Patent application number | Description | Published |
20110276945 | Validating Visual Components - Methods, systems, apparatus, and computer-readable media for validating components of a dynamic user interface in an on-demand multi-tenant service environment are disclosed. Organizations corresponding to tenants in the on-demand multi-tenant service environment are identified. A multi-tenant database system residing on multiple servers is provided for each of the identified organizations. Dynamic user interface pages associated with the organizations are identified. First and second compilation outputs based upon respective first and second invocations of a compiler configured to compile the one or more dynamic user interface pages are produced with reference to respective first and second builds of computer program code. Differences between the first and second compilation outputs are identified and presented in a user interface on a display device of the multi-tenant service environment. The differences can be identified by performing a comparison and selecting one or more differences that match a pattern specifier. | 11-10-2011 |
20120143837 | METHODS AND SYSTEMS FOR LOOSE COUPLING BETWEEN TRIGGERS AND ENTITIES - A database program includes loose triggers that are not coupled to specific entities at the time the database program is compiled. The database program provides a user interface that allows a user to couple selected entities to the loose triggers or decouple selected entities from loose triggers. The database program validates the entities that are selected by the user for coupling or decoupling and stores the coupled entities as part of the loose trigger definitions in a loose trigger metadata database. | 06-07-2012 |
20130167122 | VALIDATING VISUAL COMPONENTS - Methods, systems, apparatus, and computer-readable media for validating components of a dynamic user interface in an on-demand multi-tenant service environment are disclosed. Organizations corresponding to tenants in the on-demand multi-tenant service environment are identified. A multi-tenant database system residing on multiple servers is provided for each of the identified organizations. Dynamic user interface pages associated with the organizations are identified. First and second compilation outputs based upon respective first and second invocations of a compiler configured to compile the one or more dynamic user interface pages are produced with reference to respective first and second builds of computer program code. Differences between the first and second compilation outputs are identified and presented in a user interface on a display device of the multi-tenant service environment. The differences can be identified by performing a comparison and selecting one or more differences that match a pattern specifier. | 06-27-2013 |
20150074558 | SYSTEMS AND METHODS FOR APPLYING INTELLEGENCE AND PRIORITIZATION TO CALENDARED EVENTS - Methods and systems are provided for displaying calendared events on a mobile computing device. The method includes: receiving, by the mobile computing device, a meeting invitation including meeting information and an email address; transmitting the email address to a customer relationship management (CRM) database; receiving, by the mobile computing device, contextual information associated with the email address from the CRM database; and displaying, by the mobile computing device, the meeting information and the contextual information. | 03-12-2015 |
Patent application number | Description | Published |
20090298075 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING - Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application. | 12-03-2009 |
20100035269 | PREVENTION AND ALLEVIATION OF STERIC HINDRANCE DURING SINGLE MOLECULE SYNTHESIS - The present invention provides compositions and methods for reducing steric hindrance in the product of nucleic acid polymerase reaction. Methods and compositions of the invention encompass application of exonucleases, endonucleases, and uracil-DNA glycosylases to a nucleic acid polymerase reaction such that newly formed nucleic acid strands are modified (e.g., cleaved) while the polymerase reaction continues to proceed. | 02-11-2010 |
20110281768 | DIAGNOSTIC SEQUENCING WITH SMALL NUCLEIC ACID CIRCLES - Methods, substrates, and systems for diagnostic sequencing are provided. Small circles of nucleic acids from about 10 bases to about 200 bases can be sequenced, for example using template dependent sequencing by synthesis. The use of small circles of nucleic acids allows for repeated sequencing of the same portions of the nucleic acid, providing for higher accuracy sequence determinations. | 11-17-2011 |
20120289408 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING - Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application. | 11-15-2012 |
20130130323 | PREVENTION AND ALLEVIATION OF STERIC HINDRANCE DURING SINGLE MOLECULE SYNTHESIS - The present invention provides compositions and methods for reducing steric hindrance in the product of nucleic acid polymerase reaction. Methods and compositions of the invention encompass application of exonucleases, endonucleases, and uracil-DNA glycosylases to a nucleic acid polymerase reaction such that newly formed nucleic acid strands are modified (e.g., cleaved) while the polymerase reaction continues to proceed. | 05-23-2013 |
20130309678 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING - Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application. | 11-21-2013 |
Patent application number | Description | Published |
20090004875 | METHODS OF TRIMMING AMORPHOUS CARBON FILM FOR FORMING ULTRA THIN STRUCTURES ON A SUBSTRATE - Methods for forming an ultra thin structure using a method that includes trimming a mask layer during an etching process are provided. The embodiments described herein may be advantageously utilized to fabricate a submicron structure on a substrate having a critical dimension less than 55 nm and beyond. In one embodiment, a method of forming a submicron structure on a substrate may include providing a substrate having a patterned photoresist layer disposed on a film stack into an etch chamber, wherein the film stack includes at least a hardmask layer disposed on an underlying layer, trimming the photoresist layer to a first predetermined critical dimension, etching the hardmask layer through openings defined by the trimmed photoresist layer, trimming the hardmask layer to a second predetermined critical dimension, and etching the underlying layer through openings defined by the trimmed hardmask layer. | 01-01-2009 |
20120073974 | Non-Permeable Substrate Carrier For Electroplating - One embodiment relates to a substrate carrier for use in electroplating a plurality of substrates. The substrate carrier comprises a non-conductive carrier body on which the substrates are to be held. Electrically-conductive lines are embedded within the carrier body, and a plurality of contact clips are coupled to the electrically-conductive lines embedded within the carrier body. The contact clips hold the substrates in place and electrically couple the substrates to the electrically-conductive lines. The non-conductive carrier body is continuous so as to be impermeable to flow of electroplating solution through the non-conductive carrier body. Other embodiments, aspects and features are also disclosed. | 03-29-2012 |
