Lancaster, US
Alissa M. Lancaster, Redwood City, CA US
Patent application number | Description | Published |
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20080234220 | Methods and compositions for reducing viral genome amounts in a small target stem cell - Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition. | 09-25-2008 |
Alissa M. Lancaster, Portland, OR US
Patent application number | Description | Published |
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20110124707 | Methods And Compositions For Reducing Viral Genome Amounts In A Target Cell - Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition. | 05-26-2011 |
20120329856 | Methods And Compositions For Reducing Viral Genome Amounts In A Target Cell - Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition. | 12-27-2012 |
Andrew Lancaster, Seneca, SC US
Patent application number | Description | Published |
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20110302437 | SWITCH-OFF OF A MICRO CONTROLLER UNIT IN BATTERY MODE - Disclosed are apparatus and methodology for providing battery protection for devices operating in a battery supplied low-power mode. Micro controller operated devices (such as electricity meters) that may be stored for extended periods after manufacture and before deployment are provided backup battery protection by insertion of an overcurrent operable switch between the battery and the micro controller. A timer causes the micro controller to switch to a normal power mode after a predetermined time period during which no external supply voltage is provided. Normal power mode operation under battery powered supply only will cause the overcurrent switch to open, so as to disconnect the battery from the micro controller. Alternatively, instead of switching the micro controller to a normal power mode after a predetermined time period, the battery powered supply is shorted to ground using an internal switch of the micro controller, to achieve the same result of disconnecting the battery from the micro controller. | 12-08-2011 |
20140167528 | REMOTE DISCONNECT SAFETY MECHANISM - Electricity service may be safely remotely connected to a site by a network computing device, such as an electricity meter, even when the network computing device is not accessible at the site. The network computing device may include a service switch capable of connecting electricity service to a site, a communication module capable of receiving commands to connect or disconnect electricity service, and a safety mechanism to monitor a circuit internal to the site and to prevent the service switch from connecting electricity service to the site while a potentially unsafe condition is detected. | 06-19-2014 |
Arthur Lancaster, Austin, TX US
Patent application number | Description | Published |
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20090323555 | System and Method for Controlling and Configuring a Router - Methods and systems for configuring a network are provided. A method may include monitoring properties of a connection between a network device and a network. The method may also include detecting a change in the properties of the connection. The method may also include verifying the connection to the network is provided by a service provider when the change in the properties is detected and providing network configuration options based on the change. | 12-31-2009 |
20090327440 | System and Method for Securing a Wireless Network - Methods and systems for configuring a network are provided. A method may include monitoring properties of a connection between a network device and a network. The method may also include detecting a change in the properties of the connection. The may also include verifying the connection to the network is provided by a service provider when the change in the properties is detected and providing network configuration options based on the change. | 12-31-2009 |
Arthur L. Lancaster, Austin, TX US
Patent application number | Description | Published |
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20090113044 | SYSTEM AND METHOD OF CONFIGURING A NETWORK - Methods and systems for configuring a network are provided. A method may include monitoring properties of a connection between a computing device and a network. The method may also include detecting a change in the properties of the connection. The may also include verifying the connection to the network is provided by a service provider when the change in the properties is detected and providing network configuration options based on the change. | 04-30-2009 |
20120036240 | SYSTEM AND METHOD OF CONFIGURING A NETWORK - Methods and systems for configuring a network are described. A method may include detecting, during installation of a software program on a computing device, a router coupled to the computing device. The software program may be executable by a processor to selectively initiate a connection to a network via the router based on a security level of the router The method may also include modifying the security level of the router to satisfy a threshold security level. The threshold security level may be specified by a service provider of the network. | 02-09-2012 |
Bradley Robert Lancaster, Ralelgh, NC US
Patent application number | Description | Published |
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20120325505 | Coupler With Visibility Window - A coupler for connecting an implement to a machine includes a first mounting structure configured to attach the coupler to the implement. The first mounting structure includes a first actuator including a first cylinder rod extendable relative to a first cylinder body. The first cylinder rod has a first rod longitudinal axis. The first mounting structure also includes a first wedge attached to the first cylinder rod. The first wedge is movable between a retracted position and an extended position by the first actuator. The first wedge includes a first wedge tip insertable into the implement. The first wedge tip has a first wedge longitudinal axis. The first rod longitudinal axis is offset from the first wedge longitudinal axis to form a first opening extending through the coupler adjacent the first actuator. The coupler also includes a second mounting structure configured to attach the coupler to the machine. | 12-27-2012 |
Brian J. Lancaster, Shawnee, KS US
Patent application number | Description | Published |
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20100100394 | DISPLAYING CLINICAL PREDICTED LENGTH OF STAY OF PATIENTS FOR WORKLOAD BALANCING IN A HEALTHCARE ENVIRONMENT - A computerized system method for displaying a predicted length of stay and actual length of stay in an inpatient healthcare facility for a patient is provided. A predicted length of stay and an actual length of inpatient stay in a healthcare facility for a patient are accessed. The predicted length of stay and the actual length of inpatient stay for the patient are displayed concurrently. | 04-22-2010 |
Brittany Lancaster, Boulder, CO US
Patent application number | Description | Published |
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20100242354 | SYSTEMS AND METHODS FOR REACTOR CHEMISTRY AND CONTROL - A method, apparatus, and system for a solar-driven chemical plant that manages variations in solar energy are disclosed. Some embodiments include a solar thermal receiver to absorb concentrated solar energy, a solar driven chemical reactor contained within the solar thermal receiver, and an entrained gas biomass feed system that uses an entrainment carrier gas and supplies a variety of biomass sources fed as particles into the solar driven chemical reactor. Inner walls of the solar thermal receiver and the chemical reactor can be made from materials selected to transfer energy. Some embodiments include a control system that may be configured to balance the gasification reaction of biomass particles with the available concentrated solar energy and additional variable parameters including, but not limited to, a fixed range of particle sizes, temperature of the chemical reactor, and residence time of the particles in a reaction zone in the chemical reactor. | 09-30-2010 |
Charles E. Lancaster, Willis, TX US
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20150007994 | Open Hole Casing Run Perforating Tool - Disclosed is an open-hole casing perforation tool having projecting fins around the circumference of a mandrel that have firing mechanisms and shape charges to allow flexible operation of geological formation fracturing at desired predetermined locations in an oil or gas well bore. | 01-08-2015 |
Christine Lancaster, O'Fallon, MO US
Patent application number | Description | Published |
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20140366438 | Irrigation device - An irrigation device having a flexible container for holding water while delivering the water directly into the soil with the irrigation device having a filler neck to facilitate filling and inhibit backflow therethrough with a cap that can quickly seal the filler neck after the irrigation device is filled and a handhold useable to hold the filler neck in an elevated condition during the filling and closing of the flexible container. | 12-18-2014 |
Christopher W. Lancaster, Dayton, MN US
Patent application number | Description | Published |
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20150019278 | SYSTEM AND METHOD TO HANDLE REQUESTS FOR ACCOMMODATIONS VIA A LEAVE MANAGEMENT SYSTEM - According to some embodiments, data received via a communication device indicative of employee claims, including employee claims for one of a plurality of types of employee leave, may be processed. It may then be detected that a particular employee claim is associated with a request for accommodation. It may be automatically determined if medical information associated with the request for accommodation meets predetermined criteria, and an indication of said determination may be transmitted. | 01-15-2015 |
20150181037 | SYSTEM AND METHOD FOR IMPROVED INSURANCE CALL ROUTING AND PROCESSING - An insurance policy management system for administering and managing insurance inquiries related to disability and leave management via an interactive voice response platform that communicates with combined short term disability/leave management resources and clinical intake nurse resources. | 06-25-2015 |
Christy A. Lancaster, Seattle, WA US
Patent application number | Description | Published |
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20090022624 | MICROFLUIDIC DEVICES FOR FLUID MANIPULATION AND ANALYSIS - The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis. | 01-22-2009 |
20090081771 | SYSTEM AND METHOD FOR HEATING, COOLING AND HEAT CYCLING ON MICROFLUIDIC DEVICE - An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card. | 03-26-2009 |
20090325276 | INTEGRATED MICROFLUIDIC ASSAY DEVICES AND METHODS - Combinations of microfluidic diagnostic testing modules for simultaneous evaluations of serological and molecular biological targets are provided, and include panel testing for both antibodies (or antigens) and nucleic acid targets in one single-use device. These improvements are directed to evaluating the overall progress and activity of a pathogenic process in real time, at the point of care, not merely the presence or absence of a particular diagnostic marker, which can often be incomplete or misleading. | 12-31-2009 |
20100173395 | MICROFLUIDIC DEVICES FOR FLUID MANIPULATION AND ANALYSIS - The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis. | 07-08-2010 |
20120064612 | MICROFLUIDIC DEVICES FOR FLUID MANIPULATION AND ANALYSIS - The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis. | 03-15-2012 |
20120105600 | FUNCTIONAL IMAGING OF CELLS WITH OPTICAL PROJECTION TOMOGRAPHY - A method for 3D imaging of a biologic object ( | 05-03-2012 |
20140010736 | MICROFLUIDIC DEVICES FOR FLUID MANIPULATION AND ANALYSIS - The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis. | 01-09-2014 |
20140370581 | MICROFLUIDIC DEVICES FOR FLUID MANIPULATION AND ANALYSIS - The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis. | 12-18-2014 |
