Patent application number | Description | Published |
20100062499 | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLID- IN-2-ONE - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe. | 03-11-2010 |
20100173372 | Recombinant Halohydrin Dehalogenase Polypeptides - The present disclosure provides engineered halohydrin dehalogenase (HHDH) polypeptides having improved enzyme properties as compared to the wild-type HHDH enzyme HheC and other reference engineered HHDH polypeptides. Also provided are polynucleotides encoding the engineered HHDH enzymes, host cells capable of expressing the engineered HHDH enzymes, and methods of using the engineered HHDH enzymes to synthesize a variety of chiral compounds including chiral epoxides and chiral alcohols. | 07-08-2010 |
20120220002 | Recombinant Halohydrin Dehalogenase Polypeptides - The present disclosure provides engineered halohydrin dehalogenase (HHDH) polypeptides having improved enzyme properties as compared to the wild-type HHDH enzyme HheC and other reference engineered HHDH polypeptides. Also provided are polynucleotides encoding the engineered HHDH enzymes, host cells capable of expressing the engineered HHDH enzymes, and methods of using the engineered HHDH enzymes to synthesize a variety of chiral compounds including chiral epoxides and chiral alcohols. | 08-30-2012 |
20120322136 | POLYNUCLEOTIDES ENCODING RECOMBINANT KETOREDUCTASE POLYPEPTIDES - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe. | 12-20-2012 |
20130210098 | ENGINEERED KETOREDUCTASE POLYPEPTIDES - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe. | 08-15-2013 |
Patent application number | Description | Published |
20150132806 | KETOREDUCTASE POLYPEPTIDES - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe. | 05-14-2015 |
20150337272 | KETOREDUCTASE POLYPEPTIDES - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl (1,3-oxazolidin-3-yl))-1-(4-fluorophenyl) pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe. | 11-26-2015 |
Patent application number | Description | Published |
20090119458 | OPPORTUNISTIC BLOCK TRANSMISSION WITH TIME CONSTRAINTS - A technique for determining a data window size allows a set of predicted blocks to be transmitted along with requested blocks. A stream enabled application executing in a virtual execution environment may use the blocks when needed. | 05-07-2009 |
20090119644 | DERIVING COMPONENT STATISTICS FOR A STREAM ENABLED APPLICATION - A technique for generating component usage statistics involves associating components with blocks of a stream-enabled application. When the streaming application is executed, block requests may be logged by Block ID in a log. The frequency of component use may be estimated by analyzing the block request log with the block associations. | 05-07-2009 |
20120096224 | OPPORTUNISTIC BLOCK TRANSMISSION WITH TIME CONSTRAINTS - A technique for determining a data window size allows a set of predicted blocks to be transmitted along with requested blocks. A stream enabled application executing in a virtual execution environment may use the blocks when needed. | 04-19-2012 |
20120221792 | OPPORTUNISTIC BLOCK TRANSMISSION WITH TIME CONSTRAINTS - A technique for determining a data window size allows a set of predicted blocks to be transmitted along with requested blocks. A stream enabled application executing in a virtual execution environment may use the blocks when needed. | 08-30-2012 |
20120278555 | OPPORTUNISTIC BLOCK TRANSMISSION WITH TIME CONSTRAINTS - A technique for determining a data window size allows a set of predicted blocks to be transmitted along with requested blocks. A stream enabled application executing in a virtual execution environment may use the blocks when needed. | 11-01-2012 |
20130081009 | Streaming from a Media Device - A technique for streaming from a media device involves enabling a local device to function as a streaming server. An example of a method according to the technique includes inserting a removable storage device that includes programs associated with a streaming application, running one or more of the programs, ensuring that a streaming software player is installed, and executing a streaming-related activity associated with the streaming application. An example of a system according to the technique includes a means for providing a streaming application that expects content to be found on a media drive, a means for intercepting requests for content expected to be found on the media drive, and a means for honoring the requests with content from a different media location. | 03-28-2013 |
20150019749 | DERIVING COMPONENT STATISTICS FOR A STREAM ENABLED APPLICATION - A technique for generating component usage statistics involves associating components with blocks of a stream-enabled application. When the streaming application is executed, block requests may be logged by Block ID in a log. The frequency of component use may be estimated by analyzing the block request log with the block associations. | 01-15-2015 |
20150143351 | Streaming from a Media Device - A technique for streaming from a media device involves enabling a local device to function as a streaming server. An example of a method according to the technique includes inserting a removable storage device that includes programs associated with a streaming application, running one or more of the programs, ensuring that a streaming software player is installed, and executing a streaming-related activity associated with the streaming application. An example of a system according to the technique includes a means for providing a streaming application that expects content to be found on a media drive, a means for intercepting requests for content expected to be found on the media drive, and a means for honoring the requests with content from a different media location. | 05-21-2015 |
Patent application number | Description | Published |
20150347511 | UNIVERSAL IDENTIFIER - A user listening to a content item on a preceding device and wishes to continue with the listening experience on a subsequent device initiates a continuity request from the subsequent device to the preceding device. The preceding device responds to the received continuity request by determining a multiverse identification that is contained in the continuity request, such that the multiverse identification uniquely identifies the content item that is currently playing on the preceding device over all known playback devices with which it has communicated. The subsequent device determines if the content item exists in a local database of the subsequent device and, if it exists, the subsequent device plays the content item from the local database of the subsequent device, and otherwise obtains the content item. | 12-03-2015 |
