Patent application number | Description | Published |
20080255154 | Amido Compounds And Their Use As Pharmaceuticals - The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess. | 10-16-2008 |
20090291946 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS - The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess. | 11-26-2009 |
20100130467 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS - The present invention is directed to [1,2,4]triazolo[4,3-b][1,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. | 05-27-2010 |
20100173901 | Substituted Heterocyclic Compounds - The present invention relates to substituted heterocyclic compounds of Formula I: | 07-08-2010 |
20100240671 | SUBSTITUTED HETEROCYCLIC COMPOUNDS - The present invention relates to substituted heterocyclic compounds of Formula I or XI: | 09-23-2010 |
20110136781 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS - The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. | 06-09-2011 |
20110144113 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS - The present invention is directed to [1,2,4]triazolo[4,3-b][1,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. | 06-16-2011 |
20120015928 | Amido Compounds And Their Use As Pharmaceuticals - The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess. | 01-19-2012 |
20120122858 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS - The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess. | 05-17-2012 |
20130244999 | Substituted Heterocyclic Compounds - The present invention relates to substituted heterocyclic compounds of Formula I: | 09-19-2013 |
20130296327 | SUBSTITUTED HETEROCYLIC COMPOUNDS - The present invention relates to substituted heterocyclic compounds of Formula I or XI: | 11-07-2013 |
20130338134 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS - The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer. | 12-19-2013 |
20140171405 | Fused Pyrazoles as FGFR Inhibitors - The present invention relates to fused pyrazole derivatives, and pharmaceutical compositions including the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer. | 06-19-2014 |
20140315902 | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS - The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer. | 10-23-2014 |
20140343030 | BIPYRAZOLE DERIVATIVES AS JAK INHIBITORS - The present invention provides compounds of Formula I: | 11-20-2014 |
Patent application number | Description | Published |
20090193377 | REGULAR LOCAL CLOCK BUFFER PLACEMENT AND LATCH CLUSTERING BY ITERATIVE OPTIMIZATION - Power, routability and electromigration have become crucial issues in modem microprocessor designs. In high performance designs, clocks are the highest consumer of power. Arranging clocking components with regularity so as to minimize the capacitance of the clock nets can help reduce clock power, however, it may hurt performance due to some loss of flexibility in physically placing those components. The present invention provides techniques to optimally design a clock network by logically assigning clusters of the latches to respective clock distribution structures, placing clock pins at favored pin locations, and placing clock distribution structures directly underneath the clock pins. The clock distribution structures may be moved to favored distribution locations along the clock stripes, and new optimal clustering generated between the latches and the clock distribution structures. These three optimizations are preferably repeated iteratively to derive a local optimal solution for the clock network. | 07-30-2009 |
20130326456 | DESIGNING A ROBUST POWER EFFICIENT CLOCK DISTRIBUTION NETWORK - An electronic automation design tool with a sink locator unit creates clusters of loads from a plurality of loads within a sector of a clock network design based on balancing magnitudes of the loads among the clusters of loads and based on minimal delays of each of the clusters and respective ones of a plurality of sink locations in the sector of the clock network design. The tool determines centers of the clusters of loads, and sink locations corresponding to the centers of the clusters for connecting output terminal points of sector buffers are determined. Each of the sector buffers drive a clock signal to a corresponding one of the clusters of loads. | 12-05-2013 |
20140143746 | DIRECT CURRENT CIRCUIT ANALYSIS BASED CLOCK NETWORK DESIGN - A design tool with a direct current (DC) transformation analysis unit determines combinations of candidate sink locations for sector buffers within a sector of a clock network design. For each of the combination of candidate sink locations, the design tool transforms resistances of the sector with the combination of candidate sink locations into resistances of an electrical circuit. The design tool transforms capacitances of the sector with the combination of candidate sink locations into current sources of an electrical circuit. The design tool performs a DC circuit analysis, wherein results of the DC circuit analysis include a variance of voltage at nodes of the sector and a maximum value of current from currents flowing between pairs of the nodes of the sector. The design tool determines which of the combination of candidate sink locations has the minimum variance of voltage with the results of the DC circuit analysis. | 05-22-2014 |
