Stein, NJ
Adam Stein, Jersey City, NJ US
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20120041904 | SYSTEM AND METHOD FOR MANAGING CONTINUED ATTENTION TO DISTANCE-LEARNING CONTENT - Management of a user's continued attention to distance learning content using a general purpose computer having a central processing unit and an operating system configured to run multiple program applications concurrently. A memory stores the distance learning content. A distance learning module comprises code executable on the central processing unit, as one of the multiple program applications. The distance learning module presents the distance learning content to a user and is operable to interrupt a presentation of the distance learning content in response to prescribed events concerning another one of the multiple program applications. A method executing on a computer that an concurrently run multiple applications identifies events concerning an application other than the distance learning application, processes the identified events so as to identify a prescribed event among the identified events, and interrupts the presentation of the distance learning content in response to the prescribed event. | 02-16-2012 |
Adam Stein, Kenilworth, NJ US
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20130291415 | Poster Hanger System - The current invention discloses an easy to use poster hanger system. According to the invention a support rail is attached to the ceiling. A sign support element is attached to the support rail via sign support strings. By releasing sign support strings from string cassettes locating in the support rail, the sign support element can be pulled down for attachment of the upper end of a poster along its full length to the sign support element. The lower end of the poster is optionally attached along its full length to a bottom support element. The sign can be pushed up to a desired height by pushing the sign support element up while the sign support string is rolled back onto the string cassettes. | 11-07-2013 |
Alan Jay Stein, Junction, NJ US
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20110029684 | STAGGERCASTING WITH TEMPORAL SCALABILITY - In the transmission of streams of data, such as coded video, staggercasting, in which a primary and a secondary stream are transmitted at some relative time offset (i.e., “staggered”), allows a receiver to pre-buffer frames of the secondary stream to replace frames of the primary stream that may have been lost in transmission. In an illustrative implementation, staggercasting is performed in which the secondary stream contains a subset of the coded video frames transmitted in the primary stream. The primary stream contains reference frames, which are essential to properly decoding the video data, as well as disposable frames which are not. The secondary stream, however, contains copies of the reference frames and may contain copies of some of the disposable frames or no disposable frames at all. When frames of an interleaved stream of the primary and secondary streams are lost, such an arrangement will allow reconstruction at the receiver of an uninterrupted video stream at a temporarily reduced frame rate. | 02-03-2011 |
Alan Jay Stein, Princeton, NJ US
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20100150249 | STAGGERCASTING WITH NO CHANNEL CHANGE DELAY - An Advanced Television Systems Committee Digital Television (ATSC DTV) mobile, or handheld, device comprises a receiver for receiving a signal that includes a mobile DTV channel, which is transmitted in StaggerCast form comprising an FEC (Forward Error Correcting) stream and an encoded stream delayed in time from the FEC stream for conveying program content. The receiver decodes the received encoded stream for providing the program content and, if errors are detected in the received encoded stream, uses the received FEC stream to attempt to correct the errors. However, when the uses changes programs, or channels, to a different StaggerCast stream, the receiver decodes a received encoded stream of the different StaggerCast stream for providing the new program content even though for an initial period of time error correction by the receiver is severely limited. | 06-17-2010 |
20110211633 | LIGHT CHANGE CODING - An encoding methodology for a video encoder encodes target light change (TLC) frames in order to improve the quality of the resulting decoded video. Backward prediction is applied instead of forward prediction to the frames that are detected as TLC frames. Additionally, the last frame of the TLC activity is forced to use only intra-coding modes. | 09-01-2011 |
Alexander Stein, Secaucus, NJ US
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20120183013 | DUAL WAVEBAND TEMPERATURE DETECTOR - There are many industrial applications in which non-contact temperature sensing is useful for increasing production speed and quality, such as printing, laminating, extrusion, and metal forming. Disclosed is a non-contact temperature determining apparatus which uses two wide wavelength bands integrating sensors to determine the radiance ratio of a target and thereby determine a corresponding temperature of the target. Also disclosed is a non-contact temperature determining apparatus in which a beam splitter passes one wide wavelength band to a sensor and reflects another distinct wide wavelength band to another sensor from which temperature can be determined. A disclosed embodiment of the dual waveband temperature detector improves upon traditional and currently available ratio pyrometers by further reducing the cost of the system, making installation and use easier, and improving temperature detection for low temperature industrial applications. | 07-19-2012 |
