Kline, PA
Brad Kline, Morgantown, PA US
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20100260769 | ENDOSIALIN BINDING MOLECULES - The invention relates to novel binding molecules that specifically bind endosialin (TEM-1) including antibodies, such as monoclonal antibodies, or antigen-binding portions of antibodies, and methods and compositions comprising such binding molecules. | 10-14-2010 |
20120148592 | NEUTRALIZING ANTI-CCL20 ANTIBODIES - The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer. | 06-14-2012 |
20140045215 | NEUTRALIZING ANTI-CCL20 ANTIBODIES - The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer. | 02-13-2014 |
Charles Kline, Camp Hill, PA US
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20110105213 | Internet Based Lottery Redemption System and Methods - A method and associated system for Internet play of an instant lottery game includes supplying instant lottery tickets for purchase by players, with each of the instant lottery tickets having a game authorization code. The winning or loosing status of the instant lottery tickets is unknown to the players at the time of purchase. Each of the instant lottery tickets is provided with a unique prize claim code separate from the game authorization code. A web site is provided wherein a player enters the game authorization code via an Internet device to initiate play of the instant lottery game. The outcome of the game is then randomly determined and presented to the player via the web site. The value of a winning outcome is credited to a running tally associated with the lottery ticket and, upon the player cashing out to end the lottery game, a monetary value is assigned for the running tally associated with the unique prize claim code. The prize claim codes are stored and at defined periodic intervals, the prize claim codes are transferred to a lottery system central computer. For redemption of an instant lottery ticket, the player presents the prize claim code to a lottery redemption location wherein the presented prize claim code is verified with data from the transferred prize claim codes to determine a payout to the player for the lottery ticket. | 05-05-2011 |
20130225255 | Method for Verifying the Age or Location of a Player before Initiating Play of an Internet-Based Game - A method for verifying the age or location of a player of an Internet-based lottery game entails providing lottery tickets for purchase by players at an authorized retail location, the lottery tickets having a game authorization code that is entered by the initiate play of the Internet-based lottery game on an internet enabled device. The age of the player is verified at the retail location and a separate verification password is entered via a terminal that is in communication with to the lottery system central computer, with the password linked to the game authorization code. Upon initiating play of the game via a web site, the player enters the verification password separately from the game authorization code. An Internet game server communicates with the lottery system central computer to ensure that the entered verification password corresponds to the linked verification password prior to permitting play of the Internet-based lottery game. | 08-29-2013 |
20150066694 | Method for Verifying the Age or Location of a Player Before Initiating Play of an Internet-Based Game - A method for verifying the age or location of a player of an Internet-based lottery game entails providing lottery tickets for purchase by players at an authorized retail location, the lottery tickets having a game authorization code that is entered by the initiate play of the Internet-based lottery game on an internet enabled device. The age of the player is verified at the retail location and a separate verification password is entered via a terminal that is in communication with to the lottery system central computer, with the password linked to the game authorization code. Upon initiating play of the game via a web site, the player enters the verification password separately from the game authorization code. An Internet game server communicates with the lottery system central computer to ensure that the entered verification password corresponds to the linked verification password prior to permitting play of the Internet-based lottery game. | 03-05-2015 |
Daniel E. Kline, Quakertown, PA US
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20100083386 | Tokenized Resource Access - A method and system for unlocking diagnostic functions in a hardware device for a user. The method obtains a signed permission object for the hardware device, and validates the signed permission object. A memory of the hardware device stores a device identifier and a last recorded sequence number. The signed permission object includes a sequence number and is associated with an expiration counter having an initial value that indicates a lifetime for the signed permission object. When the signed permission object is valid, the method updates the expiration counter to decrease the lifetime of the signed permission object, stores the sequence number associated with the signed permission object as the last recorded sequence number in the hardware device, and unlocks the diagnostic functions for the user based on the signed permission object. | 04-01-2010 |
20120304311 | Tokenized Resource Access - A method and system for unlocking diagnostic functions in a hardware device for a user. The method obtains a signed permission object for the hardware device, and validates the signed permission object. A memory of the hardware device stores a device identifier and a last recorded sequence number. The signed permission object includes a sequence number and is associated with an expiration counter having an initial value that indicates a lifetime for the signed permission object. When the signed permission object is valid, the method updates the expiration counter to decrease the lifetime of the signed permission object, stores the sequence number associated with the signed permission object as the last recorded sequence number in the hardware device, and unlocks the diagnostic functions for the user based on the signed permission object. | 11-29-2012 |