20150067846 | Malicious Activity Detection of a Functional Unit - A mechanism is provided for detecting malicious activity in a functional unit of a data processing system. A set of activity values associated with a set of functional units and a set of thermal levels associated with the set of functional units are monitored. For a current activity value associated with the functional unit in the set of functional units, a determination is made as to whether a thermal level associated with the functional unit differs from a verified thermal level beyond a predetermined threshold. Responsive to the thermal level associated with the functional unit differing from the verified thermal level beyond the predetermined threshold, sending an indication of suspected abnormal activity associated with the given functional unit. | 03-05-2015 |
20150067847 | Malicious Activity Detection of a Processing Thread - A mechanism is provided for detecting malicious activity in a functional unit. For a current activity value associated with a functional unit, a determination is made as to whether a thermal level associated with the functional unit differs from a verified thermal level beyond a first predetermined threshold. Responsive to the thermal level associated with the functional unit differing from the verified thermal level beyond the first predetermined threshold, a determination is made as to whether there is a known profile of thread activity levels that substantially matches current thread activity levels. Responsive to identifying the known profile that substantially matches the current thread activity levels, thread activity levels are compared to the known profile of thread activity levels. Responsive to the thread activity levels differing from the known profile beyond a second predetermined threshold, an indication of suspected abnormal activity associated with the given functional unit is sent. | 03-05-2015 |
20150067851 | Malicious Activity Detection of a Functional Unit - A mechanism is provided for detecting malicious activity in a functional unit of a data processing system. A set of activity values associated with a set of functional units and a set of thermal levels associated with the set of functional units are monitored. For a current activity value associated with the functional unit in the set of functional units, a determination is made as to whether a thermal level associated with the functional unit differs from a verified thermal level beyond a predetermined threshold. Responsive to the thermal level associated with the functional unit differing from the verified thermal level beyond the predetermined threshold, sending an indication of suspected abnormal activity associated with the given functional unit. | 03-05-2015 |
20150067852 | Malicious Activity Detection of a Processing Thread - A mechanism is provided for detecting malicious activity in a functional unit. For a current activity value associated with a functional unit, a determination is made as to whether a thermal level associated with the functional unit differs from a verified thermal level beyond a first predetermined threshold. Responsive to the thermal level associated with the functional unit differing from the verified thermal level beyond the first predetermined threshold, a determination is made as to whether there is a known profile of thread activity levels that substantially matches current thread activity levels. Responsive to identifying the known profile that substantially matches the current thread activity levels, thread activity levels are compared to the known profile of thread activity levels. Responsive to the thread activity levels differing from the known profile beyond a second predetermined threshold, an indication of suspected abnormal activity associated with the given functional unit is sent. | 03-05-2015 |
Patent application number | Description | Published |
20090083800 | CHANNEL PATH DISPLAY OF A VIDEO NETWORK - A device may receive selection of a channel provided by a video network, determine equipment, of the video network, associated with the selected channel, determine status information of the associated equipment, determine port level details of the associated equipment, combine the associated equipment, the status information, and the port level details into a path for the selected channel, and provide the selected channel path to a user. | 03-26-2009 |
20090083818 | SEARCHING CHANNEL PATH DISPLAY OF A VIDEO NETWORK - A device may provide for display equipment associated with a channel path of a video network, receive selection of one of the equipment, provide for display the selected equipment, receive selection of a port of the selected equipment, and provide for display other equipment of the video network connected to the selected port. | 03-26-2009 |
20100153157 | METHOD AND SYSTEM FOR PROVIDING NETWORK RESOURCE GROWTH MANAGEMENT - An approach is provided for network resource growth management. Utilization of a network resource that is hierarchically associated with one or more other network resources is determined. If the utilization exceeds a first predetermined threshold, a growth notification is triggered. The growth notification specifies additional network resources required to modify the utilization of the network resource according to a second predetermined threshold. | 06-17-2010 |
20120023536 | CHANNEL PATH DISPLAY OF A VIDEO NETWORK - A device may receive selection of a channel provided by a video network, determine equipment, of the video network, associated with the selected channel, determine status information of the associated equipment, determine port level details of the associated equipment, combine the associated equipment, the status information, and the port level details into a path for the selected channel, and provide the selected channel path to a user. | 01-26-2012 |
Patent application number | Description | Published |
