Patent application number | Description | Published |
20090099523 | INFUSION PUMP ASSEMBLY - An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 04-16-2009 |
20100089475 | MEDIUM CONNECTOR - A medium connector including a passage configured to allow for the flow of medium, and a multi-portion engagement surface positioned about the passage. The multi-portion engagement surface includes a first surface portion, and a second surface portion. The first surface portion is configured to provide an interference fit with a corresponding sealing surface of a mating connector. The second surface portion is configured to provide a clearance fit with the corresponding sealing surface of the mating connector. The ratio of the first surface portion and the second surface portion is selected to regulate an engagement force between the medium connector and the mating connector. | 04-15-2010 |
20100094222 | INFUSION PUMP ASSEMBLY - An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 04-15-2010 |
20110208123 | Infusion Pump Assembly - A removable power supply cover assembly ( | 08-25-2011 |
20110230837 | INFUSION PUMP METHODS, SYSTEMS AND APPARATUS - A system for priming an infusion pump is disclosed. The system includes a priming cap including a septum and configured to matably connect with a male part comprising a needle and attached to a length of tubing for fluid, wherein when matably connected with the male part, the priming cap occludes the tubing. | 09-22-2011 |
20110313351 | INFUSION PUMP APPARATUS, METHOD AND SYSTEM - An infusion pump system is disclosed. The system includes a syringe having a plunger within the syringe barrel, the syringe having an exit end, at least one temperature determination device adjacent to the syringe, at least one device to determine the distance the plunger has moved with respect to the syringe barrel, and a pump processor in communication with the at least one temperature determination device and the at least one optical sensor, wherein when the controller determines a change in temperature and a corresponding plunger movement, the controller increases or decreases a preprogrammed basal rate of the infusion pump by a predetermined amount for a predetermined time. | 12-22-2011 |
20120083738 | INFUSION PUMP ASSEMBLY - An infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in movable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 04-05-2012 |
20120101440 | MEDICAL DEVICE INSERTION APPARATUS, SYSTEM AND METHOD - An insertion device is disclosed. The insertion device includes a base portion, a top portion slidably connected to the base portion, an introduction needle, a catheter in slidable relation to the introduction needle, and a substantially cylindrical flash chamber, the flash chamber having an inlet in fluid communication with the introduction needle. The flash chamber is connected to the base portion, the top portion slidably engages with the flash chamber, and the catheter and the top portion slidably advance with respect to the introduction needle and the base portion. | 04-26-2012 |
20120209196 | INFUSION PUMP ASSEMBLY - An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 08-16-2012 |
20120209197 | INFUSION PUMP ASSEMBLY - An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 08-16-2012 |
20130066265 | INFUSION PUMP ASSEMBLY - An infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 03-14-2013 |
20130074959 | PUMPING CASSETTE - A pump cassette is disclosed. The pump cassette includes a housing having at least, one fluid inlet line and at least one fluid outlet line. The cassette also includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from the fluid inlet line to the fluid outlet line. A hollow spike is also included on the housing as well as at least one metering pump The metering pump is fluidly connected to the hollow spike on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the fluid outlet line. | 03-28-2013 |
20130115105 | FLUID PUMPING SYSTEMS, DEVICES AND METHODS - Embodiments of the present invention relate generally to certain types of reciprocating positive-displacement pumps (which may be referred to hereinafter as “pods,” “pump pods,” or “pod pumps”) used to pump fluids, such as a biological fluid (e.g., blood or peritoneal fluid), a therapeutic fluid (e.g., a medication solution), or a surfactant fluid. The pumps may be configured specifically to impart low shear forces and low turbulence on the fluid as the fluid is pumped from an inlet to an outlet. Such pumps may be particularly useful in pumping fluids that may be damaged by such shear forces (e.g., blood, and particularly heated blood, which is prone to hemolysis) or turbulence (e.g., surfectants or other fluids that may foam or otherwise be damaged or become unstable in the presence of turbulence). | 05-09-2013 |
