Hill, MA
Andrew Arthur Hill, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20080226645 | Methods and compositions for assessment and treatment of asthma - The present invention provides methods and compositions for the assessment and treatment of asthma and other inflammatory diseases, particularly those mediated by interleukin-13 (IL-13). The present invention also provides arrays comprising markers for asthma as well as IL-13 responsiveness. The markers of the present invention can be used in methods to diagnose a patient as having asthma or an IL-13-mediated condition, to evaluate the effectiveness of potential therapeutic agents, to identify or evaluate agents capable of modulating marker expression levels, and to select a treatment for a patient suffering from asthma or an IL-13-mediated condition. | 09-18-2008 |
20090325176 | Gene Expression Profiles Associated with Asthma Exacerbation Attacks - The present invention provides methods for the assessment, diagnosis, or prognosis of asthma exacerbation, by assessing the level of expression of asthma exacerbation gene products in a sample derived from a patient. The markers of the present invention can be used in methods to identify or evaluate agents capable of modulating marker expression levels in subjects with asthma. | 12-31-2009 |
Benjamin R. Hill, Leominster, MA US
Patent application number | Description | Published |
---|---|---|
20160098757 | SYSTEM AND METHOD FOR ANNOUNCEMENTS VIA A MOBILE DEVICE - A portable communication device and a method for providing announcements to the portable communication device during a setup time. The method includes receiving data associated with one or more announcements in a mobile device through a communication network, detecting initiation of a function operable on the mobile device, the function being associated with a setup time, and upon detection of the initiation, providing an announcement to a user of the mobile device during the setup time. In one aspect, the setup time is a time period between a first instant when the function is initiated and a second instant when the initiated function become operational. | 04-07-2016 |
20160098758 | SYSTEM AND METHOD FOR ANNOUNCEMENTS VIA A MOBILE DEVICE - A portable communication device and a. method for providing announcements to the portable communication device during a setup time. The method includes receiving data associated with one or more announcements in a mobile device through a communication network, detecting initiation of a function operable on the mobile device, the function being associated with a setup time, and upon detection of the initiation, providing an announcement to a user of the mobile device during the setup time. In one aspect, the announcement is an audio recording, and the setup time is a time period between a first instant when the function is initiated and a second instant when the initiated function become operational. | 04-07-2016 |
Bruce Hill, Belmont, MA US
Patent application number | Description | Published |
---|---|---|
20160005062 | PRODUCT-DISTRIBUTION STATION OBSERVATION, REPORTING AND PROCESSING - A computer-readable medium on which are stored computer-executable executable instructions that, when executed in at least one electronic system coupled to a display device and a network, enable the at least one system to perform a method comprising at least the steps of determining the geo-location of the system, determining at least one on-sale retail product associated with the determined geo-location of the system, recording a data set indicating a current price of the determined on-sale retail product, and electronically transferring the data set and an indication of the determined geo-location over the network to a processing device. | 01-07-2016 |
Charles R. Hill, Belmont, MA US
Patent application number | Description | Published |
---|---|---|
20090007113 | SYSTEM AND METHOD FOR INITIATING THE EXECUTION OF A PROCESS - A method and computer program product for defining a plurality of tags, each of which is associated with a discrete process executable on activity content. At least one of the plurality of tags is associated with a piece of content within an activity, thus defining one or more associated tags. | 01-01-2009 |
20090172026 | PERSONALIZED INFORMATION FILTER BASED ON SOCIAL TAGS - Embodiments of the present invention address deficiencies of the art in respect to content personalization and provide a method, system and computer program product for tag-based content personalization. In an embodiment of the invention, a method for tag based personalization of content can be provided. The method can include comparing tags for a user in a social bookmarking system to keywords for content received for the user. The method further can include filtering the content when the keywords do not compare favorably with the tags. In this way, the content preference of a user can be inferred irrespective of the environment in which the content is provided as the keywords of the content can be compared with tags associated with the interests of the recipient of the content. | 07-02-2009 |
