Patent application number | Description | Published |
20080274326 | FABRIC BASED LAMINAR COMPOSITE AND METHOD FOR MANUFACTURE THEREOF - Fiber based z-directional reinforced composites having enhanced inter-laminar strength, impact toughness, transmission properties (electrical and thermal conduction) and coefficient of thermal expansion are provided. The composites include at least two substrates separated by a reinforcement zone that includes a plurality of fibers disposed in a binder resin. At least some, and in one embodiment, a majority, of the fibers are oriented so as to be substantially perpendicular to the substrates. Multi-layered composites having more than two substrate layers can also be formed. Methods for forming such composites are also provided. | 11-06-2008 |
20090035599 | HIGH EFFICIENCY BIOCONVERSION SURFACE MATERIALS - Flocked textile materials are disclosed as a support media for bacteria that actively biochemically convert noxious chemical species. Flocked fibrous netting materials as bioconversion support media are favorable to biological growth and provide excellent liquid (e.g. wastewater) flow through its structure as well as accommodating aeration processes. The disclosed support materials can be geometrically designed and positioned in many ways including stacked sheets/plies, rolled sheets in single or multi-walled tubes, and continuous belts or webs that can be self-cleaning and configured to operate in an automated process control mode. The disclosed support media facilitate development of compact and durable biofilter structures at a low cost. | 02-05-2009 |
20110262951 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers. | 10-27-2011 |
20110262952 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers which have randomly splayed terminal ends. | 10-27-2011 |
20130096463 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers which have randomly splayed terminal ends. | 04-18-2013 |
20130196363 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers. | 08-01-2013 |
20130330502 | PANEL FOR ABSORBING MECHANICAL IMPACT ENERGY AND METHOD OF MANUFACTURE - A panel for absorbing mechanical impact energy includes a substrate and a multiplicity of fibers attached, by one of their ends, to the substrate with their other ends extending away from the substrate. The panel may include a thin, porous covering layer that overlies the free ends of the fibers. The porosity of the cover and the fiber density of the fibers may allow for breathability of the panel. The panels may be flexible and may be used in body protection devices such as helmets, body armor as well as in other environments. Panels may be configured in a variety of energy absorbing arrangements for differing applications. | 12-12-2013 |
Patent application number | Description | Published |
20100029003 | System and methods for identifying miRNA targets and for altering miRNA and target expression - The present invention generally relates to microRNAs such as vertebrate microRNA (miRNA), for example, mammalian miRNA. Various aspects of the invention are directed to the detection, production, or expression of miRNA. In one aspect, the invention provides systems and methods for identifying targets of miRNA sequences. For instance, in one embodiment, gene sequences comprising UTRs are compared with miRNA sequences to determine the degree of interaction, for example, by determining a free energy measurement between the miRNA sequence and the UTR, and/or by determining complementarity between at least a portion of the miRNA sequence and the UTR. In another aspect, the invention is directed to the regulation of gene expression using miRNA. For example, gene expression within a cell may be altered by exposing the cell to an oligonucleotide comprising a sequence that is substantially antisense to at least a portion of an miRNA region of the gene, for example, antisense to a 6-mer or 7-mer portion of the miRNA. In still another aspect, the invention is directed to the treatment of cancer. For instance, in one set of embodiments, an isolated oligonucleotide comprising a sequence that is substantially antisense to an miRNA, or a portion of an miRNA, is administered to a subject having or being at risk of cancer. Yet other aspects of the invention are directed to compositions or kits including oligonucleotides comprising a sequence that is substantially antisense to an miRNA (or a portion of an miRNA), methods of promoting any of the above aspects, or the like. | 02-04-2010 |
Patent application number | Description | Published |
20100005878 | FLUID LEVEL DETECTOR - A fluid detector includes a piezoelectric element that outputs a first ultrasonic signal in response to an input electrical signal and a lens with an upper portion and a lower portion. A housing is integral with an outer surface of the wall of a container and defines a cylindrical central bore for receiving the lens. The piezoelectric element is coupled to the upper portion of the lens so that the lens focuses the first ultrasonic signal toward the wall so that it enters the wall. An ultrasonic detector is disposed adjacent the outer surface of the wall, for receiving a second ultrasonic signal from the wall that results from the first ultrasonic signal and that is affected by the presence or absence of fluid. The ultrasonic detector generates an output electrical signal corresponding to the second ultrasonic signal. | 01-14-2010 |