20120073976 | Maintainable substrate carrier for electroplating - One embodiment relates to a substrate carrier for use in electroplating a plurality of substrates. The carrier includes a non-conductive carrier body on which the substrates are placed and conductive lines embedded within the carrier body. A plurality of conductive clip attachment parts are attached in a permanent manner to the conductive lines embedded within the carrier body. A plurality of contact clips are attached in a removable manner to the clip attachment parts. The contact clips hold the substrates in place and conductively connecting the substrates with the conductive lines. Other embodiments, aspects and features are also disclosed. | 03-29-2012 |
20140034488 | NON-PERMEABLE SUBSTRATE CARRIER FOR ELECTROPLATING - One embodiment relates to a substrate carrier for use in electroplating a plurality of substrates. The substrate carrier comprises a non-conductive carrier body on which the substrates are to be held. Electrically-conductive lines are embedded within the carrier body, and a plurality of contact clips are coupled to the electrically-conductive lines embedded within the carrier body. The contact clips hold the substrates in place and electrically couple the substrates to the electrically-conductive lines. The non-conductive carrier body is continuous so as to be impermeable to flow of electroplating solution through the non-conductive carrier body. Other embodiments, aspects and features are also disclosed. | 02-06-2014 |
Patent application number | Description | Published |
20080223393 | Method and System for Imparting Strand Effect to Hair - A method of imparting hair strand effects may include identifying each of a plurality of hair strands to which to apply a hair strand effect product independently and individually, the plurality of hair strands associated with an illustration of at least one type of hair strand effects and one of a plurality of hair styles, and applying the product to each of the plurality of hair strands independently and individually subsequent to identifying the plurality of hair strands. In the alternative or in combination, a hair instruction guide may be consulted, the guide having at least one strand size associated with one of the plurality of types of hair strand effects, and a strand of hair may be identified according to the at least one strand size. A system for creating a hair strand effect may include a hair strand effect product and such a hair instruction guide. | 09-18-2008 |
20100154333 | Structural Members And Structures Using Them, And Methods - Structural members, building structures, and methods for making them, are provided that are less prone to develop squeaks. The methods include, in one aspect, placing at least one panel on the flange surfaces of joists with an activatable adhesive provided between the panel and the flange surfaces to bond the flange surfaces to the panels in an effective long lasting manner. In another aspect, adhesive is introduced into a groove array in a joist flange surface to attach a panel pre-positioned on the grooved flange surface. Building frame structures, such as subflooring assemblies, made by the methods are also provided. | 06-24-2010 |
20130333716 | Method and System for Imparting Strand Effect to Hair - A method of imparting hair strand effects may include identifying each of a plurality of hair strands to which to apply a hair strand effect product independently and individually, the plurality of hair strands associated with an illustration of at least one type of hair strand effects and one of a plurality of hair styles, and applying the product to each of the plurality of hair strands independently and individually subsequent to identifying the plurality of hair strands. In the alternative or in combination, a hair instruction guide may be consulted, the guide having at least one strand size associated with one of the plurality of types of hair strand effects, and a strand of hair may be identified according to the at least one strand size. A system for creating a hair strand effect may include a hair strand effect product and such a hair instruction guide. | 12-19-2013 |
Patent application number | Description | Published |
20110047019 | COUPON BEARING SPONSOR ACCOUNT TRANSACTION AUTHORIZATION - A transaction handler receives, for forwarding to a sponsor account's issuer, a coupon authorization request message from a merchant's acquirer that identifies the sponsor account and a coupon for an item being purchased by a consumer in a transaction with the merchant. The issuer determines eligibility of the coupon for use by the consumer, and sends an authorization response message to the merchant via its acquirer and the transaction handler for the application of a corresponding discount for the item when the coupon is eligible. One or more coupon eligibilities for the purchase of the item by the consumer from the merchant can be derived from comparisons of the transaction to predetermined times, geographies, jurisdictions, sets of merchants, and/or the number of times that coupons have been used in other transactions. The transaction handler can further process the transaction for authorization the consumer's account to pay of the transaction. | 02-24-2011 |
20110288918 | Systems and Methods for Redemption of Offers - In one aspect, a computing apparatus is configured to automate the redemption of offers, such as manufacturer coupons, which require the purchase of specific items identified in the offers for their redemption. The computing apparatus is to store offers in connection with accounts of users (e.g., credit cards, debit cards, prepaid cards). When the accounts are used to make purchases, the authorization response messages from the transaction handler may include indicators to request purchase details, if the corresponding accounts have associated offers pending for redemption. When the purchase details show that the users have made the purchases required for the redemption of the offers, the benefits of the offers are provided to the accounts of the users via statement credits. Optional email or mobile alerts may be provided to the users to report the automated redemption of the offers. | 11-24-2011 |
