Patent application number | Description | Published |
20110269739 | KINASE INHIBITORS - The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives. | 11-03-2011 |
20110281841 | Kinase Inhibitors - The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives. | 11-17-2011 |
20130274242 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS - Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I). | 10-17-2013 |
20130274274 | SUBSTITUTED PYRIDOPYRIMIDINE COMPOUNDS AND THEIR USE AS FLT3 INHIBITORS - Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I). | 10-17-2013 |
20150111883 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS - Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I). | 04-23-2015 |
Patent application number | Description | Published |
20150111535 | METHOD AND APPARATUS FOR PROVIDING SERVICE BASED ON VOICE SESSION AUTHENTICATION - An approach for providing a service over a communication session based on an authentication from a voice session is described. A voice session enhancement platform may determine that a voice session is established among a plurality of devices. The voice session enhancement platform may further retrieve one or more authentication parameters associated with the voice session for the plurality of devices. The voice session enhancement platform may also initiate a service among the plurality of devices, wherein the service is separate from the voice session. Additionally, the voice session enhancement platform may authenticate the plurality of devices for the service based on the one or more authentication parameters. | 04-23-2015 |
20150163811 | SYSTEM AND METHOD TO DELIVER DIFFERENT SERVICES OVER CELLULAR OR WIFI NETWORKS DEPENDING ON OPERATOR OR USER PREFERENCES - A method includes attaching to a Packet Data Network (PDN) supporting services over a long term evolution (LTE) network to establish a first network connection. The method includes connecting to a wireless local area network, e.g. a WiFi network, to establish a second network connection. The method further includes launching an application accessing at least one of the supported services and receiving a request from the application to switch between the first and second network connections, according to the supported service, e.g. a policy associated with the service. Switching from the first network connection to the second network connections includes connecting to the PDN via an evolved Packet Data Gateway (ePDG). | 06-11-2015 |
20150237189 | PROVIDING A CUSTOMIZED VISUAL INTERFACE BASED ON A DIALED NUMBER - A system may be configured to receive an indication that a call has been placed (e.g., to a call center), and may provide a customized visual interface. The customized visual interface may include information that is potentially relevant to a user who has placed the call, and may be based on, for example, a user profile or history information, a purchase history of goods or services offered by an entity associated with the called party. The customized visual interface may allow the user to more quickly satisfy the purposes of his or her call than through traditional audio or touchtone menus. | 08-20-2015 |
20150237196 | PROVIDING A VISUAL INTERFACE BASED ON A DIALED NUMBER - A system, or device, may be configured to receive a request to place a voice call; forgo placing the requested voice call; and present a visual interface, associated with an intended callee of the requested voice call, in lieu of placing the requested voice call. The system or device may determine to place the voice call to the original number, or to a different number, based on an input, which is based on the visual interface, from a user who may have, or may not have, made the request. | 08-20-2015 |
Patent application number | Description | Published |
20100075862 | HIGH SENSITIVITY DETERMINATION OF THE CONCENTRATION OF ANALYTE MOLECULES OR PARTICLES IN A FLUID SAMPLE - The present invention relates to methods, systems, and kits for detecting, quantifying and/or analyzing a fluid sample comprising molecules or particles at low concentration. In certain embodiments, the methods for detection and/or quantifying analyte molecules in a sample comprise capturing a plurality of analyte molecules on a substrate (e.g., an array comprising a plurality of reaction vessels). The substrate may then be exposed to additional reaction components such as at least one binding ligand. The substrate may additionally be exposed to a precursor labeling agent molecule, wherein the precursor labeling agent molecule, in some cases, is converted to a labeling agent molecule, which may be detected, either directly or indirectly, which determination may be related to the presence of and/or may be employed to quantify the analyte molecules. Although the various aspects of the present invention may use a number of different assay formats, in one embodiment, the assays are conducted in a plurality of reaction vessels defined, at least in part, by the distal ends of fiber optic strands. | 03-25-2010 |
20110212462 | ULTRA-SENSITIVE DETECTION OF MOLECULES USING DUAL DETECTION METHODS - Described herein are systems and methods for the detection of and/or determination of a measure of the concentration of analyte molecules or particles in a fluid sample. In some cases, the systems and methods employ techniques to reduce or limit the negative effects associated with non-specific binding events. Certain methods of the present invention involve associating the analyte molecules at least a first type of binding ligand and at least a second type of binding ligand, and spatially segregating the analyte molecules into a plurality of locations on a surface. The presence of an analyte molecule at or in a location may be determined by determining the presence of both the first type of binding ligand and the second type of binding ligand. | 09-01-2011 |
