Chen, MD
Allen Enfant Chen, Germantown, MD US
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20090119402 | DOMAIN NAME OWNERSHIP VALIDATION - Embodiments of the invention provide systems and methods for validating ownership of a domain name. According to one embodiment, a validating ownership of a domain name can comprise retrieving one or more domain name ownership records. For example, the one or more domain name ownership records comprise Who Is records. Validity of the one or more domain name records can be confirmed with a designated domain manager. According to one embodiment, confirming validity of the one or more domain name records with the designated domain manager can comprise authenticating the designated domain manager based on a certificate provided by the designated domain manager. | 05-07-2009 |
Antony Kuang-Shih Chen, Rockville, MD US
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20120237451 | NOVEL MOLECULAR BEACONS - The invention provides novel compositions and methods for the detection of a target molecule. Specifically, the invention provides a bimolecular beacon composition comprising two nucleic acid molecules, and methods thereof. One of the nucleic acid molecule is operably linked to a reporter detectable label and the other nucleic acid molecule is operably linked to a reference detectable label and a quencher. In some embodiments, at least one of the nucleic acid molecules comprises a single stranded overhang. | 09-20-2012 |
Chi Chen, Cockeysville, MD US
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20110201516 | ASSAY FOR DETECTING CLOSELY-RELATED SEROTYPES OF HUMAN PAPILLOMAVIRUS (HPV) - A real time Taq-Man PCR assay for detecting multiple serotypes of human papillomavirus (HPV) wherein the number of serotypes detected exceeds the number of colorimetric channels for detection. A biological sample is combined with three oligonucleotide primer/probe sets such that the probes and primers anneal to a target sequence. Each primer/probe set is at least preferential for a specific serotype of an organism. The first and second primer/probe sets are degenerate with respect to each other. The third primer/probe set is not degenerate with respect to the first and second primer/probe sets and discriminates for a third serotype. The third primer/probe set has a signal moiety that emits signal at a wavelength that is the same or different from the wavelength emitted by the signal moiety of the degenerate primer/probe set probes. The target sequences, if present, are amplified and detected. | 08-18-2011 |
20140256580 | ASSAY FOR DETECTING CLOSELY-RELATED SEROTYPES OF HUMAN PAPILLOMAVIRUS (HPV) - A real time Taq-Man PCR assay for detecting multiple serotypes of human papillomavirus (HPV) wherein the number of serotypes detected exceeds the number of colorimetric channels for detection. A biological sample is combined with three oligonucleotide primer/probe sets such that the probes and primers anneal to a target sequence. Each primer/probe set is at least preferential for a specific serotype of an organism. The first and second primer/probe sets are degenerate with respect to each other. The third primer/probe set is not degenerate with respect to the first and second primer/probe sets and discriminates for a third serotype. The third primer/probe set has a signal moiety that emits signal at a wavelength that is the same or different from the wavelength emitted by the signal moiety of the degenerate primer/probe set probes. The target sequences, if present, are amplified and detected. | 09-11-2014 |
Dong-Sheng Chen, Potomac, MD US
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20080199952 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOCOCCAL INFECTION - The invention provides polypeptides, polysaccharide-polypeptide conjugates, and expression vectors for treating or preventing pneumococcal infection. The compositions induce an anti-pneumococcal immune response when administered to a mammal. The compositions can be used prophylactically to vaccinate an individual and/or therapeutically to induce a therapeutic immune response in an infected individual. | 08-21-2008 |
Donny Chen, Baltimore, MD US
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20110219515 | MULTI-TOOL COLLAR STAY - A multi-tool collar stay is disclosed. The collar stay may be a non-bendable single piece that includes a first end, a middle section, and a second end. This single piece is shaped to substantially fit within a collar stay pocket, where the first end is tapered to be proximate to a collar tip, and a first tool may be located in the vicinity of the first end. The second end is proximate to a collar stay pocket entrance, and a second tool may be located in the vicinity of the second end. The non-bendable single piece collar stay comprises at least one of: titanium, brass, stainless steel, sterling silver, reinforced polymer, and/or a combination thereof. Examples of the first and second tool include: a bottle opener, a cutting blade, a flat head screw driver, a flat Phillips screw driver, a full Phillips screw driver, a nail file, and a ruler. | 09-15-2011 |
20110231980 | DRESS SHIRT WITH SWITCHABLE BUTTONS - A dress shirt with a modified button placket with switchable buttons is disclosed. The modified button placket provides a wearer with the ability to switch between “work” and “play” buttons for a different fashion look. The modified button placket includes a button-side section including a first button and a second button. The modified button placket also includes a button-hole side inner layer section and a button-hole side outer layer section. In some embodiments, the first button could be a more conservative “work shirt button” while the second button could be a trendier “social outing button.” If the wearer is going to a professional meeting, the wearer of dress shirt could fasten and expose only the work buttons to the outside audience. The play buttons would be left hidden behind both button-hole side inner layer and a button-hole side outer layer. | 09-29-2011 |
20110251926 | METHODS, SYSTEMS, COMPUTER PRODUCTS, AND WEBSITE FOR PROGRESSIVE E-COMMERCE - An e-commerce system where progressive incentives are displayed to entice shoppers to purchase goods is disclosed. The e-commerce system includes a database with a region of memory having data related to a first inventory of physical goods and a second inventory of digital goods. The e-commerce system also includes a website configured to facilitate an event, where the website is coupled to the database for accessing the first inventory in response to the event. The event may be a purchase of one or more physical goods. The e-commerce system further includes a webpage configured to display at least a portion of the first inventory that is available for sale, and to display one or more digital goods, where the webpage presents a locked digital good before the event occurs, and in response to one or more events occurring, the webpage presents an unlocked digital good. | 10-13-2011 |
20130124374 | METHODS, SYSTEMS, COMPUTER PRODUCTS, AND WEBSITE FOR PROGRESSIVE E-COMMERCE - An e-commerce system where progressive incentives are displayed to entice shoppers to purchase goods is disclosed. The e-commerce system includes a database with a region of memory having data related to a first inventory of physical goods and a second inventory of digital goods. The e-commerce system also includes a website configured to facilitate an event, where the website is coupled to the database for accessing the first inventory in response to the event. The event may be a purchase of one or more physical goods. The e-commerce system further includes a webpage configured to display at least a portion of the first inventory that is available for sale, and to display one or more digital goods, where the webpage presents a locked digital good before the event occurs, and in response to one or more events occurring, the webpage presents an unlocked digital good. | 05-16-2013 |
Drew T. Chen, Gaithersburg, MD US
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20130111522 | AGGREGATED CONTENT DISTRIBUTION SYSTEM AND METHOD FOR OPERATING THE SAME | 05-02-2013 |
20130212616 | METHOD AND SYSTEM FOR CONFIGURING A USER INTERFACE OF A RECEIVING UNIT FOR AN AUXILIARY REMOTE CONTROL DEVICE - A system and method for controlling a user interface comprises an auxiliary remote control device having an auxiliary remote control device identifier associated therewith and a receiving unit comprising a filter module having a filter feature for filtering content data from a set of available content data in response to an auxiliary remote control device identifier received at the receiving unit. The filter module forms filtered available content data less than the set of available content data. The receiving unit displays the user interface having the filtered available content data associated with the auxiliary remote control device on a display associated with the receiving unit. | 08-15-2013 |
Ellen T. Chen, Germantown, MD US
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20080237063 | Nanopore structured electrochemical biosensors - The present invention provides a novel biosensor and measuring method. The novel biosensor of the present invention comprises an electrode having a nanopore structured and catalytically active cyclodextrin attached thereto. The biosensor of the present invention has demonstrated robust analytical performance for direct glucose measurement without mediators or without using native enzyme, which is especially beneficial in the hypoglycemia range. | 10-02-2008 |
