Molinaro, US
Annette Molinaro, New Haven, CT US
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20100081666 | SRC ACTIVATION FOR DETERMINING CANCER PROGNOSIS AND AS A TARGET FOR CANCER THERAPY - Methods of cancer diagnosis and prognosis using biomarkers. | 04-01-2010 |
20100144540 | CORRELATION OF MOLECULAR MARKERS WITH CLINICAL OUTCOME IN GBM PATIENTS RADIATION TREATED WITH OR WITHOUT GEFITINIB - Interestingly, for prognosis, the significant biomarkers for Gefitinib-treated GBM patients (RTOG 0211) appeared to differ compared to historical, RT and non-Gefitinib-treated GBM patients. In Gefitinib-treated patients, those with higher levels of nuclear pAKT driven by PTEN loss, higher levels of nuclear pMAPK, and lower levels of nuclear pmTOR had significantly worse clinical outcomes. In contrast, in non-Gefitinib-treated patients, patients with PTEN-deficiency, and higher levels of EGFRvIII, total EGFR, IGFR1, NFkB and lower levels of nuclear Survivin appeared to have adverse clinical outcomes, highlighting the treatment-dependency of these biomarkers. | 06-10-2010 |
20140142101 | CORRELATION OF MOLECULAR MARKERS WITH CLINICAL OUTCOME IN GBM PATIENTS RADIATION TREATED WITH OR WITHOUT GEFITINIB - Interestingly, for prognosis, the significant biomarkers for Gefitinib-treated GBM patients (RTOG 0211) appeared to differ compared to historical, RT and non-Gefitinib-treated GBM patients. In Gefitinib-treated patients, those with higher levels of nuclear pAKT driven by PTEN loss, higher levels of nuclear pMAPK, and lower levels of nuclear pmTOR had significantly worse clinical outcomes. In contrast, in non-Gefitinib-treated patients, patients with PTEN-deficiency, and higher levels of EGFRvIII, total EGFR, IGFR1, NFkB and lower levels of nuclear Survivin appeared to have adverse clinical outcomes, highlighting the treatment-dependency of these biomarkers. | 05-22-2014 |
Annette M. Molinaro, New Haven, CT US
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20120003639 | CANCER BIOMARKERS AND METHODS OF USE THEREOF - Embodiments are provided for characterizing a biological sample. In some embodiments, one can estimate the risk that a subject with ductal carcinoma in situ will have a subsequent DCIS event and/or invasive cancers. | 01-05-2012 |
Anthony Molinaro, Pasadena, CA US
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20100179879 | USE OF EXTENSIBLE MARKUP LANGUAGE IN A SYSTEM AND METHOD FOR INFLUENCING A POSITION ON A SEARCH RESULT LIST GENERATED BY A COMPUTER NETWORK SEARCH ENGINE - A database search apparatus and method for generating a search result list which responds to Extensible Markup Language (XML) requests from a client to a server of an on-line marketplace. A bid management tool is operable on a client computer to manage search listings and account information of one or more advertisers. The client application communicates with the server via an XML-based application program interface. The bid management tool provides functions for reporting account activity, modifying accounts and manual, timed or event-driven changes to search listings including listings of several advertisers. | 07-15-2010 |
20150051968 | Integrated Architecture for Performing Online Advertising Allocations - An improved architecture including system and methods for online advertising placement that provide possibly defaulting advertisement tags the opportunity to serve an advertisement ahead of a lower value tag that is guaranteed to fill, resulting in higher CPMs (i.e., Cost Per Mille) for web publishers. The system and methods are configured to deterministically render an advertisement impression from a list of possibly defaulting advertisements in a JavaScript-enabled web browser. The knowledge of the complete outcome of such an “ad chain” at render-time significantly reduces complexity and latency in the supporting ad server. The system and method centers around a novel JavaScript approach to detect when an advertisement has been loaded but not defaulted. Additionally, the system and methods integrate the network and RTB demand channels by looking at all demand sources simultaneously and selecting the buyer from within the user's browser, and address predictive pricing to further enhance the online advertising placement process. | 02-19-2015 |
Anthony Frank Molinaro, Pasadena, CA US
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20140058849 | System and Methods for Generating Dynamic Market Pricing for Use in Real-Time Auctions - A system and methods for generating dynamic market pricing that is fair for both publishers and advertisers and the use of the pricing in real-time auctions. When a user views content over the internet, an online publisher provides content to the user with executable instructions, which notify an advertisement source that there is an impression for filling by an advertiser. The impression is submitted to a real-time bidding market for competing advertisers to bid to fill the impression with an advertisement. The system and methods generate dynamic pricing for the individual competing advertisers and use the dynamic pricing to compare advertiser bids to determine a highest or winning bid and a clearing price associated with the highest or winning bid. | 02-27-2014 |
Carmela Molinaro, Colonia, NJ US
