Amrein
Beat Amrein, Ruenenberg CH
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20110009317 | CONJUGATES OF INSULIN-LIKE GROWTH FACTOR-1 AND POLY(ETHYLENE GLYCOL) - A conjugate consisting of an insulin-like growth factor-1 (IGF-I) variant and one or two poly(ethylene glycol) group(s), characterized in that said IGF-I variant has an amino acid alteration at up to three amino acid positions 27, 37, 65, 68 of the wild-type IGF-I amino acid sequence so that one or two of said amino acids is/are lysine and amino acid 27 is a polar amino acid but not lysine, is conjugated via the primary amino group(s) of said lysine(s) and said poly(ethylene glycol) group(s) have an overall molecular weight of from 20 to 100 kDa is disclosed. This conjugate is useful for the treatment of neurodegenerative disorders like Alzheimer's Disease. | 01-13-2011 |
20120322732 | CONJUGATES OF INSULIN-LIKE GROWTH FACTOR-1 AND POLY(ETHYLENE GLYCOL) - A conjugate consisting of an insulin-like growth factor-1 (IGF-I) variant and one or two poly(ethylene glycol) group(s), characterized in that said IGF-I variant has an amino acid alteration at up to three amino acid positions 27, 37, 65, 68 of the wild-type IGF-I amino acid sequence so that one or two of said amino acids is/are lysine and amino acid 27 is a polar amino acid but not lysine, is conjugated via the primary amino group(s) of said lysine(s) and said poly(ethylene glycol) group(s) have an overall molecular weight of from 20 to 100 kDa is disclosed. This conjugate is useful for the treatment of neurodegenerative disorders like Alzheimer's Disease. | 12-20-2012 |
20130217623 | CONJUGATES OF INSULIN-LIKE GROWTH FACTOR-1 AND POLY(ETHYLENE GLYCOL) - A conjugate consisting of an insulin-like growth factor-1 (IGF-I) variant and one or two poly(ethylene glycol) group(s), characterized in that said IGF-I variant has an amino acid alteration at up to three amino acid positions 27, 37, 65, 68 of the wild-type IGF-I amino acid sequence so that one or two of said amino acids is/are lysine and amino acid 27 is a polar amino acid but not lysine, is conjugated via the primary amino group(s) of said lysine(s) and said poly(ethylene glycol) group(s) have an overall molecular weight of from 20 to 100 kDa is disclosed. This conjugate is useful for the treatment of neurodegenerative disorders like Alzheimer's Disease. | 08-22-2013 |
Heinz Amrein, Kriens CH
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20090017686 | Appliance connector device with integrated filter module - The present invention relates to an appliance connector device having an A plug contact, a B plug contact and a G plug contact, an A′ terminal, a B′ terminal and a G′ terminal, an electrically conducting filter jacket and a filter module, wherein the filter module has an A″ conductor, a B″ conductor and a G″ conductor, wherein the A contact is connected to the A′ terminal via the A″ conductor, wherein the B contact is connected to the B′ terminal via the B″ conductor, wherein the G contact is connected to the G′ terminal via the G″ conductor, wherein the G″ conductor of the filter module has a shielding plate extending in a cross-sectional plane of the filter jacket and wherein the filter module has capacitance elements on both sides of the shielding plate with conducting surfaces aligned parallel to the shielding plate to generate capacitances between the A″ conductor and the B″ conductor and between these conductors and the G″ conductor. With such a plug device, it is provided, in particular for improving the ground connection of the G″ conductor of the filter module, that the shielding plate is provided with a plurality of contact fingers at the edge along most of its circumference, these contact fingers being in contact with the filter jacket on the inside under elastic tension, and the filter element has a contact surface for establishing a ground connection. | 01-15-2009 |
John T. Amrein, Bonner Springs, KS US
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20120211615 | WATER METER MOUNTING BRACKET SYSTEM AND METHOD - A bracket system and method to retrofit a subsurface water meter enclosure with a mount so as to provide secure positioning means suitable for components related to a water meter such as water-usage monitoring equipment. The system is only removable from the water meter enclosure via disassembling the water meter enclosure. | 08-23-2012 |
Kurt Amrein, Itingen CH
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20090149503 | NEW 5-ARYL PYRIDINES AS 11-BETA INHIBITORS FOR THE TREATMENT OF DIABETES - Compounds of formula (I): | 06-11-2009 |
20090275573 | Imidazolidinone Derivatives as 11B-HSD1 Inhibitors - Compounds of formula | 11-05-2009 |
20100016325 | TETRAHYDROCINNOLINE DERIVATIVES - Provided herein are compounds of formula (I): | 01-21-2010 |
20130072679 | DIHYDROQUINOLINE-2-ONE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 03-21-2013 |
20130079365 | NEW BICYCLIC DIHYDROQUINOLINE-2-ONE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 03-28-2013 |
20130143863 | NEW BICYCLIC DIHYDROISOQUINOLINE-1-ONE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 06-06-2013 |