20100294034 | FLUID LEVEL DETECTOR - A transducer for use in a fluid detector for determining a presence of a fluid within a container, the transducer comprising a piezoelectric element that outputs an ultrasonic signal in response to an input electrical signal, characterized in that said transducer further comprises, a lens with an upper portion, a lower portion, and a focal point, the upper portion including a curved surface with convex side. The piezoelectric element is coupled to the upper portion of the lens so that, when the lens is disposed adjacent an outer surface of a wall of the container such that the lens is intermediate the piezoelectric element and the wall, the lens focuses the ultrasonic signal toward the focal point of the lens and on the inner surface of the wall. | 11-25-2010 |
20110219871 | FLUID LEVEL DETECTOR - A fluid detector for determining a presence of a fluid within a container, the detector including a sensor assembly with a lens and a sensor element that outputs a first ultrasonic signal in response to an input electrical signal. A generally cylindrical wall extends outwardly from an outer surface of the container and defines a housing with a cylindrical central bore having a base surface. The sensor assembly is coupled to the lens so that the lens focuses the first ultrasonic signal toward the wall. The sensor assembly is positioned such that it receives a second ultrasonic signal from the wall that results from the first ultrasonic signal. The sensor assembly then generates an output electrical signal corresponding to the second ultrasonic signal. | 09-15-2011 |
20120197141 | IMPLANTABLE ECHO DOPPLER FLOW SENSOR FOR MONITORING OF HEMODYNAMICS - Systems, devices and methods of monitoring blood flow velocity are disclosed herein. For example, one method of monitoring blood flow velocity includes: locating a blood flow velocity sensor near the ostium in the coronary sinus; and sensing towards a portion of the aorta. A second example method includes: locating a blood flow velocity sensor in a vein; and sensing towards an adjacent artery. A third example method includes: locating a blood flow velocity sensor near the tricuspid valve; and sensing towards a tricuspid valve annulus. A fourth example method includes: locating a blood flow velocity sensor right ventricular outflow tract; and sensing towards a portion of the aorta. A fifth example method includes: locating a blood flow velocity sensor in the great cardiac vein; and sensing towards a left anterior descending artery. A sixth example method includes: locating a blood flow velocity sensor in the right atrial appendage; and sensing towards a portion of the aorta. | 08-02-2012 |
20140360906 | FLUID LEVEL DETECTOR - A fluid detector for determining a presence of a fluid within a container, the detector including a sensor assembly with a lens and a sensor element that outputs a first ultrasonic signal in response to an input electrical signal. A generally cylindrical wall extends outwardly from an outer surface of the container and defines a housing with a cylindrical central bore having a base surface. The sensor assembly is coupled to the lens so that the lens focuses the first ultrasonic signal toward the wall. The sensor assembly is positioned such that it receives a second ultrasonic signal from the wall that results from the first ultrasonic signal. The sensor assembly then generates an output electrical signal corresponding to the second ultrasonic signal. | 12-11-2014 |
20150075278 | FLUID LEVEL DETECTOR - A transducer for use in a fluid detector for determining a presence of a fluid within a container, the transducer comprising a piezoelectric element that outputs an ultrasonic signal in response to an input electrical signal, characterized in that said transducer further comprises, a lens with an upper portion, a lower portion, and a focal point, the upper portion including a curved surface with convex side. The piezoelectric element is coupled to the upper portion of the lens so that, when the lens is disposed adjacent an outer surface of a wall of the container such that the lens is intermediate the piezoelectric element and the wall, the lens focuses the ultrasonic signal toward the focal point of the lens and on the inner surface of the wall. | 03-19-2015 |
20150223702 | IMPLANTABLE ECHO DOPPLER FLOW SENSOR FOR MONITORING OF HEMODYNAMICS - Systems, devices and methods of monitoring blood flow velocity are disclosed herein. For example, one method of monitoring blood flow velocity includes: locating a blood flow velocity sensor near the ostium in the coronary sinus; and sensing towards a portion of the aorta. A second example method includes: locating a blood flow velocity sensor in a vein; and sensing towards an adjacent artery. A third example method includes: locating a blood flow velocity sensor near the tricuspid valve; and sensing towards a tricuspid valve annulus. A fourth example method includes: locating a blood flow velocity sensor right ventricular outflow tract; and sensing towards a portion of the aorta. A fifth example method includes: locating a blood flow velocity sensor in the great cardiac vein; and sensing towards a left anterior descending artery. A sixth example method includes: locating a blood flow velocity sensor in the right atrial appendage; and sensing towards a portion of the aorta. | 08-13-2015 |
Patent application number | Description | Published |
20090117268 | CONDUCTIVE POLYMER COATINGS AND METHODS OF FORMING THE SAME - Conductive polymer coatings and methods of forming the same are provided. | 05-07-2009 |
20100186740 | COATING METHODS, SYSTEMS AND RELATED ARTICLES - Medical articles with coatings are disclosed herein, as well as methods and systems for depositing these coatings onto medical articles. Surfaces of such articles may be coated. The coating(s) may serve as lubricants for reducing stiction between such surfaces or between a coated surface and another surface. | 07-29-2010 |