20130254004 | COUPON BEARING SPONSOR ACCOUNT TRANSACTION AUTHORIZATION - A transaction handler receives, for forwarding to a sponsor account's issuer, a coupon authorization request message from a merchant's acquirer that identifies the sponsor account and a coupon for an item being purchased by a consumer in a transaction with the merchant. The issuer determines eligibility of the coupon for use by the consumer, and sends an authorization response message to the merchant via its acquirer and the transaction handler for the application of a corresponding discount for the item when the coupon is eligible. One or more coupon eligibilities for the purchase of the item by the consumer from the merchant can be derived from comparisons of the transaction to predetermined times, geographies, jurisdictions, sets of merchants, and/or the number of times that coupons have been used in other transactions. The transaction handler can further process the transaction for authorization the consumer's account to pay of the transaction. | 09-26-2013 |
Patent application number | Description | Published |
20080247230 | Novel monolithic, combo nonvolatile memory allowing byte, page and block write with no disturb and divided-well in the cell array using a unified cell structure and technology with a new scheme of decoder and layout - A novel FLASH-based EEPROM cell, decoder, and layout scheme are disclosed to eliminate the area-consuming divided triple-well in cell array and allows byte-erase and byte-program for high P/E cycles. Furthermore, the process-compatible FLASH cell for EEPROM part can be integrated with FLASH and ROM parts so that a superior combo, monolithic, nonvolatile memory is achieved. Unlike all previous arts, the novel combo nonvolatile memory of the present invention of ROM, EEPROM and FLASH or combination of any two is made of one unified, fully compatible, highly-scalable BN+ cell and unified process. In addition, its cell operation schemes have zero array overhead and zero disturbance during P/E operations. The novel combo nonvolatile memory is designed to meet the need in those markets requiring flexible write size in units of bytes, pages and blocks at a lower cost. | 10-09-2008 |
20110170357 | NONVOLATILE MEMORY WITH A UNIFIED CELL STRUCTURE - A novel FLASH-based EEPROM cell, decoder, and layout scheme are disclosed to eliminate the area-consuming divided triple-well in cell array and allows byte-erase and byte-program for high P/E cycles. Furthermore, the process-compatible FLASH cell for EEPROM part can be integrated with FLASH and ROM parts so that a superior combo, monolithic, nonvolatile memory is achieved. Unlike all previous arts, the novel combo nonvolatile memory of the present invention of ROM, EEPROM and FLASH or combination of any two is made of one unified, fully compatible, highly-scalable BN+ cell and unified process. In addition, its cell operation schemes have zero array overhead and zero disturbance during P/E operations. The novel combo nonvolatile memory is designed to meet the need in those markets requiring flexible write size in units of bytes, pages and blocks at a lower cost. | 07-14-2011 |
Patent application number | Description | Published |
20110167524 | METHOD AND APPARATUS OF OPERATING A SCANNING PROBE MICROSCOPE - An improved mode of AFM imaging (Peak Force Tapping (PFT) Mode) uses force as the feedback variable to reduce tip-sample interaction forces while maintaining scan speeds achievable by all existing AFM operating modes. Sample imaging and mechanical property mapping are achieved with improved resolution and high sample throughput, with the mode being workable across varying environments, including gaseous, fluidic and vacuum. Ease of use is facilitated by eliminating the need for an expert user to monitor imaging. | 07-07-2011 |
20120131702 | Method and Apparatus of Using Peak Force Tapping Mode to Measure Physical Properties of a Sample - An improved mode of AFM imaging (Peak Force Tapping (PFT) Mode) uses force as the feedback variable to reduce tip-sample interaction forces while maintaining scan speeds achievable by all existing AFM operating modes. Sample imaging and mechanical property mapping are achieved with improved resolution and high sample throughput, with the mode being workable across varying environments, including gaseous, fluidic and vacuum. Ease of use is facilitated by eliminating the need for an expert user to monitor imaging. | 05-24-2012 |
20130276174 | Method and Apparatus of Electrical Property Measurement Using an AFM Operating in Peak Force Tapping Mode - An apparatus and method of collecting topography, mechanical property data and electrical property data with an atomic force microscope (AFM) in either a single pass or a dual pass operation. PFT mode is preferably employed thus allowing the use of a wide range of probes, one benefit of which is to enhance the sensitivity of electrical property measurement. | 10-17-2013 |
20140223615 | Method and Apparatus of Operating a Scanning Probe Microscope - Methods and apparatuses are provided for automatically controlling and stabilizing aspects of a scanning probe microscope (SPM), such as an atomic force microscope (AFM), using Peak Force Tapping (PFT) Mode. In an embodiment, a controller automatically controls periodic motion of a probe relative to a sample in response to a substantially instantaneous force determined, and automatically controls a gain in a feedback loop. A gain control circuit automatically tunes a gain based on separation distances between a probe and a sample to facilitate stability. Accordingly, instability onset is quickly and accurately determined during scanning, thereby eliminating the need of expert user tuning of gains during operation. | 08-07-2014 |
Patent application number | Description | Published |
20090261078 | RADIANT ANNEAL THROUGHPUT OPTIMIZATION AND THERMAL HISTORY MINIMIZATION BY INTERLACING - The time between illumination of adjacent zones of a workpiece edge is extended by a long cool-down period or delay, by interlacing a radiation beam scanning pattern. During the cool-down period, the beam successively scans (along the fast axis) two rows separated by about half the wafer diameter, and travels back and then forth (along the slow axis) across the distance between the two rows, while the radiation beam source continuously generates the beam. | 10-22-2009 |
20100267247 | Dual Frequency Low Temperature Oxidation of a Semiconductor Device - Methods and apparatus for forming an oxide layer on a semiconductor substrate are disclosed. A two frequency plasma source is used to form a plasma in a plasma reactor. In various embodiments, different quantities of power are supplied to a power source operating at the first frequency and a power source operating at the second frequency over time. | 10-21-2010 |
20100267248 | Post Treatment Methods for Oxide Layers on Semiconductor Devices - Methods and apparatus for post treating an oxide layer on a semiconductor substrate are disclosed. In one or more embodiments, the oxide layer is formed by thermal oxidation or plasma oxidation and treated with a plasma comprising helium. The helium-containing plasma may also include hydrogen, neon, argon and combinations thereof. In one or more embodiments, a SiO | 10-21-2010 |