20140104751 | Nanobiomimetic Supercapacitors with High Rate High Energy Storage - Nanobiomimetic supercapacitors comprise an “Electron Well” and an “Electron-Dam” Membrane Electrode Assembling (MEA); the “Electron-Well” MEA compromises an electrode comprising a substrate of glassy carbon; a self-assembling membrane comprises a polymer matrix; wherein the polymer matrix is comprised of an electrically conductive copolymer; wherein the copolymer is further comprised of one or more first β-cyclodextrin molecules having at least one or more free acetyl groups; one or more polyethylene glycol molecules; one or more poly(4-vinylpyridine) molecules; and one or more second β-cyclodextrin molecules; the self-assembling membrane having a surface structure comprising one or more nanopores and pillars; the nanopores and pillars are vertically oriented on the substrate to form nanopore and pillar array; the “Electron-Dam” MEA compromises the nanopore/pillar layer sealed with an embedded hydrophobic aromatic substance having a flat lid structure; Wherein the MEA can be as either said positive or negative electrode; wherein the “Electron-Well” also can be either said as positive or negative electrode; separated by a porous insulator wetted by an electrolyte-free and air-independent organic solution; at least two current collectors are at each of the end of the MEAs. | 04-17-2014 |
20140178925 | Nanostructured Biomimetic Device with Contour Map of Multiple Variable Correlation Method to Visually Display the Cancer Progresses - The present invention provides a novel electrochemical device and a cancer cell heat release map method to visually display the cancer progresses. The novel device comprises an electrode having a nanopore biomimetic electron-relay network with imidazolium-ATP of cancer cell-water-pyridine at the active sites that mimic the electron-relaying between His 516 and N(5)-FAD of GOx for the purpose to selectively detect triple-negative breast cancer cell at single cell concentration and it rejects brain cancer cell. The device is fast in millisecond to detect cancers without sample preparation and without interference from other substances, such glucose and proteins under reagent-free conditions. A unique biomarker of the ratio of “Action/Resting” cell membrane potential can be used to monitor the cancer progress against the normal cells. A visual contour map of a multiple variable correlation method provided to assess the heat release from the cancer cells against the normal cells is presented. The device for a potential therapeutic application was demonstrated by discharge voltage pulses from the live cancer cells with release extra energy that the cells possessed until it returns to a normal status in terms of normal cell membrane action/resting potential ratio. | 06-26-2014 |
Ellen Tuanying Chen, Germantown, MD US
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20120193243 | Nanopore array structured devices for biosensing and energy Storage - The present invention provides a novel biosensing and measuring method. The biosensor of the present invention comprises an electrode having a nanopore structured and bio-communicationally active cyclodextrin attached thereto. The biosensor of the present invention has demonstrated robust analytical performance for direct glucose measurement without mediators, nor using native enzyme, nor using antibodies, which is especially beneficial in care diagnostic applications. | 08-02-2012 |
20130266888 | Apparatus and Methods for Making High Performance Fuel Cell - An electrolyte-free, oxygen-free, high power, and energy dense single fuel cell device is provided, along with methods for making and use. The fuel cell device is based on an electron-relay function using a nanostructured membrane prepared by cross-linking polymers, and having embedded within the membrane, a reactant. Use of the fuel cell device does not produce water, or CO2, and no oxygen is needed. The rechargeability of the fuel cell device revealed it can function as a portable battery. | 10-10-2013 |
Frank Chen, North Potomac, MD US
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20100070735 | EMBEDDED MAPPING INFORMATION FOR MEMORY DEVICES - Memory modules and methods of operating memory modules embed mapping information within blocks of memory cells to which the mapping information pertains. In particular, when a page is written for a logical data block, that page includes a snapshot of the current mapping information for that logical data block. In this manner, the last valid physical page of a logical data block will contain a physical/logical mapping of that block. Thus, instead of scanning every valid page of the memory device to rebuild the mapping information, the memory module may scan only for the last valid physical page of each logical data block. Once the last valid physical page is discovered for a logical data block, the latest mapping information for that logical data block may be read from that page. | 03-18-2010 |
20100082919 | DATA STREAMING FOR SOLID-STATE BULK STORAGE DEVICES - Methods and apparatus facilitate data streaming in bulk storage devices by generating linked lists containing entries for both user data and metadata. These linked lists containing mixed data types facilitate receiving and outputting user data, and to insert or ignore, respectively, metadata corresponding to that user data without interrupting flow of the user data. | 04-01-2010 |
20140250273 | RE-BUILDING MAPPING INFORMATION FOR MEMORY DEVICES - Memory modules and methods of operating memory modules re-build mapping information from data read from last valid physical pages. Corruption of mapping information is detected. A last valid physical page associated with logical data blocks is read. Mapping information is obtained from the data read from the last valid physical page, and mapping information is re-built using the mapping information obtained from the last valid pages. | 09-04-2014 |
Guokai Chen, Rockville, MD US
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20120178166 | SIMPLIFIED BASIC MEDIA FOR HUMAN PLURIPOTENT CELL CULTURE - Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving iPS cells from adult individuals under defined, xeno-free conditions are also described. | 07-12-2012 |
20120202291 | SIMPLIFIED BASIC MEDIA FOR HUMAN PLURIPOTENT CELL CULTURE - Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving iPS cells from adult individuals under defined, xeno-free conditions are also described. | 08-09-2012 |
20120301962 | VITRONECTIN-DERIVED CELL CULTURE SUBSTRATE AND USES THEREOF - Vitronectin-derived cell culture substrates and methods of using the same for culturing pluripotent stem cells are presented. | 11-29-2012 |
20130157359 | FGF HAVING ENHANCED STABILITY - Methods are provided that exploit thermostable FGF-1 proteins for support of human pluripotent stem cell cultures. Also provided are compositions containing thermostable FGF-1 for culturing of human pluripotent stem cells. | 06-20-2013 |
20130236959 | FGF-2 HAVING ENHANCED STABILITY - Thermostable FGF-2 proteins having enhanced ability to support human pluripotent stem cell cultures are provided. Also provided are methods and compositions utilizing thermostable FGF-2 proteins. | 09-12-2013 |
Haoxing Chen, Clarksburg, MD US
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20120144988 | HYDRAULIC ENERGY REDIRECTION AND RELEASE SYSTEM - An apparatus for providing protection from blast and ballistic energy is provided. The apparatus includes a liquid storage mechanism containing a liquid and a rigid layer internal to the liquid storage mechanism. The apparatus also includes a pressure release mechanism configured to allow the liquid to exit the liquid storage mechanism when a pressure sufficient to open or activate the pressure release mechanism contacts the liquid storage mechanism and presses the liquid storage mechanism against the rigid layer. | 06-14-2012 |
Heng C. Chen, Bethesda, MD US
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20090094133 | ORDERING ASSISTANT - A request is received to configure an order for services. A question tree is accessed, the question tree being related to a form that may be used to place the order. User responses are received to two or more questions included in the question tree. A configuration output is provided that identifies fields in the form to be populated and values for the fields in the form that are to be populated. | 04-09-2009 |
Hexin Chen, Boyds, MD US
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20100285031 | Hox Compositions and Methods - The present invention relates to compositions to treat HOXB7 related disorders. The invention also relates to methods treating HOXB7 related disorders. The invention further relates to kits for treating HOXB7 related disorders in a subject. The invention further relates to methods of identifying novel treatments for treating HOXB7 related disorders in a subject. | 11-11-2010 |
20130333059 | HOX COMPOSITIONS AND METHODS - The present invention relates to compositions to treat HOXB7 related disorders. The invention also relates to methods treating HOXB7 related disorders. The invention further relates to kits for treating HOXB7 related disorders in a subject. The invention further relates to methods of identifying novel treatments for treating HOXB7 related disorders in a subject. | 12-12-2013 |