Cliff Stein, Tenafly, NJ US
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20150199724 | MANAGING INVENTORY OVERBOOKING AND SMOOTHING - A system, storage device, or method can provide fair allocation of advertising resources. In some implementations, a method can include identifying multiple advertisement slots, each of the advertisement slots being associated with a capacity constraint. The method can include receiving multiple advertisement reservations, each of the advertisement reservations requesting advertisement impressions at one or more of the advertisement slots. The method can include allocating a quantity of advertisement impressions to each advertisement reservation. The method can include calculating an overbooking score for each advertisement reservation. The overbooking score indicates a degree at which the advertisement reservation is satisfied by the quantity of advertisement impressions allocated to the advertisement reservation. A higher overbooking score indicates a lower degree of satisfaction. The method can include adjusting the quantity of the advertisement impressions allocated to each advertisement reservation so as to minimize a maximum overbooking score while maintaining a maximum total allocation. | 07-16-2015 |
Clifford Stein, Tenafly, NJ US
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20110131278 | SYSTEMS AND METHODS FOR PEER-TO-PEER BANDWIDTH ALLOCATION - Apparatus, systems, and methods can operate to provide efficient data transfer in a peer-to-peer network. A list of peer computers can be accessed and sorted by a data exchange metric. A requester peer is selected by traversing the list from a peer computer with a smallest data exchange metric to a peer computer with a largest data exchange metric to identify a peer computer with a pending data block request, the peer computer with the pending data block request being the requester peer and having an associated data exchange metric. A data block is then transmitted to the requester peer and the data exchange metric associated with the requester peer is updated to provide an updated data exchange metric for the requester peer. The list of peer computers can then be resorted. Additional apparatus, systems, and methods are disclosed. | 06-02-2011 |
David Stein, Succasunna, NJ US
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20100107784 | Actuated Septa and Systems and Methods Using the Same - A device, system, and method for passively sealing a vessel containing a fluid and for sampling the fluid without carry-over or cross-contamination between the fluid sampling device, the sealing septum, and the vessel contents. The device includes an actuated septum having a plurality of septum fingers, to passively seal the vessel, and an actuation device, to open the passive seal without carry-over or cross-contamination. Each of the plurality of septum fingers includes a corresponding rib portion. The actuation device can be an actuation ring having an annulus. The plurality of septum fingers and corresponding rib portions are disposed internal or substantially internal to the vessel, while the actuation device is disposed external to the vessel. | 05-06-2010 |
20130197539 | DEVICES, SYSTEMS AND METHODS FOR MINIMALLY INVASIVE SURGERY OF THE THROAT AND OTHER PORTIONS OF MAMMALIAN BODY - Featured are systems, devices and apparatuses for use in minimally invasive surgical, diagnostic or therapeutic methods and/or techniques, in particular methods and/or techniques for a mammalian throat. In particular embodiments, a dexterity apparatus including one or more dexterity devices is featured, where each of the dexterity devices comprises surgical tools and each is configured and arranged with end-tip dexterity for enhanced manipulation. A portion of the dexterity devices is snake like, which is re-configurable (i.e., can be bent) so as to in effect maneuver the surgical tool and put the tool in a desired position with respect to the surgical site. Another portion of the dexterity device includes the surgical tool thereby providing the capability of performing surgical actions such as sewing, gripping, soft tissue manipulation, cutting and suction of saliva, blood and other materials from the surgical site. | 08-01-2013 |
20130197540 | DEVICES, SYSTEMS AND METHODS FOR MINIMALLY INVASIVE SURGERY OF THE THROAT AND OTHER PORTIONS OF MAMMALIAN BODY - Featured are systems, devices and apparatuses for use in minimally invasive surgical, diagnostic or therapeutic methods and/or techniques, in particular methods and/or techniques for a mammalian throat. In particular embodiments, a dexterity apparatus including one or more dexterity devices is featured, where each of the dexterity devices comprises surgical tools and each is configured and arranged with end-tip dexterity for enhanced manipulation. A portion of the dexterity devices is snake like, which is re-configurable (i.e., can be bent) so as to in effect maneuver the surgical tool and put the tool in a desired position with respect to the surgical site. Another portion of the dexterity device includes the surgical tool thereby providing the capability of performing surgical actions such as sewing, gripping, soft tissue manipulation, cutting and suction of saliva, blood and other materials from the surgical site. | 08-01-2013 |