20100169270 | DYNAMIC PERSISTENT ACTIVITIES IN ACTIVITY-CENTRIC COMPUTING - Embodiments of the present invention provide a method, system and computer program product for managing dynamic and persistent activity objects in an activity in an activity-centric computing (ACC) system. In an embodiment of the invention, the system can include an ACC system executing in a host server coupled both to a data store of activities and external sources of dynamic content over a computer communications network. The ACC system can be configured to manage an activity structure for an activity in the data store of activities in that the activity structure can include a hierarchical arrangement of activity objects representing underlying static content. The system also can include a dynamic activity module coupled to the ACC system. The module can include program code enabled to insert into the activity structure a dynamic activity object subscribing to one of the external sources of dynamic content to render corresponding dynamic content received from the one of the external sources. | 07-01-2010 |
Chery Hill, North Andover, MA US
Patent application number | Description | Published |
---|---|---|
20120202273 | Enzymatic Conversion Of Blood Group A, B, And AB Red Blood Cells Using Alpha-N-Acetylgalactosaminidases and Alpha-Galactosidases With Unique Substrate Specificities And Kinetic Properties - This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique α-N-acetylgalactosaminidases and α-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells. The preferred unique α-N-acetylgalactosaminidases and α-galactosidases exhibit the following characteristics: (i) exclusive, preferred or no less than 10% substrate specificity for the type A and B branched polysaccharide structures relative to measurable activity with simple mono- and disaccharide structures and aglycon derivatives hereof; (ii) optimal performance at neutral pH with blood group oligosaccharides and in enzymatic conversion of cells; and (iii) a favorable kinetic constant K | 08-09-2012 |
Cheryl Hill, North Andover, MA US
Patent application number | Description | Published |
---|---|---|
20110045569 | ENZYMATIC CONVERSION OF BLOOD GROUP A, B, AND AB RED BLOOD CELLS USING ALPHA-N- ACETYLGALACTOSAMINIDASES AND ALPHA-GALACTOSIDASES WITH UNIQUE SUBSTRATE SPECIFICITIES AND KINETIC PROPERTIES - This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique α-N-acetylgalactosaminidases and α-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells. The preferred unique α-N-acetylgalactosaminidases and α-galactosidases exhibit the following characteristics: (i) exclusive, preferred or no less than 10% substrate specificity for the type A and B branched polysaccharide structures relative to measurable activity with simple mono- and disaccharide structures and aglycon derivatives hereof; (ii) optimal performance at neutral pH with blood group oligosaccharides and in enzymatic conversion of cells; and (iii) a favorable kinetic constant K | 02-24-2011 |
20140220553 | Enzymatic Conversion of Blood Group A, B, and AB Red Blood Cells Using alpha-N-Acetylgalactosaminidases and alpha-Galactosidases with Unique Substrate Specificities and Kinetic Properties - This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique α-N-acetylgalactosaminidases and α-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells. The preferred unique α-N-acetylgalactosaminidases and α-galactosidases exhibit the following characteristics: (i) exclusive, preferred or no less than 10% substrate specificity for the type A and B branched polysaccharide structures relative to measurable activity with simple mono- and disaccharide structures and aglycon derivatives hereof: (ii) optimal performance at neutral pH with blood group oligosaccharides and in enzymatic conversion of cells: and (iii) a favorable kinetic constant Km with mono- and oligosaccharide substrates. The conversion methods of the invention use significantly lower amounts of recombinant glycosidase enzymes than previous and result in complete sera-conversion of all blood group A and B red cells. | 08-07-2014 |
Chloe Hill, Waltham, MA US
Patent application number | Description | Published |
---|---|---|
20150282628 | Bodyrest - A personal rest system includes a headrest shaped and sized to accept a frontal portion of a user's head. The headrest defines a central opening and substantially surrounds the user's face. The headrest includes at least one padded portion against which the user's head can be rested. A mechanically adjustable support frame is coupled to the headrest at an upper end of the adjustable support frame. The support frame is also coupled to a pivoting member at a lower end of said adjustable support frame. A base section is coupled to the pivoting member. The base section includes an attachment portion shaped and configured to mechanically mount the base section to a surface on which said rest system is placed. | 10-08-2015 |
Colin Hill, Somerville, MA US
Patent application number | Description | Published |
---|---|---|
