Holterman
Chet Holterman, Embrun CA
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20090074730 | NOVEL STEM CELLS, NUCLEOTIDE SEQUENCES AND PROTEINS THEREFROM - The present invention provides novel stem cells, nucleotide sequences and proteins therefrom. More specifically, the present invention provides Pax7+/Myf5− stem cells and methods for identifying and isolating them. Also provided is a MEGF10 nucleotide sequence and protein. | 03-19-2009 |
20120213751 | NOVEL STEM CELLS, NUCLEOTIDE SEQUENCES AND PROTEINS THEREFROM - The present invention provides novel stem cells, nucleotide sequences and proteins therefrom. More specifically, the present invention provides Pax7+/Myf5− stem cells and methods for identifying and isolating them. Also provided is a MEGF10 nucleotide sequence and protein. | 08-23-2012 |
Daniel Holterman, Phoenix, AZ US
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20130287772 | BIOMARKERS FOR THERANOSTICS - Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA. | 10-31-2013 |
20140148350 | CIRCULATING BIOMARKERS FOR DISEASE - Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA. | 05-29-2014 |
Daniel A. Holterman, Phoenix, AZ US
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20140141986 | CIRCULATING BIOMARKERS - Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers can be detected and optionally used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be assessed for diagnostic, prognostic or theranostic purposes, e.g., to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Examples of useful circulating biomarkers include polypeptides, nucleic acids (e.g., DNA, mRNA, microRNA) and vesicles. | 05-22-2014 |
Jan Holterman, Delden NL
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20110247389 | Device for Clamping a Tool - Disclosed is a clamping device for clamping a tool, which includes a part receiving the tool, an actuated member and an engaging member to be brought into contact with the tool. The clamping device is further provided with a transmission placed between the actuated member and the engaging member. The actuated member can be pneumatically or electrically driven, and includes for instance a pneumatic jack, an electric motor or a piezoelectric element or an electromagnet. The actuated member can also be hydraulically driven. The transmission can include a wedge-shaped member or a lever. The clamping device can be self-braking. | 10-13-2011 |
Lennart Holterman, Zoetermeer NL
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20080220014 | Recombinant viral-based malaria vaccines - The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based vaccines can be used to immunize against different | 09-11-2008 |
20100015176 | Settings for recombinant adenoviral-based vaccines - The present invention provides new uses of recombinant adenoviral vectors in vaccination regimens, such as prime/boost set-ups and subsequent vaccinations and applications for gene therapy. Moreover, the invention provides new assays to determine the best regimen for applying the most suitable recombinant viral vector in a vaccination or gene therapy setting. | 01-21-2010 |
20100172928 | Recombinant viral-based malaria vaccines - The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based vaccines can be used to immunize against different | 07-08-2010 |
20110150930 | Recombinant viral-based malaria vaccines - Described are vaccines against malarial infections, which are based on recombinant viral vectors, such as alpha viruses, adenoviruses, or vaccinia viruses. The recombinant viral-based vaccines can be used to immunize against different | 06-23-2011 |
20120082694 | Recombinant Viral-Based Malaria Vaccines - Described are vaccines against malarial infections, which are based on recombinant viral vectors, such as alpha viruses, adenoviruses, or vaccinia viruses. The recombinant viral-based vaccines can be used to immunize against different | 04-05-2012 |
Lennart Holterman, Zoetemeer NL
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20110311580 | Settings for recombinant adenoviral-based vaccines - Described are new uses of recombinant adenoviral vectors in vaccination regimens, such as prime/boost set-ups and subsequent vaccinations and applications for gene therapy. Moreover, also described are new assays to determine the best regimen for applying the most suitable recombinant viral vector in a vaccination or gene therapy setting. | 12-22-2011 |
Mark Holterman, Chicago, IL US
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20110002956 | MUTANT HUMAN CD80 AND COMPOSITIONS FOR AND METHODS OF MAKING AND USING THE SAME - Improved vaccines and methods of using the same are disclosed Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are disclosed. | 01-06-2011 |
Mark J. Holterman, River Forest, IL US
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20090232854 | USES OF BISPECIFIC ANTIBODY COATED DENDRITIC CELLS PULSED WITH ANTIGENS AND GM-CSF IN IMMUNE REGULATION - GM-CSF administered before immunization exerted a sustained suppressive effect against the induction of myasthenia gravis (MG). This suppression was associated with lowered serum autoantibody levels, reduced T cell proliferative responses to AChR, and an expansion in the population of FoxP3+ regulatory T cells. Manipulating DCs to expand regulatory T cells is useful for the control of autoimmune diseases such as myasthenia gravis MG. | 09-17-2009 |
Martijn Hermanus Maria Holterman, Wageningen NL
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20100062439 | Method for Detecting Cyst Nematodes - The present invention relates to a method for determining the presence of a cyst nematode in a sample comprising the steps of : providing a pair of bidirectional oligonucleotide primers or an oligonucleotide probe that hybridizes specifically, under stringent hybridization conditions, to a nucleic acid sequence encoding the SSU rRNA or LSU rRNA, or the complement or transcript thereof, of a sub genus-cluster of nematodes, said subgenus-cluster comprising cyst nematodes belonging to at least one species of nematode, and wherein said primers or probe do not hybridize to a nucleic acid sequence encoding the LSU rRNA, or the complement or transcript thereof, of cyst nematodes not part of said subgenus-cluster of cyst nematodes; providing a sample in which the presence of the cyst nematode is to be detected, and performing a nucleic acid detection assay on said sample using said pair of bidirectional oligonucleotide primers or said oligonucleotide probe. | 03-11-2010 |
20100081133 | Methods of Detecting Root Knot Nematodes - The present invention relates to a method of testing a sample for the presence of a | 04-01-2010 |
Steven W. Holterman, Franklin, WI US
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20110198553 | Wedge Post Base System - A wedge post-base system for adjusting the orientation of an attached post relative to a mounting surface is disclosed. The base utilizes a two-piece structure, each piece having an angled mating surface relative to an opposing surface which allows a central axis of a post mounting collar to be altered, and thus the angle of the post itself. The resulting angle addresses the issue of mounting posts on a sloped plane. A fencing system having hinged railings and balusters as well as a railing system having a hinged upper rail are also disclosed. | 08-18-2011 |