Ivan F. Stein, Short Hills, NJ US
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20130112210 | Oral Sleep Apnea Device - An oral sleep apnea device is a dental appliance designed to advance the lower jaw of a user suffering from sleep apnea while reducing lingual discomfort and the risk of harmful tooth movement and rotation during use. The present invention accomplishes this through the use of a maxillary and a mandibular dental plate coupled to the upper and lower jaw, respectively, without direct contact with the incisal or labial surfaces of the anterior teeth. Both appliances comprise a lingual surface mount. The maxillary dental plate comprises an advancement mechanism. The advancement mechanism being operatively engaged to the mandibular dental plate repositions the mandibular plate to a forward location relative to the maxillary dental plate. During the repositioning of the mandibular dental plate the mandibular lingual surface mount distributes pressure evenly to the lingual surfaces on the lower jaw, reducing localized pressure points which can cause tooth movement. | 05-09-2013 |
Jacob Ari Stein, Morristown, NJ US
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20100258359 | PORTABLE ELECTRONIC WRITING PAD - The present invention provides a writing pad device, comprising (a) a writing pad device base having a front writing surface; a plurality of writing pad device wireless signal receivers; a plurality of wireless writing pad device transmitters; a power source; and (b) a writing implement device, comprising a writing implement body having a top end portion central body portion a bottom end; a conventional writing tip capable of transferring physical material to a surface, wherein the conventional writing tip is positioned at the most terminal portion of the bottom end of the writing implement; a wireless writing tip transmitter capable of transmitting a wireless signal, positioned at the bottom end of the writing implement device, closely positioned to the conventional writing tip; a writing implement transmitter power source; and at least one activation switch, capable of controlling power to the transmitter. | 10-14-2010 |
Jeffrey Stein, Cliffwood, NJ US
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20090161657 | METHOD AND APPARATUS FOR ASSURING VOICE OVER INTERNET PROTOCOL SERVICE - In one embodiment, the present invention is a method and apparatus for assuring Voice over Internet Protocol service. In one embodiment, a system for assuring Voice over Internet Protocol service includes a performance management platform for collecting performance management data from a plurality of sources in a Voice over Internet Protocol network, for detecting at least one abnormal event in accordance with the collected performance management data, and for reporting a volume of traffic in the Voice over Internet Protocol network and a trouble ticketing system for generating a ticket identifying a root cause of the abnormal event(s). | 06-25-2009 |
20090304165 | METHOD AND APPARATUS FOR DETECTING NETWORK AND SERVICE PERFORMANCE DEGRADATIONS USING CALL DETAIL RECORDS - A method and apparatus that employ the use of CDRs to effectively monitor and proactively respond to network or service events that impact performance within a network are disclosed. For example, the method receives a plurality of call detail records (CDRs), wherein each of the plurality of call detail records comprises a plurality of fields. The method determines a n-field rule signature from each of the call detail records (CDRs), and analyzes the n-field rule signatures from the plurality of call detail records (CDRs) for detecting at least one network performance problem. | 12-10-2009 |
20100054437 | APPARATUS AND METHOD FOR MANAGING PRIORITY COMMUNICATION - A system that incorporates teachings of the present disclosure may include, for example, a server having a controller to obtain billing data associated with a plurality of calls over a Voice Over Internet Protocol network, determine special service calls being made based on the billing data, monitor for the special service calls being associated with at least one of one calling number or one network node, and determine an undesired condition based at least in part on the special service calls being made from the one calling number or through the one network node exceeding a threshold. Other embodiments are disclosed. | 03-04-2010 |
20100097947 | VoIP Network Element Performance Detection for IP NSEP Special Service - A system and method for receiving performance measurements for a communications network, generating alerts based on each performance measurement and a corresponding performance threshold, receiving network traps from network elements of the communications network, each network trap being generated by the network element based on a process measurement and a corresponding process threshold and correlating the alerts and the network traps to generate correlated alerts. | 04-22-2010 |