Cory D. Lancaster, Berkeley, CA US
Patent application number | Description | Published |
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20150175454 | RECYCLING ACTIVATED SLUDGE BY HYDRODYNAMIC SEPERATOR (HDS) TO ENABLE HIGH MLSS BIOREACTOR TO PROCESS HIGH INFLUENT FLOW AND/OR HIGH STRENGTH WASTEWATER - A wastewater treatment plant that employs an activated sludge process and a method of operating the same is described. Wastewater influent is provided to a bioreactor configured to perform activated sludge processing to develop mixed liquor suspended solids (MLSS). The MLSS is passed from the bioreactor to a hydrodynamic separator (HDS) system, where separation operations are performed on the MLSS. The separation operations generate a low concentration MLSS stream and a high concentration MLSS stream. The low concentration MLSS stream is passed from the hydrodynamic separator system via a first output to a clarifier, and the high concentration wastewater stream is passed via a second output back to the bioreactor. The clarifier performs clarification operations on the cleaned wastewater stream and then outputs an effluent flow. | 06-25-2015 |
Craig Anderson Lancaster, Mansfield, MA US
Patent application number | Description | Published |
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20130059662 | SEMI-SYNCHRONOUS MULTI-PARTICIPANT APPLICATION UPDATES - Individual participants in a multi-participant collaborative computing application may be sent intermittent updates of actions taken by other participants. These updates need not be sent to a participant's device until the participant has interacted with a specified object in the application. The participant's device may then be sent an update including object interactions of the other participants occurring since the participant's previous object interaction. The update may be used to periodically inform the participant of the actions taken by the other participants during the period between the participant's interactions. | 03-07-2013 |
20130059664 | SEMI-SYNCHRONOUS MULTI-PARTICIPANT APPLICATION UPDATES - Individual participants in a multi-participant collaborative computing application may be sent intermittent updates of actions taken by other participants. These updates need not be sent to a participant's device until the participant has interacted with a specified object in the application. The participant's device may then be sent an update including object interactions of the other participants occurring since the participant's previous object interaction. The update may be used to periodically inform the participant of the actions taken by the other participants during the period between the participant's interactions. | 03-07-2013 |
20140323229 | Semi-Synchronous Multi-Participant Application Updates - Individual participants in a multi-participant collaborative computing application may be sent intermittent updates of actions taken by other participants. These updates need not be sent to a participant's device until the participant has interacted with a specified object in the application. The participant's device may then be sent an update including object interactions of the other participants occurring since the participant's previous object interaction. The update may be used to periodically inform the participant of the actions taken by the other participants during the period between the participant's interactions. | 10-30-2014 |
Darell Lancaster, Woodruff, SC US
Patent application number | Description | Published |
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20090304874 | Laminated lidstock and package made therefrom - A laminated lidstock includes a substrate film, a support web; a pressure sensitive adhesive disposed between the substrate and support webs, and covering the substrate film and support web; a product die cut disposed in the substrate film; and an array of opening die cuts disposed in the substrate film; wherein at least one of substrate film and the support web comprises an oxygen barrier, and wherein at least one of the substrate film and the support web carries a registration device. A method of making the lidstock, and a package, are also disclosed. | 12-10-2009 |
Darren Lancaster, Campbell, CA US
Patent application number | Description | Published |
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20110252103 | Apparatus and Method for Interactive Email - A non-transitory computer readable storage medium includes executable instructions to deliver to a community of users an email with a widget including a graphical user interface that solicits input. Solicited input is collected from the community of users via the widget. The email is revised to dynamically display at least a portion of the solicited input. | 10-13-2011 |
David Lancaster, Derby, KS US
Patent application number | Description | Published |
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20120096410 | Computing Devices And Articles Of Manufacture - Computing devices, interfaces, articles of manufacture and methods of interacting with computing devices are described in some aspects of the disclosure. According to one aspect, a computing device includes a display configured to generate visual images, processing circuitry coupled with the display and configured to control the display to depict a graphical user interface which comprises a plurality of tiles of a first hierarchical level, to access user input selecting one of the tiles of the first hierarchical level which are displayed in the graphical user interface, and to control the display to depict the graphical user interface comprising a plurality of tiles of a second hierarchical level which are associated with the selected one of the tiles of the first hierarchical level as a result of the accessed user input selecting the one of the tiles of the first hierarchical level, and wherein a plurality of different data items are associated with individual ones of the tiles of the second hierarchical level and wherein the processing circuitry is configured to control the computing device to convey data of one of the data items to a user of the computing device. | 04-19-2012 |
David R. Lancaster, Troy, MI US
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20090187328 | ENGINE VACUUM ENHANCEMENT IN AN INTERNAL COMBUSTION ENGINE - A control system for an engine includes a manifold absolute pressure (MAP) module that compares MAP of an engine to a predetermined MAP and an air/spark module that decreases flow of air and that advances ignition spark when the MAP module indicates that the MAP is greater than a predetermined MAP. | 07-23-2009 |
David W. Lancaster, Houston, TX US
Patent application number | Description | Published |
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20120031829 | OIL SPILL RECOVERY VESSEL - The oil spill recovery vessel is configured particularly for operations in relatively shallow water. The vessel is of catamaran configuration, with a large number of slowly rotating discs installed on a lateral rotary axle at the bow of the vessel. A wiper bears against each of the two surfaces of each disc, with oil residue running along the wipers being collected in a holding tank or tanks on the vessel. The oil may be pumped to other storage vessels or containers. The lateral axle on which the discs are installed is free to rise upward in the event that the discs contact a solid object or a shallow bottom. Thus, the discs are of relatively large diameter to provide relatively greater surface area across the surface of the water than is the case with vessels operating with smaller diameter discs. | 02-09-2012 |
Dayne Lancaster, Frostburg, MD US
Patent application number | Description | Published |
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20090139205 | Pourable centerport inhibitor for solid propellant rocket motors - A pourable opaque centerport for solid propellant rocket motors and method for applying the same are disclosed. The pourable centerport inhibitor for solid propellant rocket motors has a curing system that includes a prepolymer and a curing agent. The prepolymer and the curing agent are combined to form a pourable polymeric binder that cures into an amorphous solid. The pourable centerport inhibitor also includes an opaque agent. The pourable centerport inhibitor may also include a plasticizer. The plasticizer, the prepolymer, and the curing agent are preferably the same type that is in the solid propellant with which it will be used in conjunction. | 06-04-2009 |
Eric W. Lancaster, Las Vegas, NV US
Gilead I. Lancaster, Redding, CT US
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20100049052 | NON-INVASIVE CARDIAC PARAMETER MEASUREMENT - Non-imaging mode system for acquiring cardiac parameters using Doppler acoustic signals. Some embodiments use only a single transducer, optionally aimed in an apical view. Some embodiments detect specifically peak events in the heart. | 02-25-2010 |
Gregory D. Lancaster, Idaho Falls, ID US
Patent application number | Description | Published |
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20080298667 | IMAGE PORTION IDENTIFICATION METHODS, IMAGE PARSING METHODS, IMAGE PARSING SYSTEMS, AND ARTICLES OF MANUFACTURE - Image portion identification methods, image parsing methods, image parsing systems, and articles of manufacture are described. According to one embodiment, an image portion identification method includes accessing data regarding an image depicting a plurality of biological substrates corresponding to at least one biological sample and indicating presence of at least one biological indicator within the biological sample and, using processing circuitry, automatically identifying a portion of the image depicting one of the biological substrates but not others of the biological substrates. | 12-04-2008 |
20080300796 | BIOLOGICAL ANALYSIS METHODS, BIOLOGICAL ANALYSIS DEVICES, AND ARTICLES OF MANUFACTURE - Biological analysis methods, biological analysis devices, and articles of manufacture are described. Biological analysis methods access data regarding one or more images of a plurality of different combinations of biological receptors which individually have reacted with one or more biological indicators of a biological sample, analyze the data, and based on the analysis, create a profile comprising values representative of the biological indicators. Other biological analysis methods first access a plurality of first values individually corresponding to a plurality of biological indicators of a first subject, second access a plurality of second values individually corresponding to a plurality of biological indicators of a second subject, analyze the first and second values with respect to one another, and provide information regarding similarity of the first subject and the second subject using the analysis. | 12-04-2008 |
Jack L. Lancaster, San Antonio, TX US
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20130085316 | Apparatus and Method for Delivery of Transcranial Magnetic Stimulation Using Biological Feedback to a Robotic Arm - Disclosed are apparatus and methods for computer-aided, robotic delivery of transcranial magnetic stimulation (TMS) using biologically derived feedback to establish coil position relative to brain functional regions. The apparatus includes a TMS coil mounted to a robotic member. The position of the stimulating coil can be automatically optimized using the TMS-induced bio-responses of various types. | 04-04-2013 |
James C. Lancaster, Clermont, FL US
Patent application number | Description | Published |
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20140024406 | SYSTEM AND METHOD FOR ASSESSING NOISE FLOOR DATA USING RADIO BLOCKING PERFORMANCE - An electronic device includes communications circuitry configured to communicate with an assistance server. The electronic device transmits a spectrum access request to the assistance server and receives, in response, an available channel list ranked by respective aggregate noise floor metric values from the assistance server. The aggregate noise floor metric value for each channel in the ranked channel list is determined by the server to account for a location of the electronic device, noise from radio frequency devices, and an adjacent channel blocking profile of the communications circuitry. | 01-23-2014 |
