In each case, one transport segment is assigned to a respective book block clamp by the control device. The control device also has a program which, if a defective or missing book block clamp is detected, actuates the collating machine in such a way that no book block is collated for that book block clamp. A method for operating a book binding machine is also provided. | 09-23-2010 |
Michael Adler, Freiburg DE
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20090162352 | ANTIBODY FORMULATION - The present invention relates to a pharmaceutical formulation comprising an anti-CD20 antibody. The formulation may additionally comprise a buffer, a surfactant and/or an isotonicity agent. | 06-25-2009 |
20100098712 | Pharmaceutical formulation of an antibody against OX40L - Pharmaceutical formulations of an antibody against OX40L and processes for making the same. | 04-22-2010 |
Michael Adler, Leipzig DE
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20090047101 | Book Binding Machine with a Book Block Transport System and Lubrication Clamp for a Book Block Transport System in a Book Binding Machine - A book binding machine includes a book block transport system and a plurality of clamps for clamping stacks of leaves. The clamps are disposed at a distance from each other and are guided in guide tracks of a machine frame. The book block transport system includes a clamp, which is also referred to as a lubrication clamp, having a device for lubricating the guide track. An applicator is assigned to each track roller of the clamp, and the lubricant is transferred to the track rollers through the use of a respective applicator such as a brush. The track rollers transfer the lubricant to contact surfaces of the guide track. A lubrication clamp for a book block transport system in a book binding machine, is also provided. | 02-19-2009 |
20120163942 | BOOK BINDING MACHINE WITH A BOOK BLOCK TRANSPORT SYSTEM AND LUBRICATION CLAMP FOR A BOOK BLOCK TRANSPORT SYSTEM IN A BOOK BINDING MACHINE - A book binding machine includes a book block transport system and a plurality of clamps for clamping stacks of leaves. The clamps are disposed at a distance from each other and are guided in guide tracks of a machine frame. The book block transport system includes a clamp, which is also referred to as a lubrication clamp, having a device for lubricating the guide track. An applicator is assigned to each track roller of the clamp, and the lubricant is transferred to the track rollers through the use of a respective applicator such as a brush. The track rollers transfer the lubricant to contact surfaces of the guide track. A lubrication clamp for a book block transport system in a book binding machine, is also provided. | 06-28-2012 |
Michael Adler, Bel Air, MD US
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20090023706 | Method of Treating Organophosphorous Poisoning - The present invention is directed to various methods for treating organophosphorus poisoning in an animal that is at risk of exposure to an organophosphorus compound or preventing organophosphorus poisoning in an animal that has been exposed to an organophosphorus compound, by administering a therapeutically effective amount of galantamine or a salt thereof, or a biologically active analog, derivative, fragment or variant thereof. | 01-22-2009 |
20110144093 | METHOD OF TREATING ORGANOPHOSPHOROUS POISONING - A method for treating organophosphorous poisoning (OP) comprising administering to a mammal at risk for OP poisoning an OP poisoning-inhibiting amount of galantamine. | 06-16-2011 |
Michael Adler, Murzelen CH
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20080289542 | Hydraulic Binder - In a hydraulic binder containing slags, aluminium-silicates and calcium sulphate, slag, in particular furnace slag, in amounts below 50% (w/w) as well as aluminium-silicates different from furnace slag, as for example flue-ash and natural aluminium-silicates, as for example basalt or andesite, in amounts of 5 to 75% (w/w) respectively related to the entire blend with the requirement that the stm of slag and aluminium-silicates is between 82 and 95.9% (w/w) and as one of the activators CaSO | 11-27-2008 |
Michael Adler, Kfar Vradim IL
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20130041234 | FLOW RATE METER - The present invention is flow rate meters which are able to accurately measure the volumetric rate of flow of a liquid through a conduit without requiring foreknowledge of the physicochemical characteristics of the liquid, e.g., for the purpose of calibration of the thermal mass flow rate. One application of the flow meters of the invention is to incorporate them in a system for measuring the flow rate of urine excreted by a catheterized patient. The invention also provides methods for using the flow rate meters. | 02-14-2013 |
20140116128 | METHOD AND APPARATUS FOR MEASURING THE FLOW RATE OF A LIQUID - The invention is an apparatus and method for measuring the flow rate of a liquid through a conduit. The apparatus is based on a flow rate meter which is adapted to accurately measure the volumetric flow rate of a liquid using a simple, cost and energy effective, and accurate method using only one temperature sensor. The method is based on applying a pulse of thermal energy to the flowing liquid and measuring the temperature increase as a function of time and energy input. By comparing these measurements to a calibration table made by performing similar measurements for known flow rates, the rate of flow can be determined. One application, which will be described to illustrate the features of the method and apparatus of the invention, is measurement of the flow rate of urine excreted by a catheterized patient. | 05-01-2014 |
Michael Adler, Dallas, TX US
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20130210413 | METHOD OF INHIBITING FUNCTIONS OF A MOBILE COMMUNICATIONS DEVICE - A method of inhibiting a function of a multi-function portable personal communications device includes determining a first position of the personal communications device, after a predetermined time interval, determining a second position of the personal communications device, determining the distance between the first position and the second position, determining the time interval in which the personal communications device moved from the first position and the second position, calculating an average velocity of the personal communications device based on the first position, the second position and the time interval and, if the average velocity of the personal communication device exceeds a predetermined value, inhibiting a function of the personal communications device. | 08-15-2013 |
Michael Adler, Newton, MA US
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20140201506 | METHOD FOR DETERMINING INSTRUCTION ORDER USING TRIGGERS - A processing engine includes separate hardware components for control processing and data processing. The instruction execution order in such a processing engine may be efficiently determined in a control processing engine based on inputs received by the control processing engine. For each instruction of a data processing engine: a status of the instruction may be set to “ready” based on a trigger for the instruction and the input received in the control processing engine; and execution of the instruction in the data processing engine may be enabled if the status of the instruction is set to “ready” and at least one processing element of the data processing engine is available. The trigger for each instruction may be a function of one or more predicate register of the control processing engine, FIFO status signals or information regarding tags. | 07-17-2014 |
Michael Adler, Framingham, MA US
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20140282821 | SYSTEMS AND METHODS FOR IDENTIFYING A SECURE APPLICATION WHEN CONNECTING TO A NETWORK - A computer system receives, from a user device, a request to access a resource within a network of an organization and receives access credentials associated with an application, a user and the user device. The computer system identifies an application identifier, a user identifier and a device identifier and determines whether the combination of these identifiers satisfies an access policy. If the combination of application identifier, user identifier and device identifier satisfies the access policy, then the computer system grants the application access to the resource within the network of the organization. | 09-18-2014 |