20150347550 | WIRELESS CONTENT SYNCHRONIZATION - Mobile devices that perform synchronization operations are configured to reduce the amount of data that must be synced to perform a media content sync operation over a wireless connection. The sync operation is implemented as a two-phase arrangement, synchronizing first in a metadata sync operation and then in a media content sync operation. The source device transmits to the destination device a last known version number of the music database that was synced to the destination device and a current version number of the media database at the source device. In response to a failure of the network connection before completion of the metadata sync operation, upon establishment of a second network connection between the source device and destination device, the metadata sync is completed only for any version numbers that indicate a version subsequent to the last version number that was synchronized over the first network connection. | 12-03-2015 |
20150350766 | MANAGING CONNECTIONS OF A USER DEVICE - Systems, methods, and computer-readable medium are provided for managing connections of user devices. For example, two source devices may be configured to maintain a data stream with one another. The data stream may enable the two source devices to identify one or more connections between each other and at least a third device. In response to receiving an event that indicates content to be provided to the third device, the data stream may be used by the source devices to configure their network connections with the third device. | 12-03-2015 |
Patent application number | Description | Published |
20130124079 | MONITORING OBJECTS ORBITING EARTH USING SATELLITE-BASED TELESCOPES - An ephemeris refinement system includes satellites with imaging devices in earth orbit to make observations of space-based objects (“target objects”) and a ground-based controller that controls the scheduling of the satellites to make the observations of the target objects and refines orbital models of the target objects. The ground-based controller determines when the target objects of interest will be near enough to a satellite for that satellite to collect an image of the target object based on an initial orbital model for the target objects. The ground-based controller directs the schedules to be uploaded to the satellites, and the satellites make observations as scheduled and download the observations to the ground-based controller. The ground-based controller then refines the initial orbital models of the target objects based on the locations of the target objects that are derived from the observations. | 05-16-2013 |
20130124174 | INTERNAL PARALLELISM IN A PARALLEL DISCRETE EVENT SIMULATION FOR SPACE SITUATIONAL AWARENESS - An internally parallel PDES (“IP-PDES”) system performs logical processes in parallel and further performs the internal processing of at least one logical process in parallel. Because the IP-PDES system is PDES-based, each logical process may have its processing performed in parallel with the other logical processes. The IP-PDES system allows for certain logical processes to be designated as internally parallel meaning that the logical process, referred to as an IP logical process, has its internal processing also performed in parallel. The IP-DES system allocates multiple nodes for such an IP logical process so that executable code of the IP logical process executes in parallel at the allocated nodes to simulate the occurrence of an event. Internal parallelism within a PDES may help overcome resource limitations and help speed up the overall simulation. | 05-16-2013 |
20130275036 | SCHEDULER FOR MONITORING OBJECTS ORBITING EARTH USING SATELLITE-BASED TELESCOPES - An ephemeris refinement system includes satellites with imaging devices in earth orbit to make observations of space-based objects (“target objects”) and a ground-based controller that controls the scheduling of the satellites to make the observations of the target objects and refines orbital models of the target objects. The ground-based controller determines when the target objects of interest will be near enough to a satellite for that satellite to collect an image of the target object based on an initial orbital model for the target objects. The ground-based controller directs the schedules to be uploaded to the satellites, and the satellites make observations as scheduled and download the observations to the ground-based controller. The ground-based controller then refines the initial orbital models of the target objects based on the locations of the target objects that are derived from the observations. | 10-17-2013 |
20140267722 | INTEGRATED TELESCOPE ASSEMBLY - The telescopes described are configured in an integrated telescope package by permanently fixing optical components of the telescope at predefined positions without having movable or adjustable components in the optical layout of the telescope to improve immunity to vibrations and other perturbations and to maintain stability of the optical alignment. | 09-18-2014 |
20140278082 | TRACKING TARGET OBJECTS ORBITING EARTH USING SATELLITE-BASED TELESCOPES - A system for tracking objects that are in earth orbit via a constellation or network of satellites having imaging devices is provided. An object tracking system includes a ground controller and, for each satellite in the constellation, an onboard controller. The ground controller receives ephemeris information for a target object and directs that ephemeris information be transmitted to the satellites. Each onboard controller receives ephemeris information for a target object, collects images of the target object based on the expected location of the target object at an expected time, identifies actual locations of the target object from the collected images, and identifies a next expected location at a next expected time based on the identified actual locations of the target object. The onboard controller processes the collected image to identify the actual location of the target object and transmits the actual location information to the ground controller. | 09-18-2014 |
20140330544 | MODELING THE LONG-TERM EVOLUTION OF SPACE DEBRIS - A space object modeling system that models the evolution of space debris is provided. The modeling system simulates interaction of space objects at simulation times throughout a simulation period. The modeling system includes a propagator that calculates the position of each object at each simulation time based on orbital parameters. The modeling system also includes a collision detector that, for each pair of objects at each simulation time, performs a collision analysis. When the distance between objects satisfies a conjunction criterion, the modeling system calculates a local minimum distance between the pair of objects based on a curve fitting to identify a time of closest approach at the simulation times and calculating the position of the objects at the identified time. When the local minimum distance satisfies a collision criterion, the modeling system models the debris created by the collision of the pair of objects. | 11-06-2014 |