Patent application number | Description | Published |
20100303928 | ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS - The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme. | 12-02-2010 |
20100330199 | ISOTHIAZOLE-PYRIDINE DERIVATES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | 12-30-2010 |
20110166145 | Stabilization of hypoxia inducible factor (HIF) alpha - The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided. | 07-07-2011 |
20110166178 | Methods for treating anemia using inhibitors of hypoxia-inducible factor (HIF) hydroxylase - The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds. | 07-07-2011 |
20110212959 | Cyanoisoquinoline Compounds and Methods of Use Thereof - The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure: | 09-01-2011 |
20130203805 | Methods for treating anemia using inhibitors of hypoxia-inducible factor (HIF) hydroxylase - The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds. | 08-08-2013 |
20130245037 | Stabilization of Hypoxia Inducible Factor (HIF) Alpha - The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided. | 09-19-2013 |
20130310565 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF - The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. | 11-21-2013 |
20140024675 | CRYSTALLINE FORMS OF A PROLYL HYDROXYLASE INHIBITOR - The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof. | 01-23-2014 |
20140024676 | CRYSTALLINE FORMS OF A PROLYL HYDROXYLASE INHIBITOR - The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof. | 01-23-2014 |
20140088101 | NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF HYPOXIA INDUCIBLE FACTOR (HIF) HYDROXYLASE - The present disclosure relates to novel compounds, methods, and compositions capable of inhibiting HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF). | 03-27-2014 |
20140221422 | NOVEL THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF - The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF). | 08-07-2014 |
20140303202 | CRYSTALLINE FORMS OF A PROLYL HYDROXYLASE INHIBITOR - The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof. | 10-09-2014 |
20140343094 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF - The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. | 11-20-2014 |
20150038528 | 4 -HYDROXY- ISOQUINOLINE COMPOUNDS AS HIF HYDROXYLASE INHIBITORS - The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias. | 02-05-2015 |
20150038529 | CRYSTALLINE FORMS OF A PROLYL HYDROXYLASE INHIBITOR - The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof. | 02-05-2015 |
20150080425 | METHODS FOR TREATING ANEMIA IN SUBJECTS HAVING KIDNEY FAILURE USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) HYDROXYLASE - The present invention provides methods for treating anemia in a subject having kidney failure by administering a compound that inhibits hypoxia-inducible factor (HIF) prolyl hydroxylase. | 03-19-2015 |
20150174110 | NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF HYPOXIA INDUCIBLE FACTOR (HIF) HYDROXYLASE - The present disclosure relates to novel compounds, methods, and compositions capable of inhibiting HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF). | 06-25-2015 |
20150175550 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS - The present invention relates to methods for making isoquinoline compounds and the intermediate compounds achieved thereby. Such compounds can be used to prepare compounds and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF). | 06-25-2015 |
20150209336 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY - The present invention relates to novel compounds according to Formula I or II, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF). Formula (I) or (II). | 07-30-2015 |
20150322015 | CRYSTALLINE FORMS OF A PROLYL HYDROXYLASE INHIBITOR - The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof. | 11-12-2015 |
20160002170 | CRYSTALLINE FORMS OF -ACETIC ACID - The present disclosure relates to crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid (Compound A), the process of preparing crystalline forms of Compound A, the pharmaceutical compositions containing them, and the methods of use thereof. | 01-07-2016 |
Patent application number | Description | Published |
20080282170 | TEMPORARY COMMUNICATION AREAS FOR A COMPUTER USER INTERFACE - Techniques are disclosed for displaying information to a user on a display device of a computer system. In one general aspect, a first view is displayed on the display device, where the first view has at least a first work area. In response to the receipt of a first input received by the computer system, a second view is displayed on the display device. The second view includes the first work area and a temporary communication area, or “pop-in window,” included within the first work area. The temporary communication area has a defined function associated therewith requiring input from a user. The temporary communication area may close after the user provides the necessary input and the defined function is performed. | 11-13-2008 |
20090171655 | RUNTIME DATA LANGUAGE SELECTION IN OBJECT INSTANCE - A method of handling different languages in an object, such as a business object includes receiving a language selection indication within a business object instance interface. Data within the business object is displayed for at least one data field in the selected language. Edited data for at least one data field within the business object is received, and other language versions of the edited data in the at least one data field may be modified. | 07-02-2009 |