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20150112067 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS - The disclosure encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, having less steps and improved yields as compared to previous synthetic methods for making these compounds, which are CGRP receptor antagonists, useful for the treatment of migraine. Conditions for an amide bond formation between an acid and amine include for example reacting the compounds of Formulae B (after salt break) and C with an amide coupling reagent and optionally an additive and an acid and/or a base in a non-reactive solvent. | 04-23-2015 |
Carmela Molinaro, Lansdale, PA US
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20120035214 | RENIN INHIBITORS - The present invention relates to biaryl piperidine-based renin inhibitor compounds, and their use in treating cardiovascular events and renal insufficiency. | 02-09-2012 |
Carmela Molinaro, West Point, PA US
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20140200197 | HIV PROTEASE INHIBITORS - The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. | 07-17-2014 |
Frank Molinaro, Milwaukee, WI US
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20080252041 | INTELLIGENT INTERLOCK FOR A MOTORCYCLE STAND - A motorcycle including a frame, an engine mounted to the frame, and a stand movable between an extended position in which the stand supports the motorcycle and a retracted position. The motorcycle includes a sensor operable to generate a stand signal indicative of at least one of the extended and retracted positions of the side stand and a controller electrically coupled to the sensor to receive the stand signal. The controller is programmed for preventing operation of the engine based on the stand signal during a first operating condition of the motorcycle and is further programmed to allow running of the engine during a second operating condition of the motorcycle, regardless of the stand signal. | 10-16-2008 |
20110320063 | HANDLEBAR CONTROL SYSTEM - A handlebar control system for a motorcycle. The system includes a controller, a network interface, a plurality of user actuated devices coupled to the controller, an electronic switch coupled to the controller, a first connector having terminals linking to motorcycle power and a network bus, and a second connector coupled to a device external to the control system. | 12-29-2011 |
Joseph Molinaro, Irvine, CA US
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20090038075 | DEVICE FOR PROVIDING ELEMENTS FOR SURVIVAL - A device for providing elements of survival, including two components that attached together form a sealed compartment. One side of the compartment is substantially flat to enable the transportation of persons or materials, and has a number of handles to facilitate transportation. | 02-12-2009 |
Joseph Molinaro, Chicago, IL US
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20130056943 | DEVICE FOR PROVIDING ELEMENTS FOR SURVIVAL - A device for providing elements of survival, including two components that are attached together to form a sealed compartment. One side of the compartment is substantially flat to enable the transportation of persons or materials, and has a number of handles to facilitate transportation. | 03-07-2013 |
Katherine Molinaro, Eagan, MN US
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20130123164 | SOLID TABLET UNIT DOSE OVEN CLEANER - A solidification matrix includes sodium hydroxide, sodium carbonate, a water charge, an anhydrous metasilicate, a polycarboxylic acid polymer or salt or derivative thereof, and additional functional ingredients. The sodium hydroxide, sodium carbonate, a water charge, an anhydrous metasilicate, a polycarboxylic acid polymer, and additional functional ingredients interact to form a hydrate solid. The solidification matrix may be used, for example, in a solid detergent composition. Methods of making solid detergent compositions are disclosed. | 05-16-2013 |
Katherine J. Molinaro, Eagan, MN US
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20130139856 | LOW FOAMING SOLID SINK DETERGENT - The present disclosure relates to compositions for use in open washing devices and methods of cleaning articles in open washing devices using the disclosed compositions. The disclosed compositions are effective at cleaning articles using the relatively less intense mechanical action of an open washing device (versus the more intense mechanical action of a closed automatic dishwasher). The disclosed compositions also generate some foam to provide visual confirmation that there is a composition in the sink, but not so much foam that the foam becomes excessive when the agitator is turned on or that the generated foam overflows the sink. Finally, the disclosed compositions are less irritating to an operator's skin, which is at least partly attributed to the lower levels of free alkalinity in the composition as measured as percent sodium oxide. | 06-06-2013 |
Katherine J. Molinaro, Inver Grove Heights, MN US
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20100298190 | STABLE ANTIMICROBIAL COMPOSITIONS INCLUDING SPORE, BACTERIA, FUNGI AND/OR ENZYME - The present invention relates to a stable antimicrobial and cleaning compositions including an amine antimicrobial agent; a borate salt; and spores (bacterial or fungal), vegetative bacteria, fungi, or enzyme, and to methods of using the composition. The composition can also include a polyol. | 11-25-2010 |
