Pratt, MA
Alex Pratt, North Andover, MA US
Patent application number | Description | Published |
---|---|---|
20150107019 | TOP-MOUNT TWIST-ON FAUCET - A top-mount faucet assembly includes a coupling mounted on a counter that selectively couples a faucet thereto. The counter coupling has a disc-shaped collar with two keepers and a land for selectively locking the faucet. The land has a v-shaped part and a n-shaped part. The faucet has a main valve body with a locking assembly. To couple the faucet to the counter coupling, the main valve body is placed over the coupling and turned clockwise so that slots align with the keepers to fix the faucet axially to the coupling. As the faucet rotates clockwise, the locking assembly rides along the v-shaped part until captured by the n-shaped part to lock the faucet in place rotationally. To uncouple the faucet from the coupling, a button is pushed so that the locking assembly moves radially inward out from the n-shaped part, then the faucet is turned counter-clockwise. | 04-23-2015 |
Daniel Pratt, Amesbury, MA US
Patent application number | Description | Published |
---|---|---|
20110176994 | Buoyant Polymer Particles for Delivery of Therapeutic Agents to the Central Nervous System - The invention provides compositions and methods for treating a subject who has suffered from a central nervous system disorder. More particularly, the invention provides sustained polymeric drug delivery systems for direct delivery of therapeutic agents into the central nervous system. | 07-21-2011 |
Dexter Pratt, Reading, MA US
Patent application number | Description | Published |
---|---|---|
20140288910 | System, method and apparatus for causal implication analysis in biological networks - Described are methods, systems and apparatus for hypothesizing a biological relationship in a biological system. A database of biological assertions is provided consisting of biological elements, relationships among the biological elements, and relationship descriptors characterizing the properties of the elements and relationships. A biological element may be selected from the database and a logical simulation may be performed within the biological database, from the selected biological element, through relationship descriptors, along a path defined by potentially causative biological elements to discern a biological element hypothetically responsible for the change in the selected biological element. The logical simulation may be either a backward logical simulation, performed upstream through the relationship descriptors to discern a hypothetical responsible biological element, or a forward logical simulation, performed downstream through the relationship descriptors to discern the extent to which the perturbation generates the observed change in the selected biological element. | 09-25-2014 |
Dexter R. Pratt, Reading, MA US
Patent application number | Description | Published |
---|---|---|
20090313189 | METHOD, SYSTEM AND APPARATUS FOR ASSEMBLING AND USING BIOLOGICAL KNOWLEDGE - Disclosed are methods, systems and apparatus for constructing assemblies of biological knowledge constituting a biological knowledge base, and for subsetting and transforming life sciences-related data and information into biological models to facilitate computation and electronic reasoning on biological information. A subset of data is extracted from a global knowledge base or repository to reconstruct a more specialized sub-knowledge base or assembly designed specifically for the purpose at hand. Assemblies generated by the invention permit selection and rational organization of seemingly diverse data into a model of any selected biological system, as defined by any desired biological criteria. These assemblies can be mined easily and can be logically reasoned with great productivity and efficiency. | 12-17-2009 |
20110270893 | System, method and apparatus for assembling and mining life science data - Method and system for managing and evaluating life science data. Life Science data is placed in a knowledge base, that may be used for a variety of analysis tasks. Creating a knowledge base from the life science data involves generating two or more nodes indicative of life science data, assigning to one or more pairs of nodes a representation descriptor that corresponds to a relationship between the nodes, and assembling the nodes and the relationship descriptor into a database, such that at least one of the nodes is joined to another node by a representation descriptor. In some embodiments, the representation descriptor includes a case frame that describes the relationships between elements of life science data. | 11-03-2011 |
Dexter Roydon Pratt, Reading, MA US
Patent application number | Description | Published |
---|---|---|
20120030162 | Method for quantifying amplitude of a response of a biological network - One or more measurement signatures are derived from a knowledge base of casual biological facts, where a signature is a collection of measured node entities and their expected directions of change with respect to a reference node. The knowledge base may be a directed network of experimentally-observed casual relationships among biological entities and processes, and a reference node represents a perturbation. A degree of activation of a signature is then assessed by scoring one or more “differential” data sets against the signature to compute an amplitude score. The amplitude score quantifies fold-changes of measurements in the signature. In one particular embodiment, the amplitude score is a weighted average of adjusted log-fold changes of measured node entities in the signature, wherein an adjustment applied to the log-fold changes is based on their expected direction of change. In an alternative embodiment, the amplitude score is based on quantity effects. | 02-02-2012 |
