Keaney
Erin Keaney, Belmont, MA US
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20130338159 | BI-HETEROARYL COMPOUNDS AS VPS34 INHIBITORS - The present invention includes novel methods of treating a disease or disorder characterized by hyperactivity of Vps34, and compound as Vps34 inhibitors; particularly compounds of Formula I or a pharmaceutically acceptable salt thereof, as well as methods of treating a disease, disorder, or syndrome associated with Vps34 inhibition, particularly hyperproliferative diseases. The present invention also includes pharmaceutical compositions including compounds of formula I and pharmaceutically acceptable salts thereof. | 12-19-2013 |
20140155402 | BI-HETEROARYL COMPOUNDS AS VPS34 INHIBITORS - The present invention includes novel methods of treating a disease or disorder characterized by hyperactivity of Vps34, and compound as Vps34 inhibitors; particularly compounds of Formula I: | 06-05-2014 |
Erin Elizabeth Keaney, Groton, MA US
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20150297363 | Prosthetic Limb - A prosthetic limb includes a plurality of extendable segments configured to adjust the length of the prosthetic limb. Also included is a first end assembly operatively coupled to the plurality of extendable segments, wherein the first end assembly is radially adjustable to manipulate the thickness of the prosthetic limb. Further included is a second end assembly operatively coupled to the plurality of extendable segments, wherein the second end assembly is radially adjustable to manipulate the thickness of the prosthetic limb. | 10-22-2015 |
Glade S. Keaney, Red Hook, NY US
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20090093903 | METHODS, SYSTEMS, AND COMPUTER PROGRAM PRODUCTS FOR AUTOMATING PROCESS AND EQUIPMENT QUALIFICATIONS IN A MANUFACTURING ENVIRONMENT - Methods, systems, and computer program products for automating process and equipment qualifications in a manufacturing environment are provided. A method includes defining a triggering event for initiating a qualification of an equipment, process module, or process. The qualification is configured to identify whether the equipment, process module, or process is operating according to specified criteria. The method also includes qualifying a monitor for use in the qualification. Upon the occurrence of the triggering event, the method includes running qualified monitors through the qualification. Based upon the results of qualifying the monitor for use in the qualification or the results of the execution of the qualification, the method includes determining and implementing a disposition for the monitor. | 04-09-2009 |
Gregg F. Keaney, Belmont, MA US
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20110213145 | Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners - The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer. | 09-01-2011 |
20130131063 | Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners - The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer. | 05-23-2013 |
20140371456 | Enzymatic Transamination of Cyclopamine Analogs - Provided are processes for the synthesis of amino analogues from ketone starting materials. | 12-18-2014 |
Gregg F. Keaney, Lexington, MA US
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20110274654 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are triazole FASN inhibitors of the formula (I): | 11-10-2011 |
20110274655 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are tetrazolone FASN inhibitors of the formula (I): | 11-10-2011 |
20120083607 | Enzymatic Transamination of Cyclopamine Analogs - Provided are processes for the synthesis of amino analogues from ketone starting materials. | 04-05-2012 |
20130243727 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are triazole FASN inhibitors of the formula (I): | 09-19-2013 |
20140079667 | TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE - Provided herein are tetrazolone FASN inhibitors of the formula (I): | 03-20-2014 |
Michael Keaney, Oak Park, CA US
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20120290724 | SYSTEM AND METHOD FOR NETWORK REDIRECTION - One embodiment of the present disclosure provides a system for identifying and directing requests for network services. During operation, the system receives at a network controller a Domain Name System (DNS) query from a client device. The system can determine if the DNS query includes a pre-defined DNS string. Further, if the DNS query includes the pre-defined DNS string, the system identifies a local portal associated with the pre-defined DNS string. Moreover, the system can direct the client device to the local portal. | 11-15-2012 |
20140280910 | HIERARCHICAL RULE-BASED ROUTING SYSTEM - The local network connection system (LNCS) is configured to balance the subscriber network traffic. Load balancing of subscriber traffic can be accomplished by logically assigning each subscriber to one of the available Internet Service Provider (ISP) links. The assignment of subscribers can be based on a rule set that determines which ISP to assign to a subscriber. The rule set can be used to balance the load on the network interfaces, the ISPs, and provide failover options for the LNCS. The system can perform network interface monitoring operations in order to determine if one or more of the network interfaces have ISP connections and are available to transport network traffic over a network, such as the Internet. | 09-18-2014 |
Richard A. Keaney, Manly AU
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20080273536 | EARLY DETECTION OF FALSE START-OF-PACKET TRIGGERS IN A WIRELESS NETWORK NODE - An apparatus, a carrier medium storing instructions to implement a method, and a method in a node of a wireless network able to receive packets that exactly or substantially conform to a wireless network standard according to which each packet includes a header having bits that have respective correct values in the case that the packet exactly conforms to the standard. The method includes receiving a start-of-packet (SOP) trigger that indicates that a packet may have been received, checking one or more bits in the header to determine whether or not they have their respective correct values, and continuing to process the packet in the case that the checking indicates that the checked bits have their respective correct values. In one implementation, the header includes a first field modulated at a known rate that has one or more reserved bit locations, and a second field modulated at a data rate indicated in the first field. In such an implementation, the checking includes processing the first field and checking one or more bits in the first field to determine whether or not they have their respective correct values, and, if the checked bits of the first field have their respective correct values, checking the second field for integrity. | 11-06-2008 |
Sean Philip Keaney, Marlton, NJ US
