Earnshaw, GB
Christopher Geoffrey Earnshaw, Cambridge GB
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20100105651 | ANTAGONISTS OF SNS SODIUM CHANNELS - Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents, formula (I): R | 04-29-2010 |
20100204224 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC SODIUM CHANNELS - Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents; wherein (1) represents (A), (B) or (C); R | 08-12-2010 |
David James Earnshaw, Nr Saffron Walden GB
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20120208194 | Preparation of Templates for Nucleic Acid Sequencing - The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: | 08-16-2012 |
David James Earnshaw, Essex GB
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20090118128 | Preparation of templates for nucleic acid sequencing - The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: | 05-07-2009 |
20100167954 | METHOD OF LIBRARY PREPARATION AVOIDING THE FORMATION OF ADAPTOR DIMERS - The invention relates to a method of preparing a library of template polynucleotides which reduces and/or prevents the formation of adaptor-dimers. The invention also relates to the use of a library of templates prepared using the method of the invention for solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a library of template polynucleotides which have common sequences at their 5′ ends and at their 3′ ends which is substantially free of adaptor-dimers. | 07-01-2010 |
20130244302 | Modified polymerases for improved incorporation of nucleotide analogues - The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3′ position of the sugar moiety that are larger in size than the naturally occurring 3′ hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing. | 09-19-2013 |
David James Earnshaw, Cambridgeshire GB
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20150024463 | MODIFIED POLYMERASES FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES - The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3′ position of the sugar moiety that are larger in size than the naturally occurring 3′ hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing. | 01-22-2015 |
David James Earnshaw, Walden Essex GB
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20090117621 | Methods of nucleic acid amplification and sequencing - The invention relates to a method of amplifying one or more nucleic acid templates on a solid support in a nucleic acid amplification reaction, for example by solid-phase PCR using one or more amplification primers attached to the solid support. The method is characterised in that the amplification primers used comprise a template-specific portion which is a sequence of at least 26 consecutive nucleotides and are not capable of annealing to target regions in the template under conditions of the amplification reaction. The method is particularly useful for amplifying human genomic DNA. | 05-07-2009 |
David James Earnshaw, Cambridge GB
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20140349891 | Preparation of Templates for Nucleic Acid Sequencing - The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: | 11-27-2014 |
Edwin Paul Earnshaw, Thriplow GB
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20080217353 | Method of Dispensing A Test Strip - In one aspect, a method of dispensing a test strip is provided in which the dispensed test strip remains stationary while the inner housing moves within an outer housing. In another embodiment, a test strip dispenser is provided that dispenses one test strip at a time. The test strip dispenser includes a movable inner housing nested inside an outer housing. A test strip dispensing system is also described. | 09-11-2008 |
20080217354 | Test Strip Dispenser - In one aspect, a method of dispensing a test strip is provided in which the dispensed test strip remains stationary while the inner housing moves within an outer housing. In another embodiment, a test strip dispenser is provided that dispenses one test strip at a time. The test strip dispenser includes a movable inner housing nested inside an outer housing. A test strip dispensing system is also described. | 09-11-2008 |
Edwin Paul Earnshaw, Herts GB
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20120043391 | SPRAY DEVICE - A spray device for connection to a reservoir of fluid for spraying, the spray device includes a dosing chamber for holding fluid; a connector for fluidly connecting the dosing chamber to the reservoir; a piston moveable from a first end of the dosing chamber to a second end of the dosing chamber so as to draw into the dosing chamber fluid from the reservoir; a spring biasing the piston towards said first end; a plunger, actuable by a user, to move the piston towards said second end against the bias of the spring; a nozzle for spraying fluid; and a user-actuable valve for selectively fluidly connecting the dosing chamber to the nozzle. | 02-23-2012 |
John Earnshaw, Sale GB
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20140167204 | SEMICONDUCTOR DIODE ASSEMBLY - TSV devices with p-n junctions that are planar have superior performance in breakdown and current handling. Junction diode assembly formed in enclosed trenches occupies less chip area compared with junction-isolation diode assembly in the known art. Diode assembly fabricated with trenches formed after the junction formation reduces fabrication cost and masking steps increase process flexibility and enable asymmetrical TSV and uni-directional TSV functions. | 06-19-2014 |
Paul Earnshaw, Royston GB
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20100218781 | Composition and Method for Dry Application of Mascara - A substantially dry mascara formulation, a mascara application composition and a method of applying the formulation is described. The substantially dry mascara formulation may be deposited on the surface of a carrier substrate and applied to the eye lashes by contacting the mascara and substrate to the eye lashes. An application tool may optionally be used to aid application of the formulation to the eye lashes. The present invention allows various desired color gradients, patterns or designs to be imparted to the eye lashes. | 09-02-2010 |
20110174328 | Ergonomic Mascara Applicator - An ergonomic applicator is provided for applying a cosmetic composition to the eyelashes. The applicator comprises a handle portion and a head portion wherein the longitudinal axis of the head portion is positioned or can be rotatably positioned at an obtuse angle with respect to the longitudinal axis of the handle. The handle being suitable dimensioned for holding between the thumb and fingers without rotation of the handle. The head portion having at its distal end means for holding a charge of cosmetic composition and transferring it to the eyelashes on contact therewith, such as but not limited to, bristles, projections, indentations fins, tines, Velcro, teeth, grooves, sponges and flocked surfaces. | 07-21-2011 |
William C. Earnshaw, Scotland GB
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20090136924 | RAPID GENERATION OF LONG SYNTHETIC CENTROMERIC TANDEM REPEATS FOR MAMMALIAN ARTIFICIAL CHROMOSOME FORMATION - Methods are described for construction of long synthetic arrays of DNA repeats, such as alphoid repeats or other repeat sequences. The methods include concatamerization of DNA into short repeats (for instance using rolling circle amplification or directional in vitro ligation), followed by assembling the short repeats into long arrays by homologous recombination during transformation into microbe cells. These methods can be described generally as Recombinational Amplification of Repeats (RAR). The long arrays are engineered centromere-like regions that allow one to construct mammalian artificial chromosomes with a predefined centromeric region structure. Artificial chromosomes, including human artificial chromosomes with a regulated centromere, and methods of their use are also provided | 05-28-2009 |