20090263480 | TASTE-MASKED PHARMACEUTICAL COMPOSITIONS PREPARED BY COACERVATION - There is provided a method for preparing an orally disintegrating tablet (ODT) composition comprising microparticles of one or more taste-masked active pharmaceutical ingredients, rapidly-dispersing microgranules, and other optional, pharmaceutically acceptable excipients wherein the ODT disintegrates rapidly with saliva in the buccal cavity forming a smooth, easy-to-swallow suspension. Furthermore, the microparticles (crystals, granules, beads or pellets containing one or more actives) with a taste-masking membrane applied by a modified solvent coacervation process comprising a water-insoluble polymer and at least one gastrosoluble inorganic or organic pore-former, exhibit a pleasant taste when placed in the oral cavity and provide rapid, substantially-complete release of the dose on entry into the stomach. | 10-22-2009 |
20140170215 | ORALLY DISINTEGRATING TABLETS AND METHODS OF MANUFACTURE - A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of rapidly dispersing microgranules prepared by granulating a sugar alcohol or a saccharide or a mixture thereof having an average particle size less than about 30 microns and a disintegrant, and a taste-masked microcapsule containing at least one drug, the microcapsule being prepared by granulating a pharmaceutically acceptable formulation comprising at least one drug in a therapeutically effective amount and at least one polymeric binder that improves resilience of the microgranules, wet milling the granulated mass, and microencapsulating the milled granules to provide microcapsules. | 06-19-2014 |
Patent application number | Description | Published |
20120010869 | VISUALIZING AUTOMATIC SPEECH RECOGNITION AND MACHINE - An automated speech processing method, system and computer program product are disclosed. In one embodiment, a speech-to-text (STT) engine is used for converting an audio input to text data in a source language, and a machine translation (MT) engine is used for translating this text data to text data in a target language. In this embodiment, the text data in the target language is rendered on a display device, and different visualization schemes are applied to different parts of the rendered text data based on defined characteristics of the STT engine and the MT engine. In one embodiment, the defined characteristics include a defined confidence value representing the accuracy of the rendered text. For example, this confidence value may be based on both the accuracy of the conversion of the audio input and the accuracy of the translation of the text data to the target language. | 01-12-2012 |
20130091161 | Self-Regulating Annotation Quality Control Mechanism - A method, apparatus and article of manufacture for determining annotation quality, including obtaining N annotations on an artifact, wherein each annotation includes a feature and N annotations include three or more annotations including an annotation provided by a first human annotator, zero or more human annotations and zero or more imposter annotations, selectively displaying the N annotations to the first human annotator, wherein the annotation provided by the first human annotator is completely visible and each of the other N−1 annotations includes a feature hidden, and determining to annotation quality of one of the N−1 annotations based on input from the first human annotator regarding the displayed annotations, wherein ability of the first human annotator to identify imposter annotations or recognize that no imposter annotation exists is gated by the quality of the first human's annotation via hiding other annotations and requiring a probe based on the first human annotator's annotation. | 04-11-2013 |
Patent application number | Description | Published |
20090101539 | MICROTUBE CONTAINER AND CARRIER FOR MULTIPLE CONTAINERS - A container for elongated objects, such as microtubes or vials, comprising a frame having a base and sides, a pair of rotatable opposing lid sections having at least two movement-resistant positions, and a rack with a plurality of holes or collars. The rack or interior bottom of the container may have features that discourage rotation of the microtubes or vials. The containers may further comprise microtubes or vials, which may be empty or filled with, for example, reagents, such as reagents for use in a predetermined process. A system of stackable carriers may be provided to hold and allow one-handed removal of a plurality of containers. The container may desirably permit one-handed opening and closing of the container and any vials contained therein, and the various lid positions may be suitable for submersion in an ice bath as well as standing upright on a laboratory bench. | 04-23-2009 |
20140147851 | METHODS AND KITS FOR DETECTING CELL-FREE PATHOGEN-SPECIFIC NUCLEIC ACIDS - The present invention relates to a method for detecting a target nucleic acid derived from a pathogen in a subject. The method comprises (a) amplifying the nucleic acid sequence of the target nucleic acid, which is obtained from a cell-free fraction of a blood sample from the subject, to produce a double stranded DNA is produced, and (b) detecting the double stranded DNA. The presence of the double stranded DNA indicates the presence of the target nucleic acid in the subject. Also provided are kits for detecting a target nucleic acid derived from a pathogen in a subject. | 05-29-2014 |
Patent application number | Description | Published |
20110071861 | Online nationalized & localized ads (text, image and video) self-creation solutions; online nationalized and localized store set up and shop solutions; and online shop together and network solutions - Revolutionary online shopping together; online nationalization and localization commercial text, image and video advertising; online nationalization and localization shopping and others have been invented. | 03-24-2011 |
