Patent application number | Description | Published |
20090023215 | Novel reagents for transfection of eukaryotic cells - Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes. | 01-22-2009 |
20090092990 | PRIMERS AND METHODS FOR THE DETECTION AND DISCRIMINATION OF NUCLEIC ACIDS - The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR. | 04-09-2009 |
20090143583 | TRANSFECTION REAGENTS - Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: | 06-04-2009 |
20090215067 | NOVEL LIPIDS FOR TRANSFECTION OF NUCLEIC ACIDS - Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided. | 08-27-2009 |
20100159593 | TRANSFECTION REAGENTS - Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: | 06-24-2010 |
20100233699 | PRIMERS AND METHODS FOR THE DETECTION AND DISCRIMINATION OF NUCLEIC ACIDS - The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR. | 09-16-2010 |
20120122760 | NOVEL LIPIDS FOR TRANSFECTION OF NUCLEIC ACIDS - Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided. | 05-17-2012 |
20120238747 | TRANSFECTION REAGENTS - Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: | 09-20-2012 |
20120253028 | METHOD FOR DEBLOCKING OF LABELED OLIGONUCLEOTIDES - The invention relates to a process for deblocking substantially a blocked, detectably labeled oligonucleotide by contacting the blocked detectably labeled oligonucleotide with an effective amount of a nucleophilic amino compound under conditions that result in substantial deblocking of the oligonucleotide, thereby giving the substantially deblocked oligonucleotide. | 10-04-2012 |
20130252239 | Primers and Methods for the Detection and Discrimination of Nucleic Acids - The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR. | 09-26-2013 |
20140066612 | METHOD FOR DEBLOCKING OF LABELED OLIGONUCLEOTIDES - The invention relates to a process for deblocking substantially a blocked, detectably labeled oligonucleotide by contacting the blocked detectably labeled oligonucleotide with an effective amount of a nucleophilic amino compound under conditions that result in substantial deblocking of the oligonucleotide, thereby giving the substantially deblocked oligonucleotide. | 03-06-2014 |
20140213637 | Agents for Improved Delivery of Nucleic Acids to Eukaryotic Cells - New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes. | 07-31-2014 |
20150037792 | PRIMERS AND METHODS FOR THE DETECTION AND DISCRIMINATION OF NUCLEIC ACIDS - The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR. | 02-05-2015 |