Patent application number | Description | Published |
20090134114 | CLOSURE SYSTEM AND METHOD OF FILLING A VIAL - A closure system for a vial comprising: an elastic closure part to engage the mouth opening, a clamp part to hold the closure part in a closing relationship with the mouth opening, the clamp part defining an upper aperture through which a region of the upper surface of the closure part is exposed when the clamp part is engaged with the vial, a cover part to engage the clamp part to cover the exposed region, the cover part engaging with the closure part to provide two or more concentric ring-shaped seals, at least part of the cover part being removable from the vial to allow access to the closure. | 05-28-2009 |
20090158612 | PROCESS FOR PREPARING A LYOPHILISED MATERIAL - A process for preparing a lyophilized material, providing a container having a penetrable envelope and containing the material in a carrier liquid, whereby the penetrable region is penetrated with a penetrator which provides a conduit through the envelope, and the carrier liquid id evaporated out of the container via the conduit, after which the penetrator is withdrawn. Apparatus suitable for performing the process is also disclosed. | 06-25-2009 |
20090306620 | MEDICINAL VIAL - Medicinal vials are provided incorporating RFID's in a way which causes them to remain associated with the vial when the vial closure is opened. Several embodiments are disclosed. In a preferred embodiment an RFID is incorporated in the vial closure system. | 12-10-2009 |
20100016807 | Syringe with Sequentially Moving Plunger Flanges - A syringe in which multiple sealing flanges are provided for sequential movement during use, to reduce sticking of the flange during use and the consequent jerking of the plunger stopper. In an embodiment longitudinally sequential flanges are linked by a flexible tube connection. | 01-21-2010 |
20100294796 | PYRAMID SHAPED NEEDLE POINT - A hollow needle comprising a shaft having a distal portion suitable for passing through an elastomer closure of a container, said shaft extending in a longitudinal direction and having a central longitudinal axis, and having an internal longitudinal conduit therein for the flow of liquid and one or more orifices communicating between the conduit and the exterior of the needle, the distal portion of the shaft being provided with a pointed end that has a profile comprising a cutting edge in the form of two part cutting edges converging in the longitudinal direction to meet at the needle point, each part cutting edge extending in a straight line in a widthways direction across a plane including the central longitudinal axis, on both widthways sides of the cutting edge the pointed end having a profile which is a non-cutting surface, wherein the pointed end of the needle tapers from an outer surface of said distal portion toward the point of the needle, and the distance, measured in a further plane defined by said two part cutting edges between the outermost ends of said part cutting edges, is smaller than the largest outer dimension of said distal portion, measured perpendicular to said central axis in said further plane. | 11-25-2010 |
20120283689 | Process for preparing a lyophilized material - A process for preparing a lyophilized material, providing a container having a penetrable envelope and containing the material in a carrier liquid, whereby the penetrable region is penetrated with a penetrator which provides a conduit through the envelope, and the carrier liquid is evaporated out of the container via the conduit, after which the penetrator is withdrawn. | 11-08-2012 |
Patent application number | Description | Published |
20090081720 | Methods for identifying stem cells based on nuclear morphotypes - Methods for identifying stem cells and other cells specific to embryogenesis and carcinogenesis, classifying tissue samples, diagnosing precancerous and cancerous or atherosclerotic lesions, testing the value of anticancer agents, discovering macromolecules specifically expressed in particular cell types, using stem cells in restorative tissue therapy as well as methods for preparing tissue samples so heteromorphic nuclear morphotypes remain intact are disclosed. | 03-26-2009 |
20090098562 | Methods for identifying stem cells based on nuclear morphotypes - Methods for identifying stem cells and other cells specific to embryogenesis and carcinogenesis, classifying tissue samples, diagnosing precancerous and cancerous or atherosclerotic lesions, testing the value of anticancer agents, discovering macromolecules specifically expressed in particular cell types, using stem cells in restorative tissue therapy as well as methods for preparing tissue samples so heteromorphic nuclear morphotypes remain intact are disclosed. | 04-16-2009 |
20090263805 | Methods of identifying point mutations in a genome that affect the risk for or the age of appearance of disease - The invention relates to a method for identifying inherited point mutations in a targeted region of the genome in a large population of individuals and determining which inherited point mutations are deleterious, harmful or beneficial. Deleterious mutations are identified directly by a method of recognition using the set of point mutations observed in a large population of juveniles. Harmful mutations are identified by comparison of the set of point mutation observed in a large set of juveniles and a large set of aged individuals of the same population. Beneficial mutations are similarly identified. | 10-22-2009 |
20090304662 | Methods for Identifying and Targeting Tumor Stem Cells Based on Nuclear Morphology - Described herein are methods for inhibiting tumor growth comprising targeting a tumor stem cell in the patient with an agent or treatment that chemically modifies a tumor stem cell-specific molecule, thereby preventing proliferation of tumor stem cells. | 12-10-2009 |
20100075366 | Methods for identifying stem cells by detecting fluorescence of cells and syncytia - Methods are disclosed for the characterization of the stage of development or pathology of a tissue sample, and for identifying pluripotent metakaryotic stem cells, comprising detecting fluorescence of cells and syncytia in fixed samples treated with a non-fluorescent Schiff's base reagent in the absence of extraneous or exogenously added fluorescent dyes. | 03-25-2010 |
20100284905 | Methods and Agents for Inhibiting Tumor Growth by Targeting the SSDNA Replication Intermediate of Tumor Stem Cells - The application is based on the observation that tumor stem cell (TSC) replication involves a replicative intermediate configuration wherein a substantial fraction of the TSC genome is present as single-stranded DNA (ssDNA) when bell-shaped nuclei commence separation into two nuclei. During this replicative intermediate configuration large amounts of ssDNA are thus present in the nuclei of cells which the applicant proposes as target for anti-tumor therapy. A method of screening for anti-tumorigenic agents targeting ssDNA and use of such agents in therapy is claimed. | 11-11-2010 |
20130203048 | Wound Healing Metakaryotic Stem Cells and Methods of Use Thereof - The invention provides methods of identifying wound healing metakaryotic stem cells, identifying molecules to modulate proliferation and/or migration of metakaryotic stem cells and molecules to treat wound healing disorders, such as blood vessel wound healing disorders, including restenosis. The invention also provides methods of diagnosing and treating wound healing disorders, such as blood vessel wound healing disorders and also of treating wounds by the use of metakaryotic stem cell transplant(s). | 08-08-2013 |
20140154672 | Methods for Identifying Stem Cells Based on Nuclear Morphotypes - Methods for identifying stem cells and other cells specific to embryogenesis and carcinogenesis, classifying tissue samples, diagnosing precancerous and cancerous or atherosclerotic lesions, testing the value of anticancer agents, discovering macromolecules specifically expressed in particular cell types, using stem cells in restorative tissue therapy as well as methods for preparing tissue samples so heteromorphic nuclear morphotypes remain intact are disclosed. | 06-05-2014 |
20140369934 | dsRNA/DNA Hybrid Genome Replication Intermediate Of Metakaryotic Stem Cells - The invention provides methods of identifying metakaryotic stem cells, as well as methods of identifying agents that selectively modulate the growth, migration, replication, and/or survival of these cells by detecting an intermediate dsRNA/DNA duplex genome. Also provided are diagnostic, prognostic, and treatment methods for disorders, such as atherosclerosis, restenosis, and benign or malignant tumors. | 12-18-2014 |