Hua-Wei Chen, Germantown, MD US
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20090022754 | Recombinant antigen for diagnosis and prevention of murine typhus - The invention relates to a recombinant immunogenic composition from | 01-22-2009 |
20090098647 | Recombinant antigens for the detection of coxiella burnetii - The invention relates to a method for the detection of prior exposure to | 04-16-2009 |
20090176214 | Recombinant antigens for the detection of Coxiella burnetii - The invention relates to a method for the detection of prior exposure to | 07-09-2009 |
20110171245 | RECOMBINANT ANTIGEN FOR DIAGNOSIS AND PREVENTION OF MURINE TYPHUS - The invention relates to a recombinant immunogenic composition from | 07-14-2011 |
20120202190 | DETECTION OF HEPATITIS B VIRUS IN BLOOD USING LAMP METHOD - A method for detection blood borne pathogen in whole blood, comprising collecting a blood sample from a subject, heating said sample for a period of time, adding said heated sample to a pre-mixed LAMP solution comprising one or more LAMP primer set, and Bst DNA polymerase to create a reaction mixture, incubating said reaction mixture for a period of time and determining the presence of blood born pathogen. | 08-09-2012 |
Huosheng Chen, Germantown, MD US
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20100183628 | RANDOM HOMOZYGOUS GENE PERTURBATION (RHGP) WITH THERMAL ASSYMETRIC INTERLACED (TAIL)-PCR - A method for identifying host genes and encoded proteins for potential targets for therapeutic intervention employs a Gene Search Vector that is either lentivirus or MMLV-based, and can be used to interrogate an entire cell genome without prior knowledge of the genomic sequence. This Random Homozygous Gene Perturbation (RUGP) technique is rapidly verifiable and is used to identify potential host targets for intervention for influenza, HIV and other viral infections. Using Thermal Assymetric Interlaced (TAIL)-PCR, the period for identification of promising targets is reduced from months to weeks or less. Specific targets including PTCH1, Robo1 and Nedd4 are reviewed in detail. | 07-22-2010 |
20140271671 | RANDOM HOMOZYGOUS GENE PERTURBATION (RHGP) WITH THERMAL ASSYMETRIC INTERLACED (TAIL)-PCR - A method for identifying host genes and encoded proteins for potential targets for therapeutic intervention employs a Gene Search Vector that is either lentivirus or MMLV-based, and can be used to interrogate an entire cell genome without prior knowledge of the genomic sequence. This Random Homozygous Gene Perturbation (RUGP) technique is rapidly verifiable and is used to identify potential host targets for intervention for influenza, HIV and other viral infections. Using Thermal Assymetric Interlaced (TAIL)-PCR, the period for identification of promising targets is reduced from months to weeks or less. Specific targets including PTCH1, Robo1 and Nedd4 are reviewed in detail. | 09-18-2014 |
James F. Chen, Potomac, MD US
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20130191137 | SYSTEMS AND METHODS FOR ELECTRONICALLY PRESCRIBING CONTROLLED SUBSTANCES - The present invention relates to a method for electronically prescribing controlled substances on a wide area network that includes a health care provider system (HCP system), an electronic prescription system (EP system), a third party identification validation system (third party IDV system), and a pharmacy system, and includes: a) the EP system receiving from the HCP system an electronic prescription entered by a provider for a controlled substance, a first identification factor, and a second identification factor; b) the EP system authenticating the first identification factor and transmitting the second identification factor to the third party IDV system for authentication; and c) upon the first identification factor being approved by the EP system and the EP system receiving approval of the second identification factor from the third party IDV system, the electronic prescription being certified for transmission to the pharmacy system as a certified electronic prescription for the controlled substance. | 07-25-2013 |
20130191138 | SYSTEMS AND METHODS FOR ELECTRNICALLY PRESCRIBING CONTROLLED SUBSTANCES - The present invention relates to a method for electronically prescribing controlled substances on a wide area network that includes a health care provider system (HCP system), an electronic prescription system (EP system), a third party identification validation system (third party IDV system), and a pharmacy system, and includes: a) the EP system receiving from the HCP system an electronic prescription entered by a provider for a controlled substance, a first identification factor, and a second identification factor; b) the EP system authenticating the first identification factor and transmitting the second identification factor to the third party IDV system for authentication; and c) upon the first identification factor being approved by the EP system and the EP system receiving approval of the second identification factor from the third party IDV system, the electronic prescription being certified for transmission to the pharmacy system as a certified electronic prescription for the controlled substance. | 07-25-2013 |
20130191139 | SYSTEMS AND METHODS FOR ELECTRONICALLY PRESCRIBING CONTROLLED SUBSTANCES - The present invention relates to a method for electronically prescribing controlled substances on a wide area network that includes a health care provider system (MCP system), an electronic prescription system (EP system), a third party identification validation system (third party IDV system), and a pharmacy system, and includes: a) the EP system receiving from the HCP system an electronic prescription entered by a provider for a controlled substance, a first identification factor, and a second identification factor; b) the EP system authenticating the first identification factor and transmitting the second identification factor to the third party IDV system for authentication; and c) upon the first identification factor being approved by the EP system and the EP system receiving approval of the second identification factor from the third party IDV system, the electronic prescription being certified for transmission to the pharmacy system as a certified electronic prescription for the controlled substance. | 07-25-2013 |
20130304510 | HEALTH INFORMATION EXCHANGE SYSTEM AND METHOD - A health information exchange (HIE) system and related methods for sharing patient medical data among a plurality of users. In one embodiment, the HIE system includes a processor executing a software application and one or more databases. Medical data may be downloaded by a first user to the system in a source file format. The system converts and stores the medical data in a data record such as an object having a different type of data structure. Upon receiving a request from a second user for the medical data in a specified destination file format, the system retrieves and converts the object containing the medical data into the specified destination file format, and sends the destination file to the second user. The source and destination file formats may be the same or different. In one embodiment, users may access and communicate with the HIE system via the Internet. | 11-14-2013 |
James K. Chen, Baltimore, MD US
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20080255059 | Regulators of the hedgehog pathway, compositions and uses related thereto - The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations. | 10-16-2008 |
Jeffrey R. Chen, Clarksville, MD US
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20090051926 | MULTIPLE FREQUENCY OPTICAL MIXER AND DEMULTIPLEXER AND APPARATUS FOR REMOTE SENSING - A pulsed laser system includes a modulator module configured to provide pulsed electrical signals and a plurality of solid-state seed sources coupled to the modulator module and configured to operate, responsive to the pulsed electrical signals, in a pulse mode. Each of the plurality of solid-state seed sources is tuned to a different frequency channel separated from any adjacent frequency channel by a frequency offset. The pulsed laser system also includes a combiner that combines outputs from each of the solid state seed sources into a single optical path and an optical doubler and demultiplexer coupled to the single optical path and providing each doubled seed frequency on a separate output path. | 02-26-2009 |
20130308663 | APPARATUS AND METHOD TO ENABLE PRECISION AND FAST LASER FREQUENCY TUNING - An apparatus and method is provided to enable precision and fast laser frequency tuning. For instance, a fast tunable slave laser may be dynamically offset-locked to a reference laser line using an optical phase-locked loop. The slave laser is heterodyned against a reference laser line to generate a beatnote that is subsequently frequency divided. The phase difference between the divided beatnote and a reference signal may be detected to generate an error signal proportional to the phase difference. The error signal is converted into appropriate feedback signals to phase lock the divided beatnote to the reference signal. The slave laser frequency target may be rapidly changed based on a combination of a dynamically changing frequency of the reference signal, the frequency dividing factor, and an effective polarity of the error signal. Feed-forward signals may be generated to accelerate the slave laser frequency switching through laser tuning ports. | 11-21-2013 |