20110207649 | STABLE ANTIMICROBIAL COMPOSITIONS INCLUDING SPORE, BACTERIA, FUNGI AND/OR ENZYME - The present invention relates to a stable antimicrobial and cleaning compositions including an amine antimicrobial agent; a borate salt; and spores (bacterial or fungal), vegetative bacteria, fungi, or enzyme, and to methods of using the composition. The composition can also include a polyol. | 08-25-2011 |
Katherine Joan Molinaro, Inver Grove Heights, MN US
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20090061017 | SHELF STABLE, REDUCED CORROSION, READY TO USE PEROXYCARBOXYLIC ACID ANTIMICROBIAL COMPOSITIONS - The present invention relates to shelf stable and/or less corrosive peroxycarboxylic acid antimicrobial compositions, including ready-to-use compositions. Shelf stable compositions can include defined ratios of hydrogen peroxide to peroxycarboxylic acid and/or hydrogen peroxide to protonated carboxylic acid, but need not include strong acid. Reduced corrosion compositions can include carboxylic acid and corrosion inhibitor at acid pH. Compositions of the invention can have advantageous activity against spores. | 03-05-2009 |
Luca Molinaro, New Castle, PA US
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20090283492 | Visual Tamper-Evident Conical Screw Cap and Neck Finish - A tamper-evident cap is disclosed including a closure member and an annular wall depending outward therefrom to a bottom rim. Annular wall has a flange or sealing member extending inwardly adjacent to the closure member and a plurality of threads spaced apart and helically positioned to cooperate with respective threads of a container neck finish having substantially the same outward shape. A band is circumferentially positioned around the bottom rim including a pull tab and teeth. The pull tab extends from a part of the band and is preferably positioned within the circumference of the band. The teeth are mounted on a boss each tooth having an inner face angled acutely relative to the rim and being designed fit with the neck finish. A cap in combination with a neck finish having a vertical wall for sealing engagement with the cap annular flange is also disclosed. | 11-19-2009 |
20110174761 | VISUAL TAMPER-EVIDENT CONICAL SCREW CAP AND NECK FINISH - A tamper-evident cap is disclosed including a closure member and an annular wall depending outward therefrom to a bottom rim. Annular wall has a flange or sealing member extending inwardly adjacent to the closure member and a plurality of threads spaced apart and helically positioned to cooperate with respective threads of a container neck finish having substantially the same outward shape. A band is circumferentially positioned around and attached to the bottom rim by ties, and includes a pull tab and teeth. The pull tab extends from a part of the band and is preferably positioned within the circumference of the band. The teeth have an inner face angled acutely relative to the rim and being designed fit with the neck finish. A cap in combination with a neck finish having a vertical wall for sealing engagement with the cap annular flange is also disclosed. | 07-21-2011 |
20120031871 | STEP TWIST ZIPPED VISUAL TAMPER-EVIDENT CAP AND NECK FINISH - A tamper-evident cap is disclosed having a circular closure member, a cylindrical annular wall depending generally from the periphery of the closure member terminating with a base and having a plurality of serrations, and a tamper-evident band circumferentially positioned around the base having teeth and attached to a portion of the base. The tamper-evident band may be mounted to the base by at least one of the teeth or attached by at least one of the serrations extending below the base. The interior and/or exterior of the cylindrical wall may be stepped. The tamper-evident band may have a groove between the teeth for retaining the tamper-evident band on a neck finish. A neck finish having at least one set of teeth and optional raised portions for securing the tamper-evident band in place is also disclosed. The neck finish may be stepped to correspond with a cap having a cylindrical wall with a stepped interior. A cap and neck finish combination for a container is also disclosed. | 02-09-2012 |
Mark Molinaro, Leo, IN US
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20100159726 | WIRING SYSTEM AND CONNECTOR THEREFOR - A wiring system that allows easy installation into a vehicle and includes a connector that allows functional signals to perform a function in a connector while passing through the connector. | 06-24-2010 |
20120170286 | INTEGRAL LAMP ASSEMBLY AND METHOD OF CONSTRUCTION THEREOF - An integral lamp assembly and method of construction thereof is provided. The integral lamp assembly includes a bulb and a plurality of terminals fixed to the bulb. The assembly further includes a socket having at least one through passage wherein the terminals extend through the at least one through passage. The assembly also includes a housing overmolded in bonded relation to at least one of the socket and the terminals such that the housing prevents the bulb from being removed from the socket and prevents the socket from being removed from the housing. | 07-05-2012 |
Mark C. Molinaro, Leo, IN US