20140148190 | SYSTEM AND METHOD FOR DETERMINING PRECISE GEO-LOCATION OF A FIXED-LOCATION RADIO DEVICE - To determine precise geographical location of a fixed-location radio device, the fixed-location radio device may enter a configuration mode and receive location data from a separate electronic device that is within close proximity to the fixed-location radio device. The location of the electronic device is used as a proxy for the location of the fixed-location radio device. | 05-29-2014 |
James G. Lancaster, Winona Lake, IN US
Patent application number | Description | Published |
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20100305710 | Knee Prosthesis - A knee joint prosthesis assembly can include a femoral component that has a medial and a lateral condyle portion connected by a patellar track portion. The femoral component can form an opening between the medial and lateral condyles. A tibial component can have a medial portion that includes a first engagement structure and a lateral portion that includes a second engagement structure. A medial bearing can have a third engagement structure formed thereon that selectively engages the first engagement structure. A lateral bearing separately formed and independent from the medial bearing can have a fourth engagement structure formed thereon that selectively engages the second engagement structure. | 12-02-2010 |
20120239159 | KNEE PROSTHESIS - A knee joint prosthesis assembly can include a femoral component that has a medial and a lateral condyle portion connected by a patellar track portion. The femoral component can form an opening between the medial and lateral condyles. A tibial component can have a medial portion that includes a first engagement structure and a lateral portion that includes a second engagement structure. A medial bearing can have a third engagement structure formed thereon that selectively engages the first engagement structure. A lateral bearing separately formed and independent from the medial bearing can have a fourth engagement structure formed thereon that selectively engages the second engagement structure. | 09-20-2012 |
20130006375 | KNEE PROSTHESIS - A knee joint prosthesis assembly according to the present disclosure can include a femoral component, a unitary tibial component, a medial bearing, and a lateral bearing. The femoral component can have a medial and a lateral condyle portion connected by a patellar track portion. The femoral component can form an opening between the medial and lateral condyles. The unitary tibial component can have a medial portion that includes a first posterior engagement lip and a first outer securing lip. The tibial component can further include a lateral portion that includes a second posterior engagement lip and a second outer securing lip. The medial bearing can have a first posterior groove formed thereon that selectively engages the first posterior engagement lip and a first outer groove that selectively engages the first outer securing lip. | 01-03-2013 |
20150032216 | KNEE PROSTHESIS - A knee joint prosthesis assembly including a femoral component and a unitary tibial component. The femoral component includes a first condyle and a second condyle. The unitary tibial component includes an engaging structure configured to rigidly secure a stationary bearing thereto. The stationary bearing is configured to articulate with the first condyle. The unitary tibial component further includes a planar tibial bearing surface configured to slidably support a mobile bearing thereon. The mobile bearing includes an inferior planar surface configured to slide along the planar tibial bearing surface and a superior surface configured to articulate with the second condyle. | 01-29-2015 |
James Justin Lancaster, Lebanon, NH US
Patent application number | Description | Published |
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20120123795 | Business method and system for ordering, purchasing and storing stem cells - An online business method and system enables donors or parents or guardians of donors to order and purchase stem-cells extracted from biological tissue sampled from the donor, such as, for example, cord-blood stem cells of a newborn baby, wherein the ordering process interfaces directly with the attending medical services, and the service steps include collection, extraction, preservation, containment, packaging, delivery and storage of the stem cells in a storage medium that can be cost-effectively maintained in a storage facility or by the donor, parent or guardian at home. In one embodiment, preservation is by freeze-drying, containment is in a vacuum vial, and storage is at room temperature. | 05-17-2012 |
James Justin Lancaster, Quechee, VT US
Patent application number | Description | Published |
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20090138415 | Automated research systems and methods for researching systems - Systems and methods that provide for automated research into the workings of one or more studied systems include automated research software modules that communicate with domain knowledge bases, research professionals, automated laboratories experiment objects, and data analysis processes, wherein automatically selected experiment objects can be run at an automated laboratory to produce experimental results, and the subsequent data-processing providing automated guidance to a next round of experiment choice and automated research. An Experiment Director rules engine chooses Experiment Objects based on user input through a Query Manager. | 05-28-2009 |
James W. Lancaster, Beatrice, NE US
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20090183481 | Height of cut adjustment system for mower cutting desk - A mower carrying a rotary cutting deck has a height of cut system for adjusting the vertical position of the deck relative to the mower frame for changing or adjusting the height of cut. The height of cut system comprises a pair of parallel cross shafts that carry a plurality of pivotal suspension linkages that connect to the deck, the cross shafts and linkages pivoting jointly with one another and with a pivotal control lever. One of the cross shafts carries a torsion spring to counterbalance the weight of the deck. The control lever is maintained in a plurality of adjusted pivotal positions by a height selection bracket fixed to the frame with the height selection bracket being capable of having its position changed or adjusted relative to the frame by a single adjustment bolt. Each suspension linkage has its effective length adjusted by turning a threaded adjuster carried at the upper end of a connecting rod that is part of each linkage to allow the deck to be leveled relative to a reference plane. The adjustment of the height selection bracket is accomplished without affecting the length adjustments previously made to any of the suspension linkages. | 07-23-2009 |
20140260161 | HEIGHT OF CUT ADJUSTMENT SYSTEM FOR MOWER CUTTING DECK - A mower carrying a rotary cutting deck has a height of cut system for adjusting the vertical position of the deck relative to the mower frame for changing or adjusting the height of cut. The height of cut system comprises a pair of parallel cross shafts that carry a plurality of pivotal suspension linkages that connect to the deck, the cross shafts and linkages pivoting jointly with one another and with a pivotal control lever. One of the cross shafts carries a torsion spring to counterbalance the weight of the deck. The control lever is maintained in a plurality of adjusted pivotal positions by a height selection bracket fixed to the frame with the height selection bracket being capable of having its position changed or adjusted relative to the frame by a single adjustment bolt. Each suspension linkage has its effective length adjusted by turning a threaded adjuster carried at the upper end of a connecting rod that is part of each linkage to allow the deck to be leveled relative to a reference plane. The adjustment of the height selection bracket is accomplished without affecting the length adjustments previously made to any of the suspension linkages. | 09-18-2014 |
20140260162 | HEIGHT OF CUT ADJUSTMENT SYSTEM FOR MOWER CUTTING DECK - A mower carrying a rotary cutting deck has a height of cut system for adjusting the vertical position of the deck relative to the mower frame for changing or adjusting the height of cut. The height of cut system comprises a pair of parallel cross shafts that carry a plurality of pivotal suspension linkages that connect to the deck, the cross shafts and linkages pivoting jointly with one another and with a pivotal control lever. One of the cross shafts carries a torsion spring to counterbalance the weight of the deck. The control lever is maintained in a plurality of adjusted pivotal positions by a height selection bracket fixed to the frame with the height selection bracket being capable of having its position changed or adjusted relative to the frame by a single adjustment bolt. Each suspension linkage has its effective length adjusted by turning a threaded adjuster carried at the upper end of a connecting rod that is part of each linkage to allow the deck to be leveled relative to a reference plane. The adjustment of the height selection bracket is accomplished without affecting the length adjustments previously made to any of the suspension linkages. | 09-18-2014 |
Jeff Lancaster, Plymouth, MN US
Patent application number | Description | Published |
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20100199124 | SYSTEMS AND METHODS FOR RECONFIGURING INPUT DEVICES - A system includes an input device having first and second input members configured to be activated by a user. The input device is configured to generate activation signals associated with activation of the first and second input members, and each of the first and second input members are associated with an input function. A processor is coupled to the input device and configured to receive the activation signals. A memory coupled to the processor, and includes a reconfiguration module configured to store the input functions assigned to the first and second input members and, upon execution of the processor, to reconfigure the input functions assigned to the input members when the first input member is inoperable. | 08-05-2010 |
20110074607 | SYSTEMS AND METHODS FOR ENHANCED AWARENESS OF CLEARANCE FROM CONFLICT FOR SURFACE TRAFFIC OPERATIONS - Systems and methods for improving pilot situational awareness in the airport vicinity. An example method determines if at least one of an aircraft or vehicle in a predefined vicinity of the airport is a conflict based on information about an installation aircraft, information received from the at least one aircraft or vehicle, and a predefined conflict envelope, when the installation aircraft is performing one of an approach to landing, a takeoff operation or a taxi operation at an airport. The method generates and outputs a conflict alert if the installation aircraft determines that the at least one aircraft or vehicle is a conflict. The method generates a clear-of-conflict advisory if the at least one aircraft or vehicle previously determined to be conflicting is determined to no longer be conflicting based on updated information received from the at least one aircraft or vehicle. | 03-31-2011 |
20110184635 | CLOSED AIRPORT SURFACE ALERTING SYSTEM - A system and a method alerts the occupant of an aircraft that the aircraft is in, or approaching, a zone of awareness associated with a closed surface at the airport. | 07-28-2011 |
20110187651 | TOUCH SCREEN HAVING ADAPTIVE INPUT PARAMETER - A method is provided for modifying input parameters of a touch panel in response to movement of the panel due to vibrations, turbulence, or a “G” force. The method includes sensing movement of a touch panel, the touch panel having a display region requiring a touch to indicate an input defined by the parameter, a threshold of the sensed movement being above which a user may be prevented from physically providing an accurate touch input due to the movement, and modifying the parameter based on the sensed movement being above the threshold. Feedback may be provided and modified in response to the parameter being satisfied by the touch. | 08-04-2011 |