20120122253 | APPARATUS AND METHOD OF ALIGNING AND POSITIONING A COLD SUBSTRATE ON A HOT SURFACE - Embodiments of the invention contemplate a method, apparatus and system that are used to support and position a substrate on a surface that is at a different temperature than the initial, or incoming, substrate temperature. Embodiments of the invention may also include a method of controlling the transfer of heat between a substrate and substrate support positioned in a processing chamber. The apparatus and methods described herein generally may also provide an inexpensive and simple way of accurately positioning a substrate on a substrate support that is positioned in a semiconductor processing chamber. Substrate processing chambers that can benefit from the various embodiments described herein include, but are not limited to RTP, CVD, PVD, ALD, plasma etching, and/or laser annealing chambers. | 05-17-2012 |
Patent application number | Description | Published |
20110196488 | DEGRADATION RESISTANT IMPLANTABLE MATERIALS AND METHODS - Methods are provided for making materials suitable for implantation in a mammal. The methods include the steps of providing a base material having a desirable surface topography, such as a polyurethane foam, contacting the base member with a silicone-based fluid material to form a coating, and allowing the coating to set to form a silicone-based structure suitable for implantation in a mammal. The base material may be removed from the coating. | 08-11-2011 |
20110313073 | FOAM-LIKE MATERIALS AND METHODS FOR PRODUCING SAME - Described herein are foam-like materials having substantially the same physical structure of polyurethane foams but with properties that can be tailored for a particular application. Methods of forming these foam-like materials are also described. | 12-22-2011 |
20120004722 | DEGRADATION RESISTANT IMPLANTABLE MATERIALS AND METHODS - Methods are provided for making materials suitable for implantation in a mammal. The methods include the steps of providing a base material having a desirable surface topography, such as a polyurethane foam, contacting the base member with a silicone-based fluid material to form a coating, and allowing the coating to set to form a silicone-based structure suitable for implantation in a mammal. The base material may be removed from the coating. | 01-05-2012 |
20120101574 | IMPLANTABLE MATERIALS - A textured breast implant is provided which generally includes a fluid fillable elastomeric shell having a texture defined by struts, for example, hollow struts, defining interconnected open cells. Methods of making the texture include applying a silicone dispersion to a base material and removing the base material from the coating to form a silicone-based structure comprising struts defining interconnected open cells, said struts including internal surfaces defining cavities within the struts. The method may further include the step of contacting the silicone based structure having cavities with a silicone dispersion to cause the silicone to enter and fill the cavities. | 04-26-2012 |
20130013062 | METHODS FOR CREATING FOAM-LIKE TEXTURE - Methods for creating a foam-like texture on an implantable material are provided. More particularly, methods for creating foam-like texture on implantable silicone materials are provided. | 01-10-2013 |
20140242258 | IMPLANTABLE MATERIALS - A textured breast implant is provided which generally includes a fluid fillable elastomeric shell having a texture defined by struts, for example, hollow struts, defining interconnected open cells. Methods of making the texture include applying a silicone dispersion to a base material and removing the base material from the coating to form a silicone-based structure comprising struts defining interconnected open cells, said struts including internal surfaces defining cavities within the struts. The method may further include the step of contacting the silicone based structure having cavities with a silicone dispersion to cause the silicone to enter and fill the cavities. | 08-28-2014 |
Patent application number | Description | Published |
20110163373 | Semiconductor device including a voltage controlled termination structure and method for fabricating same - According to one embodiment, a semiconductor device including a voltage controlled termination structure comprises an active area including a base region of a first conductivity type formed in a semiconductor body of a second conductivity type formed over a first major surface of a substrate of the second conductivity type, a termination region formed in the semiconductor body adjacent the active area and including the voltage controlled termination structure. The voltage controlled termination structure includes an electrode electrically connected to a terminal of the semiconductor device. In one embodiment, the electrode of the voltage controlled termination structure is electrically connected to a gate terminal of the semiconductor device. In one embodiment, the electrode of the voltage controlled termination structure is electrically connected to a source terminal of the semiconductor device. | 07-07-2011 |
20110284950 | Method for fabricating a shallow and narrow trench FETand related structures - Disclosed is a method for fabricating a shallow and narrow trench field-effect transistor (trench FET). The method includes forming a trench within a semiconductor substrate of a first conductivity type, the trench including sidewalls and a bottom portion. The method further includes forming a substantially uniform gate dielectric in the trench, and forming a gate electrode within said trench and over said gate dielectric. The method also includes doping the semiconductor substrate to form a channel region of a second conductivity type after forming the trench. In one embodiment, the doping step is performed after forming the gate dielectric and after forming the gate electrode. In another embodiment, the doping step is performed after forming the gate dielectric, but prior to forming the gate electrode. Structures formed by the invention's method are also disclosed. | 11-24-2011 |
20120211825 | Trench MOSFET and Method for Fabricating Same - According to an exemplary embodiment, a trench field-effect transistor (trench FET) includes a trench formed in a semiconductor substrate, the trench including a gate dielectric disposed therein. A source region is disposed adjacent the trench. The trench FET also has a gate electrode including a lower portion disposed in the trench and a proud portion extending laterally over the source region. A silicide source contact can extend vertically along a sidewall of the source region. Also, a portion of the gate dielectric can extend laterally over the semiconductor substrate. The trench FET can further include a silicide gate contact formed over the proud portion of the gate electrode. | 08-23-2012 |