Jianmeng Chen, Timonium, MD US
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20110176998 | IMAGING AND THERAPY OF VIRUS-ASSOCIATED TUMORS - The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection. | 07-21-2011 |
Jizhong Chen, Columbia, MD US
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20110058643 | SYSTEM AND METHOD FOR GENERATING X-RAYS - In one embodiment, an X-ray tube is provided. The X-ray tube comprises at least one thermionic cathode configured to generate an electron beam, a target assembly configured to generate X-rays when impinged with the electron beam emitted from the thermionic cathode, a high voltage supply unit for establishing an output voltage across the thermionic cathode and the target assembly for establishing an accelerating electric field between the thermionic cathode and the target assembly and a mesh grid disposed between the thermionic cathode and the target assembly, the mesh grid configured to operate at a voltage so as to lower the electric field applied at the surface of the thermionic cathode. Further, the voltage at the mesh grid is negatively biased with respect to the voltage at the thermionic cathode. | 03-10-2011 |
Lieping Chen, Baltimore, MD US
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20090018315 | B7-H3 and B7-H4, Novel Immunoregulatory Molecules - The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 01-15-2009 |
20090087416 | B7-H3 AND B7-H4, NOVEL IMMUNOREGULATORY MOLECULES - The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 04-02-2009 |
20090274666 | B7-H1, A NOVEL IMMUNOREGULATORY MOLECULE - The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors Also included are methods of making and using these co-stimulatory polypeptides. | 11-05-2009 |
20090304711 | Combinatorial Therapy of Cancer and Infectious Diseases with Anti-B7-H1 Antibodies - Described are uses of an agent that reduces B7-H1 interaction with PD-1, and particularly monoclonal antibodies that bind to B7-H1 and interfere with B7-H1 interaction with PD-1 in combination with a vaccine to provide synergistic effects. The application provides methods of treatment and vaccination based on the combination of these compounds on T cell responses. | 12-10-2009 |
20090317368 | B7-H1, A NOVEL IMMUNOREGULATORY MOLECULE - The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 12-24-2009 |
Lin (colin) Chen, Rockville, MD US
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20110098972 | Computer-Implemented Distributed Iteratively Reweighted Least Squares System And Method - Systems and methods are provided for performing an estimation using an iteratively reweighted least squares technique on a scenario defined by a design matrix, a response variable vector, and a parameter to be estimated. A system and method can be configured to include a root data processor, where a least squares estimate is calculated by the root data processor during each of a plurality of processing iterations. A plurality of node data processors can also be configured to: update values of a weight matrix according to a current state of the least squares estimate, determine a first intermediate value based on the design matrix and the weight matrix, determine a second intermediate value based on the design and weight matrices and the response variable vector. The root data processor calculates an updated least squares estimate based on the intermediate values. | 04-28-2011 |
Liping Chen, Bethesda, MD US
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20080273688 | Phone computing machine (PCM) - The present invention PCM (phone computing machine) uses general purpose programmable device ( | 11-06-2008 |
20130246884 | METHOD AND APPARATUS FOR WIRELESS DATA TRANSMISSION SUBJECT TO PERIODIC SIGNAL BLOCKAGES - A system and method for data transmissions in a wireless communications system, which accommodates for a periodic blockage of the transmission signal, is provided. A data stream is segmented into packets of a predetermined fixed-size for a burst-mode transmission over a channel of the communications system, wherein the transmission is subject to a periodic blockage. A forward error correction outer code is then applied to the packets of the data stream for recovery of packets subjected to the periodic blockage, and a unique word is added to each packet for acquisition of frequency, carrier phase and symbol timing of the respective packet. The packets of the data stream are interleaved based on an interleaver of a depth based at least in part on a ratio of a blockage free duration between two consecutive blockages of the periodic blockage to a duration of each blockage of the periodic blockage. | 09-19-2013 |
20140331102 | LOW DENSITY PARITY CHECK (LDPC) ENCODING AND DECODING FOR SMALL TERMINAL APPLICATIONS - Approaches are provided for closing communications channel links (e.g., for small terminal applications in satellite communications systems), at lower effective data rates, in a most power efficient manner, while still meeting regulatory requirements. Such approaches employ modulation and coding schemes that facilitate such lower effective data rates in a most power efficient manner. The new modulation and coding schemes include new low density parity check (LDPC) codes. | 11-06-2014 |
Man Chen, Bethesda, MD US
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20120315270 | RSV IMMUNOGENS, ANTIBODIES AND COMPOSITIONS THEREOF - The present invention provides immunogens that protect against RSV infection. The present invention also provides antibody proteins that protect against RSV infection. Such immunogens and antibody proteins are produced based on three-dimensional models also included in the invention. One model is of a complex between motavizumab and its antibody-binding domain on RSV fusion (F) protein. A second model is of a complex between 10 IF antibody and its antibody-binding domain on RSV F protein. The immunogens disclosed herein have been modified to elicit a humoral response against RSV F protein without eliciting a significant cell-mediated response against RSV. Such immunogens can comprise a scaffold into which RSV contact residues are embedded. The present invention also includes methods that utilize the disclosed three-dimensional models to produce immunogens and antibody proteins of the present invention. Also disclosed are methods of using the disclosed immunogens, for example to protect individuals from RSV infection. Also disclosed are methods of using the disclosed antibody proteins, for example to protect individuals from RSV infection. | 12-13-2012 |
Meng Chen, Frederick, MD US
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20100254568 | Reduced-reference visual communication quality assessment using data hiding - A method and system of communicating visual communication quality information, includes extracting reduced-reference (RR) feature data from visual content, embedding the RR feature data in the visual content; and transmitting the visual content with the embedded RR feature data. Visual communication quality is assessed by receiving visual content which includes visual content data and a first set of embedded RR feature data, retrieving the first set of RR feature data from the visual content data, and generating a second set of RR feature data from the visual content data. The second set of RR feature data corresponds to substantially identical features of the visual content data as that used to generate the first set of RR feature data. The first set of RR feature data is compared to the second first set of RR feature data to determine a quality of the visual content based upon the comparison. | 10-07-2010 |
Michael C. Chen, Potomac, MD US
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20080199952 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOCOCCAL INFECTION - The invention provides polypeptides, polysaccharide-polypeptide conjugates, and expression vectors for treating or preventing pneumococcal infection. The compositions induce an anti-pneumococcal immune response when administered to a mammal. The compositions can be used prophylactically to vaccinate an individual and/or therapeutically to induce a therapeutic immune response in an infected individual. | 08-21-2008 |
Mingkui Chen, Baltimore, MD US
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20120237449 | METHODS FOR TREATING NEURAL CELL SWELLING - A composition comprising a novel Ca | 09-20-2012 |
Molly Frances Chen, Leonardtown, MD US
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20080250541 | Intergrated, coordinated protective article and garment for continuous use - An integrated, coordinated protective article and garment for continuous use is provided, which comprises: a garment having a shirt or suit portion; a protective shield for covering substantially the chest and abdomen of the shirt or suit portion, respectively; and an array of detachable snap fasteners distributed about selected peripheral portions of the shield. The garment also has fasteners about peripheral portions thereof arranged for mating engagement with cooperating fasteners on the shield, such that rotational and lateral movements, and folding, of the shield relative to the garment are restricted. In addition, the shield is provided in colors, designs or the like for ready aesthetic coordination with the garment when the shield is attached thereto. | 10-16-2008 |
Peifeng Chen, Boyds, MD US