20120150423 | CLOSED AIRPORT SURFACE ALERTING SYSTEM - A system and a method alerts the occupant of a vehicle that the vehicle is in, or approaching, a zone of awareness associated with a closed surface at the airport. | 06-14-2012 |
20130038631 | SYSTEMS AND METHODS FOR A VIRTUAL TERRAIN DISPLAY - Embodiments of the present invention provide improved systems and methods for providing a virtual terrain display. In one embodiment, a method comprises identifying a location within an enclosure. The location is referenced against an external environment containing the enclosure. The method also comprises identifying a portion of a structure of the enclosure. The portion of the structure exists between the location and the external environment and blocks a view of the external environment. The method also comprises generating a display depicting a view of the external environment from the location; and applying a translucent structure representation to the display. The structure representation is a visual depiction of the portion of the structure and appearing in front of the depicted view without blocking the depicted view of the external environment. | 02-14-2013 |
20130120124 | METHODS AND SYSTEMS TO SUPPORT AUDITORY SIGNAL DETECTION - Methods and apparatus are provided for producing an auditory alert that comprises sonic properties to an equipment operator wearing an auditory headset prior to the presentation of the auditory alert to the operator. The method comprises measuring an at-ear ambient noise spectrum, determining frequencies within the at-ear ambient noise spectrum that have relative minimum intensities and enhancing the magnitude of the determined relative minimum intensities. The method then generates the auditory alert incorporating the enhanced relative minimum intensities. | 05-16-2013 |
Jeffrey Lancaster, Tenafly, NY US
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20100331441 | FUNCTIONALIZATION OF ORGANIC SURFACES - The present invention relates to functionalizing a surface of an organic material. For example, surfaces of materials having C—H bonds, such as polymers having C—H bonds, can be functionalized. In certain embodiments, a heterobifunctional molecule having a photoactive anchor, a spacer, and a terminal functional group is applied to the surface of an organic material that contains one or more C—H bonds. The heterobifunctional molecule can be bound to any surface having C—H bonds as the photoactive anchor can react with C—H bonds upon irradiation. The terminal functional group has a “click” functionality which can be utilized to functionalize the surface of the organic material with any desired functionalizing moiety having the orthogonal click functionality. | 12-30-2010 |
Jeffrey Lancaster, New York, NY US
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20120264881 | HETEROTRIFUNCTIONAL MOLECULES AND METHODS FOR THE SYNTHESIS OF DENDRIMERIC MATERIALS - In one aspect, the present invention is directed to dendrimers comprised of macromolecules and trifunctional branches. In another aspect, the invention relates to methods for generating dendrimeric compositions comprising macromolecules and trifunctional branches. In certain embodiments, the radial density of the dendrimeric composition is controlled by selective incorporation of branches. | 10-18-2012 |
Jeffrey B. Lancaster, Riverton, UT US
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20120026325 | OPTIMIZED MOVABLE IR FILTER IN CAMERAS - Embodiments of the present invention include a camera having two modes: a visible light imaging mode (day-mode) and an IR imaging mode (night-mode). In the visible light imaging mode, an IR filter is in line with the lens assembly. In the IR imaging mode, the IR filter is mechanically removed, and IR light is allowed to pass to the sensor. In one embodiment, in the IR imaging mode, IR lighting is provided by an IR LEDs on the camera to illuminate the scene. In one embodiment, the various components are chosen, balanced and optimized so that images captured using visible light and images captured using non-visible light are both in focus. In one embodiment, an algorithm determines when there sufficient visible light is present and when it is not, and thus determines when to switch the camera from one mode to another. | 02-02-2012 |
Jeffrey D. Lancaster, Coventry, CT US
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20090324093 | Method for comparing sectioned geometric data representations for selected objects - A method for comparing a plurality of geometrical data representations each representing a spatial boundary surface of a corresponding geometrical object which surface changes over a selected extent of the object bounded thereby through providing the plurality of geometrical data representations on a common format basis, including scaling so as to each to have a common selected extent, to thereby result in a plurality of standardized spatial boundary surface geometrical data representations and comparing them at a plurality of matching section locations along each of the common extents at each of which there is a section outline curve representations. Comparing selected features of the commonly scaled section outline curve representations for such representations at corresponding ones of the selected matched section locations provides a basis for determining similarity therebetween. | 12-31-2009 |
J. Justin Lancaster, Quechee, VT US
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20080215364 | Business method and system for ordering, purchasing and storing stem cells - An online business method and system enables donors or parents or guardians of donors to order and purchase stem-cells from biological tissue sampled from the donor, such as, for example, cord-blood stem cells of a newborn baby, wherein the ordering process interfaces directly with the attending medical services, and the service steps include collection, extraction, preservation, containment, packaging, delivery and storage of the stem cells in a storage medium that can be cost-effectively maintained by the donor, parent or guardian at home or in a custodial location. In one embodiment, preservation is by freeze-drying, containment is in a vacuum vial, and storage is at room temperature. | 09-04-2008 |
Johnathan Lancaster, Tampa, FL US
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20140017703 | BAD PHOSPHORYLATION DETERMINES OVARIAN CANCER CHEMO-SENSITIVITY AND PATIENT SURVIVAL - Despite initial sensitivity BAD-protein phosphorylation were evaluated in patient samples and cell lines as determinants of chemo-sensitivity and/or clinical outcome, and as therapeutic targets. Induced in-vitro OVCA cisplatin-resistance was associated with BAD-pathway expression. Expression of the pathway was also associated with resistance of 7 different cancers cell-types to 8 chemotherapeutic agents. Phosphorylation of the BAD-protein was associated with platinum-resistance in OVCA cells and primary OVCA specimens, and also overall patient survival. Targeted modulation of BAD-phosphorylation levels influenced cisplatin-sensitivity. A 47-gene BAD-pathway signature was associated in-vitro phospho-BAD levels and with survival of 838 patients with ovarian, breast, colon, and brain cancer. The survival advantage associated with both BAD-phosphorylation and also the BAD-pathway signature was independent of surgical cytoreductive status. The BAD apoptosis pathway influences human cancer chemo-sensitivity and overall survival. The pathway is useful as a biomarker of therapeutic response, patient survival, and therapeutic target. | 01-16-2014 |
Johnathan M. Lancaster, Tampa, FL US
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20090105167 | Predicting responsiveness to cancer therapeutics - The invention provides for compositions and methods for predicting an individual's responsitivity to cancer treatments and methods of treating cancer. In certain embodiments, the invention provides compositions and methods for predicting an individual's responsitivity to chemotherapeutics, including salvage agents, to treat cancers such as ovarian cancer. The invention also provides reagents, such as DNA microarrays, software and computer systems useful for personalizing cancer treatments, and provides methods of conducting a diagnostic business for personalizing cancer treatments. | 04-23-2009 |
20090186024 | Gene Expression Signatures for Oncogenic Pathway Deregulation - The disclosure relates to identifying deregulated pathways in cancer. In certain embodiments, the methods of the disclosure can be used to evaluate therapeutic agents for the treatment of cancer. | 07-23-2009 |
20090291452 | MICRO-RNA PROFILES ASSOCIATED WITH ENDOMETRIAL CANCER DEVELOPMENT AND RESPONSE TO CISPLATIN AND DOXORUBICIN CHEMOTHERAPY - A method predicting of cancer chemoresponse of the population of cancer cells to the one or more chemotherapeutic agents. Our ability to treat patients with advanced stage and recurrent endometrial cancer is hampered by an incomplete understanding of the molecular basis of disease development and response to therapy. A novel class of gene products called microRNA (miRNA) has recently been implicated in the etiology of several different human cancers. Altered levels of expression of specific miRNAs may contribute to cancer development in a variety of cancers such as endometrial cancer and may also influence response to cytotoxic chemotherapy or other cancer treatments. Evidence is provided that differential expression of miRNAs contributes to endometrial carcinogenesis and further associates with sensitivity of endometrial cancer cells to various chemotherapeutic agents including cisplatin and doxorubicin chemotherapy. MiRNA profiles and their gene targets show promise as biomarkers of endometrial cancer chemo-response, and as a novel class of therapeutic targets for patients with endometrial cancer. | 11-26-2009 |
20100279957 | PREDICTING RESPONSIVENESS TO CANCER THERAPEUTICS - Provided herein are methods for predicting the responsiveness of a cancer to a chemotherapeutic agent using gene expression profiles. In particular, methods for predicting the responsiveness to 5-fluorouracil, adriamycin, cytotoxan, docetaxol, etoposide, taxol, topotecan, PB kinase inhibitors and Src inhibitors are provided. Methods for developing treatment plans for individuals with cancer are also provided. Kits including gene chips and instructions for predicting responsiveness and computer readable media comprising responsivity information are also provided. | 11-04-2010 |
20100292087 | METHOD OF PREDICTING CHEMOTHERAPEUTIC RESPONSIVENESS OF CANCER - Disclosed is a method of predicting clinical tumor outcome by providing gene expression from a tumor sample. The method utilizes a novel genetic screen to identify genes that contribute to chemotherapeutic responsiveness, using formalin fixed paraffin embedded clinical samples of epithelial cancer, specifically serous ovarian cancer. The method is useful in predicting tumor responsiveness to chemotherapeutics, including alkylating agents, cisplatin, antimetabolites, plant alkaloids, and antitumor antibiotics. A microarray screen showed formalin fixed paraffin embedded samples can identify genes related to chemotherapeutic response with 86% efficiency. | 11-18-2010 |