20090204374 | Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents - Systems and methods for modeling the interactions of the several genes, proteins and other components of a cell, employing mathematical techniques to represent the interrelationships between the cell components and the manipulation of the dynamics of the cell to determine which components of a cell may be targets for interaction with therapeutic agents. A first such method is based on a cell simulation approach in which a cellular biochemical network intrinsic to a phenotype of the cell is simulated by specifying its components and their interrelationships. The various interrelationships are represented with one or more mathematical equations which are solved to simulate a first state of the cell. The simulated network is then perturbed by deleting one or more components, changing the concentration of one or more components, or modifying one or more mathematical equations representing the interrelationships between one or more of the components. The equations representing the perturbed network are solved to simulate a second state of the cell which is compared to the first state to identify the effect of the perturbation on the state of the network, thereby identifying one or more components as targets. A second method for identifying components of a cell as targets for interaction with therapeutic agents is based upon an analytical approach, in which a stable phenotype of a cell is specified and correlated to the state of the cell and the role of that cellular state to its operation. A cellular biochemical network believed to be intrinsic to that phenotype is then specified by identifying its components and their interrelationships and representing those interrelationships in one or more mathematical equations. The network is then perturbed and the equations representing the perturbed network are solved to determine whether the perturbation is likely to cause the transition of the cell from one phenotype to another, thereby identifying one or more components as targets. | 08-13-2009 |
Colin C. Hill, Somerville, MA US
Patent application number | Description | Published |
---|---|---|
20080208784 | Systems and methods for modeling and analyzing networks - The systems and methods described herein utilize a probabilistic modeling framework for reverse engineering an ensemble of causal models, from data and then forward simulating the ensemble of models to analyze and predict the behavior of the network. In certain embodiments, the systems and methods described herein include data-driven techniques for developing causal models for biological networks. Causal network models include computational representations of the causal relationships between independent variables such as a compound of interest and dependent variables such as measured DNA alterations, changes in mRNA, protein, and metabolites to phenotypic readouts of efficacy and toxicity. | 08-28-2008 |
20140025358 | SYSTEMS AND METHODS FOR MODELING AND ANALYZING NETWORKS - The systems and methods described herein utilize a probabilistic modeling framework for reverse engineering an ensemble of causal models, from data and then forward simulating the ensemble of models to analyze and predict the behavior of the network. In certain embodiments, the systems and methods described herein include data-driven techniques for developing causal models for biological networks. Causal network models include computational representations of the causal relationships between independent variables such as a compound of interest and dependent variables such as measured DNA alterations, changes in mRNA, protein, and metabolites to phenotypic readouts of efficacy and toxicity. | 01-23-2014 |
David E. Hill, Somerville, MA US
Patent application number | Description | Published |
---|---|---|
20160139127 | ONCOGENE ASSOCIATED WITH HUMAN CANCERS AND METHODS OF USE THEREOF - The present invention provides methods of treating cancer by inhibiting MECP2 and identifying cancers that will respond to therapy using MECP2 as a biomarker. | 05-19-2016 |
David E. Hill, Arlington, MA US
Patent application number | Description | Published |
---|---|---|
20080305490 | AMPLIFICATION OF HUMAN MDM2 GENE IN HUMAN TUMORS - A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MD2 protein binds to human p53 and allows the cell to escape from p53-regulated growth. | 12-11-2008 |
David Gordon Hill, Arlington, MA US
Patent application number | Description | Published |
---|---|---|
20110227754 | METHODS AND SYSTEMS FOR DATA AGGREGATION AND REPORTING - The present application is generally directed to mediums, methods, and systems for providing a data aggregator and reporting engine for utilities data. Exemplary embodiments provide procedures for aggregating and reporting data. According to exemplary embodiments, a base configuration for a data aggregator is provided. A variety of characteristics and functionality are built into the base configuration of the aggregator. Each characteristic may include a plurality of built-in options. By selecting one or more relevant options for each characteristic, a utility provider can build an aggregator that applies a custom profile to aggregate and report utilities data. The options may be selected prior to run-time, or may be selected at run-time. A dynamic reporting framework is also provided. The dynamic reporting framework allows for data aggregations to be calculated during the aggregation process without requiring that either the aggregator or the reporting framework be rebuilt or redesigned. | 09-22-2011 |
David P. Hill, Medfield, MA US
Patent application number | Description | Published |
---|---|---|