20130264636 | Trench FET with Ruggedness Enhancement Regions - According to an exemplary implementation, a field-effect transistor (FET) includes first and second gate trenches extending to a drift region of a first conductivity type. The FET also includes a base region of a second conductivity type that is situated between the first and second gate trenches. A ruggedness enhancement region is situated between the first and second gate trenches, where the ruggedness enhancement region is configured to provide an enhanced avalanche current path from a drain region to the base region when the FET is in an avalanche condition. The enhanced avalanche current path is away from the first and second gate trenches. The ruggedness enhancement region can be of the second conductivity type that includes a higher dopant concentration than the base region. Furthermore, the ruggedness enhancement region can be extending below the first and second gate trenches. | 10-10-2013 |
20140118032 | Buck Converter Power Package - One exemplary disclosed embodiment comprises a semiconductor package including a vertical conduction control transistor and a vertical conduction sync transistor. The vertical conduction control transistor may include a control source, a control gate, and a control drain that are all accessible from a bottom surface, thereby enabling electrical and direct surface mounting to a support surface. The vertical conduction sync transistor may include a sync drain on a top surface, which may be connected to a conductive clip that is coupled to the support surface. The conductive clip may also be thermally coupled to the control transistor. Accordingly, all terminals of the transistors are readily accessible through the support surface, and a power circuit, such as a buck converter power phase, may be implemented through traces of the support surface. Optionally, a driver IC may be integrated into the package, and a heatsink may be attached to the conductive clip. | 05-01-2014 |
20140167152 | Reduced Gate Charge Trench Field-Effect Transistor - In one implementation, a trench field-effect transistor (trench FET) can include a semiconductor substrate including a drain region, a drift zone over the drain region, and first and second gate trenches including a gate dielectric and respective gate electrodes disposed therein, also over the drain region. The trench FET can further include a depletion trench situated between the first and second gate trenches, the depletion trench including a trench insulator. The trench insulator adjoins the gate electrodes and the gate dielectric so as to reduce a gate charge of the trench FET. | 06-19-2014 |
20140167153 | Trench Fet Having Merged Gate Dielectric - In one implementation, a trench field-effect transistor (trench FET) includes a semiconductor substrate having a drain region, a drift zone over the drain region, and depletion trenches formed over the drain region. Each depletion trench includes a depletion trench dielectric and a depletion electrode. The trench FET can further include a respective bordering gate trench situated alongside each depletion trench, each bordering gate trench having a gate electrode and a gate dielectric. The gate dielectric is merged with the depletion trench dielectric between the depletion electrode and the gate electrode. | 06-19-2014 |
20140374825 | Power Semiconductor Device with Contiguous Gate Trenches and Offset Source Trenches - Disclosed is a power semiconductor device that includes a plurality of source trenches and adjacent source regions. The plurality of source trenches extend from a top surface of a semiconductor substrate into the semiconductor substrate. The power semiconductor device further includes a plurality of gate trenches that extend from the top of the semiconductor substrate into the semiconductor substrate, and are arranged in hexagonal or zigzag patterns. A contiguous formation is created by the plurality of gate trenches, and the plurality of gate trenches separate the plurality of source trenches from one another. | 12-25-2014 |
Patent application number | Description | Published |
20080257218 | Light Weight Additive, Method of Making and Uses Thereof - Low density additives and methods of making said additives for composite materials are provided. The low density additives have at least a partial or complete water repellant property that reduces moisture migration, absorption, and retention within a composite material in which it is incorporated into. Active sites are engineered onto the surface of the low density additives to enhance bonding of the additives within a composite matrix. Reduced water movement and enhanced bonding lead to an increased strength and durability performance for a composite material comprising such additives. Composite materials incorporating one or more engineered low density additives as also provided, such composite materials having enhanced strength and durability. Such composite materials may be made from a Hatschek process. The composite materials may be further used as interior and exterior building products. | 10-23-2008 |
20090090276 | Cementitious Formulations and Products - Cementitious formulations and their products with enhanced reactivity are provided. Formulations in certain embodiments may include at least one calcium source, a reactant and a filler in a hydrated environment, wherein the reactant, in one form, is crystalline silica that has been modified for reactivity. Enhancement of a reactant may include one or more modifications to its content, grind and/or the cement to silica ratio, as well as addition of one or more additives in the formulation, additives in the form of at least one alumina source, defoamer, catalyst and/or a clay. | 04-09-2009 |
20120152154 | CEMENTITIOUS FORMULATIONS AND PRODUCTS - Cementitious formulations and their products with enhanced reactivity are provided. Formulations in certain embodiments may include at least one calcium source, a reactant and a filler in a hydrated environment, wherein the reactant, in one form, is crystalline silica that has been modified for reactivity. Enhancement of a reactant may include one or more modifications to its content, grind and/or the cement to silica ratio, as well as addition of one or more additives in the formulation, additives in the form of at least one alumina source, defoamer, catalyst and/or a clay. | 06-21-2012 |
Patent application number | Description | Published |
20080312174 | WATER SOLUBLE CROSSLINKED POLYMERS - Compositions for siRNA delivery are described which include water soluble degradable crosslinked cationic polymers having a water soluble polyethylene glycol component, a cationic polyethyleneimine component and a degradable unit component. The composition may be used to deliver siRNA to cells, particularly cancer cells. The composition may be applied to a solid surface such as a multiwell plate so that the delivery of siRNA may be carried out on the solid surface. | 12-18-2008 |
20090105179 | DRUG CARRIERS - Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell. | 04-23-2009 |
20110257249 | DRUG CARRIERS - Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell. | 10-20-2011 |
20120093762 | NUCLEIC ACID DELIVERY COMPOUNDS - Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell. | 04-19-2012 |