20120221506 | Method for quantifying amplitude of a response of a biological network - One or more measurement signatures are derived from a knowledge base of casual biological facts, where a signature is a collection of measured node entities and their expected directions of change with respect to a reference node. The knowledge base may be a directed network of experimentally-observed casual relationships among biological entities and processes, and a reference node represents a perturbation. A degree of activation of a signature is then assessed by scoring one or more “differential” data sets against the signature to compute an amplitude score. The amplitude score quantifies fold-changes of measurements in the signature. In one particular embodiment, the amplitude score is a weighted average of adjusted log-fold changes of measured node entities in the signature, wherein an adjustment applied to the log-fold changes is based on their expected direction of change. In an alternative embodiment, the amplitude score is based on quantity effects. | 08-30-2012 |
20130046726 | Determining whether a measurement signature is specific to a biological process - A “Specificity” statistic (or metric) is computed as a means to identify amplitude scores associated with a signature that can be attributed with high probability to a specific biological entity or process represented by the signature. Preferably, Specificity is computed by assessing a likelihood of a given null hypothesis, namely, that an amplitude score is not representative of the specific signature but, instead, is representative of a general trend in the applicable data set that can be measured by any signature that is comparable to the signature of interest. In a typical implementation, a first step to compute the Specificity metric is to construct a set of comparable signatures. Next, an amplitude score is computed for each of these signatures, preferably using the same data set. Then, the Specificity metric is computed, preferably as a two-tailed p-value, by placing the amplitude score for the signature of interest on a distribution of scores for the comparable signatures. Scores that have Specificity p-values less than a particular value, e.g., 0.05, are considered to be scores that can be attributed with high confidence to the signature of interest. | 02-21-2013 |
20140297573 | Method for quantifying amplitude of a response of a biological network - One or more measurement signatures are derived from a knowledge base of casual biological facts, where a signature is a collection of measured node entities and their expected directions of change with respect to a reference node. The knowledge base may be a directed network of experimentally-observed casual relationships among biological entities and processes, and a reference node represents a perturbation. A degree of activation of a signature is then assessed by scoring one or more “differential” data sets against the signature to compute an amplitude score. The amplitude score quantifies fold-changes of measurements in the signature. In one particular embodiment, the amplitude score is a weighted average of adjusted log-fold changes of measured node entities in the signature, wherein an adjustment applied to the log-fold changes is based on their expected direction of change. In an alternative embodiment, the amplitude score is based on quantity effects. | 10-02-2014 |
George W. Pratt, Melrose, MA US
Patent application number | Description | Published |
---|---|---|
20110269243 | SYSTEMS AND METHODS RELATED TO OPTICAL NANOSENSORS COMPRISING PHOTOLUMINESCENT NANOSTRUCTURES - Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described. | 11-03-2011 |
George W. Pratt, Waban, MA US
Patent application number | Description | Published |
---|---|---|
20140220346 | MODULAR POLYMER HYDROGEL NANOPARTICLES AND METHODS OF THEIR MANUFACTURE - In certain embodiments, a nano-sized vehicle (e.g., a nanogel comprising nanoparticles) is provided herein for drug delivery with tunable biodistribution, low toxicity, and degradability, and with demonstrated targeting to bone. The composition is useful, for example, in the treatment of bone disease, particularly bone metastases from cancers such as breast, prostate, or lung cancer. | 08-07-2014 |
Gill Pratt, Lexington, MA US
Patent application number | Description | Published |
---|---|---|
20090123896 | METHOD AND APPARATUS FOR HAPTIC SIMULATION - A haptic simulation method determines a location of a needle assembly within a magneto-rheological fluid. The needle assembly within the magneto-rheological fluid is associated with a desired resistance value. A viscosity control signal representative of the desired resistance value is generated. The viscosity control signal is applied to a viscosity control device to vary a viscosity of the magneto-rheological fluid to achieve the desired resistance value. | 05-14-2009 |
20090289584 | Ultra-compact, high-performance motor controller and method of using same - Featured is a controller for a motor that is ultra-compact, with a power density of at least about 20 watts per cubic cm (W/cm | 11-26-2009 |
20090295317 | Ultra-compact, high-performance motor controller and method of using same - Featured is a controller for a motor that is ultra-compact, with a power density of at least about 20 watts per cubic cm (W/cm | 12-03-2009 |
Gill A. Pratt, Lexington, MA US
Patent application number | Description | Published |
---|---|---|
20100185855 | Data Repository and Method for Promoting Network Storage of Data - In general, the invention features methods by which more than one client program connected to a network stores the same data item on a storage device of a data repository connected to the network. In one aspect, the method comprises encrypting the data item using a key derived from the content of the data item, determining a digital fingerprint of the data item, and storing the data item on the storage device at a location or locations associated with the digital fingerprint. In a second aspect, the method comprises determining a digital fingerprint of the data item, testing for whether the data item is already stored in the repository by comparing the digital fingerprint of the data item to the digital fingerprints of data items already in storage in the repository, and challenging a client that is attempting to deposit a data item already stored in the repository, to ascertain that the client has the full data item. | 07-22-2010 |