20110275981 | ELECTRODE ASSEMBLY FOR DELIVERING A THERAPEUTIC AGENT INTO OCULAR TISSUE - A contact electrode assembly for delivering at least one therapeutic agent into ocular tissue of a subject includes a flexible dielectric layer, a first electrode portion, and a second electrode portion. The flexible dielectric includes oppositely disposed first and second surfaces. The first electrode portion is disposed on the first surface of the dielectric layer. The second electrode portion is disposed on a portion of the second surface of the dielectric layer. The second electrode portion includes an interdigitated electrode having a first comb-shaped portion defining a first plurality of fingers and a second comb-shaped portion defining a second plurality of fingers. Each of the first electrode portion, the first comb-shaped portion, and the second comb-shaped portion is electrically connectable to a signal source. | 11-10-2011 |
Frances Ann Hill, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20140353397 | ELECTROSPRAYING SYSTEMS AND ASSOCIATED METHODS - Electrospraying systems and associated methods are generally described. | 12-04-2014 |
20140353860 | ELECTRICALLY-DRIVEN FLUID FLOW AND RELATED SYSTEMS AND METHODS, INCLUDING ELECTROSPINNING AND ELECTROSPRAYING SYSTEMS AND METHODS - Systems and methods in which the flow of fluid is electrically driven, including electrospinning and electrospraying systems and methods, are generally described. | 12-04-2014 |
20160107178 | ELECTROSPRAYING SYSTEMS AND ASSOCIATED METHODS - Electrospraying systems and associated methods are generally described. | 04-21-2016 |
Gordon Hill, Arlington, MA US
Patent application number | Description | Published |
---|---|---|
20080216901 | Pressure control for vacuum processing system - A pressure control system includes a digital communication network between a pressure sensor and a pressure controller. The digital communication network is configured to communicate signals between the pressure sensor and the pressure controller. The pressure sensor is configured to measure pressure within a vacuum chamber in a processing tool. The pressure controller is responsive to pressure measurements made by the pressure sensor and communicated to the pressure controller through the digital communication network, to control the pressure within the vacuum chamber so as to maintain the pressure in the vacuum chamber at a pressure set point received from the tool. | 09-11-2008 |
20090137192 | MULTI-ZONE PRESSURE CONTROL SYSTEM - A pressure control system that controls the pressure of a fluid in a plurality of zones includes a distribution manifold, at least one main manifold connected to the distribution manifold, and at least one disposable manifold connected to the distribution manifold and the main manifold. The disposable manifold is adapted to be replaced independent of the distribution manifold and the main manifold, and is connected to each zone and to at least one vacuum source. The distribution manifold distributes the fluid to the plurality of zones, so as to cause flow of the fluid into and out of a measurement chamber located within each zone. The main manifold includes, for each zone, a pressure sensor configured to measure pressure in the measurement chamber in that zone, and a control valve configured to regulate the flow of the fluid through that zone. | 05-28-2009 |
20090314074 | Preventive Maintenance Diagnostics for Valve Systems - A valve system includes a valve and a controller that controls the valve. The valve includes a valve body, and a motor configured to deliver a torque to the valve body to cause the valve body to move between an open position and a closed position. The controller is configured to drive the motor by applying a current to the motor. The controller is configured to measure the torque delivered by the motor to the valve body, compare the calculated torque with a threshold value, and diagnose a need by the valve system for preventive maintenance when the calculated torque is substantially equal to the threshold value. The threshold value represents substantially the maximum amount of torque available from the stepper motor. | 12-24-2009 |
20110181191 | Laser-Driven Light Source - An apparatus for producing light includes a chamber and an ignition source that ionizes a gas within the chamber. The apparatus also includes at least one laser that provides energy to the ionized gas within the chamber to produce a high brightness light. The laser can provide a substantially continuous amount of energy to the ionized gas to generate a substantially continuous high brightness light. | 07-28-2011 |
20120202408 | PRESSURE REGULATION IN REMOTE ZONES - A pressure control system remotely controls pressure within one or more remote zones, each respectively connected to an enclosure through a conduit, by controlling flow of a fluid into and out of each enclosure. The pressure of the fluid is measured within each enclosure. An estimated pressure within each zone is computed, as a function of the measured pressure in the enclosure and known characteristics of the conduit and the zone. For each zone, an inlet proportional valve and an outlet proportional valve of each enclosure is operated so as to control the input flow rate of the fluid into the respective enclosure and the output flow rate of the fluid out of the enclosure as a function of a pressure set point and the estimated pressure, thereby regulating pressure within the zone in accordance with the pressure set point. | 08-09-2012 |