20130173486 | COLLABORATION CLOUD - A collaboration cloud system generates a business task and identifies participants of the business task, a process of the business task, communications among participants, and documents and objects associated with the business task. A collaborative display for the business task is generated for the participants to collaborate on the business task. The collaborative display identifies the participants of the business task, the process of the business task, the communications among participants, and the documents and objects associated with the business task. | 07-04-2013 |
20130174093 | COMPASS MENU - A compass menu is generated as a graphical user interface for an application of a computer. The graphical user interface has a compass structure with at least four branches adjacent to a central button. The graphical user interface receives a user selection on the compass structure. A menu is generated based on the user selection on the compass structure and a context of the application. The menu is displayed adjacent to the compass structure. | 07-04-2013 |
20130191767 | Semantic Zooming of Data Object Representations in a User Interface - Example systems and methods of semantic zooming of data object representations in a user interface are presented. In one implementation, a first graphical representation is presented for display. The first graphical representation represents a data object and presents first information associated with the data object. A user input indicating a zoom-in operation is received. In response to the user input, the first graphical representation is replaced with a second graphical representation representing the first data object is presented for display. The second graphical representation presents second information that includes more information than the first information. | 07-25-2013 |
20130191778 | Semantic Zooming in Regions of a User Interface - Example systems and methods of semantic zooming in a user interface are presented. In one implementation, a display including a plurality of non-overlapping regions is presented. A user selection of a first region presenting a first amount of information is received. In response to the user selection, the selected first region is enlarged, and a second amount of information greater than the first amount of information is presented in the first region. At least one remaining region is reduced in size so that the regions continue to be non-overlapping. | 07-25-2013 |
20130342580 | VIRTUAL BUSINESS DESKTOP FOR ARRANGEMENT OF OBJECTS - Methods and apparatus, including computer program products, are provided for user interfaces. In one aspect, there is provided a method. The method may include generating a virtual desktop including a plurality of objects organized in accordance with at least one of a theme and a structure; providing a navigation pane on the virtual desktop to navigate through the plurality of objects; and providing a controller to enable a multi-level zoom on at least one of the plurality of objects on the virtual desktop. Related systems, methods, and articles of manufacture are also disclosed. | 12-26-2013 |
20130346907 | SPRINGBOARD TOOLBAR - A method may include generating a desktop including a plurality of objects organized in accordance with at least one of a theme and a structure; generating a toolbar configured for presentation with the desktop; and generating, based on the multi-level zoom, a second view representative of the at least one of the plurality of objects and a third view representative of the at least one of the plurality of objects, the second view providing more content of the at least one of the plurality of objects when compared to the first view, and the third view providing more content of the at least one of the plurality of objects when compared to the second view, the first, second, and third views maintaining the same context within the toolbar, when presented with respect to the toolbar. | 12-26-2013 |
20140019190 | Process Advisor - In one aspect, there is provided a method. The method may include accessing a process model defining a business process including a plurality of steps including at least one activity and at least one object; accessing a process monitor to obtain a state of the business process including the plurality of steps including the at least one activity and the at least one object; generating a first view including the plurality of steps including the at least one activity and the at least one object and further including the state of the business process; and generating, based on the state, a second view to guide execution of the business process. Related systems, methods, and articles of manufacture are also disclosed. | 01-16-2014 |
20140137003 | CONVERSATION GRAPHICAL USER INTERFACE (GUI) - A conversation GUI may include a canvas, a feed section, and a process section. The canvas may present icons associated with documents uploaded by members of a conversation associated with the GUI, the members including a local user of the local computing system and remote users of remote computing systems, the canvas being located in a fixed section of the conversation GUI. The feed section may present messages sent by the local user and by the remote members. The process may be separate from the canvas and the feed section and include at least a first task and a second task associated with a specified process. A computing system may, upon completion of the first task, send a message to the local user indicating that the first task is complete and the second task is to be performed. | 05-15-2014 |