20120079558 | Safety and securely us personal computer working at home or anywhere instead of going and working in the office - Revolutionary safely and securely using computers work at home or on the road is invented. The architecture of Corpnetlk7 built for the platform includes components, utility programs and files majority residing on the host company's servers. They work together with local and corporate machines where configurations are made and certain programs are installed. The user will go through different steps before reaching to the corporate legacy system. Corpnetlk7 consists of Corpnetlk7 Client, Server and Corporate Side Configuration Utility, Corpnetlk7 Connection Agent, Corpnetlk7 Names Server Manager, Corpnetlk7 Enterprise App, Corpnetlk7 User App, Corpnetlk7 Security Enhancement Layers, Corpnetlk7 Programs Repository, Corpnetlk7 Programs Security Storage Lockroom, Corpnetlk7 Multithreaded Server, Corpnetlk7 Host GUI Interface and Corpnetlk7 New User Checksum etc. The user creates connectivity on the local machine and Corpnetlk7 helps the user resolve the names service. | 03-29-2012 |
20120110476 | My online 3D E library - My online 3D E library is invented. Visitor goes to the library online; check what the materials in each section in a 3D environment. They can borrow, read, listen, watch the materials in the study room or reading room and renew. They also can buy the materials. Business can create and upload the contents by themselves using our pre-designed procedures and tools or get help and support from our technical engineers. The e-commerce web application will be developed by java. Java is an application development language. It contains logic rules, packages, procedures, and triggers. Business and visitor will go through different stages to finish designing and creating contents on the website. The stages will include providing information, creating account, picking service category, picking title category, creating cover page, uploading contents and verifying etc. Business follows the developed procedures and presents their materials in the library on the shelves. Visitor can create contents using the online free tools too. | 05-03-2012 |
Patent application number | Description | Published |
20120225021 | STABLE COLLOIDAL GOLD NANOPARTICLES WITH CONTROLLABLE SURFACE MODIFICATION AND FUNCTIONALIZATION - In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%. | 09-06-2012 |
20120242987 | SURFACE-ENHANCED RAMAN SCATTERING APPARATUS AND METHODS - An apparatus for performing surface-enhanced Raman scattering (SERS) is disclosed wherein an inner surface of a container is coated with SERS active materials such as nanoparticles of noble metals. Such a container can provide a partially enclosed, optical diffuse cavity whose inner surfaces serve for dual purposes of enhancing Raman scattering of the contained analyte and optical integration, therefore improving the efficiency of optical excitation and signal collection. The container may be configured to isolate the SERS active material from the external environment. The container, which may be a cylindrical tube, may be referred to as a SERS tube. Methods of coating the inner wall of a container with pulsed laser ablation and with nanoparticle colloids, respectively, are disclosed. | 09-27-2012 |
20130189793 | Stable Colloidal Suspensions Of Gold Nanoconjugates And The Method For Preparing The Same - In the present invention, a method for determining the stability threshold amount of a stabilizer component for gold nanoparticles to prevent their aggregation in any electrolyte solution, is disclosed. The method permits for very low levels of stabilizer components to be used while still permitting conjugation with other functional ligands. The method comprises preparation of stable gold nanoparticles conjugated with different amount of stabilizing agents in deionized water first and then testing the stability of colloidal suspension of these gold nanoparticles in the presence of the electrolyte solution by monitoring the absorbance at 520 nm. The invention also comprises a method for fabrication of nanoconjugates comprising gold nanoparticles and only the stabilizer components or comprising gold nanoparticles, stabilizer components and functional ligands, which are stable in the presence of electrolytes. | 07-25-2013 |
20130243874 | NANOPARTICLES COATED WITH AMPHIPHILIC BLOCK COPOLYMERS - The present provides amphiphilic block copolymer coated surfaces (e.g., nanoparticles, medical devices, etc.) and methods of preparing such surfaces. In certain embodiments, the present invention provides amphiphilic block copolymer coated single dispersed nanoparticles, which are stable in buffer (e.g., PBS) and have neutral but functionable surfaces, and methods of preparing the same. | 09-19-2013 |
20140170070 | STABLE COLLOIDAL GOLD NANOPARTICLES WITH CONTROLLABLE SURFACE MODIFICATION AND FUNCTIONALIZATION - In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%. | 06-19-2014 |
20140213807 | Methods For Preparing Aqueous Suspension Of Precious Metal Nanoparticles - The present disclosure is directed to methods of preparing stable suspensions of precious metal nanoparticles and methods for attaching bio-molecules to the nanoparticles. The formation of nanoparticles can be accomplished by either chemical synthesis or pulsed laser ablation in a liquid. The present disclosure reveals the importance of controlling the conductivity of the dispersion medium during pulsed laser ablation in a liquid to control the particle size of the nanoparticles. The present disclosure also reveals the importance of adjusting and maintaining the conductivity in a range of 25 μS/cm or less during storage of the nanoparticles and just prior to performing bioconjugation reactions. The control of conductivity is an important process for maintaining the nanoparticles as a stable non-aggregated colloidal suspension in a dispersion medium. | 07-31-2014 |