20140209181 | FLUID CONTROL VALVES - A valve assembly comprises: a valve body including a passageway through which a first gas can be transmitted through the valve assembly; a valve flow control element movable relative to the valve body between an opened position wherein flow through the passageway is at a maximum flow, and a closed position wherein flow through the passageway is at a minimum flow, the valve flow control element is shaped so that a control gap is provided between the valve body and valve flow control element through which the first gas can flow, and the dimensions of the control gap vary depending on the position of the valve flow control element relative to the valve body; and a gas injector arrangement for selectively injecting a second gas into the control gap when the valve assembly is used to control the flow of the first gas through the passageway. The injection of the second gas when the valve flow control element is at or near its closed position helps minimize condensate being deposited on the valve flow control element, as well as reduce the closed conductance of the valve. | 07-31-2014 |
Jason F. Hill, Milford, MA US
Patent application number | Description | Published |
---|---|---|
20140319057 | CHROMATOGRAPHIC MATERIALS FOR THE SEPARATION OF UNSATURATED MOLECULES - The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group. | 10-30-2014 |
20150133294 | CHROMATOGRAPHIC MATERIALS - In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W) | 05-14-2015 |
20150136700 | CHROMATOGRAPHIC MATERIALS - The present invention provides a chromatographic stationary phase material various different types of chromatography. One example chromatographic stationary phase is represented by Formula 1 [X](W) | 05-21-2015 |
20150276690 | RAPID ANALYSIS OF STEROIDS AND STEROID DERIVATIVES - The subject technology is directed to a CO | 10-01-2015 |
Jeffrey Hill, Westford, MA US
Jennifer J. Hill, Somerville, MA US
Patent application number | Description | Published |
---|---|---|
20100021462 | GASP1: A FOLLISTATIN DOMAIN CONTAINING PROTEIN - The present invention relates to the use of a protein, GASP1, comprising at least one follistatin domain to modulate the level or activity of growth and differentiation factor-8 (GDF-8). More particularly, the invention relates to the use of GASP1 for treating disorders that are related to modulation of the level or activity of GDF-8. The invention is useful for treating muscular diseases and disorders, particularly those in which an increase in muscle tissue would be therapeutically beneficial. The invention is also useful for treating diseases and disorders related to metabolism, adipose tissue, and bone degeneration. | 01-28-2010 |
20100047259 | FOLLISTATIN DOMAIN CONTAINING PROTEINS - The present invention relates to the use of proteins comprising at least one follistatin domain to modulate the level or activity of growth and differentiation factor-8 (GDF-8). More particularly, the invention relates to the use of proteins comprising at least one follistatin domain, excluding follistatin itself, for treating disorders that are related to modulation of the level or activity of GDF-8. The invention is useful for treating muscular diseases and disorders, particularly those in which an increase in muscle tissue would be therapeutically beneficial. The invention is also useful for treating diseases and disorders related to metabolism, adipose tissue, and bone degeneration. | 02-25-2010 |
20110020372 | FOLLISTATIN DOMAIN CONTAINING PROTEINS - The present invention relates to the use of proteins comprising at least one follistatin domain to modulate the level or activity of growth and differentiation factor-8 (GDF-8). More particularly, the invention relates to the use of proteins comprising at least one follistatin domain, excluding follistatin itself, for treating disorders that are related to modulation of the level or activity of GDF-8. The invention is useful for treating muscular diseases and disorders, particularly those in which an increase in muscle tissue would be therapeutically beneficial. The invention is also useful for treating diseases and disorders related to metabolism, adipose tissue, and bone degeneration. | 01-27-2011 |
John Charles Hill, Georgetown, MA US
Patent application number | Description | Published |
---|---|---|
20090245467 | SYSTEM AND METHOD OF FAST SWITCHING FOR SPECTRAL IMAGING - A system includes a generator configured to output at least one voltage level and an x-ray source configured to generate x-rays directed toward an object. The system includes a module coupled to the output of the generator and to an input of the x-ray source and configured to switch or assist in switching an output to the x-ray source between a first voltage level and a second voltage level. | 10-01-2009 |
John Leslie Paul Hill, West Springfield, MA US
Patent application number | Description | Published |
---|---|---|
