Julio A.
Julio A. Aguirre-Ghiso, Cortlandt Manor, NY US
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20120142634 | Method of Treating Cancer with a Combination of a Proteasome Inhibitor and Salubrinal - The disclosure provides methods for treating or preventing a cancerous condition, such as multiple myeloma, by administering a therapeutically effective combination of a proteasome inhibitor and salubrinal. | 06-07-2012 |
Julio A. Aguirre-Ghiso, Niskayuna, NY US
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20100249184 | INDUCTION AND/OR MAINTENANCE OF TUMOR DORMANCY BY DISRUPTION OF UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR-INTEGRIN INTERACTION - The present invention relates to a method of inducing cancer cells into dormancy and treating cancer in a subject. This method involves administering to a subject an effective amount of a compound that disrupts interaction between urokinase plasminogen activator receptor and integrin, thereby including cancer cells into dormancy and treating cancer in the subject. Also disclosed is a method of disrupting interaction between integrin and urokinase plasminogen activator receptor on cancer cells. The present invention also relates to a method of screening for compounds effective in inducing tumor dormancy and treating cancer in a subject. | 09-30-2010 |
Julio A. Camarero, Livermore, CA US
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20100292104 | Photoswitchable Method for the Ordered Attachment of Proteins to Surfaces - Described herein is a method for the attachment of proteins to any solid support with control over the orientation of the attachment. The method is extremely efficient, not requiring the previous purification of the protein to be attached, and can be activated by UV-light. Spatially addressable arrays of multiple protein components can be generated by using standard photolithographic techniques. | 11-18-2010 |
Julio A. Camarero, Los Angeles, CA US
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20120283136 | COMPOSITIONS AND METHODS FOR THE RAPID BIOSYNTHESIS AND IN VIVO SCREENING OF BIOLOGICALLY RELEVANT PEPTIDES - This invention provides new combinatorial approaches for the biosynthesis and screening of cyclic peptides inside living cells. These novel approaches are useful for finding biologically relevant molecules, e.g., those able to inhibit the cytotoxicity of Anthrax Edema Factor. Key to this ‘living combinatorial’ approach is the use of a living cell as a micro-chemical factory for both synthesis and screening of potential inhibitors for a given molecular recognition event. | 11-08-2012 |
Julio A. Chirinos, Gamet Valley, PA US
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20150366901 | Methods of Treating Heart Failure - The present invention relates to the discovery that the administration of nitrate is an effective therapy for improving short-term and long-term outcomes in patients with heart failure, including heart failure with preserved ejection fraction (HFpEF). Thus, the present invention provides compositions and methods for the treatment or prevention of heart failure, including HFpEF, in a subject in need thereof. | 12-24-2015 |
Julio A. Garceran, Dorham, NC US
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20110248836 | LIGHTING APPARATUS WITH ENCODED INFORMATION - A solid state emitter or emitter package has an associated information containing element including machine readable encoded information that may be indicative of or enable retrieval of information useful for operation and/or control of at least one emitter An information containing element may be dynamically updateable, and may receive signals from at least one sensor arranged to sense a condition or characteristic of an emitter device. Operation of at least one emitter may be adjusted responsive to sensed values and predeveloped operating settings correlated to such values to mitigate degradation of output characteristics. A lighting device such as a lamp or light fixture may include an information exchange element arranged to communicate with an information containing element of an emitter or emitter package. Operation of a lighting device may depend on authentication of an emitter by a lighting. | 10-13-2011 |
Julio A. Garceran, Cary, NC US
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20080197369 | Double flip semiconductor device and method for fabrication - A double flip-chip semiconductor device formed by a double flip fabrication process. Epitaxial layers are grown on a substrate in the normal fashion with the n-type layers grown first and the p-type layers grown subsequently. The chip is flipped a first time and mounted to a sacrificial layer. The original substrate is removed, exposing the n-type layer, and various additional layers and treatments are added to the device. Because the n-type layer is exposed during fabrication, the layer may be processed in various ways including adding a reflective element, texturing the surface or adding microstructures to the layer to improve light extraction. The chip is flipped a second time and mounted to a support element. The sacrificial layer is then removed and additional layers and treatment are added to the device. The finished device features a configuration in which the layers maintain the same orientation with respect to the support element that they had with the original substrate on which they were grown. Processing the n-type layers, rather than the p-type layers as in a single flip process, provides greater design flexibility when selecting features to add to the device. Thus, previously unavailable processes and reflective elements may be utilized, enhancing the external quantum efficiency of the device. | 08-21-2008 |