20130274287 | PHENYL-TETRAHYDROISOQUINOLINE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 10-17-2013 |
20140128429 | NEW IMIDAZOLYLKETONE DERIVATIVES - The invention provides novel compounds having the general formula (I) | 05-08-2014 |
Matthias Amrein, Calgary CA
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20100035277 | METHOD AND APPARATUS FOR DETERMINING THE CELL ACTIVATION OF A TARGET CELL BY AN ACTIVATOR - The invention relates to a method and a device for determining the cell activation of a target cell by an activator, said method having the following steps: provision of a probe measuring device with a probe sample arrangement having a measuring probe and a sample holder; loading of the probe sample arrangement with a target cell and with an activator assigned to the target cell, the measuring probe being loaded with the activator, and the sample holder being loaded with the target cell, or vice versa; relative mutual displacement of the measuring probe and the sample holder until contact is made between the target cell and the activator by means of a displacement apparatus of the probe measuring device; recording of measurement values, indicating binding between the target cell and the activator, for the measuring probe with the probe measuring device during the relative displacement of the measuring probe and the sample holder; and determination of a dimension for the cell activation of the target cell from the measurement values recorded. | 02-11-2010 |
Matthias W. Amrein, Calgary CA
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20100173869 | TREATMENT OF SURFACTANTS - The invention relates to a method for treatment of a surfactant, in particular a pulmonary surfactant. The method is further established in that the surfactant is treated with a lipid sequestrating or cholesterol sequestrating surfactant treatment agent, in which given, in particular neutral lipids or cholesterol are selectively sequestrated by means of the surfactant treatment agent, such that the effect of the lipids and/or the effect of the cholesterol on the surfactant is reduced or reversed. | 07-08-2010 |
20130029937 | TREATMENT OF SURFACTANTS - The invention relates to a method for enhancing a surfactant, in particular a pulmonary surfactant, as well as a method for producing a surfactant enhancement agent, in particular a pulmonary surfactant enhancement agent. The invention also relates to a surfactant enhancement agent and a use of an enhancement agent for enhancing a surfactant, in particular, a pulmonary surfactant. Further, the invention relates to a method of mitigating oxidative damage to pulmonary surfactant by adding a cholesterol-sequestrating agent such as cyclodextrin. Finally, a method is provided for treating a patient having surfactant dysfunction due to oxidative damage to pulmonary surfactant by administering a surfactant-protective amount of a cholesterol-sequestrating agent to protect the surfactant from the negative effects of oxidative degradation. In the examples we show that MβCD, a cholesterol-sequestrating agent, can restore dysfunctional surfactant removed from the lungs of children with cystic fibrosis and non CF bronchiolitis to normal function. | 01-31-2013 |
Othmar Amrein, Eschenbach CH
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20110100883 | METHOD AND APPARATUS FOR THE OPTICAL INSPECTION OF WORKPIECES - The apparatus, which serves for the optical inspection of workpieces, comprises a transport device driven by a drive unit, which transport device is supplied with workpieces delivered by a loading device, which workpieces are transported by the transport device to at least one inspection position, where an optical inspection is performed, and further to at least one discharge position, where the inspected workpieces are selectively extractable by a discharge device. According to the invention, a plurality of transparent receiving bodies are firmly mounted or rotatably supported on the transport device, each of the receiving bodies comprising a recess, into which the workpieces can be inserted individually or in groups, and wherein an inspection radiation can be guided through each receiving body in order to image the held workpieces. | 05-05-2011 |
Peter Amrein, Sempach CH
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20140196608 | CAPSULE, SYSTEM, AND METHOD FOR PREPARING A BEVERAGE - The capsule according to the invention consists of a capsule body having a side wall and having a base which is integral with the side wall. The capsule comprises a lid that covers the capsule body in order to form a closed chamber, wherein said chamber contains a substance for preparing a beverage. The base can be penetrated by a device arranged outside of the capsule in order to conduct a liquid through the chamber. The capsule body is made of plastic, wherein the base has a penetration area and a reinforcement area. A central area of the base is designed at the penetration area and the reinforcement area is arranged around the penetration area. The reinforcement area is designed as at least one recessed section in the base, said section(s) running substantially in the circumferential direction. | 07-17-2014 |