Greg Kline, Greentown, PA US
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20090051875 | DIAGNOSTIC AND CORRECTIVE APPARATUS AND METHOD - This disclosure describes systems and methods which utilize outcomes analysis, empirical and on-eye diagnostic fitting outcomes, and similar patient data to determine and provide a relatively optimal corrective device for the patient, in a single-use and disposable set of devices. | 02-26-2009 |
James Bradford Kline, Morgantown, PA US
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20160046707 | NEUTRALIZING ANTI-CCL20 ANTIBODIES - The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer. | 02-18-2016 |
James E. Kline, Grantville, PA US
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20120111453 | TREE STUMP REMOVAL DEVICE - A tree stump removal device is disclosed. The device includes an annular housing having cutters attached thereto. A method of removing a tree stump is disclosed that includes lowering a tree stump removal device into the ground surrounding the tree stump to severe some or all of the horizontal roots extending from the tree stump. | 05-10-2012 |
20150068645 | TREE STUMP REMOVAL DEVICE - A tree stump removal device is disclosed. The device includes an annular housing having cutters attached thereto. A method of removing a tree stump is disclosed that includes lowering a tree stump removal device into the ground surrounding the tree stump to severe some or all of the horizontal roots extending from the tree stump. | 03-12-2015 |
J. Bradford Kline, Norristown, PA US
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20090155797 | Methods For Generating Enhanced Antibody-Producing Cell Lines With Improved Growth Characteristics - The use of mismatch repair (MMR) defective antibody producer cells offers a method to generate subclone variants with elevated protein production such as antibodies. Using MMR defective cells and animals, new cell lines and animal varieties with novel and useful properties such as enhanced protein production can be generated more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within host cells to alter endogenous genes that can yield increased titer levels of protein production. By employing this method, two genes were discovered whose suppressed expression is associated with enhanced antibody production. Suppressed expression of these genes by a variety of methods leads to increased antibody production for manufacturing as well as strategies for modulating antibody production in immunological disorders. Moreover, the suppression of these two genes in host cells can be useful for generating universal high titer protein production lines. | 06-18-2009 |
Kevin N. Kline, Southampton, PA US
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20090000035 | TWO-PIECE LIGHTWEIGHT LITTER SYSTEM - This invention is directed to a durable, compact, two-piece, light weight, load sustaining litter system for the transport of humans, animals or objects. The litter system comprises a litter frame, a fabric disposed between the structure of the frame, at least one hinge and at least one coupling mechanism. The litter system may be quickly assembled under adverse conditions and may be particularly beneficial in transporting individuals who are injured, disabled and/or incapable of movement under combat and/or emergency conditions. | 01-01-2009 |
20120102651 | TWO-PIECE LIGHTWEIGHT LITTER SYSTEM - This invention is directed to a durable, compact, two-piece, light weight, load sustaining litter system for the transport of humans, animals or objects. The litter system comprises a litter frame, a fabric disposed between the structure of the frame, at least one hinge and at least one coupling mechanism. The litter system may be quickly assembled under adverse conditions and may be particularly beneficial in transporting individuals who are injured, disabled and/or incapable of movement under combat and/or emergency conditions. | 05-03-2012 |
Kevin Roger Kline, Paxinos, PA US
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20110278808 | ADAPTABLE MOBILITY AID DEVICE FOR LEVEL AND INCLINED WALKWAYS AND FOR STAIRS - An adaptable mobility aid device is disclosed that has length-adjustable front and rear legs, a handle, and a knee support platform coupled to the legs and the handle, the legs being adjustable within a range of lengths suitable to straddle steps for ascending and descending stairways, as well as to function on the level, or on a ramp. The lengths of the legs can be adjusted in tandem via single-hand operability of an adjustment mechanism. The knee support platform provides support for an impaired lower leg of a user, not requiring the leg to contact the stairs, and also not requiring the leg to be held mid-air in a hopping motion. The handle enables one-handed use of the adaptable mobility aid device. In some embodiments, spring loaded pins or a pull bar to activate the pins, enable the single-hand operability of the adjustment mechanism. | 11-17-2011 |
20140137912 | SEGMENTED ADAPTABLE MOBILITY AID DEVICE FOR LEVEL AND INCLINED WALKWAYS AND FOR STAIRS - A segmented adaptable mobility aid device is disclosed that has length-adjustable front and rear legs, a handle, and a knee support platform coupled to the legs and the handle, the legs being adjustable within a range of lengths suitable to straddle steps for ascending and descending stairways, as well as to function on the level, or on a ramp. The lengths of the legs can be adjusted in tandem via single-hand operability of an adjustment mechanism. The knee support platform provides support for an impaired lower leg of a user, not requiring the leg to contact the stairs, and also not requiring the leg to be held mid-air in a hopping motion. The handle enables one-handed use of the segmented adaptable mobility aid device. In some embodiments, spring loaded pins or a pull bar to activate the pins, enable the single-hand operability of the adjustment mechanism. | 05-22-2014 |
