Patent application number | Description | Published |
20090124714 | POROUS RESIN PARTICLE HAVING HYDROXY GROUP OR PRIMARY AMINO GROUP AND PRODUCTION METHOD THEREOF - The present invention relates to a method for producing a porous resin particle having a functional group X, the method including: dissolving a radical polymerizable aromatic monovinyl monomer and a radical polymerizable aromatic divinyl monomer together with a polymerization initiator in an organic solvent to prepare a monomer solution, dispersing the monomer solution in water in the presence of a dispersion stabilizer to obtain a suspension polymerization reaction mixture, and performing a suspension copolymerization while adding, when 0 to 80% of the entire polymerization time of the suspension copolymerization is passed, a mercapto compound represented by the formula (I): | 05-14-2009 |
20090137692 | PRODUCTION METHOD OF POROUS RESIN PARTICLE HAVING HYDROXYL GROUP - The present invention relates to a method for producing a porous resin particle containing an aromatic vinyl compound-aromatic divinyl compound copolymer having a hydroxyl group, the method including: dissolving a monomer mixture containing an aromatic vinyl compound, an aromatic divinyl compound and a (meth)acrylic acid ester having one hydroxyl group within the molecule thereof, and a polymerization initiator in an organic solvent to obtain a solution containing the monomer mixture and the polymerization initiator; suspending the solution in water in the presence of a dispersion stabilizer; and performing a suspension copolymerization. The method of the invention is capable of easily producing a porous resin particle containing an aromatic vinyl compound-aromatic divinyl compound copolymer having a hydroxyl group, that is used as a support for solid phase synthesis and enables efficient nucleic acid synthesis. | 05-28-2009 |
20090291294 | SOLID-PHASE SUPPORT FOR NUCLEIC ACID SYNTHESIS - According to the invention, there is provided a solid-phase support for nucleic acid synthesis, which is constituted of a porous copolymer particle containing a multifunctional vinyl monomer unit having two or more vinyl groups in one molecule and a monofunctional vinyl monomer unit having one vinyl group in one molecule, in which the solid-phase support has a swelling volume when soaked in acetonitrile of 3.5 ml/g or more and has a median particle diameter measured by a laser scattering particle size distribution measuring method within a range of from 50 to 120 ρm. According to the solid-phase support for nucleic acid synthesis of the invention, a high-purity nucleic acid can be synthesized with a high yield. | 11-26-2009 |
20090292033 | PROCESS FOR PRODUCING POROUS POLYMER PARTICLES - According to the invention, there is provided a process for producing porous polymer particles, which includes: dissolving in an organic solvent a monomer mixture containing an aromatic vinyl monomer and an aromatic divinyl monomer as major components together with a polymerization initiator to obtain a monomer solution; dispersing the monomer solution in water containing a dispersant and sodium nitrite to obtain a suspension polymerization dispersion; suspension-polymerizing the monomers in the suspension polymerization dispersion to yield porous polymer particles; and separating the porous polymer particles by filtration through a filter medium, in which the sodium nitrite is incorporated into the water in an amount in the range of 0.005 to 0.1 mg per 1 g of the water. | 11-26-2009 |
20110065818 | POROUS RESIN BEAD AND METHOD FOR PRODUCING NUCLEIC ACID USING THE SAME - The present invention relates to a porous resin bead containing a first aromatic monovinyl compound-divinyl compound-(meth)acrylonitrile-second aromatic monovinyl compound copolymer, in which the second aromatic monovinyl compound contains a group capable of binding with a carboxyl group by dehydration condensation reaction, and in which the porous resin bead has a dry volume of from 2 to 3 ml/g. | 03-17-2011 |
20110065822 | POROUS RESIN BEAD AND METHOD FOR PRODUCING NUCLEIC ACID USING THE SAME - The present invention relates to a porous resin bead containing a first aromatic monovinyl compound-divinyl compound-(meth)acrylonitrile-second aromatic monovinyl compound copolymer, in which the second aromatic monovinyl compound contains a group capable of binding with a carboxyl group by dehydration condensation reaction, and in which the porous resin bead has a swelling volume in acetonitrile of from 3 to 6 ml/g. | 03-17-2011 |
20110092690 | LINKER AND SUPPORT FOR SOLID PHASE SYNTHESIS OF NUCLEIC ACID - The invention provides a universal linker capable of synthesizing nucleic acid having a phosphate group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker for solid phase synthesis of nucleic acid contains a compound represented by at least one of the following formulae | 04-21-2011 |
20130197117 | LINKER AND SUPPORT FOR SOLID PHASE SYNTHESIS OF NUCLEIC ACID - The invention provides a universal linker capable of synthesizing nucleic acid having a hydroxy group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker contains a compound represented by the formula | 08-01-2013 |
Patent application number | Description | Published |
20090118383 | PRODUCTION METHOD OF POROUS RESIN BEAD - The present invention provides a method for producing a porous resin bead containing an aromatic vinyl compound-hydroxystyrene-di(meth)acrylate copolymer, the method including: dissolving a monomer mixture containing an aromatic vinyl compound, an acyloxystyrene and a di(meth)acrylate compound, and a polymerization initiator in an organic solvent to obtain a solution containing the monomer mixture and the polymerization initiator; suspending the solution in water in the presence of a dispersion stabilizer; performing a suspension copolymerization to thereby obtain an aromatic vinyl compound-acyloxystyrene-di(meth)acrylate compound copolymer; and hydrolyzing an acyloxy group of the acyloxystyrene monomer component in the copolymer. The porous resin bead produced by the method of the present invention can be suitably used, for example, as a support for solid phase synthesis. | 05-07-2009 |
