Patent application number | Description | Published |
20110071211 | MicroRNA (miRNA) And Downstream Targets For Diagnostic And Therapeutic Purposes - The present invention relates to a promoter region of a microRNA, the use of a microRNA, in particular miR-21, and related elements for the diagnosis and for the manufacture of a medicament for the treatment and/or prevention of fibrosis and/or fibrosis related diseases. Additionally, the invention concerns antisense oligonucleotides against targets of miR-21. A cell deficient for miR-21, the promoter region and targets of miR-21 and a knock-out organism thereof are also encompassed. Finally, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis. | 03-24-2011 |
20120180147 | MICRORNA-24 - The present invention relates to a modulator, in particular an inhibitor, of microRNA-24 (miR-24) and to direct and indirect miR-24 targets for use in a method of treatment and/or prevention of ischemia, in a method of prevention of endothelial apoptosis or in a method of induction of angiogenesis. The present invention further relates to a precursor of miR-24 and to siRNAs or shRNAs against direct or indirect miR-24 targets for use in a method of treatment of angiogenesis associated with cancer. The present invention also relates to an in vitro method for diagnosing ischemia or prevalence or disposition for ischemia, and to a method for identifying a modulator of miR-24 and/or direct or indirect miR-24 targets. In addition, the present invention relates to pharmaceutical compositions or kits comprising any of the above agents, to endothelial cells devoid of expressing functional miR-24, and to a non-human, transgenic animal comprising these endothelial cells. | 07-12-2012 |
20120202201 | DEVICE AND METHOD FOR ANALYSIS OF KIDNEY FAILURE - The invention provides a method for analysis of the status of kidney function in a sample of body fluid obtained from a patient who has not been diagnosed with acute kidney injury (AKI, also referred to as acute kidney failure) or in a sample of body fluid obtained from a patient who has been diagnosed with AKI, which analysis is suitable for evaluating the prospects for long-term survival, which method for analysis comprises or consists of determining the concentration of the microRNA-210 | 08-09-2012 |
20130018084 | MICRORNA (miRNA) AND DOWNSTREAM TARGETS FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES - In some embodiments, the present invention concerns antisense oligonucleotides against targets of miR-21. In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis. | 01-17-2013 |
20140121264 | MICRORNA (miRNA) AND DOWNSTREAM TARGETS FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES - In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis. | 05-01-2014 |
20140275220 | THE miRNA-212/132 FAMILY AS A THERAPEUTIC TARGET - The present invention refers to inhibitors of microRNAs, particularly of microRNAs miR-212 and/or miR-132 for use in medicine, particularly in the diagnosis, treatment or prevention of cardiac disorders, e.g. cardiac hypertrophy-associated or autophagic disorders, and further refers to isolated nucleic acid molecules, particularly microRNAs miR-212 and/or miR-132 and related sequences, for use in medicine, particularly human medicine, more particularly in the diagnosis, treatment or prevention of disorders involving cardiac atrophy and/or dysfunctional autophagy, e.g. cardiac cachexia. | 09-18-2014 |
Patent application number | Description | Published |
20090133986 | APPARATUS FOR ACCEPTING AND DISPENSING BANKNOTES - The invention relates to an apparatus for accepting and dispensing or returning bank notes, including a pocket which is dividable by means of a dividing element into two areas for inputting and dispensing or returning bank notes, wherein the dividing element can be moved within the pocket in order to form the two areas, with a clamping element which can be moved within the pocket independently from the dividing element, in order to clamp bank notes disposed in the pocket inside the pocket and to transport them, wherein for clamping bank notes the clamping and transport element is moved in a first direction within the pocket on top of bank notes disposed in the pocket, and transports bank notes to be dispensed or returned out of the area of the dividing element at least for the most part. The dividing element is subsequently moved out of the area of the bank notes disposed in the pocket within the pocket past the clamping and transport element in a second direction that is contrary to the first direction. | 05-28-2009 |
20090134071 | APPARATUS FOR ACCEPTING AND DISPENSING BANK NOTES - The invention relates to an apparatus for accepting and dispensing or returning bank notes, including an apparatus having a pocket for accepting and dispensing or returning bank notes, which is dividable by means of a dividing element into two areas for inputting and dispensing or returning bank notes, wherein the dividing element consists of at least two non-interconnected parts which can be moved together within the pocket in order to form the two areas. Each part of the dividing element is movably arranged on a respectively opposite side wall of the pocket, as well as at least one clamping element which is disposed between the parts of the dividing element and can be moved within the pocket independently from the dividing element, in order to clamp bank notes disposed in the pocket inside the pocket. | 05-28-2009 |
20090206541 | APPARATUS FOR SINGLING OF SHEET MATERIAL - Apparatus for singling sheet material, in particular bank notes, which is inputted into an input area of the apparatus as a stack and is transported up to a singler, which transfers individual pieces of sheet material of the stack of sheet material to a sheet transport system, which transports the singled sheet material in a transport direction, a sensor disposed in transport direction upstream of the singler, which substantially extends over the width of the input area, generating signals which specify whether and in which area of the width of the input area the sheet material is present, and a control device evaluating the signals of the sensor during a transport of the stack of sheet material to the singler and comparing occurring fluctuations and changes of the signals of the sensor regarding the presence or absence of sheet material with predetermined threshold values for fluctuations and changes of the signals of the sensor, in order to derive a statement from the occurring fluctuations and changes of the signals of the sensor, whether the pieces of sheet material forming the stack of sheet material are aligned to each other with respect to their edges, and whether the stack of sheet material has an alignment which substantially is in parallel to the transport direction of the transport system. | 08-20-2009 |
20100025308 | APPARATUS AND METHOD FOR ACCEPTING OR DISPENSING BANK NOTES - The present invention relates to an apparatus and a method for accepting or dispensing or returning bank notes. An operator wishing to remove bank notes protruding from the apparatus for dispensing or returning, is assisted during removal in that the bank notes are transported towards the operator by the apparatus as soon as the operator grasps the bank notes and starts pulling or moving them out of the apparatus. | 02-04-2010 |