20100128860 | METHODS, COMPUTER PROGRAM PRODUCTS, AND SYSTEMS FOR MANAGING VOICE OVER INTERNET PROTOCOL (VOIP) NETWORK ELEMENTS - Methods, computer program products, and systems for managing VoIP network elements are provided. Methods include receiving call details records (CDRs) from a plurality of network elements. The received CDRs including disconnect cause codes and telephone call correlation identifiers. The received CDRs are correlated to telephone calls based on the telephone call correlation identifiers. Two CDR records are associated with the same telephone call when their telephone call correlation identifiers are the same. A master correlated CDR is created for each telephone call. The creating includes assigning a correlated disconnect cause code and classifying the telephone call. The assigning and classifying are responsive to the received CDRs associated with the telephone call. The master correlated CDR includes the correlated disconnect cause code and the telephone call classification. A threshold crossing alert (TCA) is generated in response to a threshold for the correlated disconnect cause code being reached. | 05-27-2010 |
20100142514 | METHOD AND APPARATUS FOR CORRELATION OF DATA SOURCES IN A VOICE OVER INTERNET PROTOCOL NETWORK - In one embodiment, a method for managing a Voice over IP (VoIP) network includes collecting a first set of data from a first source of network performance management data, each data item in the first set of data corresponding to a call made using the VoIP network; collecting a second set of data from a second source of network performance management data, each data item in the second set of data corresponding to a call made using the VoIP network and being of a different type than the first set of data; correlating the first set of data and the second set of data such that a data item from the first set of data is matched with a data item from the second set of data that corresponds to a common call made over the VoIP network; and outputting a performance report based on the correlating. | 06-10-2010 |
20110122773 | METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT, FOR CORRELATING SPECIAL SERVICE IMPACTING EVENTS - Special service impacting events in an IP network are collected and correlated. Real-time data representing occurrence of trunk group events impacting special services in trunk groups that are in service is collected, along with call detail records recorded by network elements representing occurrence of call events impacting special services and performance measurements of network elements representing occurrence of events affecting performance of the network elements impacting the special services. The collected real-time data representing occurrence of trunk group events, collected call detail record and collected performance measurements are correlated, and alarms are generated based on the correlated data. | 05-26-2011 |
20120033544 | METHOD AND APPARATUS FOR CORRELATING AND SUPPRESSING PERFORMANCE ALERTS IN INTERNET PROTOCOL NETWORKS - A method and apparatus for correlating and suppressing performance alerts in a packet network are disclosed. In one embodiment, a method for handling alerts in a packet network includes receiving a plurality of alerts relating to one or more faults in the packet network, wherein the plurality of alerts is generated from information contained in a plurality of call detail records, correlating the plurality of alerts into one or more sets of performance alerts, each of the one or more sets of performance alerts being associated with a common one of the one or more faults, and suppressing at least one further alert relating to at least one of the one or more sets. | 02-09-2012 |
20120328083 | Methods, Computer Program Products, And Systems For Managing Voice Over Internet Protocol (VOIP) Network Elements - Methods, computer program products, and systems for managing VoIP network elements are provided. Methods include receiving call details records (CDRs) from a plurality of network elements. The received CDRs including disconnect cause codes and telephone call correlation identifiers. The received CDRs are correlated to telephone calls based on the telephone call correlation identifiers. Two CDR records are associated with the same telephone call when their telephone call correlation identifiers are the same. A master correlated CDR is created for each telephone call. The creating includes assigning a correlated disconnect cause code and classifying the telephone call. The assigning and classifying are responsive to the received CDRs associated with the telephone call. The master correlated CDR includes the correlated disconnect cause code and the telephone call classification. A threshold crossing alert (TCA) is generated in response to a threshold for the correlated disconnect cause code being reached. | 12-27-2012 |
Joshua Stein, Hoboken, NJ US
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20140277205 | ROD INSERTER AND INSERTION TUBE - A spinal rod insertion instrument includes a hollow, monolithic body having a proximal end and a distal end. The body defines a passageway that extends along a first axis between the proximal and distal ends. The distal end includes first and second arms defining a slot therebetween. The first and second arms are configured to releasably retain a spinal rod therebetween. Also provided is a method of securing a spinal rod to a coupling element attached with a pedicle screw. | 09-18-2014 |