20110298371 | LED LIGHT BULBS - LED light bulbs include openings in base or cover portions, and optional forced flow elements, for convective cooling. Thermally conductive optically transmissive material may be used for cooling, optionally including fins. A LED light engine may be fabricated from a substrate via planar fabrication techiques and shaped to form a substantially rigid upright support structure. Mechanical, electrical, and thermal connections may be made between a LED light engine and a LED light bulb. | 12-08-2011 |
20140043825 | LED LIGHT BULBS - LED light bulbs include openings in base or cover portions, and optional forced flow elements, for convective cooling. Thermally conductive optically transmissive material may be used for cooling, optionally including fins. A LED light engine may be fabricated from a substrate via planar fabrication techniques and shaped to form a substantially rigid upright support structure. Mechanical, electrical, and thermal connections may be made between a LED light engine and a LED light bulb. | 02-13-2014 |
20140355270 | LED LIGHT BULBS - LED light bulbs include openings in base or cover portions, and optional forced flow elements, for convective cooling. Thermally conductive optically transmissive material may be used for cooling, optionally including fins. A LED light engine may be fabricated from a substrate via planar fabrication techniques and shaped to form a substantially rigid upright support structure. Mechanical, electrical, and thermal connections may be made between a LED light engine and a LED light bulb. | 12-04-2014 |
20150252998 | LED LIGHT BULBS - LED light bulbs include openings in base or cover portions, and optional forced flow elements, for convective cooling. Thermally conductive optically transmissive material may be used for cooling, optionally including fins. A LED light engine may be fabricated from a substrate via planar fabrication techniques and shaped to form a substantially rigid upright support structure. Mechanical, electrical, and thermal connections may be made between a LED light engine and a LED light bulb. | 09-10-2015 |
Julio A. Gonzalez, Cupertino, CA US
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20150348278 | DYNAMIC FONT ENGINE - A method may include receiving a request to render text from an application executing on at least one processor of a computing device, the request including a font usage description; determining, using the at least one processor, a display context in which the text is to be rendered on a output device communicatively coupled to the computing device; querying, using the at least one processor, a usage data source using the determined display context and font usage description to determine font characteristics for rendering the text; and rendering the text on the output device communicatively coupled to the computing device using the determined font characteristics. | 12-03-2015 |
Julio A. Monjes, Tucson, AZ US
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20090116980 | Air and water conditioner by two separated air flows - This device is a water adiabatic evaporative cooler of two separated air flows contained in a cylindrical body, there is the humid peripheral flow which comprises the components of the water evaporation system, the other is the central flow designated as the ambient dry flow where the air current produces the cooling effect. The two air flows are generated by a single axial air blower, the central zone of the air blower drives the atmospheric air through a central concentric body containing an air to water heat exchanger, this is the air to be directed to the controlled ambient, while the peripheral part of the single axial blower drives the air through an external annular adiabatic evaporation chamber, from here the cool condensed moisture goes to the heat exchanger while residual humid air is evacuated to the external atmosphere. | 05-07-2009 |
Julio A. Zimbron, Fort Collins, CO US
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20130031955 | GAS FLUX MEASUREMENT USING TRAPS - A passive sampling apparatus and method for measuring the cumulative mass of a selected gas being transported through a known cross-sectional area, for example, a soil surface, during a chosen period of time, using absorbent material, are described. Two quantities of absorbent material are disposed in a hollow container, such as a pipe section, and spaced apart such that they may be readily separated for analysis. The absorbent material closest to the soil captures the gas leaving the soil. Under reversed flow conditions, for example when the ambient air enters the ground because of fluctuations in atmospheric pressure, the upper absorbent material captures the component of interest entering the apparatus, thereby preventing this gas from entering the lower material and disturbing the measurement. The apparatus can therefore sequester the component of interest without being affected by the direction of gas transport. | 02-07-2013 |