20140094386 | METHODS OF DETERMINING A TREATMENT PROTOCOL FOR AND/OR A PROGNOSIS OF A PATIENT'S RECOVERY FROM A BRAIN INJURY RESULTING FROM A HYPOXIC EVENT - The present invention, in some embodiments, generally relates to methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury resulting from a hypoxic event. In some embodiments, methods are provided for determining a measure of the concentration of beta-amyloid peptide in a patient sample containing or suspected of containing beta-amyloid peptide. | 04-03-2014 |
Patent application number | Description | Published |
20100249185 | METHOD FOR INHIBITING TOPOISOMERASE II - The present invention relates to compounds that inhibit the activity of Hsp90 and inhibit topoisomerase II. | 09-30-2010 |
20100298331 | TRIAZINONE AND DIAZINONE DERIVATIVES USEFUL AS HSP90 INHIBITORS - The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound. | 11-25-2010 |
20110224206 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted pyrrole compounds of formula I and compositions comprising substituted tri-substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a tri-substituted’ triazole compound of the invention, or a pharmaceutical composition comprising such a compound. | 09-15-2011 |
20120122869 | TRIZAOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 05-17-2012 |
20130345219 | TRIAZINONE AND DIAZINONE DERIVATIVES USEFUL AS HSP90 INHIBITORS - The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound. | 12-26-2013 |
Patent application number | Description | Published |
20080198914 | Architecture for Systolic Nonlinear Filter Processors - Described are nonlinear filter processors having an array of polynomial nonlinear filters including a first polynomial nonlinear filter and a last polynomial nonlinear filter. The first polynomial nonlinear filter has an input terminal for receiving an input data sample. The polynomial nonlinear filters systolically pass the input data sample from the first polynomial nonlinear filter to the last polynomial nonlinear filter. Each polynomial nonlinear filter produces an output data sample based on the input data sample. In addition, each polynomial nonlinear filter other than the last polynomial nonlinear filter systolically passes the output data sample generated by that polynomial nonlinear filter to a neighboring polynomial nonlinear filter. Each polynomial nonlinear filter other than the first polynomial nonlinear filter sums a nonlinearly filtered input data sample produced by that polynomial nonlinear filter with the output data sample received from a neighboring polynomial nonlinear filter. | 08-21-2008 |
20100235674 | Systolic Merge Sorter - A sorter system includes a clock continuously generating a series of clock signals, a systolic array circuit, and control circuitry in communication with serial access memory that stores data items of a sequence to be sorted and with the systolic array circuit to supply thereto data items as input and to receive therefrom data items as output. The systolic array circuit includes at least one processing module and K−1 registers, where K is an integer value greater than two. Each processing module has at least one of the registers, each register for storing one data item. The control circuitry serially presents K data items for input to the systolic array circuit in synchronization with the clock signals. On the next clock cycle after the control circuitry presents to the systolic array circuit the last of the K data items, the data item of least value in the given subsequence is output. | 09-16-2010 |
20110279307 | High Duty Cycle Radar with Near/Far Pulse Compression Interference Mitigation - In conventional pulse compression processing, sidelobes from strong return signals may hide correlation peaks associated with weaker return signals. Example embodiments include methods of mitigating this near/far interference by weighting a received return signal or corresponding reference signal based the return signal's time of arrival, then performing pulse compression using the weighted signal to produce a correlation peak that is not hidden by sidelobes from another return. Multi-frequency processing can also be used to reduce the pulse width of the transmitted pulses and received return signals, thereby mitigating near/far interference by decreasing the overlap between signals from nearby targets. Weighting can be combined with multi-frequency pulse transmission and reception to further enhance the fidelity of the processed correlation peak. Weighting and multi-frequency processing also enable higher duty cycles than are possible with conventional pulse compression radars. | 11-17-2011 |