20140277206 | SYSTEMS AND METHODS FOR PERCUTANEOUS SPINAL FUSION - A system for percutaneous spinal fusion may include two spaced apart blades connected together by a coupling such that the blades define a percutaneous pathway from a skin incision to an implanted pedicle fastener. The coupling may be c-shaped and may have at least one flexible tab for engaging one or more holes along the length of the blades. If one of the blades becomes disconnected from the pedicle fastener, a supplemental access device may be provided comprising a tubular body having a channel therein for receiving the other of the blades. If both of the blades become disconnected, a supplemental access device may be provided comprising a gripping member received within a locking member. The gripping member may have two legs engageable with the pedicle fastener, and the locking member may move along the gripping member to prevent the legs from disengaging the pedicle fastener. | 09-18-2014 |
Neil Stein, Sea Girt, NJ US
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20150074015 | SYSTEM AND METHOD FOR DISSEMINATING A CERTIFIED ANALYSIS FOR REFERENCE MATERIALS - Systems and methods for disseminating information pertaining to a reference material or certified reference material are disclosed. In one embodiment, the system includes the certified reference material and a package containing same, the package comprising a storage medium that stores an information product in a machine-readable format, the information product comprising either a pointer to certified analysis data or the certified analysis data itself. In one embodiment, the method comprises adding a quantity of a certified reference material to a package, incorporating, on the package, a storage medium for storing the information product, and encoding the information product in the storage medium. | 03-12-2015 |
Peter T. Stein, Cherry Hill, NJ US
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20110229883 | Biochemical Markers for Disease States and Genes for Identification of Biochemical Defects - The present invention relates to a system utilizing biochemical markers and genetic markers to diagnose, predict, and/or monitor intervention of a number of diseases and conditions that have unresolved oxidative stress as an important component. The present invention relates generally to markers and assays for diagnosing, predicting, and monitoring disease, particularly disease-relevant oxidative stress and lipid metabolites and mediators. The oxidative stress, lipid metabolite and lipid mediator biochemical and genetic markers may be further combined with other disease associated or disease relevant markers in methods and assays for diagnosis, monitoring, and assessment of disease, particularly of complex diseases with multi-component factors. The system, methods and assays are applicable to various diseases, including autism, asthma, and Alzheimer's disease. | 09-22-2011 |
Philip Stein, Pennington, NJ US
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20110033393 | Hydrazone Compounds and Their Use - The present invention relates to hydrazone compounds of Formula I: | 02-10-2011 |
20140235593 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARB- OXAMIDES FOR ANTIMALARIAL THERAPIES - In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoquinoline-4-carboxamides; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating and/or preventing malaria. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 08-21-2014 |
Philip D. Stein, Pennington, NJ US
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20090011994 | NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS AND METHODS - The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I | 01-08-2009 |
20110003759 | NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS AND METHODS - The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I | 01-06-2011 |
20110144060 | SUBSTITUTED PYRAZINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS AND METHODS - The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I | 06-16-2011 |
Rhona Stein, Maplewood, NJ US
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20110171126 | Enhanced Cytotoxicity of Anti-CD74 and Anti-HLA-DR Antibodies with Interferon-Gamma - Disclosed herein are methods and compositions comprising interferon-γ (IFN-γ) and anti-CD74 or anti-HLA-DR antibodies. In preferred embodiments, the IFN-γ increases the expression of CD74 and/or HLA-DR in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 or anti-HLA-DR antibodies. The compositions and methods are of use to treat diseases involving CD74 | 07-14-2011 |
20120321556 | Enhanced Cytotoxicity of Anti-CD74 and Anti-HLA-DR Antibodies with Interferon-Gamma - Disclosed herein are methods and compositions comprising interferon-γ (IFN-γ) and anti-CD74 or anti-HLA-DR antibodies. In preferred embodiments, the IFN-γ increases the expression of CD74 and/or HLA-DR in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 or anti-HLA-DR antibodies. The compositions and methods are of use to treat diseases involving CD74 | 12-20-2012 |
Stanley Stein, East Brunswick, NJ US
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20080280813 | COMPLEX DRUG DELIVERY COMPOSITION AND METHOD FOR TREATING CANCER - The present invention relates to compositions and methods for producing a complex drug delivery system which specifically targets cancer cells, has an increase in cellular uptake, is cytotoxic, and suppresses antiapoptotic cellular defenses. | 11-13-2008 |
20090104254 | Controlled Release Hydrogels - Formulations and methods for their preparation including a hydrogel including a crosslinked matrix comprising a polymer, and a one or more liposomes containing a therapeutic agent. | 04-23-2009 |