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20140024076 | Expression Of Soluble Viral Fusion Glycoproteins In Mammalian Cells - The technology relates in part to production (i.e., expression) of recombinant viral fusion glycoproteins and nucleic acids that encode such viral fusion glycoproteins. In some embodiments, human respiratory syncytial virus fusion protein (RSV-F) and human parainfluenza virus 3 fusion protein (hPIV3-F) are expressed. | 01-23-2014 |
Peter Che-Hung Chen, Clarksville, MD US
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20090218443 | Magnetorheological fluid elastic lag damper for helicopter rotors - A MagnetoRheolocial Fluid Elastic (MRFE) lag damper system for adaptive lead-lag damping of helicopter main rotors. Embodiments include snubber dampers especially for hingeless helicopter rotors, and concentric bearing dampers. The snubber lag dampers include a flexible snubber body defining a cavity, a flexible or rigid interior (e.g., center) wall subdividing the cavity, and a flow valve in the interior wall or external to the cavity. The flexible snubber body may comprise elastomeric materials and metal rings stacked together to create a sealed MR fluid cavity. The shear deformation of the snubber body induces MR fluid flow through the valve, controlled by a magnetic field in the valve. An MRFE concentric bearing damper is also disclosed, comprising a pair of concentric tubes with elastomeric material injected and cured in an annular gap between the two tubes, and an MR fluid reservoir with piston-mounted MR valve housed inside the innermost tube. | 09-03-2009 |
20100312493 | CORROSION INSPECTION AND MONITORING SYSTEM - A system for in-situ near-real-time detection and monitoring of corrosion in structures with the ability to directly track the presence and growth of corrosion on a structure by measurement of material loss in the structure attained by analysis of high frequency wave propagation dynamics. The Corrosion Inspection and Monitoring (CIM) system utilizes low-weight in-situ transducers and unique data reduction software for detection and monitoring of corrosion in structural systems in near real-time for corrosion related damage. The CIM system provides a corrosion monitoring and tracking tool that can be deployed in the field with the structural system, and no maintenance personnel are needed for corrosion analysis. | 12-09-2010 |
Quanmin Chen, Germantown, MD US
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20130096531 | HYPODERMIC NEEDLE ASSEMBLY HAVING A TRANSITION HUB FOR ENHANCING FLUID DYNAMICS AND MICROSPHERE INJECTABILITY - A hypodermic needle assembly and a method of delivering a microsphere drug. A hypodermic needle assembly includes an injection needle; an injection device; and a hub defining a cavity including a transition portion having a first end and a second end between the first end and an inlet of the injection needle and having a gradually decreasing diameter from the first end to the second end, wherein the hub is coupled between the injection needle and the injection device such that the first end is in fluidic communication with an outlet of the injection device and the second end is in fluidic communication with the inlet of the injection needle, wherein the diameter of the cavity at the first end is larger than an outlet diameter of the injection device, and wherein the diameter at the second end is substantially the same as an inlet diameter of the injection needle. | 04-18-2013 |
Shuguan Chen, Ellicott City, MD US
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20090146816 | RF ID tag reader utlizing a scanning antenna system and method - An embodiment of the present invention provides an RF ID card reader, comprising RF ID circuitry to generate an RF ID signal, a transceiver in communication with said RF ID circuitry and an array antenna associated with said transceiver for scanning an area for at least one tag and establishing communication with at least one tag. | 06-11-2009 |
Silvia S. Chen, Derwood, MD US
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20090024223 | Crafting of cartilage - The invention is directed to producing a shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. The invention relates to a process for repairing a cartilage defect and implantation of a cartilage graft into a human or animal by crafting the cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps. | 01-22-2009 |
20090024224 | Implantation of cartilage - The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue by creating a first bore down to the bone portion of the cartilage defect, creating a second shaped bore that is concentric to and on top of the first bore to match the shape and size of the cartilage graft, treating the first bore and the second shaped bore at the defect site with a bonding agent, treating the circumferential area of the cartilage graft with a bonding agent, inserting the cartilage graft into the defect site and wherein the superficial surface of the cartilage graft is at the same height as the surrounding cartilage surface. The first and second bonding agents may be activated by applying a stimulation agent to induce sealing, integration, and restoration of the hydrodynamic environments of the recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, cleaning and disinfecting the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps. The invention is further directed toward a repaired cartilage defect. | 01-22-2009 |
20090024229 | Devitalization and recellularization of cartilage - The present invention is directed toward recellularizing a devitalized cartilage graft with viable recellularizable cells in vivo, in situ, or in vitro to render the tissue vital. The present invention is also directed toward repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, recellularizing the devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally stored between the removing cellular debris and the recellularizing steps. The present invention is directed to both recellularized cartilage grafts as well as a process for recellularizing cartilage grafts. | 01-22-2009 |
Steven Chien-Young Chen, Derwood, MD US
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20090036159 | BROADBAND COMMUNICATIONS ACCESS DEVICE - A broadband communications access device with security features. The broadband communications access devices includes a wireless access point with a wireless interface, wired interface and security interface for proving secure wired and wireless broadband communications access for home entertainment, home security and home energy management devices. | 02-05-2009 |
Tianlong Chen, Gaithersburg, MD US
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20090141945 | Integrated Portable Identification and Verification Device - An portable integrated identification and verification system is disclosed. The station includes multiple devices integrated for identifying or verifying the identity of a person. The multiple devices, which may include a camera, a document scanner, and a fingerprint scanner, are mounted in a housing along with a computing device. | 06-04-2009 |
20100070527 | SYSTEM AND METHOD FOR MANAGING VIDEO, IMAGE AND ACTIVITY DATA - A computer-implemented method for an object and activity query language wherein an object is a data type representing a thing or a being with a visual shape in an image or video frame and said activity is a data type representing an action or an event visually shown in an image or video or video frame, the method comprising the steps of storing a plurality of items in a raw data storage, said items comprising images and/or videos, processing said items in a processor and to generate and/or segment annotated information from said items and to extract object, activity and/or metadata information from said items in said first data storage, storing said annotated information in a secondary data storage, storing said extracted object, activity, and/or metadata information and said annotated information in a primary data storage, executing on a processor an identify function, wherein given a query item said identify function identifies said query item and/or finds a list of items similar to said first item; and a said query item comprises a video, a video frame, an image, a set of images, a template extracted from a video or image or images, an object, an activity, or annotated information, and displaying results of said identify function. | 03-18-2010 |
20110304543 | WIRELESS MOUSE CAPABLE CONTROLLING MULTIPLE COMPUTING DEVICES - A method to implement a wireless mouse capable of controlling multiple computing devices is disclosed. The disclosed wireless mouse has a means to store identifications of multiple signal receivers which are each connected to or are each part of a computing device; the disclosed wireless mouse has a means to select one of multiple signal receivers such that one of multiple computing devices (which has connection with selected signal receiver) as target to receive position (pointing) information for further action by the targeted computing device. | 12-15-2011 |
20120095959 | Apparatus and Method for On-Demand In-Memory Database Management Platform - A method and apparatus for constructing a memory-based database service platform, in which database can be on-loaded and off-loaded or unloaded as needed, and can reserve schedule and size of memory and other resources, including CPUs, network, backup, mirroring and recovery recourses. With the service platform, multiple different types of databases can be chosen by specifying data storage type and data operation interfaces, such as Relational Database (RDB), Biometric Database (BDB), Time Series Database (TDB), Data Driven Database (DDDB) and File-based Database (FDB) etc. Database types can be chosen either by user directly or by platform automatically or semi-automatically based on data types and data operation characteristics. | 04-19-2012 |