20090325233 | METHOD OF PRODUCING A NUCLEIC ACID - The present invention provides a method of producing a nucleic acid at high reaction efficiency and high reproducibility with a decreased variation in yield and purity among different reaction lots. A nucleic acid synthesis reaction is carried out on a first solid phase carrier capable of supporting nucleic acid synthesis contained in a solid phase carrier mixture comprising the first solid phase carrier and a second solid phase carrier that does not support nucleic acid synthesis. | 12-31-2009 |
20090326210 | POROUS RESIN BEADS AND METHOD OF PRODUCING NUCLEIC ACID USING THE SAME - The present invention provides porous resin beads containing an aromatic monovinyl compound-divinyl compound-(meth)acrylamide derivative copolymer. Preferably, the copolymer further contains as a structural unit a second aromatic monovinyl compound having a functional group capable of binding to a carboxyl group by a dehydrating condensation reaction. | 12-31-2009 |
20120010396 | PRODUCTION METHOD OF POROUS RESIN BEAD - The present invention provides a method for producing a porous resin bead containing an aromatic vinyl compound-hydroxystyrene-di(meth)acrylate copolymer, the method including: dissolving a monomer mixture containing an aromatic vinyl compound, an acyloxystyrene and a di(meth)acrylate compound, and a polymerization initiator in an organic solvent to obtain a solution containing the monomer mixture and the polymerization initiator; suspending the solution in water in the presence of a dispersion stabilizer; performing a suspension copolymerization to thereby obtain an aromatic vinyl compound-acyloxystyrene-di(meth)acrylate compound copolymer; and hydrolyzing an acyloxy group of the acyloxystyrene monomer component in the copolymer. The porous resin bead produced by the method of the present invention can be suitably used, for example, as a support for solid phase synthesis. | 01-12-2012 |
20130317206 | SOLID-PHASE SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS AND OLIGONUCLEOTIDE SYNTHESIS METHOD - The present invention provides a solid-phase support for oligonucleotide synthesis for synthesizing long chain oligonucleotide, RNA oligonucleotide and modified oligonucleotide at high synthetic quantity and high purity with a low loading amount of a linker. Provided is a solid-phase support for oligonucleotide synthesis comprising a porous resin bead having a monovinyl monomer unit, a crosslinkable vinyl monomer unit and a polyethylene glycol unit and a cleavable linker loaded on its surface, the porous resin bead having a group capable of binding to a carboxy group by a dehydration condensation reaction on its surface, the cleavable linker having a carboxy group, wherein the carboxy group of the cleavable linker is bound to the group capable of binding to a carboxy group, by a dehydration condensation reaction, and a loading amount of the cleavable linker is 1 to 80 μmol/g relative to the weight of the porous resin bead. | 11-28-2013 |
Patent application number | Description | Published |
20140281059 | ARITHMETIC PROCESSING APPARATUS AND CONTROL METHOD OF ARITHMETIC PROCESSING APPARATUS - In a multicore system in which a plurality of CPUs each including a cache memory share one main memory, a write buffer having a plurality of stages of buffers each holding data to be written to the main memory and an address of a write destination is provided between the cache memory and the main memory, and at the time of a write to the write buffer from the cache memory, an address of a write destination and the addresses stored in the buffers are compared, and when any of the buffers has an agreeing address, data is overwritten to this buffer, and the buffer is logically moved to a last stage. | 09-18-2014 |
20140282435 | PERFORMANCE PROFILING APPARATUS AND PERFORMANCE PROFILING METHOD - A performance profiling apparatus includes: a plurality of counters provided for a routine included in a program; a storage section configured to store an instruction of the program and an identification information indicating the routine of the program; a processor configured to read the instruction from the storage section and to execute a process according to the instruction; and a counter controller configured to, at the time of reading the instruction of the processor, receive the identification information of the instruction which is output from the storage section with the instruction and to instruct a first counter designated by the identification information to count up. | 09-18-2014 |
20140297963 | PROCESSING DEVICE - When an invalidation request is inputted from another processing device, a cache controller registers a set of an invalidation request address which the invalidation request has and an identifier of the other processing device which outputted the invalidation request in an invalidation history table. When a central processing unit attempts to read data at a first address not stored in a cache memory, if the first address is registered in the invalidation history table, the cache controller outputs a coherent read request containing the first address to the other processing device indicated by the identifier of the other processing device which outputted the invalidation request corresponding to the first address, or if the first address is not registered in the invalidation history table, the cache controller outputs a coherent read request containing the first address to all other processing devices. | 10-02-2014 |