20130177457 | PUMPING CASSETTE - A pumping cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod also includes a membrane that forms two balancing chambers. Also included in the cassette is at least two reciprocating pressure displacement membrane pumps. The pumps are within the housing and they pump the fluid from a fluid inlet to a fluid outlet line and pump the second fluid from a fluid inlet to a fluid outlet. | 07-11-2013 |
20130188040 | System, Method, and Apparatus for Monitoring, Regulating, or Controlling Fluid Flow - An apparatus, system and method for regulating fluid flow are disclosed. The apparatus includes a curved, elongated support member elastically deformable and having first and second ends. The apparatus also include an opposing support member configured to position a tube against the curved, elongated support member between the first and second ends. Deformation of the curved, elongated support member by movement of the first and second ends toward each other reduces an internal volume of the tube. | 07-25-2013 |
20130289485 | Infusion Pump Assembly - An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 10-31-2013 |
20140039457 | INFUSION SET IMPROVEMENTS - A method and device for adjusting the unstored length of tubing directed to improving the use of infusion sets that deliver fluids to a user. The device includes a storage module and other features for adjusting, storing and securing the length of the tubing. The method of adjusting the length of the tubing to a desired length typically comprises removably attaching the tubing to the adjuster, adjusting the tubing by wrapping the tubing around a hub or post of the adjuster, and fixing the length of the unstored tubing by attaching the tubing to a securing device such as a friction structure or fastener. | 02-06-2014 |
20140102970 | HEMODIALYSIS SYSTEMS AND METHODS - Disclosed are hemodialysis and similar dialysis systems including fluid flow circuits. Hemodialysis systems may include a blood flow path, and a dialysate flow path including balancing, mixing, and/or a directing circuits. Preparation of dialysate may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit and/or the various fluid flow paths may be isolated from electrical components. A gas supply may be provided that, when activated, is able to urge dialysate through the dialyzer and blood back to the patient. Such a system may be useful during a power failure. The hemodialysis system may also include fluid handling devices, such as pumps, valves, mixers, etc., actuated using a control fluid. The control fluid may be delivered to the fluid handling devices using a detachable external pump. The fluid handling devices may have a spheroid shape with a diaphragm dividing it into two compartments. | 04-17-2014 |
20140112828 | HEMODIALYSIS SYSTEM - A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly. | 04-24-2014 |
20140114253 | Infusion Pump Assembly - An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 04-24-2014 |
20140199193 | BLOOD TREATMENT SYSTEMS AND METHODS - The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. According to one aspect, a blood pump is configured to pump blood to a dialyzer of a hemodialysis apparatus, the blood pump comprising a pneumatically actuated or controlled reciprocating diaphragm pump. In an embodiment, the diaphragm of the pump comprises a flexible membrane formed or molded to generally conform to a curved inner wall of a pumping chamber or control chamber of the pump, wherein the diaphragm is pre-formed or molded to have a control side taking a convex shape, so that any elastic tension on the diaphragm is minimized when fully extended into a control chamber of the pump. | 07-17-2014 |
20140221749 | Endoscope with Pannable Camera - An endoscope has a pannable camera at the distal end of its insertion shaft, the pannable camera assembly being pivotable to provide a range of a field of view that can be equal to or greater than 180 degrees. A terminal light emitting element may be mounted to the camera assembly in order to illuminate the immediate field of view of the camera sensor regardless of the rotational position of the camera assembly. A fluid-carrying conduit of the insertion section may also be used to house functional components, including the camera assembly, actuation cables, a communications cable connected to the camera sensor, and/or a fiberoptic cable providing light to the light emitting element. A distal section of the endoscope handle may be rotatable relative to a proximal hand-held section of the endoscope handle, a rotary encoder being provided to convert the rotational position of the insertion shaft relative to the handle into a signal for the purpose of image orientation correction by an electronic processor. | 08-07-2014 |