20120003497 | COATING METHODS, SYSTEMS, AND RELATED ARTICLES - Coated articles and methods and systems for coating the articles are described herein. The methods and systems described herein include, but are not limited to, steps for actively or passively controlling the temperature during the coating process, steps for providing intimate contact between the substrate and the support holding the substrate in order to maximize energy transfer, and/or steps for preparing gradient coatings. Methods for depositing high molecular weight polymeric coatings, end-capped polymer coatings, coatings covalently bonded to the substrate or one another, metallic coatings, and/or multilayer coatings are also disclosed. Deposition of coatings can be accelerated and/or improved by applying an electrical potential and/or through the use of inert gases. | 01-05-2012 |
20130171546 | Coatings for Electrowetting and Electrofluidic Devices - Electrowetting devices coated with one or more polymeric layers and methods of making and using thereof are described herein. The coatings may be formed in a single layer or as multiple layers. In one embodiment the first layer deposited serves as an insulating layer of high dielectric strength while the second layer deposited serves as a hydrophobic layer of low surface energy. These materials may themselves be deposited as multiple layers to eliminate pinhole defects and maximize device yield. In one embodiment the insulating layer would be a vapor deposited silicone polymeric material including, but not limited to, polytrivinyltrimethylcyclotrisiloxane or polyHVDS. In another embodiment the insulating layer may be a vapor deposited ceramic such as SiO | 07-04-2013 |
20140135708 | Coating Methods and Coated Syringe - Medical articles with coatings are disclosed herein, as well as methods and systems for depositing these coatings onto medical articles. Surfaces of such articles may be coated. The coating(s) may serve as lubricants for reducing suction between such surfaces or between a coated surface and another surface. | 05-15-2014 |
20150079284 | Methods for Coating Articles - Coated articles and methods and systems for coating the articles are described herein. The methods and systems described herein include, but are not limited to, steps for actively or passively controlling the temperature during the coating process, steps for providing intimate contact between the substrate and the support holding the substrate in order to maximize energy transfer, and/or steps for preparing gradient coatings. Methods for depositing high molecular weight polymeric coatings, end-capped polymer coatings, coatings covalently bonded to the substrate or one another, metallic coatings, and/or multilayer coatings are also disclosed. Deposition of coatings can be accelerated and/or improved by applying an electrical potential and/or through the use of inert gases. | 03-19-2015 |
Patent application number | Description | Published |
20110144054 | Polyol and Polyether Iron Oxide Complexes as Pharmacological and/or MRI Contrast Agents - Pharmacological compositions, and methods for administration, of the type employing an iron oxide complex with a polyol or polyether. The methods of administration may comprise parenteral administration of an effective dose of the complex formulated in a biocompatible liquid delivered at a rate of from about 1 mL/sec to less than 1 mL/min and wherein upon administration the complex provides minimal detectable free iron in a subject, and minimal incidence of anaphylaxis. The pharmacological compositions are of the type employing a polyol or polyether iron oxide complex, which, upon parenteral administration to a subject, are substantially immunosilent, provide minimal anaphylaxis and minimal free iron, and undergo minimal dissolution in vivo. | 06-16-2011 |
20120003160 | Macrophage-Enhanced MRI (MEMRI) in a Single Imaging Session - Methods for performing macrophage-enhanced MRI, utilizing a macrophage imaging agent, in a single imaging session are provided. The macrophage imaging agent may be an ultrasmall superparamagnetic iron oxide particle. One embodiment includes administering a macrophage imaging agent to the subject during an administration session then allowing a passage of time sufficient for accumulation of the agent in macrophages of the subject. Subsequently, in a single imaging session, a macrophage-enhanced magnetic resonance image is acquired to target macrophages and a different magnetic resonance image is acquired to target physiological phenomenon other than macrophages. Additional embodiments provide methods wherein the acquisition of a different magnetic resonance image is achieved by vascular-enhanced MRI protocols or perfusion-enhanced MRI protocols, or combinations thereof. Further embodiments provide methods for utilizing acquired images in assessment of treatment of disease. | 01-05-2012 |
20130121929 | Polyol and Polyether Iron Oxide Complexes as Pharmacological and/or MRI Contrast Agents - Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods. | 05-16-2013 |
20140178310 | Polyol and Polyether Iron Oxide Complexes as Pharmacological and/or MRI Contrast Agents - Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods. | 06-26-2014 |
20140296509 | Polyol and Polyether Iron Oxide Complexes as Pharmacological and/or MRI Contrast Agents - Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods. | 10-02-2014 |
Patent application number | Description | Published |