20140296551 | CONJUGATED GOLD NANOPARTICLES - The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic) | 10-02-2014 |
Patent application number | Description | Published |
20120294956 | INHIBITION OF DYNAMIN RELATED PROTEIN 1 TO PROMOTE CELL DEATH - The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries that (i) Drp1 disruption-induced mitochondrial hyperfusion is functionally linked to the cell cycle regulation apparatus, so that Drp1 inhibition results in a disruption of the cell cycle and DNA aberrancies; (ii) inhibition of both Drp1 and ATR are synthetic lethal causing increased DNA damage and apoptotic cell death; and (iii) even in resistant cell lines, Drp1 inhibitor (e.g., mdivi-1) together with a second antiproliferative agent (e.g., cisplatin or carboplatin) act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies. | 11-22-2012 |
20150017262 | INHIBITION OF DYNAMIN RELATED PROTEIN 1 TO PROMOTE CELL DEATH - The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries that (i) Drp1 disruption-induced mitochondrial hyperfusion is functionally linked to the cell cycle regulation apparatus, so that Drp1 inhibition results in a disruption of the cell cycle and DNA aberrancies; (ii) inhibition of both Drp1 and ATR are synthetic lethal causing increased DNA damage and apoptotic cell death; and (iii) even in resistant cell lines, Drp1 inhibitor (e.g., mdivi-1) together with a second antiproliferative agent (e.g., cisplatin or carboplatin) act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies. | 01-15-2015 |
Patent application number | Description | Published |
20090065465 | Reaction Bottle with Pressure Release - A reaction bottle comprising: a container, with a container top and a container interior; a bottle cap removeably attachable to the container top, the bottle cap having a cap top and a cap cavity; a septa attached to the bottle cap and configured to releasably seal the container when the bottle cap is attached to the container top; a needle holder attached to the cap top; a hollow needle attached to the needle holder and located in the cap cavity; a needle conduit in fluid communication with the hollow needle; wherein the septa is configured to deform from an at rest state into a punctured state when pressure within the container interior reaches a first threshold value and the septa deforms into the cavity and is punctured by the hollow needle, and the septa is further configured to return to the at rest state when the pressure within the container reaches a second threshold value and the septa reseals upon being no longer punctured by the hollow needle. A reaction bottle comprising: a container, with a container top and a container interior; a bottle cap removeably attachable to the container top, the bottle cap having a cap top and a cap cavity; a septa attached to the bottle cap and configured to releasably seal the container when the bottle cap is attached to the container top; a needle holder attached to the cap top; a hollow needle attached to the needle holder and located in the cap cavity; a needle conduit in fluid communication with the hollow needle; a pivot member located in the cavity, and attached to the cap top; at least one linearly moveable member located in the cavity and in operational communication with the septa; a pivoting member located in the cavity, the pivoting member having a first end and a second end, the first end in operable communication with the linearly moveable member, and wherein the pivoting member is configured to pivot about the pivot member; an extended member attached to the needle holder, and in operable communication with the second end of the pivoting member; wherein the septa is configured to deform from an at rest state into a second state when pressure within the container interior reaches a first threshold value and the septa deforms and moves the linearly moveable member up towards the cap top, whereupon the pivoting member pivots about the pivot member, and the pivoting member pushes down on the extended member, such that the needle holder and hollow needle are moved down towards the septa, whereupon the septa is punctured by the hollow needle, and the septa is further configured to return to the at rest state when the pressure within the container reaches a second threshold value thus allowing the linearly moveable member to move to its original position thus causing the pivoting member to pivot about the pivot member, and thus move the extended member up towards the cap top, and the needle holder and hollow needle moves up toward the cap top along with the extended member, thus moving the hollow needle away form the septa whereupon the septa reseals upon being no longer punctured by the hollow needle. | 03-12-2009 |
Patent application number | Description | Published |
20090105284 | Aminocyclohexanes as Dipeptidyl Peptidase-IV for the Treatment or Prevention of Diabetes - The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. | 04-23-2009 |
20090270467 | Aminocyclohexanes as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes - The present invention is directed to novel substituted aminocyclohexanes of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. | 10-29-2009 |
20100234403 | Aminotetrahydropyrans as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes - The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. | 09-16-2010 |
20110224195 | HETEROCYCLIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES - The present invention is directed to substituted six-membered heterocyclic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as obesity and diabetes, particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. | 09-15-2011 |