20140232108 | MEDIUM CONNECTOR - A medium connector including a passage configured to allow for the flow of medium, and a multi-portion engagement surface positioned about the passage. The multi-portion engagement surface includes a first surface portion, and a second surface portion. The first surface portion is configured to provide an interference fit with a corresponding sealing surface of a mating connector. The second surface portion is configured to provide a clearance fit with the corresponding sealing surface of the mating connector. The ratio of the first surface portion and the second surface portion is selected to regulate an engagement force between the medium connector and the mating connector. | 08-21-2014 |
20140243739 | INFUSION PUMP APPARATUS, METHOD AND SYSTEM - An infusion pump system is disclosed. The system includes a syringe having a plunger within the syringe barrel, the syringe having an exit end, at least one temperature determination device adjacent to the syringe, at least one device to determine the distance the plunger has moved with respect to the syringe barrel, and a pump processor in communication with the at least one temperature determination device and the at least one optical sensor, wherein when the controller determines a change in temperature and a corresponding plunger movement, the controller increases or decreases a preprogrammed basal rate of the infusion pump by a predetermined amount for a predetermined time. | 08-28-2014 |
20140257237 | Infusion Pump Methods, Systems and Apparatus - A system for priming an infusion pump is disclosed. The system includes a priming cap including a septum and configured to matably connect with a male part comprising a needle and attached to a length of tubing for fluid, wherein when matably connected with the male part, the priming cap occludes the tubing. | 09-11-2014 |
20140299544 | BLOOD TREATMENT SYSTEMS AND METHODS - The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. According to one aspect, a blood pump is configured to pump blood to a dialyzer of a hemodialysis apparatus, the blood pump comprising a pneumatically actuated or controlled reciprocating diaphragm pump. In an embodiment, the diaphragm of the pump comprises a flexible membrane formed or molded to generally conform to a curved inner wall of a pumping chamber or control chamber of the pump, wherein the diaphragm is pre-formed or molded to have a control side taking a convex shape, so that any elastic tension on the diaphragm is minimized when fully extended into a control chamber of the pump. In another aspect, a system for monitoring the adequacy of blood flow in a blood line of the hemodialysis apparatus allows a controller to suspend dialysate pumping operations if the adequacy of blood flow in the blood line is sub-optimal, and to present information on a display on the quality of blood flow in the blood line. | 10-09-2014 |
20140319041 | HEMODIALYSIS SYSTEMS AND METHODS - Disclosed are hemodialysis and similar dialysis systems including fluid flow circuits. Hemodialysis systems may include a blood flow path, and a dialysate flow path including balancing, mixing, and/or a directing circuits. Preparation of dialysate may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit and/or the various fluid flow paths may be isolated from electrical components. A gas supply may be provided that, when activated, is able to urge dialysate through the dialyzer and blood back to the patient. Such a system may be useful during a power failure. The hemodialysis system may also include fluid handling to devices, such as pumps, valves, mixers, etc., actuated using a control fluid. The control fluid may be delivered to the fluid handling devices using a detachable external pump. The fluid handling devices may have a spheroid shape with a diaphragm dividing it into two compartments. | 10-30-2014 |
20150050166 | FLUID PUMPING SYSTEMS, DEVICES AND METHODS - Embodiments of the present invention relate generally to certain types of reciprocating positive-displacement pumps (which may be referred to hereinafter as “pods,” “pump pods,” or “pod pumps”) used to pump fluids, such as a biological fluid (e.g., blood or peritoneal fluid), a therapeutic fluid (e.g., a medication solution), or a surfactant fluid. The pumps may be configured specifically to impart low shear forces and low turbulence on the fluid as the fluid is pumped from an inlet to an outlet. Such pumps may be particularly useful in pumping fluids that may be damaged by such shear forces (e.g., blood, and particularly heated blood, which is prone to hemolysis) or turbulence (e.g., surfectants or other fluids that may foam or otherwise be damaged or become unstable in the presence of turbulence). | 02-19-2015 |
20150125319 | PUMPING CASSETTE - A pumping cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod also includes a membrane that forms two balancing chambers. Also included in the cassette is at least two reciprocating pressure displacement membrane pumps. The pumps are within the housing and they pump the fluid from a fluid inlet to a fluid outlet line and pump the second fluid from a fluid inlet to a fluid outlet. | 05-07-2015 |