20080314926 | MODULAR BEVERAGE DISPENSING SYSTEM AND METHOD - A mobile beverage dispensing unit includes a replaceable syrup module, a replaceable liquid module, and a replaceable mixing module. The replaceable mixing module creates a beverage by mixing liquid that is dispensed from the replaceable liquid module and syrup that is contained in the replaceable syrup module to create a beverage. The mobile beverage dispensing unit may contain a replaceable dispensing module that dispenses the beverage that is formed in the replaceable mixing module. A plumbing module may connect the replaceable liquid module and the replaceable syrup module to the replaceable mixing module and may also connect the replaceable mixing module to the replaceable dispensing unit. A user may cause the beverage to be dispensed from the replaceable dispensing module by operating a dispensing mechanism that controls the flow of the beverage. | 12-25-2008 |
20100273602 | TRACTION DRIVE SYSTEM - A traction drive system for an articulated robotic arm. The traction drive system can include an input drive disk, a spider, an array of traction balls, a traction plate, an output drive shaft, a clamping device to load the traction balls, and an absolute rotation position sensor system. The rotation of the output drive shaft can be coupled to the rotation of the input drive disk while the traction balls are frictionally engaged to the drive disk surface and traction plate surface. The rotational connection can be decoupled when the traction balls are not frictionally engaged to the drive disk surface and traction plate surface. A rotational position sensor located in proximity to the traction drive can provide absolute rotational position feedback of the output drive shaft. | 10-28-2010 |
20110257565 | SEPARABLE SYSTEM FOR APPLYING COMPRESSION AND THERMAL TREATMENT - The invention relates to a separable device for the application of compression and thermal therapy to a patient. A first section includes a reservoir, liquid pump and a thermal exchange system for the application of thermal therapy as well as a dock. The second section of the device includes an air compressor and at least one controller for the application of compression therapy and can be operated independently from the first section. Additionally, the second section may be engaged with a dock of the first section. | 10-20-2011 |
20120061418 | DELIVERY SYSTEM - A product delivery system for delivering a product from a storage area to a dispensing area, such as for use in a vending machine. The product delivery system may include a vacuum holding device, a robotic positioning system, a reel and cable system, and a controller. A feature is the provision of a picker head with a built-in vacuum generating source that may be carried by a robotically movable arm system. | 03-15-2012 |
Patent application number | Description | Published |
20090149395 | NOVEL MACROCYCLIC POLYENE LACTAMS - The invention relates generally to novel macrocyclic polyene lactams and their analogs, to processes for the preparation of these novel macrocyclic polyene lactams, to pharmaceutical compositions comprising the novel macrocyclic polyene lactams; and to methods of using the novel macrocyclic polyene lactams to treat or inhibit various disorders. | 06-11-2009 |
20090156514 | NOVEL MACROLACTAM COMPOUNDS - The invention relates generally to novel macrolactams and their analogs, to processes for the preparation of these novel macrolactams, to pharmaceutical compositions comprising the novel macrolactams; and to methods of using the novel macrolactams to treat or inhibit various disorders. | 06-18-2009 |
20100130450 | Methods of Treating Fungal Infections - Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators are disclosed. | 05-27-2010 |
20100216852 | METHODS FOR SCREENING ANTIMICROBIAL AND ANTIVIRAL COMPOUNDS AND USES THEREOF - The invention features compounds that have antibacterial activity, their use for the treatment of bacterial infections, screening methods that use whole animals or plant seedlings to identify compounds that inhibit a pathogen in the animal or plant, and screening methods to identify compounds that increase the lifespan of an organism. | 08-26-2010 |
20110046142 | ANTIBIOTIC COMPOUNDS - Methods for identifying prodrug antibiotic compounds and direct inhibitory antibiotic compounds utilizing various screens are provided. Also provided are methods for treating infections using these compounds. | 02-24-2011 |
20110136752 | NOVEL ANTIBIOTICS - The invention relates generally to novel antibiotics and their analogs, to processes for the preparation of these novel antibiotics, to pharmaceutical compositions comprising the novel antibiotics; and to methods of using the novel antibiotics to treat or inhibit various disorders. | 06-09-2011 |
20120232110 | Antimicrobial Compounds - This disclosure relates to compositions including certain compounds identified by a quantitative, high throughput assay to be effective in inhibiting the ability of a bacterium to kill a host organism, as well as methods for using these compounds for treating bacterial infections. | 09-13-2012 |
20120252820 | METHODS OF TREATING FUNGAL INFECTIONS - Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators to treat fungal infections are disclosed. | 10-04-2012 |
20120302613 | NOVEL ANTIBIOTICS - The invention relates generally to novel antibiotics and their analogs, to processes for the preparation of these novel antibiotics, to pharmaceutical compositions comprising the novel antibiotics; and to methods of using the novel antibiotics to treat or inhibit various disorders. | 11-29-2012 |