20110221626 | HOUSING FOR AIRCRAFT MOUNTED COMPONENTS - A traffic collision avoidance system device is provided. The device includes a radome having an antenna contained therein. A chassis is bonded to the radome by a layer of bonding material about the chassis periphery. A housing is provided having a substantially flat bottom portion and a wall extended about a periphery to define a interior portion. A second bonding layer disposed between the housing and the radome within the interior portion to form a seal. | 09-15-2011 |
20120326915 | HOUSING FOR AIRCRAFT MOUNTED COMPONENTS - A traffic collision avoidance system (TCAS) device is provided. The device includes a radome having an antenna. A chassis is bonded to said radome about a periphery by a skirt layer. A housing is adhesively bonded to the radome, the skirt layer and the chassis. The housing has a substantially flat bottom portion with a wall extended about a periphery, the wall forming a lap joint with the chassis and radome. | 12-27-2012 |
Jonathan Hill, Brookline, MA US
Patent application number | Description | Published |
---|---|---|
20120225820 | PEPTIDES ASSOCIATED WITH HLA-DR MHC CLASS II MOLECULE AND INVOLVED IN RHEUMATOID ARTHRITIS - Antigenic peptides that bind to MHC Class II molecules with the shared epitope referred to as HLA-DR molecules are disclosed. More specifically, are citrullinated antigenic peptides having an increased affinity for HLA-DR molecules and associated with rheumatoid arthritis. These novel peptides provide the basis for new methods of diagnosis and treatment of rheumatoid arthritis. | 09-06-2012 |
Kristopher K. Hill, Ipswich, MA US
Patent application number | Description | Published |
---|---|---|
20110053122 | NUTRITIONAL ANALYSIS SYSTEM AND METHOD - A system and method for analyzing food and liquid consumed by a human subject based on factors such as, but not limited to, age, gender, physical activity level, height and weight to obtain the sum of food's nutritive values and comparing that data to optimal levels, generating a report based on the comparison and allowing the subject to generate reports based on modified, proposed nutrient intakes, the reports showing possible outcomes resulting from altering the diet for the better. | 03-03-2011 |
Lawrence W. Hill, Eastham, MA US
Patent application number | Description | Published |
---|---|---|
20090149202 | SYSTEM AND METHOD FOR DETERMINATION OF POSITION - A system and method of determining and reporting on the position of a wireless device relative to a group of other wireless devices dispersed within a specified geographic area. The system includes at least one Query Unit, three or more Responding Units disposed at determinable locations within the specified geographic area, and one or more Mobile Units, which may correspond to additional Responding Units or units that function only as receivers. The Query Unit sequentially queries the Responding Units, and, responsive to the respective query messages, the Responding Units transmit corresponding response messages. One or more of the Mobile Units receive the query and response messages, and generate, for each query-response message pair, a set of time-difference-of-arrival (TDOA) measurements, which are used by the Mobile Units to determine their positions relative to the Responding Units. The Mobile Units record the times-of-arrival (TOAs) of the query message and the response messages at their respective receivers, and calculate the TDOAs based on the recorded TOAs. The TDOAs are then analyzed to determine the time differences due to the differences in lengths of the respective message propagation paths. The position of each Mobile Unit can then be computed using computation techniques typically employed in Long Range Navigation (LORAN) receivers, or any other suitable computation technique. | 06-11-2009 |
20100188265 | Network Providing Vehicles with Improved Traffic Status Information - A vehicle communication network provides information about traffic conditions in a local area on a near real time basis. An RF transceiver in a vehicle communicates with other transceivers in other vehicles to relay traffic condition related information. The traffic information can be provided to local vehicles equipped with transceivers, or roadside devices that participate in the communication network. The traffic information is derived from data that may include time, position, velocity, acceleration or other information related to traffic flow. The data can be derived from a GPS, accelerometer or other devices that are typically prevalent in automobiles, whether as standalone units or integrated into the automobile. The transceivers can implement an emergency messaging construct to permit rapid dissemination of traffic information that may be derived from collisions, slowdowns, congestion or other traffic conditions that may prompt drivers to slowdown or otherwise increase vehicle spacing. The vehicle network can be implemented using add-on equipment in conjunction with PNDs or smart cellular telephones, or as a standalone device that is optionally integrated into a PND or vehicle. | 07-29-2010 |
Lawrence W. Hill, North Eastham, MA US
Patent application number | Description | Published |
---|---|---|
