Hamilton, CT
Andrew Hamilton, Guilford, CT US
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20080312287 | Compound and Methods For the Treatment of Cancer and Malaria - Formula (I): Where R | 12-18-2008 |
20090220586 | PROTEOMIMETIC COMPOUNDS AS INHIBITORS OF THE INTERACTION OF NUCLEAR RECEPTOR WITH COACTIVATOR PEPTIDES - The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha and/or beta), androgen receptors, thyroid receptors and peroxisome proliferators-activated receptors, among others. Compounds according to the present invention may be useful in the treatment of a variety of disease states or conditions which are mediated through nuclear receptors. | 09-03-2009 |
20100297608 | Systems and Methods for CMOS-Compatible Silicon Nano-Wire Sensors with Biochemical and Cellular Interfaces - The systems and methods described herein include a sensor for suitable for sensing chemical and biological substances. The sensor comprises a semiconductor layer formed in or on a substrate and a channel having nano-scale dimensions formed in the semiconductor layer, where the structure creates an electrically conducting pathway between a first contact and a second contact on the semiconductor layer. In certain preferred embodiments, the nano-scale channel has a trapezoidal cross-section with an effective width and exposed lateral faces, where the effective width is selected to have same order of magnitude as a Debye length (L | 11-25-2010 |
Andrew D. Hamilton, New Haven, CT US
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20090318684 | ROCK INHIBITORS AND USES THEREOF - The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are compounds that inhibit Rho-protein associated kinase function. Compounds of the invention include piperazinyl pyridines, piperazinylmethyl pyridines, piperazinyl ureas and carbamates, piperazinyl pyridines and quinoilines (including isoquinliones) as well as piperazinyl (including piperazinylmethyl) pyridines and quinolines (including isoquinolines). Compounds of the invention disrupt Rho-kinase activation and function and significantly inhibit tumor cell growth and induce tumor cell death. | 12-24-2009 |
Andrew D. Hamilton, Guilford, CT US
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20080221123 | Piperazinone Compounds as Anti-Tumor and Anti-Cancer Agents and Methods of Treatment - The present invention relates to piperazinone compounds, pharmaceutical compositions containing those compounds and methods of treating tumors and cancer, among other disease states and conditions in mammalian patients, especially including humans. | 09-11-2008 |
20090318367 | Use of SH2 STAT3/STAT1 Peptidomimetics as Anticancer Drugs - The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention display selective inhibition of specific STAT isoform homo-dimerization. The peptidomimetic probes of STAT1 function, described herein, provide the means to preferentially inhibit STAT1 over STAT3 through the exploration of the C-terminus. | 12-24-2009 |
20100009397 | SUBSTRATE-MIMETIC AKT INHIBITOR - Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3 residue were characterized. Functionally homologous non-peptide groups were substituted for the amino acids of the GSK-3 creating a hybrid peptide-non-peptide and non-peptide compounds capable of binding to Akt. The non-peptide compounds show increased stability and rigidity compared to peptide counterparts and are less susceptible to degradation. The bound non-peptide compounds exhibit an inhibitory effect on Akt, similar to peptide-based Akt inhibitors. | 01-14-2010 |
20100222352 | Compounds and Methods for the Treatment of Viruses and Cancer - The present invention relates to compounds according to the formula I: Where R | 09-02-2010 |
20110223661 | INHIBITORS OF STAT3 - Disclosed herein are compounds derived from a chemical structure according to the formula (I) wherein X comprises oxygen or sulfur, R | 09-15-2011 |
Andrew D. Hamilton, Guildford, CT US
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20090131487 | GROWTH FACTOR-BINDING COMPOUNDS AND METHODS OF USE - Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods of administering and using the growth factor binding compounds or the growth factor binding compositions are also taught. These novel growth factor binding compounds are useful for treating angiogenesis, excessive cellular proliferation, tumor growth, and a combination thereof as well as inhibiting growth factor binding to cells and phosphorylation. | 05-21-2009 |
20100210516 | Growth Factor Binding Molecules - Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growth factors and are suitable for treating a subject having tumors or restinosis. In one embodiment a platelet-derived growth factor binding molecule is disclosed that is used to inhibit tumor growth and angiogenesis in solid tumors. | 08-19-2010 |
Gary Hamilton, Middletown, CT US
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20130055881 | NON-CERAMIC STRUCTURAL PANEL WITH BALLISTIC PROTECTION - An armor panel includes a multiple of pins which penetrate a first skin, a high molecular weight polyethylene fiber composite material layer and a second skin which integrates ballistic protection into load bearing structure. | 03-07-2013 |