20120107264 | NUCLEIC ACID DELIVERY COMPOUNDS - Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell. | 05-03-2012 |
Patent application number | Description | Published |
20110180679 | WEIGHT PLATE - A weight plate for securing portable structures employing a low-profile, planar plate having an aperture formed therethrough. The aperture is configured so as to allow the base of the leg of a structure to pass through. The plate is subsequently transposed so as to lock the base of the leg underneath the plate while the leg of the shelter passes through the plate and an opposite side of the plate extends away form the leg. | 07-28-2011 |
20110308559 | Shelter With Extended Eaves - A shelter that includes a slider and a strut mechanism mounted on support posts of the shelter that automatically actuate and extend from the side of the support posts when the shelter is expanded from its collapsed state. The strut mechanism provides support for an eave that extends outside from all or a portion of the perimeter of the shelter defined by the corners of the support posts. An automatic hard-stop mechanism is incorporated into the support posts that prevent the eave sliders and strut mechanisms from becoming over-extended. The support posts are configured and oriented relative to the other components of the shelter frame and shelter boundary so to minimize the footprint or size of the shelter when in the collapsed state. Accordingly, the protected and shaded area offered by the shelter is greatly increased without sacrificing the stability and strength of the shelter, complicating the operation of the shelter, or increasing the weight, storability or cost of the shelter. | 12-22-2011 |
20140102497 | Shelter With Extended Eaves - A shelter that includes a slider and a strut mechanism mounted on support posts of the shelter that automatically actuate and extend from the side of the support posts when the shelter is expanded from its collapsed state. The strut mechanism provides support for an eave that extends outside from all or a portion of the perimeter of the shelter defined by the corners of the support posts. An automatic hard-stop mechanism is incorporated into the support posts that prevent the eave sliders and strut mechanisms from becoming over-extended. The support posts are configured and oriented relative to the other components of the shelter frame and shelter boundary so to minimize the footprint or size of the shelter when in the collapsed state. Accordingly, the protected and shaded area offered by the shelter is greatly increased without sacrificing the stability and strength of the shelter, complicating the operation of the shelter, or increasing the weight, storability or cost of the shelter. | 04-17-2014 |
Patent application number | Description | Published |
20110070580 | Methods, Compositions, and Kits for Amplifying and Sequencing Polynucleotides - In one aspect, there are provided methods of amplifying and sequencing a polynucleotide. In some embodiments, the method includes (a) amplifying the polynucleotide with at least one amplification primer, a processive amplification polymerase, a sequencing primer, a sequencing polymerase, deoxynucleoside triphosphates suitable for template-dependent primer extension, and one or more terminating nucleotides, the incubation being carried out at a first temperature suitable for amplifying the polynucleotide with the processive amplification polymerase; (b) incubating the product of step (a) at a second temperature suitable for forming a plurality of differently-sized extended sequencing primers with the sequencing polymerase; (c) evaluating the extended sequencing primers in order to determine the sequence of the polynucleotide. The reactions at the first and second temperatures can be carried out in a single reaction vessel. In other aspects, compositions and kits for carrying out the methods are also provided. | 03-24-2011 |
20120135414 | CHEMICALLY-ENHANCED PRIMER COMPOSITIONS, METHODS AND KITS - A composition is provided comprising a negatively charged group, an oligonucleotide sequence and at least none or one nuclease-resistant linkage group to form a chemically-enhanced primer. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the primer as well as a method of preparing DNA for sequencing and a method of sequencing DNA and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition under conditions in which excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded. | 05-31-2012 |
20120270211 | CHEMICALLY-ENHANCED PRIMER COMPOSITIONS, METHODS AND KITS - A chemically-enhanced primer is provided comprising a negatively charged moiety (NCM), an oligonucleotide sequence having a) non-nuclease resistant inter-nucleotide linkages or b) at least one nuclease resistance inter-nucleotide linkage. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the chemically-enhanced primer as well as a method of preparing DNA for sequencing, a method of sequencing DNA, and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition wherein excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded. | 10-25-2012 |
20130344492 | METHODS, COMPOSITIONS, AND KITS FOR AMPLIFYING AND SEQUENCING POLYNUCLEOTIDES - In one aspect, there are provided methods of amplifying and sequencing a polynucleotide. In some embodiments, the method includes (a) amplifying the polynucleotide with at least one amplification primer, a processive amplification polymerase, a sequencing primer, a sequencing polymerase, deoxynucleoside triphosphates suitable for template-dependent primer extension, and one or more terminating nucleotides, the incubation being carried out at a first temperature suitable for amplifying the polynucleotide with the processive amplification polymerase; (b) incubating the product of step (a) at a second temperature suitable for forming a plurality of differently-sized extended sequencing primers with the sequencing polymerase; (c) evaluating the extended sequencing primers in order to determine the sequence of the polynucleotide. The reactions at the first and second temperatures can be carried out in a single reaction vessel. In other aspects, compositions and kits for carrying out the methods are also provided. | 12-26-2013 |
20140099645 | CHEMICALLY-ENHANCED PRIMER COMPOSITIONS, METHODS AND KITS - A composition is provided comprising a negatively charged group, an oligonucleotide sequence and at least none or one nuclease-resistant linkage group to form a chemically-enhanced primer. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the primer as well as a method of preparing DNA for sequencing and a method of sequencing DNA and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition under conditions in which excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded. | 04-10-2014 |