20090167513 | Integrated Vehicular Positioning and Communications System - A wireless vehicular positioning and communications system that combines inter-vehicular ranging and a self-organizing TDMA MAC protocol to both achieve more accurate positioning than is possible with GPS positioning and provide a deterministic channel for inter-vehicle communication. The band used for the system is divided into time slots, with each vehicle being able to obtain a time slot autonomously. Within a time slot, there is a ranging signal which occupies the full bandwidth; following the ranging signal, the band is divided into sub-bands. Some of the sub-bands are used to send packets according to the TDMA MAC protocol, and thus provide the deterministic channel; others are used for a non-deterministic channel which may be used for packets following the Internet Protocols. The system also uses mesh networking to permit vehicles to obtain advance warning of abnormal conditions in other vehicles. | 07-02-2009 |
20150140458 | Method and Apparatus for Cleaning Catalyst of a Power Cell - A method of cleaning power cells in an array of power cells, comprising coupling at least one first power cell to second power cells in an array of power cells and causing the second power cells to drive the at least one first power cell with a voltage to clean catalyst on the at least one first power cell. | 05-21-2015 |
Mark Hill, Wellesley, MA US
Patent application number | Description | Published |
---|---|---|
20150120534 | SYSTEM AND METHOD FOR CONTROLLING A WIRELESS TRACKING DEVICE ALARM - A wireless tracking device may have a unique identifier that identifies the item to which it is attached, distinguishing that item from the other items in a secured location. A database may contain information regarding the item attached to the wireless tracking device. A store may be a secured location, and an item may be authorized to leave the store when it is sold. A checkout process may include scanning a machine-readable code associated with the wireless tracking device. Once the checkout is complete and the customer has paid for the item, the database may be updated to disable the alarm for the wireless tracking device. Based on the information in the database, a wireless tracking device detector may determine whether or not to generate an alarm when the wireless tracking device is detected leaving the secured location. | 04-30-2015 |
Misha K. Hill, Jamaica Plain, MA US
Patent application number | Description | Published |
---|---|---|
20140126733 | User Interface for ANR Headphones with Active Hear-Through - An active noise reducing headphone has an active noise-cancelling mode and an active hear-through mode, and changes between the noise-cancelling mode and the hear-through mode based on detection of a user touching a housing of the headphone or based on a command signal received from an external device. In another aspect, a signal processor in the headphone is configured to change between the active noise-cancelling and active hear-through modes based on a comparison of signals from a feed-forward microphone and a feedback microphone. During the hear-through mode, the signal processor detects high-frequency signals in the feed-forward path exceeding a threshold level indicative of abnormally high acoustic coupling of the output transducer to the feed-forward microphone, and applies a compressing limiter to the feed-forward path until the high-frequency signals are no longer detected at levels above the threshold. | 05-08-2014 |
Pamela Hill, Waltham, MA US
Patent application number | Description | Published |
---|---|---|
20080312255 | PIPERDINE COMPOUNDS AND USES THEREOF-911 - Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. | 12-18-2008 |
20100173909 | PIPERIDINE COMPOUNDS AND USES THEREOF - 596 - Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. | 07-08-2010 |
20100179150 | ANTIBACTERIAL PIPERDINE DERIVATIVES - Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. | 07-15-2010 |
20100190745 | HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF - Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. | 07-29-2010 |
20100261719 | CHEMICAL COMPOUNDS - In one aspect, the present invention relates to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, wherein: n is 1 to 4; and R | 10-14-2010 |
20100286181 | PYRROLE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY - Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. | 11-11-2010 |
20110178064 | SPIRO CONDENSED BARBITURIC ACID DERIVATIVES FOR USE AS ANTIBACTERIAL - In one aspect, the present invention relates to compounds of Formula (I): to pharmaceutically acceptable salts thereof, to methods of using them to treat bacterial infections, and to method for their preparation. | 07-21-2011 |
20120028979 | 2-(PIPERIDIN-1-YL)-4-HETEROCYCLYL-THIAZOLE-5-CARBOXYLIC ACID DERIVATIVES AGAINST BACTERIAL INFECTIONS - Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. | 02-02-2012 |
20130150366 | CHEMICAL COMPOUNDS - Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use in the treatment of bacterial infections are also described. | 06-13-2013 |