20140031275 | METHODS OF ERADICATING BACTERIAL CELL POPULATIONS - Disclosed herein are methods and compositions for the eradication of bacterial infections. In particular, methods and compositions are disclosed for the eradication of persister and slow growing bacterial cell populations. In particular embodiments, the methods and compositions disclosed herein are useful for eradication of biofilms. | 01-30-2014 |
20140194345 | NOVEL DEPSIPEPTIDE AND USES THEREOF - The present invention relates generally to novel depsipeptides, to methods for the preparation of these novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides to treat or inhibit various disorders. | 07-10-2014 |
20140199372 | MICROBIAL GROWTH FACTORS - Disclosed are methods of cultivating or isolating a microorganism using one or more quinones as growth factors. Also disclosed are methods of treating a mammalian species with deficiency in symbionts using such compounds. | 07-17-2014 |
20140200241 | PRODRUGS FOR TREATING MICROBIAL INFECTIONS - Disclosed are methods of inhibiting the growth of pathogens using prodrug compounds as described herein. Also disclosed are methods of treating microbial infections using such compounds. | 07-17-2014 |
20140202964 | ANTIMICROBIAL POLYCATIONIC SAND FILTER FOR WATER DISINFECTION - A composition comprised of sand and a hydrophobic polycationic polymer covalently bonded to the sand is provided. Exemplary polycationic polymer are N,N-hexyl, methyl-PEI or N,N-dodecyl, methyl-PEI. This antimicrobial polycationic sand filter uses the antimicrobial properties of hydrophobic polycations (N-hexylated polyethylenimine). The sand filter inactivates microorganisms, as water is run through the sand. Preliminary sand washing methods can be used regenerate the inactivation efficacy. Unlike traditional water disinfectants, the polycationic sand filter does not create harmful disinfection byproducts and does not require large chemical and energy consumption. | 07-24-2014 |
20150011397 | METHODS FOR QUANTITATIVE DETERMINATION OF MULTIPLE PROTEINS IN COMPLEX MIXTURES - In various embodiments, the present invention relates generally to analysis of complex mixtures and, more specifically, to detection and quantitative determination of multiple proteins, protein modifications, and protein-nucleic acid interactions in those complex mixtures. | 01-08-2015 |
20150011398 | METHODS FOR QUANTITATIVE DETERMINATION OF PROTEIN-NUCLEIC ACID INTERACTIONS IN COMPLEX MIXTURES - In various embodiments, the present invention relates generally to analysis of complex mixtures and, more specifically, to detection and quantitative determination of multiple proteins, protein modifications, and protein-nucleic acid interactions in those complex mixtures. | 01-08-2015 |
Patent application number | Description | Published |
20140316217 | SYSTEM AND METHOD FOR MONITORING ANESTHESIA AND SEDATION USING MEASURES OF BRAIN COHERENCE AND SYNCHRONY - A system and method for monitoring and controlling the administration of at least one drug having anesthetic properties are provided. In certain embodiments, the method includes assembling physiological data, obtained from a plurality of sensors placed on a subject, into sets of time-series data, separating, from the sets of time-series data, a plurality of low frequency signals, and determining, from the plurality of low frequency signals, at least one of coherence information and synchrony information. The method can also include identifying, using the at least one of the coherence information and the synchrony information, spatiotemporal signatures indicative of at least one of a current state and a predicted future state of the patient consistent with the administration of at least one drug having anesthetic properties and generating a report indicating at least one of the current state and the predicted future state of the patient induced by the drug. | 10-23-2014 |
20150011907 | Systems and Methods To Infer Brain State During Burst Suppression - Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject's brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles. The method further includes determining, based on the comparison, a likelihood of a brain state of the subject underlying the burst suppression state, and generating a report indicative of the likelihood of the determined brain state. | 01-08-2015 |
Patent application number | Description | Published |
20110008468 | Uses of chemicals to modulate GSK-3 signaling for treatment of bipolar disorder and other brain disorders - Aspects of this invention are related, at least in part, to the use of chemical compounds able to inhibit GSK-3 and/or to stabilize β-catenin and formulations thereof. Some aspects of this invention relate to compositions comprising such compounds. Some aspects of the invention provide methods of using such compounds and/or compositions in the treatment of subjects having a neurological disease and/or psychiatric disorder. Some aspects of this invention provide methods of using ruboxistaurin, enzastaurin, sunitinib, midostaurin, lestaurtinib, 7-hydroxystaurosporine, and/or Chir99021 in the treatment of subjects having a neurological disease and/or psychiatric disorder. In some embodiments, compounds are administered in combination with Lithium. | 01-13-2011 |
20140107141 | KINASE INHIBITORS AND METHODS OF USE THEREOF - The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychriatic disorders, metabolic disorders, and cancer. | 04-17-2014 |
20150191427 | INHIBITORS OF HISTONE DEACETYLASE - The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein X | 07-09-2015 |