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20120318869 | HYBRID-TYPE BIOPTICAL LASER SCANNING AND DIGITAL IMAGING SYSTEM SUPPORTING AUTOMATIC OBJECT MOTION DETECTION AT THE EDGES OF A 3D SCANNING VOLUME - A hybrid-type bi-optical bar code symbol reading system having a vertical housing section with a vertical scanning window, and a horizontal housing section with a horizontal scanning window, from which laser scanning planes are projected and intersect within a 3D scanning volume defined between the vertical and horizontal scanning windows. An automatic object edge-motion detection subsystem is provided for detecting the entry and exit of objects at the edge of the 3D scanning volume, and generating control signals in response thereto. A digital imaging subsystem is supported within the system housing and automatically projects a field of view (FOV) within the 3D scanning volume in response to control signals generated by the automatic object edge-motion detection subsystem and timer settings managed by a system controller. | 12-20-2012 |
Stephen Keaney, Longmeadow, MA US
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20090153550 | Virtual object rendering system and method - There is provided a virtual object rendering system comprising a camera, at least one sensor for sensing perspective data corresponding to a camera perspective, a communication interface configured to send the perspective data to a virtual object rendering computer, and the virtual object rendering computer having one or more virtual objects, the virtual object rendering computer configured to determine the camera perspective from the perspective data, and to perform the virtual object rendering by redrawing the one or more virtual objects to align the one or more virtual objects with the camera perspective. The virtual object rendering computer may be further configured to produce a merged image of the one or more redrawn virtual objects and a camera image received from the camera. | 06-18-2009 |
Stephen Keaney, Groton, MA US
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20090112227 | Tenaculum Stabilizer Device - An apparatus for treating tissue, comprising a sheath defining a lumen sized and shaped to receive a treatment device therein, a guide member coupled to the sheath and extending a predetermined distance substantially parallel to a longitudinal axis of the sheath, and a stabilizer element for engaging an anchoring device coupled to tissue to stabilize the sheath and the treatment device, the stabilizing element being movably coupled to the guide member for movement therealong substantially parallel to the longitudinal axis of the sheath wherein, when in a proximal-most position, the stabilizer element is located proximally of a proximal end of the guide member. | 04-30-2009 |
Stephen S. Keaney, Groton, MA US
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20090125014 | Thermal Ablation System - A thermal ablation system comprises a fluid handling unit receiving fluid from a fluid source at a first pressure, the fluid handling unit including a heater heating the fluid to a desired temperature and a pump and an introducer including a sheath which, when in an operative position, is received within a hollow organ, the sheath including a delivery lumen introducing fluid heated by the heater to the hollow organ and a return lumen withdrawing fluid from the hollow organ and returning the withdrawn fluid to the console via a return lumen, wherein the pump increases a pressure of the fluid between the fluid source and the delivery lumen of the introducer. | 05-14-2009 |
20090158842 | HTA Fluid Level and Fluid Type Measurement - Apparatus for measuring an amount of ablation fluid circulating in a system for ablating tissue comprises a plurality of electrical contacts located within an ablation fluid receiving chamber of the system, the contacts being located at various heights and a data processing arrangement coupled to the contacts to receive data corresponding to electrical conductance between pairs of the contacts, the data processing arrangement determining a height of fluid in the chamber based on the measured conductance levels and determining based on the determined height, whether an amount of fluid circulating through the system is within a desired range. | 06-25-2009 |
20100094268 | Indirect Fluid Flow Measurement - A method for ablating tissue comprising controlling a heating element using a variable phase angle control to heat an ablation fluid to a desired temperature and determining a heating percentage corresponding to a percentage of a maximum available heating power represented by a current level of power supplied to the heating element and, when the heating percentage remains below a threshold level for a predetermined period of time, indicating a flow obstruction condition of the fluid. | 04-15-2010 |
20120157983 | Thermal Ablation System - A thermal ablation system comprises a fluid handling unit receiving fluid from a fluid source at a first pressure, the fluid handling unit including a heater heating the fluid to a desired temperature and a pump and an introducer including a sheath which, when in an operative position, is received within a hollow organ, the sheath including a delivery lumen introducing fluid heated by the heater to the hollow organ and a return lumen withdrawing fluid from the hollow organ and returning the withdrawn fluid to the console via a return lumen, wherein the pump increases a pressure of the fluid between the fluid source and the delivery lumen of the introducer. | 06-21-2012 |
20120165805 | Indirect Fluid Flow Measurement - A method for ablating tissue comprising controlling a heating element using a variable phase angle control to heat an ablation fluid to a desired temperature and determining a heating percentage corresponding to a percentage of a maximum available heating power represented by a current level of power supplied to the heating element and, when the heating percentage remains below a threshold level for a predetermined period of time, indicating a flow obstruction condition of the fluid. | 06-28-2012 |
20120167678 | HTA Fluid Level and Fluid Type Measurement - Apparatus for measuring an amount of ablation fluid circulating in a system for ablating tissue comprises a plurality of electrical contacts located within an ablation fluid receiving chamber of the system, the contacts being located at various heights and a data processing arrangement coupled to the contacts to receive data corresponding to electrical conductance between pairs of the contacts, the data processing arrangement determining a height of fluid in the chamber based on the measured conductance levels and determining based on the determined height, whether an amount of fluid circulating through the system is within a desired range. | 07-05-2012 |
20140309630 | Thermal Ablation System - A thermal ablation system comprises a fluid handling unit receiving fluid from a fluid source at a first pressure, the fluid handling unit including a heater heating the fluid to a desired temperature and a pump and an introducer including a sheath which, when in an operative position, is received within a hollow organ, the sheath including a delivery lumen introducing fluid heated by the heater to the hollow organ and a return lumen withdrawing fluid from the hollow organ and returning the withdrawn fluid to the console via a return lumen, wherein the pump increases a pressure of the fluid between the fluid source and the delivery lumen of the introducer. | 10-16-2014 |