Patent application number | Description | Published |
20130216509 | CHIMERIC RECEPTORS WITH 4-1BB STIMULATORY SIGNALING DOMAIN - The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use. | 08-22-2013 |
20130266551 | CHIMERIC RECEPTORS WITH 4-1BB STIMULATORY SIGNALING DOMAIN - The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use. | 10-10-2013 |
20140302608 | Modified Effector Cell (or Chimeric Receptor) for Treating Disialoganglioside GD2-Expressing Neoplasia - A modified effector cell includes a non-reversibly produced vector-encoded anti-G | 10-09-2014 |
20140328812 | CHIMERIC RECEPTORS WITH 4-1BB STIMULATORY SIGNALING DOMAIN - The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use. | 11-06-2014 |
20140341869 | CHIMERIC RECEPTORS WITH 4-1BB STIMULATORY SIGNALING DOMAIN - The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use. | 11-20-2014 |
20150139943 | CHIMERIC RECEPTORS AND USES THEREOF IN IMMUNE THERAPY - Disclosed herein are chimeric receptors comprising an extracellular domain with affinity and specific for the Fc portion of an immunoglobulin molecule (Ig) (e.g., an extracellular ligand-binding domain of F158 FCGR3A or V158 FCGR3A variant); a transmembrane domain (e.g., a transmembrane domain of CD8α); at least one co-stimulatory signaling domain (e.g., a co-stimulatory signaling domain of 4-1BB); and a cytoplasmic signaling domain comprising an immunoreceptor tyrosine-based activation motif (ITAM) (e.g., a cytoplasmic signaling domain of CD3ζ). Also provided herein are nucleic acids encoding such chimeric receptors and immune cells expressing the chimeric receptors. Such immune cells can be used to enhance antibody-dependent cell-mediated cytotoxicity and/or to enhance antibody-based immunotherapy, such as cancer immunotherapy. | 05-21-2015 |
Patent application number | Description | Published |
20120221645 | AUTOMATIC MEDIA ASSET UPDATE OVER AN ONLINE SOCIAL NETWORK - An electronic program guide is displayed where the program guide indicates the various media being consumed by a plurality of users. Such users can be linked together via a relationship from a social networking website. In addition, the grid can display broadcast channel listings. The grid optionally provides the feature of adding and removing corresponding user and channel listings. | 08-30-2012 |
20120222061 | AUTOMATIC MEDIA ASSET UPDATE OVER AN ONLINE SOCIAL NETWORK - In response to a request for media, a determination is made whether a user should receive the requested media. When the user has the proper content privilege, a content manager will authorize the delivery of such content. Otherwise, alternative content is delivered to the user based on the content privileges. | 08-30-2012 |
20130219440 | APPARATUS AND METHOD FOR SIMULCAST OVER A VARIABLE BANDWIDTH CHANNEL - A method comprising the steps of outputting periodically a schedule for a transmission of a plurality of multimedia contents to a client receiver over a unidirectional data communication channel; transmitting said schedule to said client receiver over said communication channel before said transmission of said plurality of multimedia contents, said schedule including a metadata indicating a plurality of broadcast times for respective ones of said plurality of multimedia contents for selectively activating said client receiver in accordance with said plurality of broadcast times; estimating first and second available bandwidths of said communication channel at respective ones of first and second points in time; selecting one multimedia content file of a given compression level for transmission in response to a change of available bandwidth of said communication channel between said first and second points in time so that said plurality of multimedia contents may be received at said client receiver in accordance with respective ones of said plurality of broadcast times; and transmitting said selected multimedia content file to said client receiver. | 08-22-2013 |
20130232522 | SYSTEMS AND METHODS FOR REAL-TIME UNIFIED MEDIA PREVIEW - A centralized media device accesses media sources via a networked system to display a unified preview of media contents stored on different devices. The unified previews are provided in real-time, pushing previews to multiple user devices. The centralized media device can employ user profile information to tailor the unified previews to individuals. It can also employ external sources to obtain relevant content images and information to provide to a user. The centralized media device can operate independently of the type of media, media source and/or viewing devices. | 09-05-2013 |
20130268974 | ASSOCIATING INFORMATION WITH ELECTRONIC PROGRAM GUIDE ENTRIES - An information processor determines what media content is currently and/or could be displayed on a primary viewing screen. The information processor then mines other sources of information to obtain associated information. This information can then be accessed by a user as raw data and/or further processed by the information processor and then accessed by the user. Typically, the associated information is displayed on a secondary screen. This allows, for example, an electronic programming guide to be enhanced with additional information. | 10-10-2013 |
20140184470 | MULTI-SCREEN INTERACTIONS - A secondary screen device sends information relating to media content viewed on a primary screen device to the primary screen device. The information sent can be altered and/or unaltered information. The secondary screen device can send the information to the primary screen device automatically and/or manually via a user interface on the secondary screen device. In some instances, an intermediate device can be employed to relay the information from the secondary screen device to the primary screen device. The intermediate device can also process the information received from the secondary screen device before sending it to the primary screen device. | 07-03-2014 |
20140297632 | REALTIME SEARCH GRID UPDATES - A search engine performs searches on displayed information to facilitate in limiting the search results and increasing relevancy. The search engine allows user inputs to influence a search boundary and/or a search result. The search boundaries and/or search results can also be influenced by social networking information and the like. The search results can be dynamically filtered by the search engine as the user enters in their search criteria. The searched information is limited to what is visually seen by a user on a screen/display device. This significantly reduces the displayed results and lets the user instantly see what their search parameters will yield. | 10-02-2014 |