Patent application number | Description | Published |
20090124609 | Fused heterocyclic derivatives and methods of use - Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. | 05-14-2009 |
20090124612 | Fused heterocyclic derivatives and methods of use - Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. | 05-14-2009 |
20090318436 | Fused heterocyclic derivatives and methods of use - Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. | 12-24-2009 |
20120107275 | FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE - Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. | 05-03-2012 |
20130158019 | PYRIMIDINE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE - Compounds of Formula I are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula I have the following structure: | 06-20-2013 |
20130217668 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE - Compounds of Formula (I) are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula (I) have the following structure: where the definitions of the variables are provided herein. | 08-22-2013 |
20140107109 | AMINO-DIHYDROTHIAZINE AND AMINO-DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 04-17-2014 |
20150038497 | BRIDGED BICYCLIC AMINO THIAZINE DIOXIDE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 02-05-2015 |
Patent application number | Description | Published |
20100296508 | SYSTEM AND METHOD FOR BYPASSING DATA FROM EGRESS FACILITIES - An open architecture platform bypasses data from the facilities of a telecommunications carrier, e.g. an incumbent local exchange carrier, by distinguishing between voice and data traffic, and handling voice and data traffic separately. An SS7 gateway receives and transmits SS7 signaling messages with the platform. When signaling for a call arrives, the SS7 gateway informs a control server on the platform. The control server manages the platform resources, including the SS7 gateway, tandem network access servers (NASs) and modem NASs. A tandem NAS receives the call over bearer channels. The control server determines whether the incoming call is voice traffic or data traffic, by the dialed number, and instructs the tandem NAS how to handle the call. Voiced traffic is transmitted to a switch for transmission from the platform. Data traffic is terminated at a modem NAS, where it is converted into a form suitable for a data network, such as a private data network or an Internet services provider (ISP). The converted data is sent by routers to the data network. The data network need not convert the data, as the function has already been provided by the platform. In lieu of a conversion, the modems can create a tunnel (a virtual private network) between a remote server and the data network. | 11-25-2010 |
20120177195 | VOICE OVER DATA TELECOMMUNICATIONS NETWORK ARCHITECTURE - The present invention describes a system and method for communicating voice and data over a packet-switched network that is adapted to coexist and communicate with a legacy PSTN. The system permits packet switching of voice calls and data calls through a data network from and to any of a LEC, a customer facility or a direct IP connection on the data network. The system includes soft switch sites, gateway sites, a data network, a provisioning component, a network event component and a network management component. The system interfaces with customer facilities (e.g., a PBX), carrier facilities (e.g., a LEC) and legacy signaling networks (e.g., SS7) to handle calls between any combination of on-network and off-network callers. | 07-12-2012 |
20130070757 | VOICE OVER DATA TELECOMMUNICATIONS NETWORK ARCHITECTURE - The present invention describes a system and method for communicating voice and data over a packet-switched network that is adapted to coexist and communicate with a legacy PSTN. The system permits packet switching of voice calls and data calls through a data network from and to any of a LEC, a customer facility or a direct IP connection on the data network. The system includes soft switch sites, gateway sites, a data network, a provisioning component, a network event component and a network management component. The system interfaces with customer facilities (e.g., a PBX), carrier facilities (e.g., a LEC) and legacy signaling networks (e.g., SS7) to handle calls between any combination of on-network and off-network callers. | 03-21-2013 |
20130294439 | SYSTEM AND METHOD FOR BYPASSING DATA FROM EGRESS FACILITIES - An open architecture platform bypasses data from the facilities of a telecommunications carrier, e.g. an incumbent local exchange carrier, by distinguishing between voice and data traffic, and handling voice and data traffic separately. An SS7 gateway receives and transmits SS7 signaling messages with the platform. When signaling for a call arrives, the SS7 gateway informs a control server on the platform. The control server manages the platform resources, including the SS7 gateway, tandem network access servers (NASs) and modem NASs. A tandem NAS receives the call over bearer channels. The control server determines whether the incoming call is voice traffic or data traffic, by the dialed number, and instructs the tandem NAS how to handle the call. Voiced traffic is transmitted to a switch for transmission from the platform. Data traffic is terminated at a modem NAS, where it is converted into a form suitable for a data network, such as a private data network or an Internet services provider (ISP). The converted data is sent by routers to the data network. The data network need not convert the data, as the function has already been provided by the platform. In lieu of a conversion, the modems can create a tunnel (a virtual private network) between a remote server and the data network. | 11-07-2013 |