20110307685 | Processor for Large Graph Algorithm Computations and Matrix Operations - A multiprocessor system and method for performing matrix operations includes multiple processors cooperatively performing a sparse matrix operation. Distributed among the processors are non-zero matrix elements of first and second sparse matrices. Mapped across the processors are the matrix elements of a results matrix. Each processor receives, from the other processors, non-zero matrix elements of the first matrix that had been distributed to those other processors and generates partial results based on the received non-zero matrix elements of the first matrix and on the non-zero matrix elements of the second matrix distributed to that processor. Each processor receives those partial results generated by other processors and associated with the matrix elements of the results matrix mapped to that processor. Each processor generates a final value for each matrix element of the results matrix mapped to that processor based on the partial results generated by that processor and on the partial results received from the other processors associated with that matrix element of the results matrix. | 12-15-2011 |
20120013494 | Time Varying Quantization-based Linearity Enhancement of Signal Converters and Mixed-signal Systems - A signal-linearization system and method reduces nonlinear distortions in a digitized signal generated by an analog-to-digital converter (ADC) when converting an analog input signal from analog to digital form. A signal adder adds a dither waveform to the analog input signal. An ADC includes sample-and-hold (S/H) circuitry and quantizer circuitry. The ADC converts the analog input signal with the added dither waveform into a digitized signal. The dither waveform operates to suppress nonlinear distortions attributed to the quantizer circuitry. A linearizer processor performs nonlinear equalization (NLEQ) on the digitized signal to suppress nonlinear distortions attributed to the S/H circuitry. A dither waveform removal module removes a digital counterpart of the dither waveform from the digitized signal. | 01-19-2012 |
20130278455 | EFFICIENT PULSE DOPPLER RADAR WITH NO BLIND RANGES, RANGE AMBIGUITIES, BLIND SPEEDS, OR DOPPLER AMBIGUITIES - A Doppler radar system that avoids blind ranges, range ambiguities, blind speed and/or Doppler ambiguities. Pulse width, repetition interval and pulse type are varied from pulse to pulse within a coherent processing interval. | 10-24-2013 |
20140153399 | MULTIPROCESSOR COMMUNICATION NETWORKS - A parallel multiprocessor system includes a packet-switching communication network comprising a plurality of processor nodes operating concurrently in parallel. Each processor node generates messages to be sent simultaneously to a plurality of other processor nodes in the communication network. Each message is divided into a plurality of packets having a common destination processor node. Each processor node has an arbiter that determines an order in which to forward the packets onto the network toward their destination processor nodes and a network interface that sends the packets onto the network in accordance with the determined order. The determined order operates to substantially avoid sending consecutive packets from a given source processor node to a given destination processor node and to randomize the destination processor nodes of those packets presently traversing the communication network. | 06-05-2014 |
20140258689 | PROCESSOR FOR LARGE GRAPH ALGORITHM COMPUTATIONS AND MATRIX OPERATIONS - A node processor and method for performing matrix operations includes storing, in memory, non-zero matrix elements of a first sparse matrix, non-zero matrix elements of a second sparse matrix, and matrix elements of a sparse results matrix mapped to the node processor. A matrix communications module exchanges with other node processors, non-zero matrix elements of one or more of the first sparse matrix, second sparse matrix, and sparse results matrix. An arithmetic logic unit generates partial results based on the non-zero matrix elements of the first sparse matrix and on the non-zero matrix elements of the second sparse matrix stored in memory. The arithmetic logic unit further generates a final value for each matrix element of the sparse results matrix mapped to the node processor based on the partial results generated by the arithmetic logic unit and on partial results received from the other node processors. | 09-11-2014 |
Patent application number | Description | Published |
20120126809 | Nuclear Magnetic Resonance Tool With Movable Magnets - Methods and systems are provided that enable logging while drilling NMR measurements to be made with a tool having magnets with positions adjustable or movable relative to each other. Such movement can affect the depth of investigation of the NMR tool. A variety of moving assemblies can be used to effectuate the movement, which can be performed either at the surface or downhole. The tool also can include a magnetically permeable member to control the magnetic field gradient. | 05-24-2012 |
20120169334 | MICROCOIL NMR FOR DOWNHOLE MICROFLUIDICS PLATFORM - Methods and related apparatuses of a downhole micro nuclear magnetic resonance (NMR) device having a resonant tuning (LC) circuit for use in a formation for collecting NMR signals from a fluid in the formation while under downhole pressures and temperatures. The downhole micro NMR device includes: a micro tube for the flowing fluid to flow therethrough; at least one magnet disposed about the micro tube; and at least one micro RF coil structured and arranged approximate to the micro tube and tuned to a Larmor frequency corresponding to a applied magnetic field from the at least one magnet. | 07-05-2012 |
