Harbury
Pehr Harbury, Portola Valley, CA US
Patent application number | Description | Published |
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20150087532 | AFFINITY REAGENTS FOR PROTEIN PURIFICATION - Disclosed herein are methods and compositions for purifying proteins from crude solutions. | 03-26-2015 |
20150209753 | MONOLITHS WITH ATTACHED RECOGNITION COMPOUNDS, ARRAYS THEREOF AND USES THEREOF - Provided herein are monoliths with attached recognition compounds which selectively bind ligands, methods of preparing such monoliths, arrays thereof and uses thereof. For example, monoliths provide herein can be used in columns and arrays thereof. | 07-30-2015 |
Pehr A.b. Harbury, Stanford, CA US
Patent application number | Description | Published |
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20090131675 | Methods for structural analysis of proteins - The invention provides methods and compositions for protein structure analysis, including substrate binding sites, sites of protein-protein interactions, three dimensional structure analysis, and stability, all with single amino acid resolution. In general, the subject methods involve introduction of cysteine residues, which serve as probes for physical analysis, into a protein by translational misincorporation in vivo. In many embodiments, proteins containing misincorporated cysteine residues are reacted with a crosslinking agent that covalently links misincorporated cysteine residues to a proximal amino acid in the folded protein. These methods, termed “MXLINK” methods, may be used for protein tertiary structure analysis. In other embodiments, cysteine-misincorporated proteins are used in protein footprinting methods, termed “MPAX” or “MSX” methods. | 05-21-2009 |
Pehr A.b. Harbury, San Francisco, CA US
Patent application number | Description | Published |
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20150315569 | METHOD FOR SCREENING A NUCLEIC ACID-PROGRAMMED SMALL MOLECULE LIBRARY - Provided herein is method of screening, comprising: a) combining a nucleic acid-programmed small molecule library with: an enzyme, and a substrate for the enzyme, wherein each of the members of the library comprises a test agent that is linked to an nucleic acid tag that encodes the test agent and the combining results in transferring a chemoselective functional group from the substrate onto at least some of the members of the library; b) isolating the library members onto which the chemoselective functional group has been covalently transferred; and c) amplifying the nucleic acid tags of the library members isolated in step b) to produce an amplification product. Libraries and kits for performing the method are also provided as are compounds and pharmaceutical compositions thereof. | 11-05-2015 |