20120095963 | Apparatus and method for on-demand in-memory database management platform - A method and apparatus for constructing a memory-based database service platform, in which database can be on-loaded and off-loaded or unloaded as needed, and can reserve schedule and size of memory and other resources, including CPUs, network, backup, mirroring and recovery recourses. With the service platform, multiple different types of databases can be chosen by specifying data storage type and data operation interfaces, such as Relational Database (RDB), Biometric Database (BDB), Time Series Database (TDB), Data Driven Database (DDDB) and File-based Database (FDB) etc. Database types can be chosen either by user directly or by platform automatically or semi-automatically based on data types and data operation characteristics. | 04-19-2012 |
20120096233 | Apparatus and Method for On-Demand In-Memory Database Management Platform - A method and apparatus for constructing a memory-based database service platform, in which database can be on-loaded and off-loaded or unloaded as needed, and can reserve schedule and size of memory and other resources, including CPUs, network, backup, mirroring and recovery recourses. With the service platform, multiple different types of databases can be chosen by specifying data storage type and data operation interfaces, such as Relational Database (RDB), Biometric Database (BDB), Time Series Database (TDB), Data Driven Database (DDDB) and File-based Database (FDB) etc. Database types can be chosen either by user directly or by platform automatically or semi-automatically based on data types and data operation characteristics. | 04-19-2012 |
Wei-Chiang Chen, Baltimore, MD US
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20110076497 | COATED CARBON NANOTUBES AND METHOD FOR THEIR PREPARATION - Polymer coated carbon nanotube (NT) particles having NT particles with a solid polymer layer around the surface of each NT particle are presented. The NT particles can be isolated NTs or can include bundles of NTs. A method for preparation of the polymer coated carbon NT particles involves an aqueous dispersion that has a water insoluble first monomer contained in an emulsion-like nano-environment about the NT particles that undergoes an interfacial polymerization with a water soluble second monomer added to the dispersion. | 03-31-2011 |
20130071003 | SYSTEM AND DEVICE FOR CHARACTERIZING CELLS - A diagnostic device includes a microscope configured to obtain image data on a plurality of cells and a computing device. The computing device is configured to receive the image data, identify at least a portion of each of the plurality of cells based on the received image data, determine at least one of a value of a morphological parameter for each identified at least a portion of the plurality of cells or a relative organization among the identified at least a portion of the plurality of cells, and calculate statistics for the plurality of cells based on the at least one of the determined values of the morphological parameter or the determined relative organization, the statistics including information suitable for distinguishing metastatic cells from non-metastatic cells. The diagnostic device further includes an output device configured to output the statistics for diagnosis. | 03-21-2013 |
Weiran Chen, Columbia, MD US
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20090298095 | Immortalization of cells including neuronal cells - The instant invention provides methods for immortalizing cells. The invention further provides immortalized cell lines, e.g., neuronal cell lines, and methods of using these cell lines in screening assays. | 12-03-2009 |
20140303203 | COMPOUNDS FOR TREATING PERIPHERAL; NEUROPATHIES AND OTHER NEURODEGENERATIVE; DISORDERS - Compounds and methods for treating or preventing a neurodegenerative disease, disorder or condition associated with the overall activity of hsp90 but not with the ATPase activity of hsp90, including peripheral neuropathy, such as peripheral neuropathy caused by chemotherapy or diabetes, disorders 5 of the central nervous system, such as Alzheimer's disease and Parkinsons disease, and motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), in a subject are provided. | 10-09-2014 |
Weizao Chen, Frederick, MD US
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20110104163 | ANTI-HIV DOMAIN ANTIBODIES AND METHOD OF MAKING AND USING SAME - The invention provides single domain antibodies and derivatives thereof that bind antigens of interest, which are stable, soluble, and do not tend to aggregate. The invention also provides methods for constructing a dAb library and methods for screening dAb libraries to identify the dAb of the invention. The invention also provide methods of treating or preventing conditions by antigen neutralization by administering the dAbs of the invention. | 05-05-2011 |
20120195897 | HUMAN DOMAIN ANTIBODIES AGAINST COMPONENTS OF THE HUMAN INSULIN-LIKE GROWTH FACTOR (IGF) SYSTEM - The invention provides antibodies or antibody fragments that bind to insulin-like growth factor (IGF) 1 receptor (IGF-1R) or IGF-2, as well as method of using the antibodies for inhibiting the IGF-mediated signaling pathway, inhibiting IGF-1R signaling, and treating cancer. The invention also provides a method of detecting the presence of IGF-1R or IGF-2 in a sample using the inventive antibodies and antibody fragments. | 08-02-2012 |
20130108636 | HIGH-AFFINITY FULLY FUNCTIONAL SOLUBLE SINGLE-DOMAIN HUMAN CD4, ANTIBODIES, AND RELATED FUSION PROTEINS | 05-02-2013 |
20140271646 | MONOSPECIFIC AND BISPECIFIC HUMAN MONOCLONAL ANTIBODIES TARGETING INSULIN-LIKE GROWTH FACTOR II (IGF-II) - Monoclonal antibodies (mAbs), antigen binding fragments and engineered antibody domains (eAds) that specifically bind IGF-II are disclosed herein. In some embodiments, these mAbs and eAds are included in a bispecific mAb. In some embodiments, the bispecific antibody specifically binds two different epitopes of IGF-II. Methods of using these mAbs, antigen binding fragments, and eAds, bispecific antibodies, and nucleic acids encoding these mAbs, antigen binding fragments, and eAds, bispecific antibodies are also disclosed. | 09-18-2014 |
Wenlu Chen, Catonsville, MD US
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20090022443 | Thermo-Optic Devices Providing Thermal Recirculation - Thermo-optical devices providing heater recirculation in an integrated optical device are described. The thermo-optical devices include at least one waveguide having a non-linear path length in thermal communication with a thermal device. Methods of fabrication and use are also disclosed. | 01-22-2009 |
20090022444 | THERMO-OPTIC DEVICES PROVIDING THERMAL RECIRCULATION - Thermo-optical devices providing heater recirculation in an integrated optical device are described. The thermo-optical devices include at least one waveguide having a non-linear path length in thermal communication with a thermal device. Methods of fabrication and use are also disclosed. | 01-22-2009 |
20090022465 | THERMO-OPTIC DEVICES PROVIDING THERMAL RECIRCULATION - Thermo-optical devices providing heater recirculation in an integrated optical device are described. The thermo-optical devices include at least one waveguide having a non-linear path length in thermal communication with a thermal device. Methods of fabrication and use are also disclosed. | 01-22-2009 |
20100233837 | THERMO-OPTIC DEVICES PROVIDING THERMAL RECIRCULATION - Thermo-optical devices providing heater recirculation in an integrated optical device are described. The thermo-optical devices include at least one waveguide having a non-linear path length in thermal communication with a thermal device. Methods of fabrication and use are also disclosed. | 09-16-2010 |
Xia Chen, Columbia, MD US
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20100050828 | ELECTRONIC TORQUE WRENCH WITH A MANUAL INPUT DEVICE - A torque wrench including a handle attached to a drive member and a transducer that senses the torque transferred from the handle to the drive member and outputs a first signal corresponding to the transferred torque. An analog mechanical input device disposed on the handle that simultaneously defines a set point and indicates the set point. A comparator receives the first signal from the transducer, receives the set point, compares the first signal from the transducer to the set point, and outputs a second signal. The mechanical input device does not display a real time measurement of the torque transferred to the work piece prior to reaching the set point. | 03-04-2010 |
20110162493 | RATCHETING DEVICE FOR AN ELECTRONIC TORQUE WRENCH - An electronic torque wrench including a wrench body, a wrench head configured to engage a workpiece, a first sensor producing a first output signal, that is proportional to an amount of torque being applied to the workpiece, a grip handle, a second sensor producing a second output signal that is proportional to an amount of rotation being applied to the workpiece, a user interface including an input device for inputting a preset torque value, and a processor for converting the first output signal into a current torque value, comparing the current torque value to the preset torque value, and converting the second output signal into a first angle value through which the workpiece has been rotated after the current torque value exceeds the preset torque value. | 07-07-2011 |