20120229135 | CONTINUOUS WETTABILITY LOGGING BASED ON NMR MEASUREMENTS - A method for utilizing received formation data to determine one or more fluid instance such as reservoir wettability while in one of a subterranean environment or a surface environment. The method comprising: (a) obtaining at least one set of formation data wherein the set of formation data includes magnetic resonance data from two or more samples within an approximate common characteristic region in the reservoir; (b) computing from the at least one set of received formation data a first fluid instance of the one or more fluid instance using at least two mathematical variables from the group consisting of one of oil saturation, water saturation, T | 09-13-2012 |
20120273193 | NMR ANALYSIS OF UNCONVENTIONAL RESERVOIR ROCK SAMPLES - Systems and methods for magic angle spinning nuclear magnetic resonance analysis of samples from unconventional reservoirs are described. Fast and inexpensive methods are described that can provide reliable information on TOC content, type, and maturity (via the relative abundances of different hydrocarbons, for example) without the need for more extensive sample preparation or destruction. If care is taken during sample recovery and storage, NMR can also yield an estimate of gas-in-place, including detailed typing (e.g. methane vs. ethane). The described MAS NMR analysis is used to determine various properties of unconventional reservoirs, including gas and oil shales, which are useful in evaluating their worth and producibility. | 11-01-2012 |
20130063142 | Multiple Coils for NMR Well-logging Measurements - An NMR apparatus disposed in a wellbore and having an array of two or more NMR sensors located at substantially the same axial position on the NMR apparatus and having different directional sensitivities is used to acquire an NMR signal from at least two of the two or more NMR sensors. The NMR signals are combined to obtain borehole information. The borehole information may include an azimuthal image of the formation surrounding the borehole. The azimuthal image may be a formation porosity image, a formation bound fluid image, a T2 distribution image, a T2 log mean image, a formation permeability image, or a formation fluid viscosity image. If two or more pre-amplifiers and receiver circuitry are also provided, the NMR signals may be combined prior to passing through the pre-amplifiers and receiver circuitry to improve the signal to noise ratio of the total signal from the desired sample space. | 03-14-2013 |
20130106413 | System and Method for Measuring Borehole Geometry While Drilling | 05-02-2013 |
20130234704 | METHOD AND SYSTEM FOR APPLYING NMR PULSE SEQUENCES WITH INTERACTING SHELLS - A method and system for determining a nuclear magnetic resonance (NMR) property are described herein. The method includes applying a static magnetic field to a substance and applying an NMR pulse sequence to the substance. The NMR pulse sequence comprises a first pulse sequence segment applied at a first frequency to a shell and a second pulse sequence segment applied at a second frequency. The first pulse sequence segment generates a resonant signal in the shell and the second pulse sequence segment generates a characteristic within the resonant signal. The resonant signal is detected and an NMR property is determined using the characteristic within the detected resonant signal. | 09-12-2013 |
20130234705 | METHOD AND SYSTEM FOR APPLYING NMR PULSE SEQUENCES USING DIFFERENT FREQUENCIES - A method and system for applying nuclear magnetic resonance (NMR) sequences to a substance are described herein. The method includes applying an NMR pulse sequence to the substance using a non-resonant transmitter circuit. The NMR pulse sequence includes a first pulse sequence segment applied at a first frequency to a first shell within the substance and a second pulse sequence segment applied at a second frequency to a second shell. The second pulse sequence segment is initiated before the first shell reaches thermal equilibrium. In some cases, the first pulse sequence segment and the second pulse sequence segment are interposed within each other. Such NMR pulse sequences, with multiple pulse sequence segments, can also be applied to different atomic nuclei. | 09-12-2013 |
20130234706 | SYSTEM AND METHOD FOR PROCESSING MAGNETIC RESONANCE SIGNALS - A broadband magnetic resonance (MR) receiver is described herein. The MR receiver can be used to process nuclear magnetic resonance (NMR) signals. The MR receiver includes a transformer that amplifies the MR signals and a preamplifier that receives the MR signals from the transformer. The preamplifier includes a common-drain amplifier stage and a common-source amplifier stage. | 09-12-2013 |
20130325408 | TWO DIMENSIONAL NMR OF DIFFUSION AND RELAXATION FOR MATERIAL CHARACTERIZATION - Processing nuclear magnetic resonance data to obtain information regarding material properties is described. This processing can include, for example, compression techniques that can be implemented to lower the required operating memory. In some embodiments, a compression technique can be chosen based on the available operating memory of the computer system. By doing so, an efficient compression algorithm can be selected. In some embodiments, a Lanczos bidiagonalization algorithm, for example, an IRLBA algorithm, can be used for data compression. | 12-05-2013 |