20140377747 | CHEMICALLY-ENHANCED PRIMER COMPOSITIONS, METHODS AND KITS - A chemically-enhanced primer is provided comprising a negatively charged moiety (NCM), an oligonucleotide sequence having a) non-nuclease resistant inter-nucleotide linkages or b) at least one nuclease resistance inter-nucleotide linkage. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the chemically-enhanced primer as well as a method of preparing DNA for sequencing, a method of sequencing DNA, and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition wherein excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded. | 12-25-2014 |
Patent application number | Description | Published |
20110137940 | Methods And Apparatus For Selecting Updates To Associated Records To Publish On An Information Feed In An On-Demand Database Service Environment - Disclosed are systems, apparatus, methods, and computer readable media for selecting updates to associated records to publish on an information feed in an on-demand database service environment. In one embodiment, one or more updates associated with a data record are accessed. The one or more updates are stored in a database. The data record is a parent record, and the one or more updates relate to one or more child records associated with the parent record. The one or more updates are provided as one or more candidates for publication on an information feed associated with the data record, where the information feed is capable of being displayed on a display device. A number of the candidates is selected for publication on the information feed based on one or more criteria. | 06-09-2011 |
20120078917 | Methods And Apparatus For Selecting Updates To Associated Records To Publish On An Information Feed Using Importance Weights In An On-Demand Database Service Environment - Disclosed are systems, apparatus, methods, and computer readable media for selecting updates to associated records to publish on an information feed in an on-demand database service environment. In one embodiment, one or more updates associated with a data record are stored in a database. One or more criteria are applied to the one or more updates to generate an importance weight associated with each update. The one or more importance weights are compared with a designated threshold. When one or more importance weights are identified as meeting or exceeding the designated threshold, the one or more updates associated with the identified one or more importance weights are provided as one or more candidates for publication on an information feed associated with the data record, where the information feed is capable of being displayed on a display device. | 03-29-2012 |
20120078981 | Methods and Apparatus for Suppressing Network Feed Activities Using an Information Feed in an On-Demand Database Service Environment - Disclosed are systems, apparatus, methods, and computer readable media for suppressing network feed activities using an information feed in an on-demand database service environment. In one embodiment, a message is received, including data indicative of a user action. An entity associated with the user action is identified, where the entity is a type of record stored in a database. A type of the entity is identified. It is determined whether the entity type is a prohibited entity type. When the entity type is not a prohibited entity type, the message data is saved to one or more tables in the database. The tables are configured to store feed items of an information feed capable of being displayed on a device. When the entity type is a prohibited entity type, the saving of the message data, to the one or more tables in the database configured to store the feed items, is prohibited. | 03-29-2012 |
20140019459 | Methods And Apparatus For Selecting Updates To Associated Records To Publish On An Information Feed In An On-Demand Database Service Environment - Disclosed are systems, apparatus, methods, and computer readable media for selecting updates to associated records to publish on an information feed in an on-demand database service environment. In one embodiment, one or more updates associated with a data record are stored in a database. One or more criteria are applied to the one or more updates to generate a score associated with each update. The score is compared with a designated threshold. When the score is identified as meeting or exceeding the designated threshold, the one or more updates are provided as one or more candidates for publication on an information feed associated with the data record, where the information feed is capable of being displayed on a display device. | 01-16-2014 |
20140222814 | METHODS AND APPARATUS FOR SUPPRESSING NETWORK FEED ACTIVITIES USING AN INFORMATION FEED IN AN ON-DEMAND DATABASE SERVICE ENVIRONMENT - Disclosed are systems, apparatus, methods, and computer readable media for suppressing network feed activities using an information feed in an on-demand database service environment. In one embodiment, a message is received, including data indicative of a user action. An entity associated with the user action is identified, where the entity is a type of record stored in a database. A type of the entity is identified. It is determined whether the entity type is a prohibited entity type. When the entity type is not a prohibited entity type, the message data is saved to one or more tables in the database. The tables are configured to store feed items of an information feed capable of being displayed on a device. When the entity type is a prohibited entity type, the saving of the message data, to the one or more tables in the database configured to store the feed items, is prohibited. | 08-07-2014 |
Patent application number | Description | Published |
20090143405 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST - Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula I | 06-04-2009 |
20090143575 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS - Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotizing agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders. | 06-04-2009 |
20100087429 | SPIRO-TRICYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I | 04-08-2010 |
20100261728 | TRP-M8 RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS - Tetrahydroisoquinoline compounds of formula (I), and compositions containing them, for the treatment of acute, inflammatory and neurophatic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neurophatic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders. | 10-14-2010 |
20110118234 | Urea Compounds as Gamma Secretase Modulators - The present invention provides compounds Formula (I) that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. | 05-19-2011 |
20110251190 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula I | 10-13-2011 |
Patent application number | Description | Published |
20100112571 | COMPOSITIONS AND METHODS FOR DETECTING MUTATIONS IN JAK2 NUCLEIC ACID - The invention disclosed herein is based on the identification of novel mutations in the JAK2 gene and JAK2 protein. The invention provides compositions and methods useful for diagnosing hematopoietic diseases including, for example, myeloproliferative diseases. The invention also provides compositions and methods useful for determining a prognosis of an individual diagnosed as having a hematopoietic disease. | 05-06-2010 |