20120149734 | AMINOTETRAHYDROPYRANS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES - The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. | 06-14-2012 |
20120277240 | SUBSTITUTED AMINOTETRAHYDROTHIOPYRANS AND DERIVATIVES THEREOF AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES - The present invention is directed to novel substituted aminotetrahydrothiopyrans and derivatives thereof of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. | 11-01-2012 |
20130123237 | NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS - Novel compounds of structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension. | 05-16-2013 |
20130203786 | SUBSTITUTED SEVEN-MEMBERED HETEROCYCLIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES - The present invention is directed to novel amino-substituted seven-membered heterocyclic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. | 08-08-2013 |
20130331372 | Cyclic Amine Substituted Oxazolidinone CETP Inhibitor - Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A | 12-12-2013 |
Patent application number | Description | Published |
20100258961 | Method for making silicone hydrogel contact lenses - The invention provide a method for making silicone hydrogel based on the Lightstream Technology from a monomer mixture with a curing time of less than about 100 seconds. The present invention is also related to silicone hydrogel contact lenses made according to methods of the invention. | 10-14-2010 |
20110102736 | SILICONE HYDROGEL LENS WITH A GRAFTED HYDROPHILIC COATING - The invention provides a cost-effective method for applying a hydrophilic coating onto a silicone hydrogel contact lens based on Fenton chemistry. The hydrophilic coating is covalently attached onto the contact lens at room temperature without UV irradiation. The invention also provides silicone hydrogel contact lenses having a hydrophilic coating obtained according to the method of the invention. | 05-05-2011 |
20110133350 | METHODS FOR INCREASING THE ION PERMEABILITY OF CONTACT LENSES - Described herein are methods for increasing the ion permeability of a silicone hydrogel contact lens by adding a small amount of an ion-permeability-enhancing (“IP-enhancing”) hydrophilic vinylic monomer or macromer into a lens-forming material for cast-molding silicone hydrogel contact lenses, while not altering significantly the water content and/or the oxygen permeability of resultant lenses from the lens-forming material. | 06-09-2011 |
20120026457 | SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING - The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave. | 02-02-2012 |
20120172478 | METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES - The invention provide a method for making silicone hydrogel based on the Lightstream Technology from a monomer mixture with a curing time of less than about 100 seconds. The present invention is also related to silicone hydrogel contact lenses made according to methods of the invention. | 07-05-2012 |
20130308093 | SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING - The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave. | 11-21-2013 |
20140356965 | METHOD FOR DETERMINING THE SURFACE CONCENTRATION OF CARBOXYL GROUPS ON A LENS - The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C | 12-04-2014 |
Patent application number | Description | Published |
20120276278 | MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON - The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon. | 11-01-2012 |
20130224309 | ANTIMICROBIAL MEDICAL DEVICES - The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time. | 08-29-2013 |
20130228943 | ANTIMICROBIAL MEDICAL DEVICES - The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time. | 09-05-2013 |
Patent application number | Description | Published |
20080258727 | METHOD FOR PRODUCING A MAGNETIC RESONANCE IMAGE USING AN ULTRA-SHORT ECHO TIME - A method for producing a magnetic resonance image using an ultra-short echo time. The method includes applying a pulse sequence to an object, detecting a spirally encoded and phase encoded magnetic resonance signal associated with the object, and reconstructing the magnetic resonance image based on the spirally encoded and phase encoded magnetic resonance signal. The pulse sequence includes a slab-selective radiofrequency pulse, a slab-selective gradient pulse, a plurality of variable duration slice encoding gradient pulses, a plurality of first spiral encoding gradient pulses, and a plurality of second spiral encoding gradient pulses. The detection of the spirally encoded and phase encoded magnetic resonance signal occurs concurrently with the application of one of the plurality of first spiral encoding gradient pulses and with the application of one of the plurality of second spiral encoding gradient pulses. | 10-23-2008 |
20100231218 | Method for Producing A Magnetic Resonance Image of an Object Having a Short T2 Relaxation Time - A method for producing a magnetic resonance image using an ultra-short echo time. The method includes applying a pulse sequence to an object, detecting a spirally encoded and phase encoded magnetic resonance signal associated with the object, and reconstructing the magnetic resonance image based on the spirally encoded and phase encoded magnetic resonance signal. The pulse sequence includes a slab-selective radiofrequency pulse, a slab-selective gradient pulse, a plurality of variable duration slice encoding gradient pulses, a plurality of first spiral encoding gradient pulses, and a plurality of second spiral encoding gradient pulses. The detection of the spirally encoded and phase encoded magnetic resonance signal occurs concurrently with the application of one of the plurality of first spiral encoding gradient pulses and with the application of one of the plurality of second spiral encoding gradient pulses. | 09-16-2010 |