Patent application number | Description | Published |
20100188443 | SENSOR-BASED FEEDBACK FOR DISPLAY APPARATUS - The invention relates to methods and apparatus for feedback control of image and color quality in a direct-view MEMS display apparatus. The display apparatus includes a lamp capable of providing light, a sensor capable of detecting information indicative of characteristics of light provided by the lamp and outputting a sensor signal based at least partially on the information, and control circuitry for controlling illumination of the lamp based at least partially on the sensor signal. | 07-29-2010 |
20110148948 | CIRCUITS FOR CONTROLLING DISPLAY APPARATUS - A method of operating a display including loading image data to pixels in multiple rows of pixels in an array of pixels during a data loading phase, actuating the pixels in the multiple rows during an update phase, and illuminating at least one lamp during an lamp illumination phase to illuminate the actuated pixels to form an image on the display, in which each of the loading, actuating and illuminating phases partially overlap in time. | 06-23-2011 |
20110164067 | CIRCUITS FOR CONTROLLING DISPLAY APPARATUS - The invention relates to methods and apparatus for forming images on a display utilizing a control matrix to control the movement of MEMS-based light modulators. | 07-07-2011 |
20120320111 | DIRECT-VIEW MEMS DISPLAY DEVICES AND METHODS FOR GENERATING IMAGES THEREON - A direct-view display includes an array of MEMS light modulators and a control matrix formed on a transparent substrate, where each light modulator can be driven into at least two states, and a controller for controlling the states of each light modulator in the array. The control matrix transmits data and actuation voltages to the array. The controller includes an input, a processor, a memory, and an output. The input receives image data encoding an image frame for display. The processor derives a plurality of sub-frame data sets from the image data, where each sub-frame data set indicates desired states of light modulators in multiple rows and multiple columns of the array. The memory stores the plurality of sub-frame data sets. The output outputs the plurality of sub-frame data sets according to an output sequence to drive light modulators into the states indicated in the sub-frame data sets. | 12-20-2012 |
20120320112 | DIRECT-VIEW MEMS DISPLAY DEVICES AND METHODS FOR GENERATING IMAGES THEREON - A direct-view display includes an array of MEMS light modulators and a control matrix formed on a transparent substrate, where each light modulator can be driven into at least two states, and a controller for controlling the states of each light modulator in the array. The control matrix transmits data and actuation voltages to the array. The controller includes an input, a processor, a memory, and an output. The input receives image data encoding an image frame for display. The processor derives a plurality of sub-frame data sets from the image data, where each sub-frame data set indicates desired states of light modulators in multiple rows and multiple columns of the array. The memory stores the plurality of sub-frame data sets. The output outputs the plurality of sub-frame data sets according to an output sequence to drive light modulators into the states indicated in the sub-frame data sets. | 12-20-2012 |
20120320113 | DIRECT-VIEW MEMS DISPLAY DEVICES AND METHODS FOR GENERATING IMAGES THEREON - A direct-view display includes an array of MEMS light modulators and a control matrix formed on a transparent substrate, where each light modulator can be driven into at least two states, and a controller for controlling the states of each light modulator in the array. The control matrix transmits data and actuation voltages to the array. The controller includes an input, a processor, a memory, and an output. The input receives image data encoding an image frame for display. The processor derives a plurality of sub-frame data sets from the image data, where each sub-frame data set indicates desired states of light modulators in multiple rows and multiple columns of the array. The memory stores the plurality of sub-frame data sets. The output outputs the plurality of sub-frame data sets according to an output sequence to drive light modulators into the states indicated in the sub-frame data sets. | 12-20-2012 |
20130069929 | CIRCUITS FOR CONTROLLING DISPLAY APPARATUS - A display includes an array of light modulators each having a first actuator and a second actuator. A control matrix includes a circuit having a first state inverter having an output coupled to an input of a second state inverter. A data store capacitor is coupled to an input of the first inverter and configured to store a data voltage corresponding to a future pixel state of the pixel. A first update interconnect is coupled to the first state inverter and configured such that altering a voltage applied to the first update interconnect causes the first actuator to respond to the stored data voltage. A second update interconnect is coupled to the second state inverter and configured such that altering a voltage applied to the second update interconnect causes the second actuator to respond to a voltage state of the first inverter. | 03-21-2013 |
20130342522 | CIRCUITS FOR CONTROLLING DISPLAY APPARATUS - The invention relates to methods and apparatus for forming images on a display utilizing a control matrix to control the movement of MEMs-based light modulators. | 12-26-2013 |