20100305058 | INDIVIDUALIZED CANCER TREATMENTS - The invention provides for compositions and methods for predicting an individual's responsitivity to cancer treatments and methods of treating cancer. In certain embodiments, the invention provides compositions and methods for predicting an individual's responsitivity to chemotherapeutics, including platinum-based chemotherapeutics, to treat cancers such as ovarian cancer. Furthermore, the invention provides for compositions and methods for predicting an individual's responsivity to salvage therapeutic agents. By predicting if an individual will or will not respond to platinum-based chemotherapeutics, a physician can reduce side effects and toxicity by administering a particular additional salvage therapeutic agent. This type of personalized medical treatment for ovarian cancer allows for more efficient treatment of individuals suffering from ovarian cancer. The invention also provides reagents, such as DNA microarrays, software and computer systems useful for personalizing cancer treatments, and provides methods of conducting a diagnostic business for personalizing cancer treatments. | 12-02-2010 |
20110166095 | CANCER PLATINUM RESISTANCE DETECTION AND SENSITIZATION METHOD - The phosphorylation status of the BAD protein is a determinant of ovarian cancer cell responsiveness to platinum chemotherapy. Indirect manipulation of BAD phosphorylation status influences cisplatin sensitivity. BAD phosphorylation represents a biomarker that predicts platinum sensitivity and is a therapeutic target to increase platinum sensitivity. The methods employ phospho-specific antibody against a particular amino acid residue or site. Phospho-specific protein characterization methods include immunohistochemical (IHC), flow cytometric, immunofluorescent, capture-and-detection, or reversed phase assay. | 07-07-2011 |
20130344168 | Compositions and Methods APC, CREB, and BAD Pathways to Assess and Affect Cancer - Disclosed are compositions and methods for assessing the apoptosis and survival BAD phosphorylation pathway (BAD pathway); and/or (2) the cell cycle role of APC in cell cycle regulation pathway (APC pathway); and/or (3) the transcription CREB pathway (CREB pathway) and for using these pathways to assess, treat, monitor, prognose, diagnose, etc. subjects with cancer. Also disclosed are compositions and methods for identifying molecular pathways that are common to one or more chemotherapeutic agents for the treatment of an oncological disorder, for screening for compounds or agents that can be used to treat ovarian cancer, and for selecting for compounds or agents that can enhance the cytotoxic response of cisplatin, carboplatin, and/or paclitaxel against a cancer cell, such as an ovarian cancer cell or cell line. | 12-26-2013 |
20150080249 | O-GLYCAN PATHWAY OVARIAN CANCER SIGNATURE - Biomarkers, methods, assays, and kits are provided for determining the prognosis of and treating a patient with ovarian cancer. Also disclosed are biomarkers, methods, assays, and kits for predicting the sensitivity of ovarian cancer cells to chemotherapy. | 03-19-2015 |
20150140124 | METHOD OF DIAGNOSING, TREATING AND DETERMINING PROGRESSION AND SURVIVAL OF CANCER CELLS USING BCL-2 ANTAGONIST OF CELL DEATH (BAD) PATHWAY GENE SIGNATURE - The present invention relates to the BAD pathway's influence on development, progression, chemo-sensitivity, and overall survival for multiple human cancers and its potential as a therapeutic target to increase chemo-sensitivity. BAD pathway expression was associated with the development and/or progression of breast, colon, and endometrial cancers, relapse-free survival from breast cancer, and overall survival from ovarian, colon, and brain cancers. Expression was also associated with in vitro sensitivity to a range of cytotoxic agents. pBAD levels were higher in cancer versus immortalized normal cells and chemo-resistant versus—sensitive cancer cells and associated with increased cell proliferation. | 05-21-2015 |
20150154368 | METHODS AND APPARATUSES USING MOLECULAR FINGERPRINTS TO PROVIDE TARGETED THERAPEUTIC STRATEGIES - Methods and apparatuses using molecular fingerprints to provide targeted therapeutic strategies are disclosed herein. The molecular fingerprints can be maintained and dynamically updated based on newly discovered and relevant information to improve individualized care. | 06-04-2015 |
Johnathan Mark Lancaster, Tampa, FL US
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20100190662 | METHODS AND MATERIALS FOR DETECTION, DIAGNOSIS AND MANAGEMENT OF OVARIAN CANCER - The subject invention concerns methods using a panel of proteins to detect, diagnose, and monitor therapy during treatment of ovarian cancer in a female patient. The proteins were identified using proteomics analyses of plasma samples obtained preoperatively from ovarian cancer patients versus those of healthy control women. Such a panel has utility for the diagnosis of ovarian cancer, screening for ovarian cancer and possibly therapeutic monitoring. | 07-29-2010 |
20130011393 | BAD PATHWAY GENE SIGNATURE - The invention provides materials and methods for prognosing cancer, and predicting an individual's responsiveness to cancer treatments, methods of treating cancer, and materials and methods for obtaining BAD pathway gene expression profiles useful in carrying out the methods of the invention. | 01-10-2013 |
20130059015 | Human Cancer micro-RNA Expression Profiles Predictive of Chemo-Response - Disclosed are identified and successfully targeted microRNAs (miRNAs) associated with human cancer cell line response to a range of anti-cancer agents. The strategy of integrating in vitro miRNA expression and drug sensitivity data not only aid in the characterization of determinants of cytotoxic response, but also in the identification of novel therapeutic targets. | 03-07-2013 |
20140162891 | METHODS AND MATERIALS FOR DETECTION, DIAGNOSIS AND MANAGEMENT OF OVARIAN CANCER - The subject invention concerns methods using a panel of proteins to detect, diagnose, and monitor therapy during treatment of ovarian cancer in a female patient. The proteins were identified using proteomics analyses of plasma samples obtained preoperatively from ovarian cancer patients versus those of healthy control women. Such a panel has utility for the diagnosis of ovarian cancer, screening for ovarian cancer and possibly therapeutic monitoring. | 06-12-2014 |
John Berns Lancaster, Lawrence, KS US
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20130343443 | METHOD AND SYSTEM FOR IMPULSIVE NOISE CLASSIFICATION AND MITIGATION - A system for classifying impulsive noise on a communications signal comprises an impulse signal generator, an integrator, a first comparator, and an impulse peak detector. The impulse signal generator receives a communications signal that includes impulsive noise and is configured to provide an impulse signal that includes just the impulsive noise. The integrator receives the impulse signal and integrates the impulse signal to determine the power of the impulse signal. The first comparator receives the impulse signal and is configured to compare the impulse signal to a first reference signal and indicate the time during which the value of the impulse signal is greater than the value of the first reference signal. The impulse peak detector receives the impulse signal and is configured to process the impulse signal, compare the processed signal to a second reference signal, and detect the peak value of the impulse signal. | 12-26-2013 |
20140142878 | DENSITY FUNCTION CENTRIC SIGNAL PROCESSING - A circuit for direct current (DC) offset estimation comprises a quantile value circuit and a signal processor. The quantile value circuit determines a plurality of quantile values of an input signal and includes a plurality of quantile filters. Each quantile filter includes a comparator, a level shifter, a monotonic transfer function component, and a latched integrator. The comparator compares the input signal and a quantile value. The level shifter shifts the output of the comparator. The monotonic transfer function component determines the magnitude of the shifted signal and provide a transfer function signal. The latched integrator suppresses transient characteristics of the transfer function signal and provide the quantile value. The signal processor is configured to calculate a weighted average of the quantile values to yield a DC offset estimate. | 05-22-2014 |
Jordan Lancaster, Tucson, AZ US
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20120128637 | Cellular Seeding and Co-Culture of a Three Dimensional Fibroblast Construct - The present invention provides methods for cellular seeding onto three-dimensional fibroblast constructs, three-dimensional fibroblast constructs seeded with muscle cells, and uses therefore. | 05-24-2012 |
Joseph M. Lancaster, St. Louis, MO US
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20140114908 | Method and Apparatus for Accelerated Format Translation of Data in a Delimited Data Format - Various methods and apparatuses are described for performing high speed format translations of incoming data, where the incoming data is arranged in a delimited data format. As an example, the data in the delimited data format can be translated to a fixed field format using pipelined operations. A reconfigurable logic device can be used in exemplary embodiments as a platform for the format translation. | 04-24-2014 |
20140114929 | Method and Apparatus for Accelerated Format Translation of Data in a Delimited Data Format - Various methods and apparatuses are described for performing high speed format translations of incoming data, where the incoming data is arranged in a delimited data format. As an example, the data in the delimited data format can be translated to a mapped variable field format using pipelined operations. A reconfigurable logic device can be used in exemplary embodiments as a platform for the format translation. | 04-24-2014 |
Joseph Marion Lancaster, St. Louis, MO US
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20110231446 | Method and Apparatus for Performing Similarity Searching - A system and method for performing similarity searching is disclosed. This includes a programmable logic device configured to include a pipeline that comprises a matching stage, the matching stage being configured to receive a data stream comprising a plurality of possible matches between a plurality of data strings and a plurality of substrings of a query string. The pipeline may further include an ungapped extension prefilter stage located downstream from the matching stage, the prefilter stage being configured to shift through pattern matches between the data strings and the plurality of substrings of a query string and provide a score so that only pattern matches that exceed a user defined score will pass downstream from the prefilter stage. The matching stage may include at least one Bloom filter. | 09-22-2011 |
20140067830 | Method and Apparatus for Performing Similarity Searching - A system and method for performing similarity searching is disclosed wherein programmable logic devices such as field programmable gate arrays (FPGAs) can be used to implement Bloom filters for identifying possible matches between a query and data. The Bloom filters can be implemented in a parallel architecture where the different parallel Bloom filters share access to the same memory units. | 03-06-2014 |
Kathy Lancaster, West Babylon, NY US
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20100146682 | EAR MUFF - An ear muff is disclosed having an inner layer having a first elongated oval opening to insert the ear therethrough; an outer layer coupled to the inner layer; a flexible core to support the inner layer disposed between the inner layer and the outer layer and having a second elongated oval opening consistent with the first elongated oval opening of the inner layer to insert the ear therethrough; a pocket defined by an area between the inner layer and the outer layer in which the flexible core is disposed and in which the ear is inserted; and a plurality of hair layers disposed upon the outer layer; wherein the ear muff is self supported on the ear. | 06-17-2010 |
Keith Lancaster, Houston, TX US
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20080228512 | CROSS-JURISDICTIONAL TOWING ADMINISTRATION AND DATA MANAGEMENT SYSTEM - Systems, computer programs, and methods for managing information corresponding to a plurality of vehicles are disclosed. The systems include a database for storing information corresponding to a plurality of vehicles, wherein at least one of the plurality of vehicles are non-consent tows and a plurality of user interfaces. Each user interface is configured to manage one or more pieces of information regarding one or more of the plurality of vehicles. | 09-18-2008 |