20150174320 | Infusion Pump Assembly - A fluid connector assembly. The fluid connector assembly includes a tab portion including a slot; a plug portion slidably connected to the tab portion the plug portion comprising a fluid path and a disc, the disc configured to seat within the slot; a catch feature located on a first end of the tab portion and configured to interact with a reservoir; and a latching feature located on a second end of the tab portion, the latching feature configured to interact and lock onto the reservoir, wherein force applied to the plug portion may overcome a threshold force and unseat the disc from the slot wherein the plug portion moves with respect to the tab portion. | 06-25-2015 |
20150196699 | BLOOD TREATMENT SYSTEMS AND METHODS - The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. According to one aspect, a blood pump is configured to pump blood to a dialyzer of a hemodialysis apparatus, the blood pump comprising a pneumatically actuated or controlled reciprocating diaphragm pump. In an embodiment, the diaphragm of the pump comprises a flexible membrane formed or molded to generally conform to a curved inner wall of a pumping chamber or control chamber of the pump, wherein the diaphragm is pre-formed or molded to have a control side taking a convex shape, so that any elastic tension on the diaphragm is minimized when fully extended into a control chamber of the pump. In another aspect, a system for monitoring the adequacy of blood flow in a blood line of the hemodialysis apparatus allows a controller to suspend dialysate pumping operations if the adequacy of blood flow in the blood line is sub-optimal, and to present information on a display on the quality of blood flow in the blood line. | 07-16-2015 |
20150204807 | SENSOR APPARATUS SYSTEMS, DEVICES AND METHODS - A sensor apparatus and sensor apparatus system for use in conjunction with a cassette, including a disposable or replaceable cassette. In some embodiments, the cassette includes a thermal well for permitting the sensing of various properties of a subject media. The thermal well includes a hollow housing of a thermally conductive material. In other embodiments, the cassette includes sensor leads for sensing of various properties of a subject media. The thermal well has an inner surface shaped so as to form a mating relationship with a sensing probe. The mating thermally couples the inner surface with a sensing probe. In some embodiments, the thermal well is located on a disposable portion and the sensing probe on a reusable portion. | 07-23-2015 |
20150265760 | CASSETTE SYSTEM INTEGRATED APPARATUS - A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes. | 09-24-2015 |
20150343193 | INFUSION SET IMPROVEMENTS - A method and device for adjusting the unstored length of tubing directed to improving the use of infusion sets that deliver fluids to a user. The device includes a storage module and other features for adjusting, storing and securing the length of the tubing. The method of adjusting the length of the tubing to a desired length typically comprises removably attaching the tubing to the adjuster, adjusting the tubing by wrapping the tubing around a hub or post of the adjuster, and fixing the length of the unstored tubing by attaching the tubing to a securing device such as a friction structure or fastener. | 12-03-2015 |
Patent application number | Description | Published |
20080305114 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 12-11-2008 |
20090175857 | Human Antibodies That Bind Human IL-12 And Methods For Producing - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 07-09-2009 |
20090269302 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 10-29-2009 |
20120213792 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 08-23-2012 |
20120244168 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 09-27-2012 |
20120308514 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 12-06-2012 |
Patent application number | Description | Published |
20120099733 | AUDIO ADJUSTMENT SYSTEM - A stereo widening system and associated signal processing algorithms are described herein that can, in several embodiments, widen a stereo image with fewer processing resources than existing crosstalk cancellation systems. These system and algorithms can advantageously be implemented in a handheld device or other device with speakers placed close together, thereby improving the stereo effect produced with such devices at lower computational cost. However, the systems and algorithms described herein are not limited to handheld devices, but can more generally be implemented in any device with multiple speakers. | 04-26-2012 |