20140043223 | CIRCUITS FOR CONTROLLING DISPLAY APPARATUS - An apparatus includes a plurality of display elements arranged in an array and a control matrix coupled to the plurality of display elements to communicate data and drive voltages to the display elements. For each display element, the control matrix includes an actuation circuit coupling a voltage source to the display element. The control matrix is configured to apply an actuation voltage to an actuator of the display element throughout an actuation stroke of the actuator and to initiate the actuation of the actuator after a pre-charging signal that initiated the application of the actuation voltage to the actuator has been deactivated. | 02-13-2014 |
20140085274 | DISPLAY DEVICES AND DISPLAY ADDRESSING METHODS UTILIZING VARIABLE ROW LOADING TIMES - An apparatus includes an array of pixels formed on a substrate, a set of data drivers, and a controller. The set of data drivers is configured to output data signals to the pixels. The data signals are representative of subsequent states of each respective pixel. The controller is configured to allocate a first period of time and a second period of time for the data drivers. The first period of time is used to load data into the first set of the pixels, which are located within a first distance from the data drivers. The second period of time is used to load data into a second set of pixels, which are located at distance from the data drivers that is greater than the first distance. The second period of time is longer than the first period of time. | 03-27-2014 |
20140168235 | DISPLAY APPARATUS WITH DENSELY PACKED ELECTROMECHANICAL SYSTEMS DISPLAY ELEMENTS - This disclosure provides systems, methods and apparatus for reducing undesired capacitance and electrostatic attraction among components of electromechanical systems (EMS) displays. An apparatus includes an array of display elements, a control matrix, and an electric insulation layer. The display elements each include a movable light blocking component coupled to a conductive beam. The control matrix includes a plurality of interconnects, including at least one switched interconnect, which passes under and is electrically isolated from at least one of the conductive beam and the movable light blocking component | 06-19-2014 |
20140210864 | LOW-VOLTAGE MEMS SHUTTER ASSEMBLIES - This disclosure provides systems, methods and apparatus for providing relatively thinner and less stiff compliant beams for a shutter assembly. A protective coating is deposited and patterned over the shutter assembly before it is released from a sacrificial mold over which the shutter assembly is formed. Because some primary surfaces of the compliant beams are in contact with the sacrificial mold, these primary surfaces are not coated with the protective coating. Therefore, when the shutter assembly is finally released, the resulting compliant beams are relatively thinner and less stiff providing a reduction in an actuation voltage used to operate the shutter assembly. In some instances, the protective coating is patterned into discontinuous segments before release. | 07-31-2014 |
20140268273 | INTEGRATED ELEVATED APERTURE LAYER AND DISPLAY APPARATUS - This disclosure provides systems, methods and apparatus for displaying images. One such apparatus includes a substrate, an elevated aperture layer (EAL) defining a plurality of apertures formed therethrough, a plurality of anchors for supporting the EAL over the substrate and a plurality of display elements positioned between the substrate and the EAL. Each of the display elements may correspond to at least one respective aperture of the plurality of apertures defined by the EAL. Each display element also includes a movable portion supported over the substrate by a corresponding anchor supporting the EAL over the substrate. In some implementations, one or more light dispersion elements may be disposed in optical paths passing through the apertures defined by the EAL. | 09-18-2014 |
20140268275 | DISPLAY APPARATUS INCORPORATING AN INTERCONNECT-SUPPORTING ELEVATED APERTURE LAYER - This disclosure provides systems, methods and apparatus for displaying images. Some such apparatus include a transparent substrate, a display element formed on the substrate, a light blocking elevated aperture layer (EAL) supported over the substrate by an anchor formed on the substrate, and an electrical interconnect disposed on the EAL for carrying an electrical signal to the display element. The electrical interconnect can include one or more of a data voltage interconnect, a scan-line interconnect or a global interconnect. In some implementations, a dielectric layer can separate the electrical interconnect from the EAL. The EAL can include an aperture formed through it that corresponds to the display element. In some implementations, a second electrical interconnect disposed on the substrate can be electrically coupled to a plurality of display elements. | 09-18-2014 |
20140333598 | Display Apparatus Incorporating Varying Threshold Voltage Transistors - This disclosure provides systems, methods and apparatus for controlling pixels of a display apparatus. An apparatus including a plurality of pixels can be controlled by a control matrix. The control matrix includes for each pixel a first transistor that has a first threshold voltage and a second transistor that has a second threshold voltage. A single data interconnect provides a common data voltage to the first and second transistors to control the states of corresponding first and second light modulators. | 11-13-2014 |