20140132259 | NMR METHOD TO DETERMINE GRAIN SIZE DISTRIBUTION IN MIXED SATURATION - A method for determining particle size distribution of a subsurface rock formation having pore spaced filled with at least two different fluids using measurements of at least one nuclear magnetic resonance property thereof made from within a wellbore penetrating the rock formation includes determining a distribution of nuclear magnetic relaxation times from the measurements of the at least one nuclear magnetic resonance property. A fractional volume of the pore spaces occupied by each of the at least two fluids is determined. A surface relaxivity of the rock formation for portions of the rock pore spaces occupied by each of the at least two fluids is determined from a measurement of a formation parameter. The relaxation time distribution and the surface relaxivities are used to determine the particle size distribution. | 05-15-2014 |
20140184220 | METHOD FOR NUCLEAR MAGNETIC RESONANCE DIFFUSION MEASUREMENTS - A method and system for determining a property of a substance using nuclear magnetic resonance (NMR) is described herein. The method includes applying a NMR pulse sequence to the substance. The NMR pulse sequence includes a first set of pulses and a second set of pulses. The first set of pulses and the second set of pulses encode for overlapping diffusion times. By overlapping diffusion times, the NMR pulse sequence can be used to measure a diffusion coefficient for a first diffusion time, a diffusion coefficient for a second diffusion time, and a correlation between the two overlapping diffusion times. This information, in turn, can be used to differentiate between intrinsic bulk diffusivity of the substance and the reduced diffusivity of the substance caused by restricted diffusion. | 07-03-2014 |
20150042337 | MAGNETIC RESONANCE TRANSMITTER - A transmitter for a magnetic resonance (MR) system, such as nuclear magnetic resonance (NMR) system, is described herein. The transmitter includes a coil for applying NMR pulse sequences to a substance. The coil includes a first coil section and a second coil section. The first coil section and second coil section pass current in opposite polarity. The transmitter may also include a transmitter circuit for generating the NMR pulse sequences and providing the NMR pulse sequences to the coil. The transmitter circuit includes a first switch that selectively powers the first coil section and a second switch that selectively powers the second coil section. Operation of the first switch and the second switch generates the NMR pulse sequences. | 02-12-2015 |
20150115953 | METHOD AND APPARATUS FOR DETERMINING MUD CONTAMINATION OF FORMATION FLUID - A formation fluid sample is analyzed using NMR spectroscopy to obtain a NMR spectrum. The NMR spectrum is then analyzed to find evidence of the amount of olefins present in the sample. The amount of olefins present in the sample can then be correlated to the level of contamination of the sample. In one embodiment, a | 04-30-2015 |
20150115954 | NON-RESONANT MAGNETIC RESONANCE TRANSMITTER WITH POWER FACTOR CORRECTION - A non-resonant transmitter for a magnetic resonance (MR) system, such as a nuclear magnetic resonance (NMR) system, is described herein. The transmitter includes a coil for applying NMR pulse sequences to a substance. The coil is coupled to a circuit that includes a capacitor, a number of switches, and a power source. The transmitter operates in two modes. In a charging mode, the switches decouple the coil from the capacitor and the capacitor is charged by the power source. In a discharging mode, a radio frequency pulse is generated and the switches couple and decouple the coil from the capacitor so that the capacitor provides power to the coil. The addition of the capacitor improves the power factor of the circuit and reduces power draw from the power source. | 04-30-2015 |
Patent application number | Description | Published |
20100010744 | MONTE CARLO METHOD FOR LAPLACE INVERSION OF NMR DATA - Methods and related systems are described for extracting information about a system of nuclear spins including: performing a plurality of Nuclear Magnetic Resonance (NMR) measurements on the system of nuclear spins; acquiring NMR data from each of the plurality of NMR measurements; performing data inversion using an random-sampler to generate an ensemble of spectra so as to extract information about the system of nuclear spins; and analyzing the performed random-sampler inversion results to extract information about the system of nuclear spins. | 01-14-2010 |
20100237860 | CONTINUOUS WETTABILITY LOGGING BASED ON NMR MEASUREMENTS - A method for utilizing received formation data to determine one or more fluid instance such as reservoir wettability while in one of a subterranean environment or a surface environment. The method comprising: (a) obtaining at least one set of formation data wherein the set of formation data includes magnetic resonance data from two or more samples within an approximate common characteristic region in the reservoir; (b) computing from the at least one set of received formation data a first fluid instance of the one or more fluid instance using at least two mathematical variables from the group consisting of one of oil saturation, water saturation, T | 09-23-2010 |