20110053197 | UBIQUITIN PROTEASOME SYSTEM PROFILING AND THE USE THEREOF IN CLINICAL APPLICATIONS FOR CANCER DIAGNOSIS - Provided herein are methods for the diagnosis, prognosis, or management of neoplastic diseases, i.e. cancer, and other diseases using profiles of the ubiquitin-proteasome system determined from acellular body fluids or cell-containing samples. Further provided are methods of predicting response to therapy in certain populations of cancer patients. | 03-03-2011 |
20110053198 | UBIQUITIN PROTEASOME SYSTEM PROFILING AND THE USE THEREOF IN CLINICAL APPLICATIONS FOR PROLIFERATIVE HEMATOLOGICAL DISORDERS - Provided herein are methods for the diagnosis, prognosis, or management of proliferative hematological disorders and other diseases using profiles of the ubiquitin-proteasome system determined from acellular body fluids or cell-containing samples. Further provided are methods of predicting response to therapy in certain populations of leukemia patients. | 03-03-2011 |
20110053199 | UBIQUITIN PROTEASOME SYSTEM PROFILING AND THE USE THEREOF IN CLINICAL APPLICATIONS FOR CANCER DIAGNOSIS - Provided herein are methods for the diagnosis, prognosis, or management of neoplastic diseases, i.e. cancer, and other diseases using profiles of the ubiquitin-protcasome system determined from acellular body fluids or cell-containing samples. Further provided are methods of predicting response to therapy in certain populations of cancer patients. | 03-03-2011 |
20110072889 | BCR-ABL TRUNCATION MUTATIONS - Truncation variants of BCR-ABL mRNA that produces BCR-ABL proteins with a truncated C-terminus and its role in resistance to treatment with kinase inhibitors is described. Vectors for expressing the truncated gene products are described as well as recombinant cells that express the truncated gene products from cDNA constructs. Also provided are methods compositions and kits for detecting the BCR-ABL truncation variants. Also provided are methods for determining the prognosis of a patient diagnosed as having myeloproliferative disease, and methods for predicting the likelihood for resistance to a treatment with tyrosine kinase inhibitor in a patient diagnosed as having myeloproliferative disease. Additionally, methods for screening BCR-ABL tyrosine kinase domain inhibitors which rely on the recombinant cells are also disclosed. | 03-31-2011 |
20120003653 | COMPOSITIONS AND METHODS FOR DETECTING MUTATIONS IN JAK2 NUCLEIC ACID - The invention disclosed herein is based on the identification of novel mutations in the JAK2 gene and JAK2 protein. The invention provides compositions and methods useful for diagnosing hematopoietic diseases including, for example, myeloproliferative diseases. The invention also provides compositions and methods useful for determining a prognosis of an individual diagnosed as having a hematopoietic disease. | 01-05-2012 |
20120171670 | BCR-ABL1 SPLICE VARIANTS AND USES THEREOF - The present invention is based on BCR-ABL1 splice variants which result from insertion and/or truncation of the bcr-abl1 transcript and the finding that these variants provide resistance to kinase domain inhibitors such as imatinib, nilotinib and dasatinib. | 07-05-2012 |
20120329049 | BCR-ABL1 SPLICE VARIANTS AND USES THEREOF - The present invention is based on BCR-ABL1 splice variants which result from insertion and/or truncation of the BCR-ABL1 transcript and the finding that these variants provide resistance to kinase domain inhibitors such as imatinib, nilotinib and dasatinib. | 12-27-2012 |
20130288236 | WT1 MUTATIONS FOR PROGNOSIS OF MYELOPROLIFERATIVE DISORDERS - The invention provides methods for determining the prognosis of a patient diagnosed with a leukemia, including B-cell chronic lymphocytic leukemia, by measuring mutations of the WT1 gene in a biological sample. The invention also relates to the diagnosis of leukemia, including B-cell chronic lymphocytic leukemia. | 10-31-2013 |
20130295562 | METHODS FOR DETECTING RISK OF MYELODYSPLASTIC SYNDROME BY GENOTYPIC ANALYSIS - The present invention provides methods for detecting the risk of developing leukemia using genotyping analysis, for example of a SNP located in the promoter region of EPO. The present invention also provides kits and nucleic acids for the detection of the risk genotype. | 11-07-2013 |
20140057270 | COMPOSITIONS AND METHODS FOR DETECTING MUTATIONS IN JAK2 NUCLEIC ACID - The invention disclosed herein is based on the identification of novel mutations in the JAK2 gene and JAK2 protein. The invention provides compositions and methods useful for diagnosing hematopoietic diseases including, for example, myeloproliferalive diseases. The invention also provides compositions and methods useful for determining a prognosis of an individual diagnosed as having a hematopoietic disease. | 02-27-2014 |
20140141427 | BCR-ABL1 SPLICE VARIANTS AND USES THEREOF - The present invention is based on BCR-ABL1 splice variants which result from insertion and/or truncation of the bcr-abl1 transcript and the finding that these variants provide resistance to kinase domain inhibitors such as imatinib, nilotinib and dasatinib. | 05-22-2014 |
20150080255 | MPL MUTATIONS IN JAK2 V617F NEGATIVE PATIENTS WITH MYELOPROLIFERATIVE DISEASE - The invention provides compositions and methods for diagnosing a patient as having a myeloproliferative disease by identifying mutations in the MPL gene or gene products. | 03-19-2015 |
Patent application number | Description | Published |
20100305316 | PROCESSES FOR PREPARING (R)-8-CHLORO-1-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE AND INTERMEDIATES THEREOF - The present invention provides processes and intermediates for the preparation of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and salts thereof which are useful as serotonin-2C (5-HT2C) receptor agonists for the treatment of, for example, obesity. | 12-02-2010 |
20110015438 | PROCESS FOR THE PREPARATION OF INTERMEDIATES RELATED TOTHE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5,-TETRAHYDRO-1H-3-BENZAZEPINE - The present invention provides processes and intermediates useful in the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, a serotonin (5-HT) receptor agonist that is useful in the treatment or prophylaxis of, for example, central nervous system disorders, such as obesity. | 01-20-2011 |
20120295947 | PROCESSES FOR THE PREPARATION OF (R)-2-(7-(4-CYCLOPENTYL-3-(TRIFLUOROMETHYL)BENZYLOXY)-1,2,3,4-TETRAHYDROC- YCLOPENTA[B]INDOL-3-YL)ACETIC ACID AND SALTS THEREOF - The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (Ia) and salts thereof, an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis). | 11-22-2012 |
20140357690 | PROCESSES FOR THE PREPARATION OF (R)-2-(7-(4-CYCLOPENTYL-3-(TRIFLUOROMETHYL)BENZYLOXY)-1,2,3,4-TETRAHYDROC- YCLOPENTA[B]INDOL-3-YL)ACETIC ACID AND SALTS THEREOF - The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (Ia) and salts thereof, an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis). | 12-04-2014 |