20120170756 | IMMERSIVE AUDIO RENDERING SYSTEM - A depth processing system can employ stereo speakers to achieve immersive effects. The depth processing system can advantageously manipulate phase and/or amplitude information to render audio along a listener's median plane, thereby rendering audio along varying depths. In one embodiment, the depth processing system analyzes left and right stereo input signals to infer depth, which may change over time. The depth processing system can then vary the phase and/or amplitude decorrelation between the audio signals over time to enhance the sense of depth already present in the audio signals, thereby creating an immersive depth effect. | 07-05-2012 |
20120170757 | IMMERSIVE AUDIO RENDERING SYSTEM - A depth processing system can employ stereo speakers to achieve immersive effects. The depth processing system can advantageously manipulate phase and/or amplitude information to render audio along a listener's median plane, thereby rendering audio along varying depths. In one embodiment, the depth processing system analyzes left and right stereo input signals to infer depth, which may change over time. The depth processing system can then vary the phase and/or amplitude decorrelation between the audio signals over time to enhance the sense of depth already present in the audio signals, thereby creating an immersive depth effect. | 07-05-2012 |
20130030800 | ADAPTIVE VOICE INTELLIGIBILITY PROCESSOR - Systems and methods for adaptively processing speech to improve voice intelligibility are described. These systems and methods can adaptively identify and track formant locations, thereby enabling formants to be emphasized as they change. As a result, these systems and methods can improve near-end intelligibility, even in noisy environments. The systems and methods can be implemented in Voice-over IP (VoIP) applications, telephone and/or video conference applications (including on cellular phones, smart phones, and the like), laptop and tablet communications, and the like. The systems and methods can also enhance non-voiced speech, which can include speech generated without the vocal track, such as transient speech. | 01-31-2013 |
20130096926 | AUDIO ADJUSTMENT SYSTEM - An audio adjustment system is provided that can output a user interface customized by the provider of the audio system instead of the electronic device manufacturer. Such an arrangement can save both field engineers and manufacturers a significant amount of time. Advantageously, in certain embodiments, such an audio adjustment system can be provided without knowledge of the electronic device's firmware. Instead, the audio adjustment system can communicate with the electronic device through an existing audio interface in the electronic device to enable a user to control audio enhancement parameters in the electronic device. For instance, the audio adjustment system can control the electronic device via an audio input jack on the electronic device. The electronic device can also include decoding features for decoding communications sent by the audio adjustment system. | 04-18-2013 |
20130097510 | AUDIO ADJUSTMENT SYSTEM - An audio adjustment system is provided that can output a user interface customized by the provider of the audio system instead of the electronic device manufacturer. Such an arrangement can save both field engineers and manufacturers a significant amount of time. Advantageously, in certain embodiments, such an audio adjustment system can be provided without knowledge of the electronic device's firmware. Instead, the audio adjustment system can communicate with the electronic device through an existing audio interface in the electronic device to enable a user to control audio enhancement parameters in the electronic device. For instance, the audio adjustment system can control the electronic device via an audio input jack on the electronic device. | 04-18-2013 |
20130163784 | BASS ENHANCEMENT SYSTEM - A bass enhancement system can provide an enhanced bass effect for speakers, including relatively small speakers. The bass enhancement system can apply one or more bass enhancements to an input audio signal. For example, the bass enhancement system can exploit how the human ear processes overtones and harmonics of low-frequency sounds to create the perception that non-existent (or attenuated) low-frequency sounds are being emitted from a loudspeaker. The bass enhancement system can generate harmonics of at least some low-frequency fundamental frequencies in one embodiment. Playback of at least some harmonics of a low-frequency fundamental frequency can cause a listener to perceive the playback of the low-frequency fundamental frequency. Advantageously, in certain embodiments, the bass enhancement system can generate these harmonics without performing processing-intensive pitch-detection techniques or the like to identify the fundamental frequencies. | 06-27-2013 |
