Patent application number | Description | Published |
20110166028 | METHODS FOR PREDICTING TREATMENT RESPONSE BASED ON THE EXPRESSION PROFILES OF BIOMARKER GENES IN NOTCH MEDIATED CANCERS - The invention relates to the identification and use of gene expression profiles with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. The same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. The methods may further comprise selecting a treatment based on the classifying step. | 07-07-2011 |
20130178391 | METHODS FOR PREDICTING TREATMENT RESPONSE BASED ON THE EXPRESSION PROFILES OF BIOMARKER GENES IN NOTCH MEDIATED CANCERS - The invention relates to the identification and use of gene expression profiles, or patterns, with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. It is to be understood and will be appreciated that the same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. Classifying may include stratifying the tumor (and thus stratifying a subject having the tumor), e.g., for a clinical trial. The methods may further comprise selecting a treatment based on the classifying step. The gene expression profiles may also aid in the early identification of patients who may be failing a therapeutic protocol with a gamma secretase inhibitor and thus provide the basis for early intervention. | 07-11-2013 |
Patent application number | Description | Published |
20080240936 | Portable air compressor - A wheelbarrow compressor is disclosed that includes a base and a first reservoir and a second reservoir having bottom portions located at opposite sides of the base. The base is located below an uppermost surface of the first and the second reservoirs. A handle assembly is attached with a first portion of at least one of the reservoirs and a wheel assembly is attached with a second portion of the at least one of the reservoirs. A pump and a motor are operatively connected with the reservoirs and are disposed on the base and between the reservoirs. | 10-02-2008 |
20080273994 | AIR COMPRESSOR SYSTEM - An air compressor includes a compressor pump, a first air tank and a second air tank. The first air tank is in fluid communication with the output of the compressor pump and the second tank. The air compressor can be operated with the second air tank physically connected to the first air tank, or with the second air tank removed from the first air tank. | 11-06-2008 |
20100047085 | PORTABLE AIR COMPRESSOR - A wheelbarrow compressor is disclosed that includes first and second reservoirs having first and second portions, a handle assembly attached with the first portion and a wheel assembly attached with the second portion, and at least one first secondary handle and at least one second secondary handle. The at least one first secondary handle is attached to at least one of the reservoirs. The at least one second secondary handle is attached to at least one of the reservoirs. One of the secondary handles is located closer to the second portion than the other of the secondary handles. The handle assembly is not either of the secondary handles. | 02-25-2010 |
20100111717 | AIR COMPRESSOR ASSEMBLY INCLUDING DETACHABLE TOOL STORAGE BIN - An air compressor assembly is disclosed. The air compressor assembly includes a substantially curved frame including a lower frame portion and an upper frame portion, a fluid tank carried by the lower frame portion, a compressor mechanism carried by the lower frame portion, and a storage bin including an engagement mechanism releasably coupled to the upper frame portion. | 05-06-2010 |
20100290929 | PORTABLE AIR COMPRESSOR - An air compressor includes a compressor unit having a motor with a motor housing, a pump operably coupled to the motor and having a pump housing formed as a single piece with a portion of the motor housing, and a first tank fluidly connected to the pump to receive pressurized air from the pump when operated by the motor. The air compressor also includes a tank unit removably coupled to the compressor unit in a stacked arrangement. The tank unit includes a second tank fluidly connected to the pump to receive pressurized air from the pump when operated by the motor. | 11-18-2010 |
20110158828 | PORTABLE AIR COMPRESSOR - A portable air compressor includes an air tank for storing compressed air, the air tank having a generally flattened spherical shape defining a circumference lying in a plane oriented substantially perpendicular to a support surface in a resting position. The portable air compressor also includes compressor components in fluid communication with the air tank for providing compressed air to the air tank, the compressor components positioned adjacent to the air tank substantially on one side of the plane. At least one foot is coupled to the air tank and extends substantially parallel to the plane, the at least one foot for at least partially supporting the air compressor on the support surface such that the plane is oriented substantially perpendicular to the support surface. A handle extends from the air tank substantially parallel to the plane and in a direction generally opposite the at least one foot. | 06-30-2011 |
20120321488 | PORTABLE AIR COMPRESSOR - A wheelbarrow compressor has a resting position and a transport position. First and second reservoirs contain a compressed fluid, and the second reservoir is fluidly separate from the first reservoir. The second reservoir is positioned above the first reservoir in a generally vertical direction when the wheelbarrow compressor is in the resting position. A handle assembly is attached at a rear end of the wheelbarrow compressor, and a wheel assembly attached at a front end of the wheelbarrow compressor generally opposite the rear end. A pump is fluidly connected to the first and second reservoirs for providing the compressed fluid thereto, and a motor is operatively connected to the pump to drive the pump. The pump and motor are positioned adjacent the first and second reservoirs in a generally horizontal direction when the wheelbarrow compressor is in the resting position. | 12-20-2012 |