20100315081 | METHOD FOR DETERMINING FORMATION PARTICLE SIZE DISTRIBUTION USING WELL LOGGING MEASUREMENTS - A method for determining particle size distribution of a subsurface rock formation using measurements of at least one nuclear magnetic resonance property made from within a wellbore penetrating the rock formation includes determining a distribution of nuclear magnetic relaxation times from the measurements of the at least one nuclear magnetic resonance property. A surface relaxivity of the formation is determined from measurements of a formation parameter. The relaxation time distribution and surface relaxivity are used to determine the particle size distribution. | 12-16-2010 |
20110105886 | DIFFUSION-BASED MAGNETIC RESONANCE METHODS FOR CHARACTERIZING BONE STRUCTURE - A method of in vitro or in vivo nuclear magnetic resonance and/or magnetic resonance imaging, to determine bone properties by measuring the effects of molecular diffusion inside the bone specimen to derive parameters that are related to the structure of the trabecular bones. The method is a non-invasive probe that provides topological information on trabecular bone without requiring a full high-resolution image of its structure, and is compatible with clinical use. | 05-05-2011 |
20110198078 | FORMATION EVALUATION INSTRUMENT AND METHOD - Subsurface formation evaluation comprising, for example, sealing a portion of a wall of a wellbore penetrating the formation, forming a hole through the sealed portion of the wellbore wall, injecting an injection fluid into the formation through the hole, and determining a saturation of the injection fluid in the formation by measuring a property of the formation proximate the hole while maintaining the sealed portion of the wellbore wall. | 08-18-2011 |
20120001629 | NON-RESONANT LOGGING TOOLS - Methods and systems are provided for tools having non-resonant circuits for analyzing a formation and/or a sample. For example, nuclear magnetic resonance and resistivity tools can make use of a non-resonant excitation coil and/or a detection coil. These coils can achieve desired frequencies by the use of switches, thereby removing the requirement of tuning circuits that are typical in conventional tools. | 01-05-2012 |
20130154635 | INTEGRATED NMR TRANSCEIVER ARRAY - The present disclosure relates to an integrated nuclear magnetic resonance (NMR) transceiver array, the array including a plurality of integrated NMR transceiver circuits disposed on a single chip. At least one of the plurality of integrated NMR transceiver circuits includes a transmitter that receives and outputs a radio frequency (RF) pulse train and a receiver that receives an NMR signal. | 06-20-2013 |
20130162247 | REFOCUSING PULSES AND EXCITATION PULSES FOR NMR LOGGING - Illustrative embodiments are directed to applying a nuclear magnetic resonance sequence to a substance within an inhomogeneous static magnetic field. Various embodiments include applying a series of refocusing pulses to the substance, each refocusing pulse in the series of refocusing pulses having at least two segments, and a total pulse duration less than or equal to approximately 1.414 times T | 06-27-2013 |
20130176026 | Magnetic Resonance Imaging Methods - A method of investigating an object using nuclear magnetic resonance (NMR) equipment includes generating a one-dimensional projection of the object for each of a plurality of echoes utilizing echo train signal indications resulting from pulse sequences, and utilizing the plurality of one-dimensional projections, for each of the plurality of echoes, generating NMR image data for at least one location in the object. The NMR image data may be displayed. The displayed data may include a T2 decay curve, a T2 value display, a T2 distribution graph, or petrophysical data for at least one object location. | 07-11-2013 |
20130187648 | ESTIMATING AND DISPLAYING MOLECULAR SIZE INFORMATION OF A SUBSTANCE - Estimating and displaying information about the size of molecules within a substance from nuclear magnetic resonance (NMR) maps and/or logs. Methods include utilizing a relationship between the molecular size (e.g., mean chain length), and either a moment of diffusion or a relaxation distribution, to create a scale on a two-dimensional map. In one case, applying the relationship between the molecular size, and either a moment of diffusion or a relaxation distribution, to one-dimensional diffusion or relaxation distributions for the purpose of estimating the mean chain length of molecules within the substance. In another case, a method includes determining mean chain lengths of molecules within a substance and providing a one-dimensional NMR log showing the mean chain lengths at a plurality of depths. In some cases, the NMR log includes actuatable regions for examining two-dimensional NMR maps or chain length distributions of the substance corresponding with distinct depths of the substance. | 07-25-2013 |
20150022202 | METHOD FOR ANALYZING FORMATION SAMPLES USING NMR MEASUREMENTS - Methods for analyzing a formation samples using nuclear magnetic resonance (NMR) are described herein. One method includes performing an NMR measurement of the formation sample to obtain NMR data. The NMR measurement detects NMR signals with echo times of less than or equal to 100 microseconds. The NMR data is analyzed to determine a measure of organic hydrogen content of the formation sample, such as (i) total organic hydrogen content, (ii) kerogen content, (iii) bitumen content, and/or (iv) oil content. | 01-22-2015 |