20130272542 | SYSTEM FOR ADJUSTING LOUDNESS OF AUDIO SIGNALS IN REAL TIME - A method of adjusting a loudness of an audio signal in real time may include receiving an electronic audio signal and dividing the audio signal into a plurality of frames. Processing of the frames may be performed in real time. The processing may include measuring initial loudness values for blocks of samples in a frame to produce a plurality of initial loudness values, and computing a weighted average of at least some of the initial loudness values. The weights may be selected based on one or more of the recency of the initial loudness values, variation of the initial loudness values, and estimated information content of the audio signal. The processing may further include selectively discarding at least some of the loudness values that reach an adaptive loudness threshold. Weights can be adjusted based on the variation of the loudness values of the audio signal. | 10-17-2013 |
20130272543 | SYSTEM FOR ADJUSTING LOUDNESS OF AUDIO SIGNALS IN REAL TIME - A method of adjusting a loudness of an audio signal in real time may include receiving an electronic audio signal and dividing the audio signal into a plurality of frames. Processing of the frames may be performed in real time. The processing may include measuring initial loudness values for blocks of samples in a frame to produce a plurality of initial loudness values, and computing a weighted average of at least some of the initial loudness values. The weights may be selected based on one or more of the recency of the initial loudness values, variation of the initial loudness values, and estimated information content of the audio signal. The processing may further include selectively discarding at least some of the loudness values that reach an adaptive loudness threshold. Weights can be adjusted based on the variation of the loudness values of the audio signal. | 10-17-2013 |
20140177854 | SYSTEMS AND METHODS OF FREQUENCY RESPONSE CORRECTION FOR CONSUMER ELECTRONIC DEVICES - Frequency response correction systems and methods for consumer electronic (CE) devices are disclosed. Applying one or more of disclosed techniques can improve a consumer's listening experience. The frequency response of a CE device can be corrected to remove or attenuate salient, undesirable features of with minimal user interaction. Audio quality can be tuned for optimal or near optimal performance even at maximum or near maximum volume levels substantially without fluctuations, clipping, or any other distortions. In some embodiments, audio response of the CE device can be captured, smoothed, and corrected. Correction parameters can be stored on the CE device. | 06-26-2014 |
20140177871 | SYSTEMS AND METHODS OF FREQUENCY RESPONSE CORRECTION FOR CONSUMER ELECTRONIC DEVICES - Frequency response correction systems and methods for consumer electronic (CE) devices are disclosed. Applying one or more of disclosed techniques can improve a consumer's listening experience. The frequency response of a CE device can be corrected to remove or attenuate salient, undesirable features of with minimal user interaction. Audio quality can be tuned for optimal or near optimal performance even at maximum or near maximum volume levels substantially without fluctuations, clipping, or any other distortions. In some embodiments, audio response of the CE device can be captured, smoothed, and corrected. Correction parameters can be stored on the CE device. | 06-26-2014 |
Patent application number | Description | Published |
20090063638 | Method and Apparatus for Processing Messages in Messaging System - Techniques are disclosed for processing messages in a messaging system, particularly during an overload condition. For example, a method of processing messages of an instant messaging system includes the following steps. A message from a first instant messaging user is received during an overload condition. A message type associated with the received message is determined. The method then decides whether to send the message to a second instant messaging user based on the determined message type of the received message. In another method, processing messages in an instant messaging system includes the following steps. Presence information associated with a first instant messaging system user is received. The presence information is sent to a second instant messaging system user when the second messaging system user requests the presence information associated with the first instant messaging system user. | 03-05-2009 |
20090177779 | Methods and Apparatus for Randomization of Periodic Behavior in Communication Network - A technique for use in a client, wherein the client supports a state-based signaling protocol (e.g., Session Initiation Protocol or SIP), includes initiating a given session state between the client and a server that also supports the state-based signaling protocol, and refreshing the given session state in a randomized manner. Further, a technique for use in a server, wherein the server supports a state-based signaling protocol (again, e.g., SIP), includes randomly assigning an expiration time duration for a given session state between the server and a client that also supports the state-based signaling protocol, and reporting the randomly assigned expiration time for the given session state to the client. By randomizing various behaviors of the client, the server, or both, bursty traffic in the communication network is reduced or eliminated. | 07-09-2009 |