Xia Chen, Clarksville, MD US
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20120132043 | RATCHETING MECHANICAL TORQUE WRENCH WITH AN ELECTRONIC SENSOR AND DISPLAY DEVICE - A mechanical torque wrench for engaging a workpiece, including a wrench body, a wrench head with a workpiece engaging portion and a bar, the wrench head being pivotably secured to the wrench body, a set spring, a pawl disposed between the bar and the set spring, and a dial screw, wherein rotation of the dial screw in a first direction compresses the set spring. A resistive element is coupled to the dial screw and produces an output signal. A first sensor produces a first output signal that is proportional to an amount of rotation of the mechanical torque wrench. A processor converts the resistive element output signal into an equivalent torque value indicating a preset torque to be applied by and converts the first output signal into a first angle value. A user interface includes a display for displaying the equivalent torque value. The application of a torque greater than the preset torque causes the wrench head to pivot relative to the wrench body. | 05-31-2012 |
20130207830 | HANDHELD LOCATING DEVICE - A locating device disposable on a surface has a housing, a capacitance sensor, a radar sensor, and an inductance sensor. The locating device also has a motion sensor disposed for detecting at least one motion parameter. A controller receives data from the capacitance sensor, the radar sensor, the inductance sensor and the motion sensor, and determines from the data a presence of objects disposed within or behind the surface. A display is used for displaying a graphical representation of the objects disposed within or behind the surface. | 08-15-2013 |
20140326113 | RATCHETING DEVICE FOR AN ELECTRONIC TORQUE WRENCH - An electronic torque wrench including a wrench body, a wrench head configured to engage a workpiece, a first sensor producing a first output signal, that is proportional to an amount of torque being applied to the workpiece, a grip handle, a second sensor producing a second output signal that is proportional to an amount of rotation being applied to the workpiece, a user interface including an input device for inputting a preset torque value, and a processor for converting the first output signal into a current torque value, comparing the current torque value to the preset torque value, and converting the second output signal into a first angle value through which the workpiece has been rotated after the current torque value exceeds the preset torque value. | 11-06-2014 |
Xiaochun Chen, Baltimore, MD US
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20110124649 | INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS - Described herein are novel pyrimidine-pyridine compounds, methods of inhibiting methionine aminopeptidase and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, wherein a compound of the invention is administered to a subject. | 05-26-2011 |
Yin Chen, Baltimore, MD US
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20130157683 | INDOOR LOCALIZATION USING COMMERCIAL FREQUENCY-MODULATED SIGNALS - A commercial frequency-modulated (FM) radio signal indoor localization system and method for finding a location of a mobile embedded device (such as a smartphone) within a building. Indoor localization is performed by receiving commercial FM radio signals on the device, analyzing the signals using signal quality metrics, and generating signal quality vectors for each signal and signal quality metric used for the signal. The signal quality metric can be any physical signal quality indicator. The signal quality vectors are added to obtain a current location fingerprint. The current location fingerprint is compared to fingerprints stored in a fingerprint database. The location associated with the stored fingerprint that is the closest match to the current fingerprint location is designated as the current location in the building of the mobile embedded device. Locally generated radio signals can be used in conjunction with the commercial FM radio signals to improve localization accuracy. | 06-20-2013 |
20130344892 | INDOOR LOCALIZATION USING COMMERCIAL FREQUENCY-MODULATED SIGNALS - A commercial frequency-modulated (FM) radio signal indoor localization system and method for finding a location of a mobile embedded device (such as a smartphone) within a building. Indoor localization is performed by receiving commercial FM radio signals on the device, analyzing the signals using signal quality metrics, and generating signal quality vectors for each signal and signal quality metric used for the signal. The signal quality metric can be any physical signal quality indicator. The signal quality vectors are added to obtain a current location fingerprint. The current location fingerprint is compared to fingerprints stored in a fingerprint database. The location associated with the stored fingerprint that is the closest match to the current fingerprint location is designated as the current location in the building of the mobile embedded device. Locally generated radio signals can be used in conjunction with the commercial FM radio signals to improve localization accuracy. | 12-26-2013 |
Yiwang Chen, Potomac, MD US
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20130131423 | Methods to detect and treat diseases - The current invention discloses methods to treat disease caused by virus infection, bacterial infection, parasites infection, autoimmune disease, disease caused by production of unwanted antibodies, sepsis as well as methods to treat cancer and methods for virus infection detection using blood purification method. The current invention provides a method to treat pathogen infection by inactivating the pathogens in the blood. During the treatment, blood is withdrawn from a patient and is separated into its plasma and cellular components. The plasma portion is treated with physical means such as UV radiation to inactivate the pathogens inside and then is returned to the patient. The current invention also provide a method to treat cancer especially to prevent tumor metastasis and tumor recurrence by removing and/or inactivating (e.g. killing) the circulating tumor cells (CTC) in the blood after removing the tumor or treating the tumor with therapeutical means. | 05-23-2013 |
Yongbo Chen, Germantown, MD US
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20090079545 | FLEXIBLE RFID TAG DEVICE AND METHOD FOR CONSTRUCTING SAME - The present invention relates generally to a flexible RFID tag comprising an RFID inlay and added protection via one or more means of encapsulation, and method of constructing a flexible RFID tag. | 03-26-2009 |
Yuanxiu Chen, Potomac, MD US
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20120071544 | Methods For Identifying Compounds Effective To Increase The Expression Or Activity Of Aspartyl Aminopeptidase In Mammalian Pancreatic Islet Cells, And Methods For Decreasing Angiotensin II Levels In Mammalian Pancreatic Islet Cells - The methods provided herein are based on the discovery, as described in more detail herein, that aspartyl aminopeptidase (DAP) is expressed in mammalian pancreatic islet cells and that increased DAP expression results in decreased angiotensin II (Ang II) levels in the islet cells. Methods are provided for identifying compounds effective to increase the expression and/or activity of DAP in mammalian pancreatic islet cells and thereby are effective to decrease Ang II levels in the islet cells. Methods are also provided for decreasing Ang II levels in a subject having Ang II induced pancreas islet cell dysfunction and/or suffering or susceptible to type 1 diabetes, as well as for the treatment or prevention of type 1 diabetes comprising administering to the subject a therapeutically effective amount of the compound identified according to the methods herein. | 03-22-2012 |
Yud R. Chen, Laurel, MD US
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20090087033 | Method and system for wholesomeness inspection of freshly slaughtered chickens on a processing line - An imaging system containing an electron-multiplying charge-coupled device detector and line-scan spectrograph is used for identifying wholesome and unwholesome freshly slaughtered chicken carcasses on high-speed commercial chicken processing lines. Multispectral imaging algorithms allow for real-time online identification of wholesome and unwholesome chicken carcasses. | 04-02-2009 |
20120008835 | Method and System for Wholesomeness Inspection of Freshly Slaughtered Chickens on a Processing Line - An imaging system containing an electron-multiplying charge-coupled device detector and line-scan spectrograph is used for identifying wholesome and unwholesome freshly slaughtered chicken carcasses on high-speed commercial chicken processing lines. Multispectral imaging algorithms allow for real-time online identification of wholesome and unwholesome chicken carcasses. | 01-12-2012 |
Yud-Ren Chen, Laurel, MD US