Patent application number | Description | Published |
20110222747 | IMAGE CLASSIFICATION BASED ON IMAGE SEGMENTATION - The invention relates to a system ( | 09-15-2011 |
20120098838 | GENERATING VIEWS OF MEDICAL IMAGES - A system for generating a view of a medical image comprises an input ( | 04-26-2012 |
20120191720 | RETRIEVING RADIOLOGICAL STUDIES USING AN IMAGE-BASED QUERY - The invention relates to a system ( | 07-26-2012 |
20120327075 | SYSTEM FOR RAPID AND ACCURATE QUANTITATIVE ASSESSMENT OF TRAUMATIC BRAIN INJURY - A system and method for automatic segmentation, performed by selecting a deformable model of an anatomical structure of interest imaged in a volumetric image, the deformable model formed of a plurality of polygons including vertices and edges, displaying the deformable model on a display, detecting a feature point of the anatomical structure of interest corresponding to each of the plurality of polygons and adapting the deformable model by moving each of the vertices toward the corresponding feature points until the deformable model morphs to a boundary of the anatomical structure of interest, forming a segmentation of the anatomical structure of interest. | 12-27-2012 |
20130066189 | NORMATIVE DATASET FOR NEUROPSYCHIATRIC DISORDERS - A system and method for identifying an abnormality of an anatomical structure. The system and method segments, using a processor, the anatomical structure imaged in a volumetric image of a plurality of control patients to produce a control segmentation of the anatomical structures of each of the control patients, obtains a normative dataset by extracting a statistical representation of a morphology of the control segmentations, segments the anatomical structure of a patient being analyzed for abnormalities to produce a patient segmentation and compares the patient segmentation to the normative dataset obtained from the control segmentations. | 03-14-2013 |
20130275124 | GENERATION OF PICTORIAL REPORTING DIAGRAMS OF LESIONS IN ANATOMICAL STRUCTURES - The invention relates to a system (SYS) for automatically extracting a location of an abnormality with respect to an anatomical structure from a report, the system comprising a tokenizer (U | 10-17-2013 |
20140003697 | METHOD AND SYSTEM FOR INTELLIGENT LINKING OF MEDICAL DATA | 01-02-2014 |
20140149407 | REPORT VIEWER USIGN RADIOLOGICAL DESCRIPTORS - A method and a report viewer for viewing a structured report, such as medical report describing radiological images using descriptors selected from a predefined list of descriptors, includes the acts of opening the medical report; and in response to the opening act, searching for a further report related to the descriptors of the medical report, and highlighting words and/or sentences in the further report that match keywords derived from the descriptors. The medical report and the further report may be displayed simultaneously with the words and/or sentences being highlighted. The further report may include an unstructured text report, and the method further includes mapping the descriptors to findings in the text report and highlighting the findings. | 05-29-2014 |
20140172456 | METHOD AND SYSTEM FOR PRESENTING SUMMARIZED INFORMATION OF MEDICAL REPORTS - A system and method for presenting summarized information of medical reports. The system and method receiving a plurality of medical reports, each medical report including a plurality of sections, each of the sections including text content, correlating corresponding sections of each of the medical reports into section types, extracting the text content of the sections of the medical reports for a selected section type and aggregating, into a single display, the text content of the sections of all the medical reports for the selected section type. | 06-19-2014 |
20140278554 | USING IMAGE REFERENCES IN RADIOLOGY REPORTS TO SUPPORT REPORT-TO-IMAGE NAVIGATION - A system, method and computer readable storage medium for retrieving a narrative report for at least one study including a plurality of images of a patient from a memory, determining text structure boundaries to identify and classify each text structure in the narrative report, determining image references in each text structure of the narrative report, extracting image references from text structures classified as including an image reference and determining a study to which an extracted image reference corresponds. | 09-18-2014 |
20140288970 | IDENTIFYING RELEVANT IMAGING EXAMINATION RECOMMENDATIONS FOR A PATIENT FROM PRIOR MEDICAL REPORTS OF THE PATIENT TO FACILITATE DETERMINING A FOLLOW UP IMAGING EXAMINATION(S) FOR THE PATIENT - A method for identifying relevant follow-up recommendations from medical reports includes identifying with a processor follow-up recommendations in electronically formatted prior medical reports, and visually presenting, via a display monitor, the identified follow-up recommendations. A computing apparatus ( | 09-25-2014 |
20140297269 | ASSOCIATING PARTS OF A DOCUMENT BASED ON SEMANTIC SIMILARITY - A system for processing at least one document ( | 10-02-2014 |
20140316770 | PROCESSING A REPORT - A system for processing a report, comprising a natural language processing unit ( | 10-23-2014 |
20140343925 | TEXT ANALYSIS SYSTEM - A text analysis system is described. A natural language input unit ( | 11-20-2014 |