20140137724 | STRUCTURAL BALLISTIC PROTECTION PANEL - According an embodiment, a structural panel includes, among other things, a stiff composite material that establishes a base layer of the panel. A high molecular weight polyethylene fiber composite material establishes a ballistic protection layer of the panel that is secured to the base layer. A second composite material layer received against the ballistic protection layer such that the ballistic protection layer is situated between the second composite material layer and the base layer for providing a depth for recessed features. | 05-22-2014 |
Robert Hamilton, Torrington, CT US
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20090239079 | Process for Preventing Plating on a Portion of a Molded Plastic Part - The present invention relates to a method of incorporating a catalytic poison into a non-plating grade resin portion of a double shot molded plastic part, to retard the tendency of any electroless plating chemistry to be deposited on that portion that contains the catalytic poison. After surface treatment, only one portion of the molded part becomes receptive to electroless plating while the other portion does not. | 09-24-2009 |
20100323109 | Selective Deposition of Metal on Plastic Substrates - The present invention relates to a method of selectively plating a plastic article comprising a first polymer resin portion and a second polymer resin portion, wherein said first polymer resin portion is not rendered plateable by sulfonation and said second polymer resin portion is rendered plateable by sulfonation. The method comprises the steps of sulfonating the plastic article, activating the sulfonated plastic article to accept plating thereon, and plating the sulfonated and activated article in an electroless plating bath. The plastic article is selectively plated such that the first polymer resin portion does not have plating thereon and the second polymer resin portion is electrolessly plated. | 12-23-2010 |
20110183082 | Method for Improving Plating on Non-Conductive Substrates - A method of treating a laser-activated thermoplastic substrate having a metal compound dispersed therein is described. The substrate is contacted with an aqueous composition comprising: (i) a thiol functional organic compound; (ii) an ethoxylated alcohol surfactant; and (iii) xanthan gum. By use of the treatment composition, when the substrate is subsequently laser-activated and plated by electroless plating, extraneous plating of the substrate is substantially eliminated. | 07-28-2011 |
20130136869 | Method for Improving Plating on Non-Conductive Substrates - A method of treating a laser-activated thermoplastic substrate having a metal compound dispersed therein is described. The substrate is contacted with an aqueous composition comprising: (i) a thiol functional organic compound; (ii) an ethoxylated alcohol surfactant; and (iii) xanthan gum. By use of the treatment composition, when the substrate is subsequently laser-activated and plated by electroless plating, extraneous plating of the substrate is substantially eliminated. | 05-30-2013 |
20130209689 | Sulfonation of Plastic and Composite Materials - A method of preparing a plastic article to accept plating thereon is proposed. At least a portion of the plastic article is rendered plateable by sulfonation. The method includes the steps of: (a) exposing the plastic article to an atmosphere containing a sulfonating agent to sulfonate at least a portion of the plastic article; (b) conditioning the sulfonated article with an alkaline conditioner; (c) activating the plastic article with an ionic palladium activator; and (d) contacting the plastic article with an accelerator to react with adsorbed palladium increase the catalytic activity of at least the portion of the plastic article. | 08-15-2013 |
Terry L. Hamilton, Danbury, CT US
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20100119930 | Alkaline cell with improved separator - An alkaline cell with improved separator. The separator is formed of two sheets. The two sheets are wound into a tube shape and the bottom edge of the wound separator is folded and heat sealed. The facing surfaces of the two sheets forming the separator body are not glued or bonded together. The two separator sheets may overlap laterally so that a portion of each sheet forms a different portion of the separator outside surface. Alternatively, the separator may be formed of two sheets wherein the first sheet forms an outer layer which completely covers the second sheet. One sheet is preferably composed of a blend of polyvinylalcohol fibers and rayon fibers and the other sheet composed of polyvinylalcohol fibers and wood pulp fibers. | 05-13-2010 |
Terry Lee Hamilton, Danbury, CT US
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20120031809 | DISPLAY PACKAGE - A display package comprising a shell having a cavity therein sized to house therein at least one product having a consumer-activated feature, wherein the at least one product is movable inside the cavity, the shell comprising at least one aperture structured and configured to allow a consumer to touch the at least one product inside the shell thereby moving and positioning the at least one product to register the consumer-activated feature with the at least one aperture so that the consumer-activated feature is at least partially exposed through the at least one aperture. | 02-09-2012 |