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20090185182 | Simultaneous Acquisition of Fluorescence and Reflectance Imaging Techniques with a Single Imaging Device for Multitask Inspection - A hyperspectral reflectance and fluorescence line-scan imaging system is used for on-line quality and safety inspection of agricultural commodities. The system simultaneously acquires hyperspectral/multispectral combinations of both fluorescence and reflectance images of the agricultural commodities. | 07-23-2009 |
20090309967 | Hand-held inspection tool and method - The hand-held inspection tool enhances the ability of an on-site inspector to detect and communicate the presence of contamination on an object or in an area. An on-site inspector directs an excitation light in the sensing head of the tool into an area of interest. If the targeted contamination is present, the excitation light causes the contamination to emit fluorescence. The emitted fluorescent light passes through a narrow spectral band-pass video camera filter and is detected by a video camera mounted in the tool sensing head. The video camera transmits the image to a display visible to the on-site inspector. The invention also includes a means of recording, documenting, and wirelessly communicating the inspection process so that remotely located personnel can view the inspection, and respond to the inspection findings in real time. | 12-17-2009 |
Yuhong Chen, Frederick, MD US
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20090304923 | Microwave Synthesis of Metal-Carbon Nanotube Composites - The present disclosure provides for improved soluble carbon nanotube (“CNT”) composites at least partially coated with a metal material, and improved methods for the synthesis, generation or formation of substantially soluble carbon nanotube composites via heating conditions (e.g., microwave reactions). For example, the present disclosure provides for methods for the rapid, controllable, environmentally-friendly formation of substantially soluble carbon nanotube composites via in-situ microwave-assisted reactions, wherein the carbon nanotube composites are at least partially coated with nanometal particles (e.g., nanoplatinum particles), and wherein the nanocomposites are substantially soluble in water and/or in organic solvents (e.g., o-dichlorobenzene (ODCB), chloroform, tetrahydrofuran (THF), ethanol, toluene, hexane and DMF). | 12-10-2009 |
Yun Chen, Clarksburg, MD US
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20120144988 | HYDRAULIC ENERGY REDIRECTION AND RELEASE SYSTEM - An apparatus for providing protection from blast and ballistic energy is provided. The apparatus includes a liquid storage mechanism containing a liquid and a rigid layer internal to the liquid storage mechanism. The apparatus also includes a pressure release mechanism configured to allow the liquid to exit the liquid storage mechanism when a pressure sufficient to open or activate the pressure release mechanism contacts the liquid storage mechanism and presses the liquid storage mechanism against the rigid layer. | 06-14-2012 |
Yung-Jui Chen, Ellicott City, MD US
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20090317033 | INTEGRATED CIRCUIT AND PHOTONIC BOARD THEREOF - An integrated circuit (IC) including at least a first and a second logical blocks and a photonic board is provided. The photonic board connects with the first and the second logical blocks through a eutectic bonding technology, and communicates at least a logical signal of the first logical block to the second logical block by light conduction. | 12-24-2009 |
Zhaochun Chen, North Potomac, MD US
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20100119520 | MONOCLONAL ANTIBODIES THAT NEUTRALIZE ANTHRAX TOXINS - The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention. | 05-13-2010 |
20110223163 | MONOCLONAL ANTIBODIES THAT REACT WITH THE CAPSULE OF BACILLUS ANTHRACIS - The present disclosure relates to monoclonal antibodies that bind poly-γ-D-glutamic acid (γDPGA), which is present on the surface of | 09-15-2011 |
20120171196 | MONOCLONAL ANTIBODIES THAT NEUTRALIZE ANTHRAX TOXINS - The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention. | 07-05-2012 |
20130287787 | MONOCLONAL ANTIBODIES THAT REACT WITH THE CAPSULE OF BACILLUS ANTHRACIS - The present disclosure relates to monoclonal antibodies that bind poly-γ-D-glutamic acid (γDPGA), which is present on the surface of | 10-31-2013 |
20150017153 | MONOCLONAL ANTIBODIES THAT NEUTRALIZE ANTHRAX TOXINS - The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention. | 01-15-2015 |
Zhaochun Chen, Potomac, MD US
Patent application number | Description | Published |
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20090155250 | MONOCLONAL ANTIBODIES AGAINST ORTHOPOXVIRUSES - The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention. | 06-18-2009 |
20100074892 | Monoclonal Antibodies That Neutralize Anthrax Protective Antigen (PA) Toxin - The present invention relates to monoclonal antibodies that bind or neutralize anthrax protective antigen (PA) toxin. The invention provides such antibodies, fragments of such antibodies retaining anthrax PA toxin-binding ability, fully human or humanized antibodies retaining anthrax PA toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention. | 03-25-2010 |
20110243840 | MONOCLONAL ANTIBODIES AGAINST ORTHOPOXVIRUSES - The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention. | 10-06-2011 |
20130251704 | MONOCLONAL ANTIBODIES AGAINST ORTHOPOXVIRUSES - The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention. | 09-26-2013 |
Zhiyong Chen, Gaithersburg, MD US
Patent application number | Description | Published |
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20130042332 | Device and method for inducing brain injury in animal test subjects - An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology. | 02-14-2013 |
20140343458 | Device and method for inducing brain injury in animal test subjects - An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology. | 11-20-2014 |
Zhiyun Chen, Rockville, MD US
Patent application number | Description | Published |
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20110056841 | SYSTEM AND METHOD FOR DIRECT CONVERSION OF SOLAR ENERGY TO CHEMICAL ENERGY - Semiconductor nano-sized particles possess unique properties, which make them ideal candidates for applications in solar electrochemical cells to produce chemical energy from solar energy. Coupled nanocrystal photoelectrochemical cells and several applications improve the efficiency of solar to chemical energy conversion. | 03-10-2011 |
20110315914 | NANOCOMPOSITES WITH HIGH DIELECTRIC CONSTANT - A nanocomposite with high dielectric constant includes both ferroelectric with non-ferroelectric fillers. This may improve, not only the dielectric constant of the nanocomposite but also provide additional thermal, electrical, optical, mechanical, or chemical properties to the nanocomposite for specific applications. | 12-29-2011 |
20130136897 | RESISTS FOR LITHOGRAPHY - New routes involving multi-step reversible photo-chemical reactions using two-step techniques to provide non-linear resist for lithography are described in this disclosure. They may provide exposure quadratically dependant on the intensity of the light. Several specific examples, including but not limited to using nanocrystals, are also described. Combined with double patterning, these approaches may create sub-diffraction limit feature density. | 05-30-2013 |
20140322549 | HIGH REFRACTIVE INDEX NANOCOMPOSITE - The current disclosure relates to a nanocomposites coating including metal oxide nanocrystals, the nanocomposites further include a mixture of acrylates monomers and oligomers to provide a curable coating that provides high refractive index, high transmittance, and high temperature stability. | 10-30-2014 |
Zhiyun Chen, Silver Spring, MD US
Patent application number | Description | Published |
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20090220756 | REVERSIBLE PHOTO BLEACHABLE MATERIALS BASED ON NANO SIZED SEMICONDUCTOR PARTICLES AND THEIR OPTICAL APPLICATIONS - Semiconductor nano-particles, due to their specific physical properties, can be used as reversible photo-bleachable materials for a wide spectrum, from far infrared to deep UV. Applications include, reversible contrast enhancement layer (R-CEL) in optical lithography, lithography mask inspection and writing and optical storage technologies. | 09-03-2009 |
20090239161 | APPLICATIONS OF SEMICONDUCTOR NANO-SIZED PARTICLES FOR PHOTOLITHOGRAPHY - Semiconductor nano-sized particles possess unique optical properties, which make them ideal candidates for various applications in the UV photolithography. In this patent several such applications, including using semiconductor nano-sized particles or semiconductor nano-sized particle containing materials as highly refractive medium in immersion lithography, as anti-reflection coating in optics, as pellicle in lithography and as sensitizer in UV photoresists are described. | 09-24-2009 |
20110281221 | APPLICATIONS OF SEMICONDUCTOR NANO-SIZED PARTICLES FOR PHOTOLITHOGRAPHY - Semiconductor nano-sized particles possess unique optical properties, which make them ideal candidates for various applications in the UV photolithography. In this patent several such applications, including using semiconductor nano-sized particles or semiconductor nano-sized particle containing materials as highly refractive medium in immersion lithography, as anti-reflection coating in optics, as pellicle in lithography and as sensitizer in UV photoresists are described. | 11-17-2011 |