20110033503 | DRESSING COMPOSITIONS AND METHODS - Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solutions are sprayed simultaneously through a common orifice. Cross-linking via formation of thioether or disulfide bonds is initiated upon mixing, providing rapid gelation. The hydrogel components can be derivatized with RGD peptides or analogs thereof to promote retention in/on a body compartment such as the skin, surface of the eye, or a mucosa such as the vaginal mucosa. The cross-links are reversed using a reducing solution enabling easy removal of the hydrogel by dissolution. Processes for preparation of the cross-linker, RGD derivatized PEG and RGD-linked agents are also disclosed. | 02-10-2011 |
20110087004 | ENHANCED ORAL TRANSCOMPARTMENTAL DELIVERY OF THERAPEUTIC OR DIAGNOSTIC AGENTS - The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent. | 04-14-2011 |
20110117024 | NANOCARRIER AND NANOGEL COMPOSITIONS - Novel classes of multi-arm polyalkylene oxide-based materials including PEG nanocarriers, nanogel particles, and aggregated nanogel particles are disclosed. These classes of compositions may be associated with therapeutic agents and targeting moieties, or visibility enhancing agents, and may have a modified surface structure. In some embodiments the PEG-based materials can be made to provide relatively high drug loads with improved solubility and targeted delivery. | 05-19-2011 |
20110135732 | MULTIPLE PHASE CROSS-LINKED COMPOSITIONS AND USES THEREOF - The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. The matrix may comprise one or more phases in addition to an aqueous phase, such as a solid and/or oil phase. The matrix of the invention has at least one controlled release in-vivo kinetic profile, and may have additional profiles for the same agent. The matrix may also comprise more than one therapeutic agent, and each additional therapeutic agent may have one or more controlled release in-vivo kinetic profile. | 06-09-2011 |
20120093723 | NANOCARRIER COMPOSITIONS AND METHODS - This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable difunctional moiety, as well as methods of using this nanocarrier. | 04-19-2012 |
20120183578 | POLYETHYLENE GLYCOL-BASED DENDRONS - The instant invention relates to polyethylene glycol-based dendrons, otherwise known as PEGtide dendrons, compositions thereof and methods of use. | 07-19-2012 |
20130072447 | ENHANCED ORAL TRANSCOMPARTMENTAL DELIVERY OF THERAPEUTIC OR DIAGANOSTIC AGENTS - The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent. | 03-21-2013 |
20140010862 | MULTIFUNCTIONAL BIODEGRADABLE PEG NANOCARRIER-BASED HYDROGELS FOR PREVENTING HIV TRANSMISSION - A multifunctional polyethylene glycol-based hydrogel that includes a multi-arm polyethylene glycol cross-linking unit covalently bound to at least four multi-arm polyethylene glycol nanocarrier units, wherein each nanocarrier unit includes an agent coupled to the nanocarrier unit and each agent is selected from pH-lowering agents, bioadhesion agents, microbicidal-spermicidal agents, and agents that inhibit free and cell-associated HIV binding, provided that each nanocarrier unit comprises a different agent. | 01-09-2014 |
20150087591 | Novel Composition for Extracorporeal Reduction of Beta-Amyloids and Process for Producing Thereof - The present invention provides a safe, reliable, and economical process for preparing an improved dialysis fluid formulation effective for extracorporeal treatment, through a blood filtration process, of a Beta-Amyloid associated pathological condition in a subject, said process comprises preparing a composition comprising KLVFF peptide, or a variant thereof, as the capturing and binding agent, and a carrier therefor, and mixing said composition with a dialysate solution. The process utilizes a compact, inexpensive, and simple standard dialysis machine that extracorporeally removes Beta-Amyloids without allowing escape of the Beta-Amyloids back into a subject's body, without having to intricately evaluate the performance and characteristics of a dialysis membrane, and without putting the health condition of the subject at risk. | 03-26-2015 |
Steven Bruce Stein, Morristown, NJ US
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20100258359 | PORTABLE ELECTRONIC WRITING PAD - The present invention provides a writing pad device, comprising (a) a writing pad device base having a front writing surface; a plurality of writing pad device wireless signal receivers; a plurality of wireless writing pad device transmitters; a power source; and (b) a writing implement device, comprising a writing implement body having a top end portion central body portion a bottom end; a conventional writing tip capable of transferring physical material to a surface, wherein the conventional writing tip is positioned at the most terminal portion of the bottom end of the writing implement; a wireless writing tip transmitter capable of transmitting a wireless signal, positioned at the bottom end of the writing implement device, closely positioned to the conventional writing tip; a writing implement transmitter power source; and at least one activation switch, capable of controlling power to the transmitter. | 10-14-2010 |
T. P. Stein, Cherry Hill, NJ US
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20110237669 | Polyunsaturated Fatty Acids Interactions and Oxidative Stress Disorders - This invention relates to the identification and treatment of the effects of products derived from oxidative pathways for polyunsaturated fatty acid (PUFA) metabolism, i.e., oxidative stress in a patient by monitoring the metabolism of DHA or by administering DHA. | 09-29-2011 |