Kenneth Lancaster, Boulder, CO US
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20080228512 | CROSS-JURISDICTIONAL TOWING ADMINISTRATION AND DATA MANAGEMENT SYSTEM - Systems, computer programs, and methods for managing information corresponding to a plurality of vehicles are disclosed. The systems include a database for storing information corresponding to a plurality of vehicles, wherein at least one of the plurality of vehicles are non-consent tows and a plurality of user interfaces. Each user interface is configured to manage one or more pieces of information regarding one or more of the plurality of vehicles. | 09-18-2008 |
Kent Lancaster, Sturgis, MI US
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20130065121 | STAMPED BATTERY GRID WITH EMBOSSED BORDER AND KINKED GRID WIRES - A grid for a battery having a plurality of spaced apart vertically extending and horizontally extending grid wire elements with each grid wire element having opposed ends joined to one of a plurality of nodes to define a plurality of open spaces and with selected ones of the grid wire elements being joined at one of their ends to frame elements. Oppositely facing sides of the grid wire elements define first and second planes that are parallel to each other. Selected ones of the frame elements have an undulating cross section across the width thereof with an apex of the undulation on one side of the grid being tangential to or terminating at a third plane that is separate from and parallel to the first and second planes. | 03-14-2013 |
Larry Lancaster, Alameda, CA US
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20140351361 | DEPLOYMENT OF AN UPGRADE TO A STORAGE SYSTEM BASED ON CORRELATION ANALYSIS OF MEASUREMENTS OF THE STORAGE SYSTEM - Described herein are methods, systems and machine-readable media that facilitate an analysis of the contributing factors of storage system latency. The variation over time of the storage system latency is measured, along with the variation over time of the activity of various processes and/or components, the various processes and/or components being potentially contributing factors to the storage system latency. The latency measurements are correlated with the process and/or component measurements. High correlation, while not providing direct evidence of the causation of latency, is nevertheless used to identify likely factors (i.e., processes, components) contributing to latency. The latency measurements are plotted over time, the plot including supplemental information indicating, at any time instant, likely factors contributing to the storage system latency. | 11-27-2014 |
Larry Lancaster, Alamedon, CA US
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20140095699 | EVENT SUPPRESSION METHOD AND SYSTEM - A method and system for managing and dynamically suppressing event notification is provided. The method and system receives an indication of an event from a storage environment to be processed by a support system according to a set of default delivery parameters. Next, the method and system determines if one or more event specific delivery parameters have been associated with the event. If this is the case, then the method and system modifies the default delivery parameters for the information associated with the event according to the one or more event specific delivery parameters. These event specific delivery parameters are also used to determine when to transmit a notification of the event to the support system. The dynamic suppression of events combines events gathered into an event log together into a set of one or more recurring events. From these events, the method and system then identifies a high frequency subset as one or more recurring events considered to occur at a higher frequency compared with a low frequency subset having one or more recurring events that occur at a lower frequency. Based on this information gathered, the method and system then eliminates a portion of the events in the high frequency subset until the frequency of events in the high frequency subset approximates the frequency of events in the low frequency subset. | 04-03-2014 |
Mark Lancaster, Brooks, GA US
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20100114392 | Real-Time Power Line Rating - Real-time power line rating may be provided. First, sensor data may be received corresponding to a conductor of a power line. The sensor data may provide real-time weather conditions for the conductor's environment. The sensor data may be received from a sensor device configured to collect the sensor data. The sensor data may correspond to the weather conditions at a location of the sensor device on the power line. Next, design limitations for the power line having the conductor may be received. The conductor of the power line may have a design ampacity based upon the design limitations and assumed weather conditions for the conductor's environment. Then a dynamic ampacity may be calculated for the power line based upon the received sensor data and the received design limitations for the power line. The power line may then be operated according to the calculated dynamic ampacity instead of the design ampacity. | 05-06-2010 |
20110238374 | Power Line Maintenance Monitoring - Maintenance monitoring may be provided. First, a plurality of status data respectively corresponding to a plurality of components on a power line may be collected. Then the collected plurality of status data may be analyzed to determine when a one of the collected plurality of status data is outside of a normal operation range for a one of the plurality of components corresponding to the one of the collected plurality of status data. Next, results of the collected data analysis may be displayed. The results may indicate that the one of the collected plurality of status data is outside of the normal operation range for the one of the plurality of components corresponding to the one of the collected plurality of status data. | 09-29-2011 |
20120261158 | Electrical Transmission Cables With Composite Cores - The present invention discloses electrical cables containing a cable core and a plurality of conductive elements surrounding the cable core. The cable core contains at least one composite core, and each composite core contains a rod which contains a plurality of unidirectionally aligned fiber rovings embedded within a thermoplastic polymer matrix, and surrounded by a capping layer. | 10-18-2012 |
20120278011 | Power Line Maintenance Monitoring - Monitoring may be provided. First, data may be received comprising a current location of a point on a span of conductor or a current angle of a section of the span of conductor. Next, a sag may be calculated of the span of conductor based upon the current location of the point on the span of conductor and the current angle of the section of the span of conductor. An alert may then be provided when the calculated sag is outside of a predetermined range for the span. | 11-01-2012 |
20130179079 | Real-Time Power Line Rating - Real-time power line rating may be provided. First, sensor data may be received corresponding to a conductor of a power line. The sensor data may provide real-time weather conditions for the conductor's environment. The sensor data may be received from a sensor device configured to collect the sensor data. The sensor data may correspond to the weather conditions at a location of the sensor device on the power line. Next, design limitations for the power line having the conductor may be received. The conductor of the power line may have a design ampacity based upon the design limitations and assumed weather conditions for the conductor's environment. Then a dynamic ampacity may be calculated for the power line based upon the received sensor data and the received design limitations for the power line. The power line may then be operated according to the calculated dynamic ampacity instead of the design ampacity. | 07-11-2013 |
Mark Lancaster, Cleburne, TX US
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20110132223 | Non-explosive power source for actuating a subsurface tool - A power source for actuating a subsurface tool is described herein, the power source comprising thermite in a quantity sufficient to generate a thermite reaction, and a polymer disposed in association with the thermite. The polymer produces a gas when the thermite reaction occurs, the gas slowing the thermite reaction. The slowed thermite reaction enables a continuous pressure to be provided to the subsurface tool over a period of time, providing superior actuation over a conventional explosive power charge, through a non-explosive reaction. | 06-09-2011 |
20120216701 | Non-explosive power source for actuating a subsurface tool - A power source for applying a force to an object includes thermite in a quantity sufficient to generate a thermite reaction, and a gas producing substance disposed in association with the thermite. The gas producing substance produces a gas when the thermite reaction. The thermite reaction, the gas, or combinations thereof provide a force to the object. | 08-30-2012 |
20140137761 | NON-EXPLOSIVE POWER SOURCE FOR ACTUATING A SUBSURFACE TOOL - Power sources and methods for applying a force to an object include use of thermite in a quantity sufficient to generate a thermite reaction, and a gas producing substance disposed in association with the thermite. The gas producing substance produces a gas when the thermite reaction occurs. The thermite reaction, the gas, or combinations thereof provide a force to the object. The gas can slow the thermite reaction to enable slower or continuous application of force while being non-extinguishing of the thermite reaction. The gas can further control heat transfer from the thermite reaction to adjacent objects. | 05-22-2014 |
Mark A. Lancaster, Brooks, GA US
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20140251653 | Hybrid Conductor Core - An electric conductor may be provided. The electric conductor may comprise a conductor core and a plurality of conductor strands wrapped around the conductor core. The conductor core may comprise a plurality of core strands comprising an overall number of strands. The plurality of core strands may comprise a first portion of core strands and a second portion of core strands. The first portion of core strands may comprise a first number of strands. The first portion of core strands may comprise steel. The second portion of core strands may comprise a second number of strands. The second portion of core strands may comprise a composite material. A ratio of the first number of strands to the overall number of strands and a ratio of the second number of strands to the overall number of strands may be optimized to give the conductor core a predetermined characteristic. | 09-11-2014 |
Mark A. Lancaster, Scottsdale, AZ US
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20100245143 | ANALOG-TO-DIGITAL CONVERSION MODULE ADAPTED FOR IRREGULAR SAMPLING SEQUENCES - Apparatus and methods are provided for performing a sampling sequence for a plurality of samples. An analog-to-digital conversion module comprises a sampling module, a register, and a sampling control module coupled to the sampling module and the register. The sampling module is configured to convert analog signals into corresponding digital values in response to sampling trigger signals and the register is configured to maintain scan mode criteria for a plurality of samples. The sampling control module is configured to identify a scan mode criterion for a respective sample of the plurality of samples, automatically generate a sampling trigger signal when the scan mode criterion for the respective sample is equal to a first value, and generate the sampling trigger signal in response to a timing trigger signal when the scan mode criterion for the respective sample is equal to a second value. | 09-30-2010 |
Mary J. Lancaster, Richland, WA US