20120136459 | ACTIVE ANKLE FOOT ORTHOSIS - An Active Ankle Foot Orthosis (AAFO) is provided where the impedance of an orthotic joint is modulated throughout the walking cycle to treat ankle foot gait pathology, such as drop foot gait. During controlled plantar flexion, a biomimetic torsional spring control is applied where orthotic joint stiffness is actively adjusted to minimize forefoot collisions with the ground. Throughout late stance, joint impedance is minimized so as not to impede powered plantar flexion movements, and during the swing phase, a torsional spring-damper (PD) control lifts the foot to provide toe clearance. To assess the clinical effects of variable-impedance control, kinetic and kinematic gait data were collected on two drop foot participants wearing the AAFO. It has been found that actively adjusting joint impedance reduces the occurrence of slap foot, allows greater powered plantar flexion, and provides for less kinematic difference during swing when compared to normals. | 05-31-2012 |
20150127117 | ACTIVE ANKLE FOOT ORTHOSIS - An Active Ankle Foot Orthosis (AAFO) is provided where the impedance of an orthotic joint is modulated throughout the walking cycle to treat ankle foot gait pathology, such as drop foot gait. During controlled plantar flexion, a biomimetic torsional spring control is applied where orthotic joint stiffness is actively adjusted to minimize forefoot collisions with the ground. Throughout late stance, joint impedance is minimized so as not to impede powered plantar flexion movements, and during the swing phase, a torsional spring-damper (PD) control lifts the foot to provide toe clearance. To assess the clinical effects of variable-impedance control, kinetic and kinematic gait data were collected on two drop foot participants wearing the AAFO. It has been found that actively adjusting joint impedance reduces the occurrence of slap foot, allows greater powered plantar flexion, and provides for less kinematic difference during swing when compared to normals. | 05-07-2015 |
James M. Pratt, Needham, MA US
Patent application number | Description | Published |
---|---|---|
20100236169 | Wall panel system - A wall panel retention system including an upper panel retention structure incorporating the ceiling molding and a lower panel retention structure incorporating the base molding with retention structures for holding the sides of the wall panels to the building wall. | 09-23-2010 |
Jeffrey Pratt, Orange, MA US
Patent application number | Description | Published |
---|---|---|
20090311449 | METHOD OF MANUFACTURING AN INSULATED, IMPACT RESISTANT WINDOW - An insulated glass unit (IGU) is provided. The IGU meets the industry standards for impact resistance while significantly reducing the weight of the IGU compared to conventional IGUs. In particular, the two pane IGUs of the present invention can meet or exceed industry standards for various wind storm criteria while reducing the weight and cost of the IGU. The IGU only requires one layer of film to meet the performance of previous IOU designs that require two or more layers of film laminated to two or more surfaces of glass. | 12-17-2009 |
Jeffrey R. Pratt, Groton, MA US
Patent application number | Description | Published |
---|---|---|
20150227591 | System and Method for Automatically Validating Classified Data Objects - A method, system and computer-usable medium are disclosed for enhancing a classification system to include an automatic classification validation system. The automatic classification validation system takes the classification results and automatically validates them for correctness. More specifically, the automatic classification validation system analyzes the data objects in the categories and, if any outliers are identified, then determines a context of the data object from a plurality of records contained within a certain category to determine the context. The classification validation system then uses the context of the data object to validate the classification. | 08-13-2015 |
J. Mark Pratt, Berlin, MA US
Patent application number | Description | Published |
---|---|---|
20090240916 | Fault Resilient/Fault Tolerant Computing - A fault tolerant/fault resilient computer system includes a first coserver and a second coserver. The first coserver includes a first application environment (AE) processor and a first I/O subsystem processor on a first common motherboard. The second coserver includes a second AE processor and a second I/O subsystem processor on a second common motherboard. | 09-24-2009 |
Jonathan S. Pratt, Holden, MA US
Patent application number | Description | Published |
---|---|---|
20120018956 | SEAL ASSEMBLY - A seal assembly is disclosed for use between a housing and a rotatable shaft protruding exteriorly from the housing, with the shat being journalled for rotation in an eccentric cartridge which in turn is rotatably adjustable. The seal assembly comprises a circular flinger mounted on the shaft for rotation therewith. The flinger has radially outwardly projecting flanges defining an axial space therebetween. A seal carrier surrounds the flinger and has axially spaced first and second inner rims projecting radially inwardly into the space between the flanges of the flinger. Ring seals are carried by the seal carriers. The inner rims are resiliently urged to maintain the ring seals in contact with the flinger flanges. | 01-26-2012 |
Steven J. Pratt, Acton, MA US
Patent application number | Description | Published |
---|---|---|
20090161150 | LASER COLOR COPY IMAGE PROCESSING INDEPENDENT OF CLASSIFICATIONS - An apparatus and a method are described for processing and reproducing a document including both text and half-tone images without generating undesirable image artifacts. A band-pass FIR filter with a predetermined frequency response is used to transform pixels in an input image to sharpen text edge and smooth pre-half-toned areas, and perform error diffusion and cluster dot screening methods on the transformed pixels. The FIR filter has unity gain at DC to preserve image brightness. An integrated error diffused cluster-dot screening approach is used to suppress moiré and other image artifacts, while providing a robust, crisp output. | 06-25-2009 |