20150077102 | METHOD AND SYSTEM FOR APPLYING NQR PULSE SEQUENCES - A method and system for applying nuclear quadrupole resonance (NQR) sequences to a substance and determining presence of a chemical species within the substance using the sequences are described herein. The method includes applying an NQR pulse sequence to the substance using a non-resonant transmitter circuit. The method further includes detecting a NQR signal within the substance and determining presence of a chemical species within the substance using the NQR signal. | 03-19-2015 |
20150153433 | METHOD FOR NUCLEAR MAGNETIC RESONANCE DIFFUSION MEASUREMENTS - A method and system for determining a property of a substance using nuclear magnetic resonance (NMR) is described herein. The method includes applying a NMR pulse sequence to the substance. The NMR pulse sequence includes a first set of pulses and a second set of pulses. The first set of pulses and the second set of pulses encode for overlapping diffusion times. By overlapping diffusion times, the NMR pulse sequence can be used to measure a diffusion coefficient for a first diffusion time, a diffusion coefficient for a second diffusion time, and a correlation between the two overlapping diffusion times. This information, in turn, can be used to differentiate between intrinsic bulk diffusivity of the substance and the reduced diffusivity of the substance caused by restricted diffusion. | 06-04-2015 |
20150192011 | METHODS AND APPARATUS FOR OIL SAMPLE ANALYSIS USING J-EDIT NUCLEAR MAGNETIC RESONANCE - A hydrocarbon sample is subjected to a chemically selective J-editing nuclear magnetic resonance (NMR) pulse sequence. Resulting signals are analyzed in order to identify a coupling frequency present in at least one molecule of the hydrocarbon sample. A J-coupling frequency of approximately 150 Hz is indicative of a component having an internal double bonded carbon atom (i.e., an olefin). The presence of an olefin in a hydrocarbon sample can be indicative of the presence of a synthetic based mud (SBM) in the sample. | 07-09-2015 |
20150219782 | LOGGING IN GAS SHALE AND OTHER UNCONVENTIONAL RESERVOIRS - Apparatus and methods for characterizing hydrocarbons in a subterranean formation including sending and measuring NMR signals; analyzing the signals to form a distribution; and estimating a property of a formation from the distribution, wherein the sending comprises pulse sequences configured for a formation pore size, and wherein the computing comprises porosity. Apparatus and methods for characterizing hydrocarbons in a subterranean formation including sending and measuring NMR signals; analyzing the signals to form a distribution; and estimating a property of a formation from the distribution, wherein the formation comprises a distribution of pore sizes of about 10 nm or more, and wherein the computing comprises natural gas composition. | 08-06-2015 |
20150253454 | NMR PROBE AND METHODS OF USE - A coaxial nuclear magnetic resonance (NMR) probe and related methods are described herein. The coaxial NMR probe includes a housing with a fluid inlet, a fluid outlet, a longitudinal axis, and an interior volume. The housing contains a fluid sample that is analyzed by the probe. The coaxial NMR probe also includes an elongated conductor disposed along the longitudinal axis of the housing. The elongated conductor generates an oscillating electromagnetic field within the interior volume of the housing. The oscillating electromagnetic field produces a NMR signal within the fluid sample. The elongated conductor may also be used to receive this NMR signal. The NMR signal is then analyzed to determine information about the fluid sample. Various NMR pulse sequences for use with this coaxial probe and other coaxial probes are also described herein. | 09-10-2015 |
20150260813 | SYSTEM AND METHOD FOR PROCESSING MAGNETIC RESONANCE SIGNALS - A magnetic resonance (MR) receiver is described herein. The MR receiver can be used to process nuclear magnetic resonance (NMR) signals. The MR receiver includes a transformer that amplifies the MR signals and a preamplifier that receives the MR signals from the transformer. The preamplifier can include a transimpedance amplifier circuit with an input stage that includes a field effect transistor. | 09-17-2015 |
20150268323 | MULTI-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE METHODS FOR CHARACTERIZING FLUIDS - Methods are disclosed for characterizing samples containing a plurality of molecular species through the use of multi-dimensional spectra obtained by processing of measurements resulting from pulse sequences combining NMR spectroscopy and NMR relaxation techniques. | 09-24-2015 |
20150292316 | Asymmetric Excluder For Downhole Logging Tool - A downhole tool includes a cylindrical housing. A magnet and an antenna may be positioned within the housing. An excluder may be positioned around the housing, and a thickness of the excluder may vary around the housing. | 10-15-2015 |
20150346378 | Identifying and Removing Artifacts from Multi-Dimensional Distribution Functions - Systems and methods for generating a multi-dimensional distribution function. First data and second data may be received in response to one or more radiofrequency pulses that are transmitted into a subterranean formation. The first data may include Carr-Purcell-Meiboom-Gill data, and the second data may include diffusion editing data with initial echo spacings longer than subsequent echo spacings. The second data may be inverted. A multi-dimensional distribution function may be determined using the inverted second data. | 12-03-2015 |
Patent application number | Description | Published |