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20140273573 | VEHICLE LAMP SOCKET ASSEMBLY - A vehicle lamp socket assembly includes a housing, a body, a sealant, and a terminal blade. The housing has a cavity and has a connector with a socket. The housing also has a pass-through spanning between the cavity and the socket. In assembly, the body is received in the housing and has a retainer that holds a vehicle lamp. The sealant is located at the pass-through and fills a section or more of the pass-through. And the terminal blade extends through the pass-through and through the sealant. | 09-18-2014 |
Matthew P. Molinaro, Eagan, MN US
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20140263404 | SOLID PRODUCT DISPENSER - A method and apparatus for dispensing a solution of a solid product in a fluid. A freestanding apparatus comprises an inlet portion through which fluid enters, a reaction portion in which the fluid encounters and dissolves the product to form a solution, and an outlet portion from which the solution exits the apparatus. Fluid may encounter the product from a single direction or multiple directions, and from the top or the bottom. The apparatus can include a fluid diverter for directing fluid to the desired portion of the solid product. The apparatus may be configured to receive a particularly shaped solid product, and may comprise a lid or gate to prevent fluid from contacting the product undesirably. | 09-18-2014 |
Michael Molinaro, New York, NY US
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20140174846 | PROTECTIVE CASE FOR A MOBILE DEVICE AND SOUND AMPLIFICATION FEATURE THEREOF - Protective cases for use with mobile devices (phones and tables) are disclosed herein and include a sound amplification feature which is integral to the case and serves to amplify the sound emitted from the speaker of the mobile device. | 06-26-2014 |
Nicholas L. Molinaro, Mendham, NJ US
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20120202186 | INTERACTIVE COMMUNITY NETWORK FOR YOUTH ATHLETICS - An interactive community network for youth athletics system, comprising a processor and memory comprising program instructions. The program instructions are executable by the processor to store a series of educational messages, each education message being associated with at least one youth athletics core development factor and a threshold range of aggregated numerical scores. Questions are issued, each question corresponding to a youth athletics core development factor. Selectable answers to each question are provided, each selectable answer corresponding to a numerical score. A series of user answers to the questions are received. The numerical scores by youth athletics core development factor are aggregated to create the aggregated numerical score for each corresponding youth athletics core development factor. One of the series of specific educational messages is selected for display when the aggregated numerical score for a corresponding youth athletics core development factor falls within the threshold range. | 08-09-2012 |
Tom Molinaro, Pleasant Hill, CA US
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20090159641 | Forming Solder Balls on Substrates - A mask (stencil) having cells (openings) is disposed on a surface of a heater stage, and is then filled (printed) with solder paste. Then a substrate is assembled to the opposite side of the mask. Then the solder paste is reflowed. This may be done partially inverted. Then the mask is separated from the substrate, either before or after cooling. Solder balls are thus formed on the substrate, which may be a semiconductor wafer. A biased chuck urges the substrate into intimate contact with the mask. A method for printing the mask with solder paste is described. Methods of forming high aspect ratio solder bumps (including balls and reflowable interconnect structures) are described. | 06-25-2009 |
20100089983 | Forming Solder Balls on Substrates - A mask (stencil) having cells (openings) is disposed on a surface of a heater stage, and is then filled (printed) with solder paste. Then a substrate is assembled to the opposite side of the mask. Then the solder paste is reflowed. This may be done partially inverted. Then the mask is separated from the substrate, either before or after cooling. Solder balls are thus formed on the substrate, which may be a semiconductor wafer. A biased chuck urges the substrate into intimate contact with the mask. A method for printing the mask with solder paste is described. Methods of forming high aspect ratio solder bumps (including balls and reflowable interconnect structures) are described. | 04-15-2010 |
20110304505 | Electronic Tracking System - An ordnance usable against a living body, the ordnance having a tracking module with a transmitter that can use at least a portion of the body as an antenna. In preferred embodiments, the tracking module is releasably coupled to a carrier, and a pointed tip is disposed on at least one of the tracking module and the carrier. The module preferably includes a circuit that provides location information to the transmitter, and optionally provides additional information, including at least one of motion, compass, pressure, oxygen, and heart beat information. Transmission can occur at any suitable interval, including for example, at least three times during a ten minute period. The transmitter can optionally transmit a no heart beat signal, failure signal, and/or low battery signal. Preferred systems include a receiver that can send an interrogation signal, and the ordnance can include an interrogation receiving circuit for receiving interrogation signals. | 12-15-2011 |