Laura Kline, Harleysville, PA US
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20100143962 | NANOPARTICULATE POLYCOSANOL FORMULATIONS & NOVEL POLYCOSANOL COMBINATIONS - The invention provides a culture device comprising a plurality of culture units, wherein each unit comprises a culture chamber, an inlet port for liquid supply of the culture and an outlet port for discharging liquid from the unit, wherein the inlet port is in fluid communication with the culture chamber and the culture chamber is in fluid communication with the outlet port for allowing a liquid flow through the culture chamber. The culture device is particularly suitable for testing immune cells and immunofunction in vitro. Aspects of the invention include a culture device and associated methods for cultivating immune cells and an in vitro method of analysing the effect of a test compound on immune cells. | 06-10-2010 |
20100297252 | NANOPARTICULATE MELOXICAM FORMULATIONS - The present invention is directed to nanoparticulate compositions comprising meloxicam particles having an effective average particle size of less than about 2000 nm. | 11-25-2010 |
20140141083 | NANOPARTICULATE MELOXICAM FORMULATIONS - The present invention is directed to nanoparticulate compositions comprising meloxicam particles having an effective average particle size of less than about 2000 nm. | 05-22-2014 |
Laura J. Kline, Harleysville, PA US
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20110165251 | LIQUID DOSAGE COMPOSITIONS OF STABLE NANOPARTICULATE ACTIVE AGENTS - The present invention relates to liquid dosage compositions of stable nanoparticulate active agents. The liquid dosage compositions of the invention include osmotically active crystal growth inhibitors that stabilize the nanoparticulate active agents against crystal and particle size growth of the active agent. | 07-07-2011 |
Mary C. Kline, Glen Rock, PA US
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20130150315 | Anti-Protozoal for Apicomplexan Protozoa - The invention comprising the heretofore veterinary anti-protozoal decoquinate and one or both of a redox drug or macrolide drug for prophylaxis or treatment of | 06-13-2013 |
20130203808 | Drug for degradation and treatment of biofilms - The invention comprising decoquinate and one or both of a redox drug or macrolide drug for prophylaxis or treatment of certain biofilms and plaques in humans and animals. | 08-08-2013 |
Mary Ellen Kline, Lancaster, PA US
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20090123502 | MULTI-LAYERED FONDANT CONTAINING CHEWING GUM - The present invention is directed to a multi-layered chewing gum, comprising alternative layers of a chewing gum region comprising a chewing gum composition containing a gum base and a fondant, each layer being separate and discrete and co-extensive, said multilayered chewing gum comprised of at least three layers, wherein the outer layers are comprised of said chewing gum composition, and the fondant layer is sandwiched between the layers comprised of a chewing gum region, said fondant comprised of a first component selected from tastant, a flavor, a sensate and a functional agent and the gum region being comprised of a second component selected from tastant flavor, sensate and a functionality, said first component being distinct from said second component. | 05-14-2009 |
20140302203 | Sealed, Edible Film Packets and Methods of Making and Using Them - The invention provides, in one aspect, a method of making a confectionery packet or sachet formed with an edible film and enclosing a center composition. The packet or sachet can be designed to be placed in the mouth, where the film dissolves and the center composition is released. In preferred embodiments, the center composition comprises a sugar alcohol, such as xylitol, that creates a cooling sensation. Many other flavors and/or colors or sensates can also be used in the center composition, and some embodiments include breath-freshening, anti-bacterial, nutriceutical, or pharmaceutical compositions in the center composition. The invention also comprises the edible packets or sachets, especially those composed of film with a desired retained water level suitable for producing a self-sealing film and/or an edible film packet that is stable at room temperature for at least six to twelve months. | 10-09-2014 |
Richard Scott Kline, Mechanicsburg, PA US
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20110021082 | HIGH DENSITY BACKPLANE CONNECTOR HAVING IMPROVED TERMINAL ARRANGEMENT - A high density backplane connector ( | 01-27-2011 |
20110237103 | WATERPROOF AUDIO JACK AND METHOD OF MAKING THE SAME - An audio jack includes an insulative housing and a number of contacts retained therein. The insulative housing defines a receiving space for receiving a corresponding plug and a number of mounting holes extending inwardly from a mounting wall thereof. Each contact has a tail portion for connecting with a circuit board. A plenty of elastomeric material is filled into the mounting holes around the contacts to make the insulative housing being sealed except the receiving space. | 09-29-2011 |
20110305419 | CONNECTOR ASSEMBLY HAVING GUIDING DEVICE FOR ALIGNING OPTIC MODULE - A connector assembly ( | 12-15-2011 |
Timothy R. Kline, State College, PA US
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20120202225 | METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS - Methods and devices for evaluating a sample from a subject for detecting a target red blood cell protein or antibody are disclosed. In one embodiment, optimized antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell preparation), thus allowing for more efficient detection and reduced test time. In other embodiments, the invention provides methods and devices for target capturing that include a substantially planar surface, optionally having an optimized angle, for capture. Alternative solid phase geometries for capture are disclosed. Optimized methods for cell deposition are also disclosed. Thus, optimized methods, devices, kits, assays for evaluating a sample are disclosed. | 08-09-2012 |