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20150106941 | Computer-Implemented Security Evaluation Methods, Security Evaluation Systems, and Articles of Manufacture - Computer-implemented security evaluation methods, security evaluation systems, and articles of manufacture are described. According to one aspect, a computer-implemented security evaluation method includes accessing information regarding a physical architecture and a cyber architecture of a facility, building a model of the facility comprising a plurality of physical areas of the physical architecture, a plurality of cyber areas of the cyber architecture, and a plurality of pathways between the physical areas and the cyber areas, identifying a target within the facility, executing the model a plurality of times to simulate a plurality of attacks against the target by an adversary traversing at least one of the areas in the physical domain and at least one of the areas in the cyber domain, and using results of the executing, providing information regarding a security risk of the facility with respect to the target. | 04-16-2015 |
Nicholas Lancaster, Tupelo, MS US
Patent application number | Description | Published |
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20110128972 | PEER TO PEER DYNAMIC NETWORK LINK ACCELERATION - A peer to peer dynamic network acceleration method and apparatus provide enhanced communications directly between two or more enhanced clients. The enhanced clients may comprise a front-end, a back-end, or both. In general, the front-end and back-end of the enhanced clients work in concert to translate data into an enhanced protocol for communication between the enhanced clients. The enhanced protocol may provide acceleration, security, error correction, and other benefits. Data from various applications may be seamlessly translated between a first protocol and the enhanced protocol, such that the applications need not be modified to use the enhanced protocol. The enhanced clients may automatically detect one another to establish an enhanced communications channel automatically. | 06-02-2011 |
20140317309 | SYSTEM AND DEVICES FACILITATING DYNAMIC NETWORK LINK ACCELERATION - A peer to peer dynamic network acceleration method and apparatus provide enhanced communications directly between two or more enhanced devices, such as enhanced clients. The enhanced clients may comprise a front-end, a back-end, or both. In general, the front-end and back-end of the enhanced clients work in concert to translate data into an enhanced protocol for communication between the enhanced clients. The enhanced protocol may provide acceleration, security, error correction, and other benefits. Data from various applications may be seamlessly translated between a first protocol and the enhanced protocol, such that the applications need not be modified to use the enhanced protocol. The enhanced clients may automatically detect one another to establish an enhanced communications channel automatically. | 10-23-2014 |
Nicholaus Ray Lancaster, Azle, TX US
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20150130631 | Method of and System for Automatically Adjusting Airflow and Sensors for Use Therewith - A method of and system for automatically adjusting airflow and sensors for use therewith are disclosed. A sensor assembly includes a first face on an opposite side of the sensor assembly relative to a second face. The assembly includes an electrical plug on the first face and an electrical outlet on the second face. The electrical outlet is of a same type that is complimentary to the electrical plug on the first face. The assembly includes a sensor for sensing a value of an environmental variable in a space and a sensor communication system for transmitting and receiving information. A sensor system includes a plurality of sensor assemblies disposed in a building. Each sensor assembly includes a sensor for sensing a value of an environmental variable of the space within which the sensor is placed. The system determines gradient values for the sensed environmental variable. | 05-14-2015 |
20150133043 | Method of and System for Automatically Adjusting Airflow - A method of and system for automatically adjusting airflow is presented. A system includes a controlled supply register that has an airflow adjusting mechanism that controls an aperture through which air passes and a register sensor that senses a value of an environmental variable in system duct work. The register also includes a communication system and a processor system that controls the airflow adjusting mechanism. The system also includes a sensor platform that senses an environmental variable in a space and transmits and receives information. The system also includes a controller that receives information about the environmental variables and a desired set point for the environmental variable in the space. The controller determines a target airflow to achieve the desired set point and transmits information about the target airflow. The register receives information about the target airflow and controls the register adjusting mechanism to achieve the target airflow. | 05-14-2015 |
Robert A. Lancaster, Hilton, NY US
Patent application number | Description | Published |
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20090035470 | PNEUMATICALLY ADJUSTABLE APPARATUS FOR COATING TONER FUSING BELT SUBSTRATE AND METHOD FOR USING SAME - An apparatus for enabling the uniform application of a layer of a coating composition to a tubular substrate includes a shaft, and upper and lower circular rim members of equal diameter that are concentrically attached to the shaft. A pneumatically inflatable tube disposed on each circular rim member has an outer diameter that is variable with changes in its internal pressure. A first flexible cylindrical sheet in contact with the inflatable tubes has parallel edges that form a first slit sufficiently wide to permit movement of the first sheet in response to pressure variation in the tubes. A second flexible cylindrical sheet surrounding the first cylindrical sheet has parallel edges that form a second slit sufficiently wide to permit movement of the second sheet also in response to pressure variation. The second slit is laterally displaced from the first slit, and the second cylindrical sheet has a diameter nearly equal to the specified diameter of the substrate. Each of the tubes is inflatable to a pressure sufficient to provide the substrate with a smooth cylindrical outer surface for uniform application of a coating. | 02-05-2009 |
20110159222 | FLUOROCARBON THERMOPLASTIC MATERIALS CURED WITH ORGANIC PRIMARY AMINES - A composition comprising a fluorocarbon thermoplastic random copolymer having the subunits of: | 06-30-2011 |
Rodney Earl Lancaster, Houston, TX US
Patent application number | Description | Published |
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20120247787 | Injector Head For Coiled Tubing Systems - An injector head used in coiled tubing systems including at least two opposed counter-rotating chain loops having a first end and a second end, the chain loops having a chain. The injector head further includes a fixed drive sprocket disposed at the first end of a chain loop and a floating sprocket disposed at the second end of the chain loop. In the injector head, there is a force applied to the floating bottom sprocket to maintain the chain loop at a desired chain tension. Additionally, the injector head includes a tension cylinder that automatically maintains the chain loop at the desired chain tension. | 10-04-2012 |
Ron Lancaster, Hopkinton, MA US
Ronald R. Lancaster, Rockwall, TX US
Patent application number | Description | Published |
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20120248100 | Access shield for shipping container - The present invention is for an access shield for a shipping container, which container has a pair of doors and a plurality of supporting feet. An access shield for the shipping container is placed under the door end of the shipping container and is contained by the shipping container's weight with a pair of locking arms positioned behind the shipping container's feet to block access into a shipping container. | 10-04-2012 |
Ted H. Lancaster, Suffield, CT US
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20090243220 | FLUID BARRIERS WITH FLEXIBLE BACKING MATERIAL AND METHODS OF REPAIRING AND MANUFACTURING THE SAME - A component to be repaired includes a relatively rigid plate. On a surface that may have been subject to fracture, a resin material is first laid down, then a relatively flexible material is positioned outwardly of the resin material to repair the barrier. A part may also be formed initially with the flexible material. In another feature of this application, a method of forming a barrier includes providing a composite material, and applying a relatively flexible material on a surface of the composite material, and concurrently molding the relatively flexible material with the composite material using a composite mold. | 10-01-2009 |
Thomas M. Lancaster, Stoneham, MA US
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20100130726 | METHODS FOR REDUCING THE MITOGENICITY OF LECTIN COMPOSITIONS - Methods for reducing the T-cell mitogenicity of lectin compositions are provided. In one aspect this is achieved by chemically modifying mitogenic lectin compositions under optimized conditions. Additionally or alternatively, the reduction in T-cell mitogenicity is achieved by removing unmodified subunits chemically modified mixtures. Modified lectin compositions with reduced T-cell mitogenicity are also provided as are uses of the inventive compositions. | 05-27-2010 |
20110275560 | SYNTHETIC CONJUGATES AND USES THEREOF - The present disclosure provides a cross-linked material comprising conjugates which include two or more separate affinity ligands bound to a non-polymeric framework, wherein the molecular weight of the non-polymeric framework is less than 10,000 Da; and multivalent cross-linking agents that non-covalently bind the affinity ligands of the conjugates and thereby cross-link the conjugates to form a cross-linked material, wherein the non-covalent bonds between the multivalent cross-linking agents and the affinity ligands are competitively dissociated in the presence of excess amounts of a target molecule. The present disclosure also provides methods of making and methods of using these materials. In other aspects, the present disclosure provides exemplary conjugates including conjugates for use in glucose responsive cross-linked materials. | 11-10-2011 |
20110281791 | CRYSTALLINE INSULIN-CONJUGATES - The present disclosure provides crystalline insulin-conjugates. The present disclosure also provides formulations, methods of treatment, methods of administering, and methods of making that encompass these crystalline insulin-conjugates. | 11-17-2011 |
20110281792 | BINDING-SITE MODIFIED LECTINS AND USES THEREOF - In one aspect, the disclosure provides cross-linked materials that include multivalent lectins with at least two binding sites for glucose, wherein the lectins include at least one covalently linked affinity ligand which is capable of competing with glucose for binding with at least one of said binding sites; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with glucose for binding with the lectins at said binding sites and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between lectins and affinity ligands on different conjugates. These materials are designed to release amounts of conjugate in response to desired concentrations of glucose. Depending on the end application, in various embodiments, the conjugates may also include a drug and/or a detectable label. | 11-17-2011 |
20110281939 | POLYNUCLEOTIDE APTAMER-BASED CROSS-LINKED MATERIALS AND USES THEREOF - In one aspect, the disclosure provides cross-linked materials that include multivalent polynucleotide aptamers that bind a target molecule; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with the target molecule for binding with the aptamers and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between aptamers and affinity ligands on different conjugates. These materials are designed to release amounts of conjugate in response to desired concentrations of the target molecule. Depending on the end application, in various embodiments, the conjugates may also include a drug and/or a detectable label. The drug, detectable label and affinity ligands may be covalently or non-covalently bound to the conjugate framework. | 11-17-2011 |