20090123517 | MEDICAL DEVICES FOR RELEASING THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME - An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted. | 05-14-2009 |
20090157166 | Medical Devices Having Porous Component For Controlled Diffusion - According to an aspect of the present invention, implantable or insertable medical devices are provided which contain the following: (a) substrate having one or more depressions that contain at least one therapeutic agent and (b) a porous membrane disposed over the substrate and the one or more depressions, which regulate transport of chemical species between the therapeutic-agent-containing depressions and the exterior of the device. The substrate and the porous membrane are formed of different materials each with a different thermal expansion coefficient. Moreover, one of the substrate and the porous membrane at least partially surrounds the other. Other aspects of the present invention are directed to methods of making such medical devices, and methods of treatment using such medical devices. | 06-18-2009 |
20090263445 | MEDICAL DEVICES COMPRISING SPRAY DRIED MICROPARTICLES - An implantable or insertable medical device which includes (a) a tacky polymeric region and (b) spray dried microparticles, which are adhered to the tacky polymeric region. The present invention is further directed to methods of forming such medical devices, and methods of releasing a therapeutic agent within a patient using such medical devices. | 10-22-2009 |
20110275704 | Stable Formulations for Lyophilizing Therapeutic Particles - The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles. | 11-10-2011 |
20110294717 | Therapeutic Polymeric Nanoparticle Compositions with High Glass Transition Temperature or High Molecular Weight Copolymers - The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles. | 12-01-2011 |
20120027820 | Stable Formulations for Lyophilizing Therapeutic Particles - The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles. | 02-02-2012 |
20120140790 | Therapeutic Polymeric Nanoparticle Compositions with High Glass Transition Termperature or High Molecular Weight Copolymers - The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles. | 06-07-2012 |
20130108668 | Therapeutic Polymeric Nanoparticles Comprising Epothilone and Methods of Making and Using Same | 05-02-2013 |
20130230568 | Stable Formulations for Lyophilizing Therapeutic Particles - The entire contents of all patents, published patent applications, websites, and other references cited herein are hereby expressly incorporated herein in their entireties by reference. | 09-05-2013 |
20130243863 | Stable Formulations for Lyophilizing Therapeutic Particles - The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles. | 09-19-2013 |
20130295183 | Stable Formulations for Lyophilizing Therapeutic Particles - The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles. | 11-07-2013 |
20130295191 | Stable Formulations for Lyophilizing Therapeutic Particles - The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles. | 11-07-2013 |
20140178475 | Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same - The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles. | 06-26-2014 |
20140186452 | Process for Preparing Therapeutic Nanoparticles - The present disclosure generally relates to a process for preparing therapeutic nanoparticles, where the process includes combining a therapeutic agent with an organic acid. The therapeutic nanoparticles may have, for example, improved drug loading and/or drug release properties. | 07-03-2014 |
20140248358 | Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same - The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles. | 09-04-2014 |
20140249158 | Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same - The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles. | 09-04-2014 |
20150056300 | THERAPEUTIC NANOPARTICLES WITH HIGH MOLECULAR WEIGHT COPOLYMERS - The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 0.1 to about 40 weight percent of a therapeutic agent and about 10 to about 90 weight percent a diblock poly(lactic) acid-poly(ethylene)glycol copolymer or a diblock poly(lactic)-co-poly(glycolic) acid-poly(ethylene)glycol copolymer, wherein the diblock poly(lactic) acid-poly(ethylene)glycol copolymer comprises poly(lactic) acid having a number average molecule weight of about 30 kDa to about 90 kDa or the diblock poly(lactic)-co-poly(glycolic) acid-poly(ethylene)glycol copolymer comprises poly(lactic)-co-poly(glycolic) acid having a number average molecule weight of about 30 kDa to about 90 kDa. | 02-26-2015 |
20150110837 | Therapeutic Polymeric Nanoparticles Comprising Epothilone and Methods of Making and Using Same - The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 0.2 to about 20 weight percent of epothilone, e.g. epothilone B; and about 50 to about 99 weight percent biocompatible polymer. | 04-23-2015 |
20150258102 | THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME - The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid and a therapeutic agent (1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea), or pharmaceutically acceptable salts thereof, and a polymer. Other aspects include methods of making and using such nanoparticles. | 09-17-2015 |
20150283081 | STABLE FORMULATIONS FOR LYOPHILIZING THERAPEUTIC PARTICLES - The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles. | 10-08-2015 |