20150237179 | BACKWARD LOOKING ROBUST HEADER COMPRESSION RECEIVER - Robust Header Compression (ROHC) offers a way to compress packet header information for more efficient transmission of data. The compression is achieved through various confidence modes set up by the transmitter and the receiver. The Initialization and Refresh state (IR) is the first state of the compressor. This provides a complete, uncompressed context of the data that is being transmitted. In typically operation, the ROHC compressor will periodically transmit IR packets providing context information allowing the ROHC decompressor to decompress one or more packets following the IR packet. However, under certain conditions such as decompressor start-up, it is possible for the decompressor to miss an IR packet. Exemplary methods and apparatus are described in which a decompressor uses a later-received IR packet to decompress earlier packets for which the decompressor had not received context information. | 08-20-2015 |
20150256885 | METHOD FOR DETERMINING CONTENT FOR A PERSONAL CHANNEL - Creating a listing of suggested content and programming for a virtual channel is performed by generating rankings of previously viewed or accessed content. The method determines whether such content is either cyclical in nature as being related to a series or if such content is broadcasted less frequently. Once such rankings are determined, the listings of suggested (other) content will have a number of entries per time segment which represent the highest ranked suggested per time segment | 09-10-2015 |
Patent application number | Description | Published |
20080221320 | Process For The Preparation Of 10,11-Dihydro-10-Hydroxy-5H-Dibenz[B,F]Azepine-5-Carboxyamide - A process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxyamide by hydrolysis of 5-cyano-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine with peroxy compounds in alkali medium and in the presence of solvents. | 09-11-2008 |
20090105472 | Process for the preparation of (S)-(+)-10,11-Dihydro-10-hydroxy-5H-dibenz (B,F) azepine-5-carboxamide - (S)-(+)-10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxyamide is prepared starting from racemic 5-cyano-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine by phthaloylation, separation of the diastereomeric salts of the phthaloyl derivative with (S)-phenylethylamine, hydrolysis of the (S, S) salt to (S)-(+)-5-cyano-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine and hydrolysis of the nitrile group of the latter to amido group, by treatment with peroxy compounds in alkali medium. | 04-23-2009 |
Patent application number | Description | Published |
20120239671 | SYSTEM AND METHOD FOR OPTIMIZING AND ROUTING HEALTH INFORMATION - A method is disclosed to receive health information request (HIR), including health information request query (HIRQ) and health information request data (HIRD), and to metatag the received HIR. The metatagged HIR is reconciled based on a semantic concept and HIRS is returned. | 09-20-2012 |
20130124523 | SYSTEMS AND METHODS FOR MEDICAL INFORMATION ANALYSIS WITH DEIDENTIFICATION AND REIDENTIFICATION - A medical information navigation engine is useful in association with at least one electronic health record system. The engine decouples identifying information from clinical data from electronic health records. The clinical data includes clinical narrative having discrete data and textual data. The identifying information is stored. Additionally, the identifying information is associated with a token in the clinical data. The clinical data may then be indexed. The discrete data and the textual data in the clinical data may then be mined. Mining includes extracting at least one relevant event from the discrete data and the textual data. Next, the clinical data and identifying information may be reintegrated using the token. The event associated with the mined discrete data and textual data may then be exported. The system may also provide a validation tool for users, including clinicians, to search and view clinical data. The exported event may be used to alter treatment of a patient. | 05-16-2013 |
20130253949 | SYSTEMS AND METHODS FOR EXTRACTION OF CLINICAL KNOWLEDGE WITH REIMBURSEMENT POTENTIAL - A computerized Medical Information Navigation Engine (“MINE”) extracts clinical knowledge, by identifying coded elements with reimbursement potential contributing to payoff based on clinical history, and subtracting coded elements documented in an encounter from the coded elements, based on business logic. The MINE sorts the remaining coded elements in accordance with one optimization criteria to payoff based on clinical history. | 09-26-2013 |
20130262142 | SYSTEMS AND METHODS FOR MINING AGGREGATED CLINICAL DOCUMENTATION USING CONCEPT ASSOCIATIONS - A medical processor computes concept associations by mining aggregated data from patient documents thereby reducing risk of PHI exposure. The processor identifies clinically relevant terms in patient documents, compute associations between pairs of clinically relevant terms using co-occurrences, and filter out random associations. A knowledge provider receives user query concepts, retrieves patient concepts, and extracts relevant apixions from an association matrix. The knowledge provider intersects relevant apixions with patient concepts, ranks and provides the results to the user. | 10-03-2013 |
20130275153 | METHOD OF OPTIMIZING PATIENT-RELATED OUTCOMES - A medical information navigation engine (“MINE”) is provided. In some embodiments, the system computes a current patient encounter vector for a current patient encounter, and then an optimal patient encounter vector is computed by assuming a best case patient encounter in accordance with the organizational objectives. The system is then able to compute the difference between the best case encounter and the current patient encounter. This difference is used to compute a corresponding payoff using an intelligent matrix. | 10-17-2013 |
20140046697 | MEDICAL INFORMATION NAVIGATION ENGINE (MINE) SYSTEM - A medical information navigation engine (MINE) for transacting medical information by receiving medical information from a medical sources, identifying, mapping, and consolidating the received medical information by a back-end medical processor, presenting access to specific relevant data, based on a user's security privileges, within the identified, mapped, and consolidated medical information, based on user-specific functions or roles by a front-end medical processor, and generating user-customized processed medical information to a plurality of users, with at least a portion of the user-customize processed medical information being provided to each of the plurality of users based on its relevancy to each user's specific function or role and each user's associated security privileges. | 02-13-2014 |
20140200916 | SYSTEM AND METHOD FOR OPTIMIZING AND ROUTING HEALTH INFORMATION - A method is disclosed to receive health information request (HIR), including health information request query (HIRQ) and health information request data (HIRD), and to metatag the received HIR. The metatagged HIR is reconciled based on a semantic concept and HIRS is returned. | 07-17-2014 |