20140379364 | INTELLIGENT COMPUTER-GUIDED STRUCTURED REPORTING FOR EFFICIENCY AND CLINICAL DECISION SUPPORT - A method includes receiving a signal indicative of an experience level of a clinician evaluating patient data, and, in response to determining whether the experience level satisfies a predetermined experience level threshold, prompting, via a graphical user interface, for an input indicating a first impression based on the evaluation of the patient data, automatically populating a first sub-set of the fields in the electronically formatted structured medical report based on the first impression, populating a second different sub-set of the fields in the electronically formatted structured medical report based on an input indicative of clinician selected entries, finalizing the electronically formatted structured medical report in response to clinician confirmation of the populated electronically formatted structured medical report, and storing the finalized electronically formatted structured medical report in a data repository. | 12-25-2014 |
20150033111 | Document Creation System and Semantic macro Editor - A document creation system is disclosed. A text input unit ( | 01-29-2015 |
Patent application number | Description | Published |
20140070380 | BRIDGE INTERCONNECT WITH AIR GAP IN PACKAGE ASSEMBLY - Embodiments of the present disclosure are directed towards techniques and configurations for a bridge interconnect assembly that can be embedded in a package assembly. In one embodiment, a package assembly includes a package substrate configured to route electrical signals between a first die and a second die and a bridge embedded in the package substrate and configured to route the electrical signals between the first die and the second die, the bridge including a bridge substrate, one or more through-hole vias (THVs) formed through the bridge substrate, and one or more traces disposed on a surface of the bridge substrate to route the electrical signals between the first die and the second die. Routing features including traces and a ground plane of the bridge interconnect assembly may be separated by an air gap. Other embodiments may be described and/or claimed. | 03-13-2014 |
20140071646 | ROUTING DESIGN FOR HIGH SPEED INPUT/OUTPUT LINKS - Certain embodiments relate to routing structures and their formation. In one embodiment a routing structure includes a first region including a first layer comprising alternating signal traces and ground traces separated by a dielectric. The first region also includes a second layer including alternating signal traces and ground traces separated by a dielectric, wherein the second layer signal positioned over the first layer ground traces, and the second layer ground traces positioned over the first layer signal traces. The first region may also include additional layers of alternating signal and ground traces. The first region may also be formed with the ground traces having a width that is larger than that of the signal traces. The routing structure may also include a second region including pads to which the traces are coupled. Other embodiments are described and claimed. | 03-13-2014 |
20140117552 | X-LINE ROUTING FOR DENSE MULTI-CHIP-PACKAGE INTERCONNECTS - X-line routing arrangements for dense multi-chip-package interconnects are described. In an example, an electronic signal routing structure includes a substrate. A plurality of layers of conductive traces is disposed above the substrate. A first pair of ground traces is disposed in a first of the plurality of layers of conductive traces. A signal trace is disposed in a second of the plurality of layers of conductive traces, below the first layer. A second pair of ground traces is disposed in a third of the plurality of layers of conductive traces, below the first layer. The first and second pairs of ground traces and the signal trace provide an X-pattern routing from a cross-sectional perspective. | 05-01-2014 |
20140160707 | NON-UNIFORM SUBSTRATE STACKUP - Some embodiments described herein include apparatuses and methods of forming such apparatuses. One such embodiment may include a routing arrangement having pads to be coupled to a semiconductor die, with a first trace coupled to a first pad among the pads, and a second trace coupled to a second pad among the pads. The first and second traces may have different thicknesses. Other embodiments including additional apparatuses and methods are described. | 06-12-2014 |
20140217579 | HIGH DENSITY PACKAGE INTERCONNECTS - Electronic assemblies and methods including the formation of interconnect structures are described. In one embodiment an apparatus includes semiconductor die and a first metal bump on the die, the first metal bump including a surface having a first part and a second part. The apparatus also includes a solder resistant coating covering the first part of the surface and leaving the second part of the surface uncovered. Other embodiments are described and claimed. | 08-07-2014 |
20140268614 | COUPLED VIAS FOR CHANNEL CROSS-TALK REDUCTION - Capacitively coupled vertical transitions may be configured with a desired amount of mutual capacitance to at least partially cancel crosstalk for an overall channel crosstalk (e.g., FEXT) reduction. In embodiments, capacitive coupling of adjacent vertical transitions is achieved with overlapping metal surfaces within the vertical transitions. In embodiments, one or more of the overlapping metal surfaces are vias, via pads, or metal stub features extending off a vertical transition. In embodiments, signal paths with overlapped vertical transitions are utilized to achieve crosstalk reduction of more than one victim-aggressor pair and/or to achieve crosstalk reduction of more than two aggressors. In embodiments, capacitively coupled vertical transitions are implemented in a package substrate, an interposer, or a printed circuit board. | 09-18-2014 |