20110301083 | CONJUGATE BASED SYSTEMS FOR CONTROLLED DRUG DELIVERY - Conjugates which comprise a drug and a ligand which includes a first saccharide; wherein the conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a second saccharide. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation. | 12-08-2011 |
20120010134 | SOLUBLE NON-DEPOT INSULIN CONJUGATES AND USES THEREOF - In one aspect, the disclosure provides a conjugate comprising an insulin molecule having an A-chain and a B-chain; an affinity ligand covalently bound to the A-chain; and a monovalent glucose binding agent covalently bound to the B-chain, wherein the affinity ligand competes with glucose for non-covalent binding with the monovalent glucose binding agent. In the absence of glucose, the monovalent glucose binding agent binds the affinity ligand to produce a “closed” inactive form of the insulin molecule. When free glucose is added, it competes with the affinity ligand for binding with the monovalent glucose binding agent to produce an “open” active form of the insulin molecule. The monovalent glucose binding agent and affinity ligand are covalently bound to the insulin molecule. The disclosure also provides methods of using these conjugates and methods of making these conjugates. In another aspect, the disclosure provides exemplary conjugates. The disclosure also provides alternative conjugates that are not necessarily activated by glucose. | 01-12-2012 |
20120014908 | TERMINALLY-FUNCTIONALIZED CONJUGATES AND USES THEREOF - The present disclosure provides inter alia conjugates of formula (I): wherein n, R1, R2, Rx, Z, X, Y and Z are as defined herein. A conjugate of formula (I) can also be converted to a conjugate of formulae (II) or (III) as described herein. Without limitation, the conjugates can be used to make controlled release materials and chemical sensors. | 01-19-2012 |
20120046223 | EXOGENOUSLY TRIGGERED CONTROLLED RELEASE MATERIALS AND USES THEREOF - The disclosure provides cross-linked materials that include multivalent cross-linking agents that bind an exogenous target molecule; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, where in the two or more affinity ligands compete with the exogenous target molecule for binding with the cross-linking a agents and wherein conjugates are cross-linked within the material as a result of non-covalent interact ions between cross-linking agents and affinity ligands on different conjugates. The conjugates also include a drug. | 02-23-2012 |
20120135919 | POLYMER-DRUG CONJUGATES - A conjugate that includes a drug covalently linked to a polymer. Upon administration, the conjugate is digested by an enzyme that is present at the site of administration thereby releasing a therapeutic agent. The conjugate may demonstrate substantially the same pharmacokinetic and pharmacodynamic behavior as the drug itself. A material for controllably releasing a conjugate in response to the local concentration of a molecular indicator. The material includes a plurality of conjugates and a plurality of multivalent cross-linking agents. The polymers of the conjugates include an analog of the indicator within their covalent structure. The multivalent cross-linking agents include cross-link receptors that interact with the indicator analog and thereby cross-link the conjugates. These non-covalent interactions are competitively disrupted when an amount of the molecular indicator is present thereby causing the material to release the conjugate in a manner that is dependent on the local concentration of indicator. | 05-31-2012 |
20130131310 | DRUG-LIGAND CONJUGATES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO - The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: (I) wherein each of X, Alk, and W are as defined and described herein. | 05-23-2013 |
20130190475 | DRUG-LIGAND CONJUGATES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO - The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: I wherein each of X, Alk | 07-25-2013 |
20130190476 | RECOMBINANTLY EXPRESSED INSULIN POLYPEPTIDES AND USES THEREOF - The present disclosure provides recombinantly expressed insulin polypeptides that comprise an N-linked glycan motif. The N-linked glycan motif is not present in wild-type insulins and enables the recombinant expression of glycosylated insulin polypeptides (e.g., in yeast cells). Based on results obtained with synthetic glycosylated insulin conjugates we predict that when these recombinant glycosylated insulin polypeptides are administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the glycosylated insulin polypeptide will be sensitive to serum concentrations of glucose (or an exogenous saccharide such as alpha-methyl mannose). Exemplary insulin polypeptides, polynucleotides encoding these insulin polypeptides, glycosylated insulin polypeptides, pharmaceutical formulations and sustained release formulations are provided in addition to methods of use and preparation. | 07-25-2013 |
20130302825 | USES OF MACROPHAGE MANNOSE RECEPTOR TO SCREEN COMPOUNDS AND USES OF THESE COMPOUNDS - Methods and associated compositions of matter (e.g., kits, cell lines, etc.) for screening compounds that bind to macrophase mannose receptor (MMR). Compounds identified by these methods and drug conjugates that includes these compounds are also encompassed as are their uses in the manufacture of medicaments. | 11-14-2013 |
20130324702 | RECOMBINANT LECTINS, BINDING-SITE MODIFIED LECTINS AND USES THEREOF - In one aspect, the disclosure provides cross-linked materials that include multivalent lectins with at least two binding sites for glucose, wherein the lectins include at least one affinity ligand which is capable of competing with glucose for binding with at least one of said binding sites and is covalently linked to a cysteine residue of the lectins; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with glucose for binding with the lectins at said binding sites and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between lectins and affinity ligands on different conjugates. These materials are designed to release amounts of conjugate in response to desired concentrations of glucose. Depending on the end application, in various embodiments, the conjugates may also include a drug and/or a detectable label. | 12-05-2013 |
20140037699 | SOLUBLE NON-DEPOT INSULIN CONJUGATES AND USES THEREOF - In one aspect, the disclosure provides a conjugate comprising an insulin molecule having an A-chain and a B-chain; an affinity ligand covalently bound to the A-chain; and a monovalent glucose binding agent covalently bound to the B-chain, wherein the affinity ligand competes with glucose for non-covalent binding with the monovalent glucose binding agent. In the absence of glucose, the monovalent glucose binding agent binds the affinity ligand to produce a “closed” inactive form of the insulin molecule. When free glucose is added, it competes with the affinity ligand for binding with the monovalent glucose binding agent to produce an “open” active form of the insulin molecule. The monovalent glucose binding agent and affinity ligand are covalently bound to the insulin molecule. The disclosure also provides methods of using these conjugates and methods of making these conjugates. In another aspect, the disclosure provides exemplary conjugates. The disclosure also provides alternative conjugates that are not necessarily activated by glucose. | 02-06-2014 |
20140121159 | TERMINALLY FUNCTIONALIZED CONJUGATES AND USES THEREOF - The present disclosure provides inter alia conjugates of formula (I): | 05-01-2014 |
20140256622 | EXOGENOUSLY TRIGGERED CONTROLLED RELEASE MATERIALS AND USES THEREOF - The disclosure provides cross-linked materials that include multivalent cross-linking agents that bind an exogenous target molecule; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with the exogenous target molecule for binding with the cross-linking agents and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between cross-linking agents and affinity ligands on different conjugates. The conjugates also include a drug. | 09-11-2014 |
20140274888 | CONJUGATE BASED SYSTEMS FOR CONTROLLED DRUG DELIVERY - Conjugates which comprise a drug and a ligand which includes a first saccharide; wherein the conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a second saccharide. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation. | 09-18-2014 |
20140275476 | CRYSTALLINE INSULIN-CONJUGATES - The present disclosure provides crystalline insulin-conjugates. The present disclosure also provides formulations, methods of treatment, methods of administering, and methods of making that encompass these crystalline insulin-conjugates. | 09-18-2014 |
20140342980 | BINDING-SITE MODIFIED LECTINS AND USES THEREOF - In one aspect, the disclosure provides cross-linked materials that include multivalent lectins with at least two binding sites for glucose, wherein the lectins include at least one covalently linked affinity ligand which is capable of competing with glucose for binding with at least one of said binding sites; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with glucose for binding with the lectins at said binding sites and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between lectins and affinity ligands on different conjugates. These materials are designed to release amounts of conjugate in response to desired concentrations of glucose. Depending on the end application, in various embodiments, the conjugates may also include a drug and/or a detectable label. | 11-20-2014 |
Timothy Lancaster, Evansville, IN US
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20110044759 | Erosion control ballast and soil confinement mat - An erosion control ballast and soil confinement mat for use in water flow conditions is provided. The mat is made of a non-buoyant, relatively heavy and substantially flexible material with a plurality of pores stamped or pre-cast therein that allow for the inflow of water, the establishment of vegetation growth through the mat, and the in-filling of the pores with supplemental ballast materials such as gravel or soil. The bottom side of the mat has protrusions that extend into the underlying surface to prevent horizontal shifting and confine soil materials and/or another erosion control mat such as an erosion control blanket or turf reinforcement mat, while also preventing migration of the mat itself under high shear force water flow. The top surface of the mat may be provided with flaps that cover the pore openings during periods of strong water flow to prevent excessive water flow from entering the pores and eroding the underlying soil. | 02-24-2011 |
Timothy L. Lancaster, Evansville, IN US
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20130309012 | SELF-ANCHORING TURF REINFORCEMENT MAT AND REUSABLE SEDIMENT FILTRATION MAT - A three dimensional high strength tightly woven turf reinforcement mat (TRM) or reusable sediment filtration mat designed to trap soil particles in water flow and provide a shear plane to prevent soil wash-out from within and beneath the mat. The mat includes a corrugated body structure integrally extruded or interwoven with a bottom layer that together form a plurality of parabolic sediment entrapment chambers. As sediment bed load moves with water flow into the woven structure, water flow forces sediment through openings in the woven surface of the corrugated body structure and into the chambers where the captured sediment serves as ballast to self-anchor the mat. The mat may also be incorporated during manufacture and/or during/after installation with polyacrylamides, chitosans or other soil flocculating/aggregating chemicals for increased sediment aggregation and capturing. | 11-21-2013 |