Patent application number | Description | Published |
20100303879 | SILANE-FUNCTIONALIZED HYDROPHOBIC a(1-4)GLUCOPYRANOSE POLYMERS AND POLYMERIC MATRICES FOR IMPLANTATION OR INJECTION - Silane-functionalized hydrophobic α(1→4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic α(1→4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent. | 12-02-2010 |
20100316687 | HYDROPHOBIC POLYSACCHARIDES WITH DIESTER- OR CARBONATE ESTER-CONTAINING LINKAGES HAVING ENHANCED DEGRADATION - Hydrophobic α(1→4)glucopyranose polymers with enhanced degradation properties are described. Between the α(1→4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described. | 12-16-2010 |
20110076314 | HYDROPHOBIC POLYSACCHARIDES WITH SILYL ETHER LINKAGES HAVING ENHANCED DEGRADATION AND MEDICAL ARTICLES MADE THEREFROM - Hydrophobic α(1→4)glucopyranose polymers with enhanced degradation properties are described. Between the α(1→4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a silyl ether chemistry that facilitates degradation of the polymer. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described. | 03-31-2011 |
20110076337 | EMULSIONS CONTAINING ARYLBORONIC ACIDS AND MEDICAL ARTICLES MADE THEREFROM - The invention provides emulsion compositions that include a hydrophobic compound and an arylboronic acid. An exemplary emulsion comprises a hydrophobic polymer and a halogenated arylboronic acid. Use of an arylboronic acid provides the emulsion with exceptional stability. The stability provides advantages for the formation of articles formed from the emulsion, including microparticles, as well as other implantable or injectable medical articles having polymeric matrices. | 03-31-2011 |
20110144373 | WATER-SOLUBLE DEGRADABLE PHOTO-CROSSLINKER - Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers. | 06-16-2011 |
20110159101 | SILYL ETHER-MODIFIED HYDROPHILIC POLYMERS AND USES FOR MEDICAL ARTICLES - Silane-functionalized hydrophilic polymers and polymeric matrices are described. Hydrophilic matrices can be formed from the polymers, and can be used in association with the preparation of implantable and injectable medical devices. Exemplary devices include those having a durable lubricious coating formed from the hydrophilic polymers. | 06-30-2011 |
20110245367 | DEGRADABLE PHOTO-CROSSLINKER - Described herein is a degradable linking agent of formula Photo | 10-06-2011 |
20120149934 | PHOTO-CROSSLINKER - Described herein is a linking agent that includes a polymeric or non-polymeric core molecule and one or more photoreactive groups covalently attached to the core molecule by one or more linking elements that include a urea linkage, a carbamate linkage, or a combination thereof. | 06-14-2012 |
20130143056 | PHOTO-VINYL LINKING AGENTS - Embodiments of the invention include linking agents including photo groups and vinyl groups and coatings and devices that incorporate such linking agents, along with related methods. Exemplary methods herein include methods of priming substrates and methods of coating substrates using compounds having the formula R | 06-06-2013 |
20130261566 | HYDROPHILIC POLYMERIC COATINGS FOR MEDICAL ARTICLES WITH VISUALIZATION MOIETY - The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties. | 10-03-2013 |
20130302529 | BORON-CONTAINING LINKING AGENTS - Embodiments of the invention include linking agents including borate, borazine, or boronate groups and coatings and devices that incorporate such linking agents, along with related methods. Other embodiments are also included herein. | 11-14-2013 |
20140200411 | CONDUCTIVE POLYMERS AND USES - Disclosed herein are activatable conductive compositions and methods of making and using activatable conductive compositions. In particular, activatable conductive monomers polymers are described and electrically conductive coatings that include activatable conductive polymers. | 07-17-2014 |
20150034488 | CONDUCTIVE POLYMERIC COATINGS AND METHODS - Embodiments of the invention include conductive polymeric coatings and methods of making the same. In an embodiment, the invention includes a method of electrodepositing a conductive polymeric coating onto a substrate surface. The method can include contacting the substrate surface with a solution comprising a monomer, a counterion, and a solvent; exposing the solution to an electrical potential, wherein the surface serves as an electrode in the application of the electrical potential; and alternating the electrical potential between a lower potential and a higher potential to form the conductive polymeric coating on the substrate surface. Other embodiments are also included herein. | 02-05-2015 |
20150196497 | CONTROLLED RELEASE MATRIX BARRIER STRUCTURE FOR SUBCUTANEOUS MEDICAL DEVICES - A biocompatible polymeric controlled release matrix barrier structure for delivery of one or more bioactive agents from an implantable medical device is described. In an embodiment, a biocompatible polymeric controlled release matrix barrier structure is included. The biocompatible polymeric controlled release matrix can include a body structure formed of a compliant material comprising one or more compliant biocompatible polymers and one or more bioactive agents. The body structure can define a central aperture through which a subcutaneous element of an implantable medical device passes. Other embodiments are included herein. | 07-16-2015 |