20090222564 | Apparatus and Method for Supporting Connection Establishment in an Offload of Network Protocol Processing - A number of improvements in network adapters that offload protocol processing from the host processor are provided. Specifically, a mechanism for improving connection establishment in a system utilizing an offload network adapter is provided. The connection establishment mechanism provides the ability to offload connection establishment and maintenance of connection state information to the offload network adapter. As a result of this offloading of connection establishment and state information maintenance, the number of communications needed between the host system and the offload network adapter may be reduced. In addition, offloading of these functions to the offload network adapter permits bulk notification of established connections and state information to the host system rather than piecemeal notifications as is present in known computing systems. | 09-03-2009 |
20110119367 | Methods and Apparatus for Randomization of Periodic Behavior in Communication Network - A technique for use in a client, wherein the client supports a state-based signaling protocol (e.g., Session Initiation Protocol or SIP), includes initiating a given session state between the client and a server that also supports the state-based signaling protocol, and refreshing the given session state in a randomized manner. Further, a technique for use in a server, wherein the server supports a state-based signaling protocol (again, e.g., SIP), includes randomly assigning an expiration time duration for a given session state between the server and a client that also supports the state-based signaling protocol, and reporting the randomly assigned expiration time for the given session state to the client. By randomizing various behaviors of the client, the server, or both, bursty traffic in the communication network is reduced or eliminated. | 05-19-2011 |
20110161456 | Apparatus and Method for Supporting Memory Management in an Offload of Network Protocol Processing - A number of improvements in network adapters that offload protocol processing from the host processor are provided. Specifically, mechanisms for handling memory management and optimization within a system utilizing an offload network adapter are provided. The memory management mechanism permits both buffered sending and receiving of data as well as zero-copy sending and receiving of data. In addition, the memory management mechanism permits grouping of DMA buffers that can be shared among specified connections based on any number of attributes. The memory management mechanism further permits partial send and receive buffer operation, delaying of DMA requests so that they may be communicated to the host system in bulk, and expedited transfer of data to the host system. | 06-30-2011 |
20110167134 | Apparatus and Method for Supporting Memory Management in an Offload of Network Protocol Processing - A number of improvements in network adapters that offload protocol processing from the host processor are provided. Specifically, mechanisms for handling memory management and optimization within a system utilizing an offload network adapter are provided. The memory management mechanism permits both buffered sending and receiving of data as well as zero-copy sending and receiving of data. In addition, the memory management mechanism permits grouping of DMA buffers that can be shared among specified connections based on any number of attributes. The memory management mechanism further permits partial send and receive buffer operation, delaying of DMA requests so that they may be communicated to the host system in bulk, and expedited transfer of data to the host system. | 07-07-2011 |
20120005652 | Method and System for Lazy Data Serialization in Computer Communications - A method of transmitting information to a receiving computer systems includes determining in a processing unit of a computer whether a receiving computer system can receive the information without converting a local format of the information into a canonical format of the information, if it is determined that the receiving computer system cannot receive the information without converting the local format into the canonical format, then converting the local format to the canonical format and transmitting the information to the receiving computer system, and if it is determined that the receiving computer system can receive the information without converting the local format into the canonical format, then transmitting the information to the receiving computer system. | 01-05-2012 |