Patent application number | Description | Published |
20130344126 | BIOERODABLE POLY(ETHERESTERAMIDES) AND MEDICAL ARTICLE USES - Bioerodable poly(etheresteramides) and matrices formed therefrom, such as medical device coatings, are described. The matrices show desirable erosion properties desirable for therapeutic use. The matrices can include a bioactive agent which can be used to treat medical conditions. | 12-26-2013 |
20140162083 | STILBENE-BASED REACTIVE COMPOUNDS, POLYMERIC MATRICES FORMED THEREFROM, AND ARTICLES VISUALIZABLE BY FLUORESCENCE - The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage. | 06-12-2014 |
20150017219 | SOLVENT METHODS FOR PREPARING CRYSTALLINE MACROLIDE PARTICULATES, COMPOSITIONS, AND ARTICLES CONTAINING PARTICULATES - The invention provides therapeutic particulates including a macrolide, such as rapamycin, in solid state crystalline form, having a size of 20 μm or less, or 10 μm or less. The particulates are formed in one method by preparing a composition with a macrolide and first (e.g., xylene) and second (e.g., an alcohol, acetone, or acetonitrile) solvents. In the composition a maximum solubility for the macrolide that is greater than a maximum solubility of the macrolide dissolved in either the first or second solvent individually. The first and second solvents are then evaporated from the composition to provide the macrolide particulates. In another method, the particulates can be formed by a method including sonication and stirring/evaporation steps, and the particulates can be obtained from a supersaturated solution, formed during the process. Particulates display desirable low polydispersity, and can be used in therapeutic compositions, or can be associated with an implantable or insertable medical device for the treatment of a subject. | 01-15-2015 |
Patent application number | Description | Published |
20090144229 | STATIC QUERY OPTIMIZATION FOR LINQ - Systems and methods that optimize query translations at compile time in LINQ languages. An optimization component optimizes algebraic trees and rewrites an expression composed from sequence operators into a more efficient expression(s). A compiler associated with the optimization component can receive syntax (e.g., query comprehensions, query expressions) to turn into standard sequence operators that can operate on arbitrary collections. The compiler can then perform transformations on the algebraic trees, such as push filter conditions upwards or downwards and/or to combine filter conditions. | 06-04-2009 |
20090328012 | COMPILER IN A MANAGED APPLICATION CONTEXT - A batch compiler is employed to enable compilation of code provided at runtime. A managed application receives code during execution and invokes the compiler to transform the code to enable it to execute within the context of the receiving application. Among other things, employment of a batch compiler preserves investments made to such compilers while also opening up new scenarios in application scripting and/or hosting that are otherwise unavailable. | 12-31-2009 |
20100180264 | HANDLING MULTIPLE DEFINITION OF TYPES - User assemblies can be created by a compiler that can handle more than one type definition during execution. Local copies are created for respective authoritative types in a code library, and the local copies are marked with a local type identifier. An authoritative type identifier (e.g., a globally unique identifier (GUID)) is copied from the authoritative type to the local type, and functions and properties associated with the local type are also copied from the authoritative type. Authoritative types are resolved for requested types when a local assembly references a local type from a compiled user assembly. The local type can be identified by a local type identifier, and an authoritative type can be retrieved from the code library that has a same authoritative type identifier as the requested type. A local copy of the retrieved authoritative type can be copied to the local assembly under compilation. The compiler can then emit user assemblies that comprise merely local types. | 07-15-2010 |
20110167088 | EFFICIENT IMMUTABLE SYNTAX REPRESENTATION WITH INCREMENTAL CHANGE - Efficient immutable syntax representation with parent pointers under incremental change is enabled by creating a data structure comprising at least one tree structure that allows both upward and downward references in the tree and a tree structure that is immutable (read-only), and allows parts of itself to be re-used in other data structures. The data structure described enables tools to search and target particular sub trees. The fragment of the tree representing the targeted sub tree is produced as it is used. The rest of the tree is not produced. The read-only tree retains relative information, allowing it to be reassembled and shared. | 07-07-2011 |