Randal Hill, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20100317249 | Article Comprising Fibers And A Method Of Forming The Same - An article is provided that comprises fibers, as is a method of forming the article. The fibers comprise an organopolysiloxane component selected from (i) an organopolysiloxane having the formula (R3SiOi/2)w(R2Siθ2/2)x(RSiθ3/2)y(Siθ4/2)z (I), wherein each R is selected from the group of an inorganic group, an organic group, and combinations thereof, w is from 0 to 0.95, x is from 0 to 0.95, y is from 0 to 1, z is from 0 to 0.9, and w+x+y+z=1, and (ii) a cured product of said organopolysiloxane having the formula (I), and combinations of (i) and (ii), provided that the fibers are free from organic polymers, organic copolymers, and organosiloxane-organic copolymers. The method of forming the article includes the step of forming fibers from a composition. The composition used to form the fibers comprises the organopolysiloxane having the formula (I), provided that the composition is free from organic polymers, all-organic copolymers, and organosiloxane-organic copolymers. The article exhibits excellent hydrophobicity and maximized fire resistance. | 12-16-2010 |
Randall M. Hill, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20100130082 | Highly Reactive Multilayer Assembled Coating of Metal Oxides on Organic and Inorganic Substrates - One aspect of the invention relates to a method of preparing metal oxide coated substrates for various potential applications, and the coated substrate formed thereby. | 05-27-2010 |
Randall M. Hill, Ayer, MA US
Patent application number | Description | Published |
---|---|---|
20120008188 | MULTI-COLOR ELECTRO-OPTIC DISPLAYS - An electro-optic display comprising at least two separate layers of electro-optic material, with one of these layers being capable of displaying at least one optical state which cannot be displayed by the other layer. The display is driven by a single set of electrodes between which both layers are sandwiched, the two layers being controllable at least partially independently of one another. Another form of the invention uses three different types of particles within a single electrophoretic layer, with the three types of particles being arranged to shutter independently of one another. | 01-12-2012 |
20140055841 | MULTI-COLOR ELECTRO-OPTIC DISPLAYS - An electro-optic display comprising at least two separate layers of electro-optic material, with one of these layers being capable of displaying at least one optical state which cannot be displayed by the other layer. The display is driven by a single set of electrodes between which both layers are sandwiched, the two layers being controllable at least partially independently of one another. Another form of the invention uses three different types of particles within a single electrophoretic layer, with the three types of particles being arranged to shutter independently of one another. | 02-27-2014 |
Randal M. Hill, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20110165811 | Article Formed From Electrospinning A Dispersion - An article of fibers includes a cured compound. The fibers are formed from electrospinning a dispersion. The dispersion includes a liquid and a condensation curable compound. A content of the liquid in the dispersion is reduced such that the condensation curable compound cures. The article is formed from a method of manufacturing which includes the step of forming the dispersion. The method also includes the step of electro spinning the dispersion to reduce the content of the liquid such that the condensation curable compound cures. | 07-07-2011 |
Raymond Hill, Rowley, MA US
Patent application number | Description | Published |
---|---|---|
20090114840 | Ion sources, systems and methods - Ion sources, systems and methods are disclosed. | 05-07-2009 |
20090289196 | Deflection Signal Compensation for Charged Particle Beam - Charged particles that are in transit through a deflection system when the beam is repositioned do not received the correct deflection force and are misdirected. By independently applying signals to the multiple stages of a deflection system, the number of misdirected particles during a pixel change is reduced. | 11-26-2009 |
20100025578 | Dual Beam System - A dual beam system includes an ion beam system and a scanning electron microscope with a magnetic objective lens. The ion beam system is adapted to operate optimally in the presence of the magnetic field from the SEM objective lens, so that the objective lens is not turned off during operation of the ion beam. An optional secondary particle detector and an optional charge neutralization flood gun are adapted to operate in the presence of the magnetic field. The magnetic objective lens is designed to have a constant heat signature, regardless of the strength of magnetic field being produced, so that the system does not need time to stabilize when the magnetic field is changed. | 02-04-2010 |
20110127428 | ELECTRON DETECTION SYSTEMS AND METHODS - Systems and methods to detect electrons from one or more samples are disclosed. In some embodiments, the systems and methods involve one or more magnetic field sources, for deflecting secondary electrons emitted from the surface of the samples. | 06-02-2011 |
20110180722 | ALIGNING CHARGED PARTICLE BEAMS - Disclosed are systems ( | 07-28-2011 |
20110309263 | Dual Beam System - A dual beam system includes an ion beam system and a scanning electron microscope with a magnetic objective lens. The ion beam system is adapted to operate optimally in the presence of the magnetic field from the SEM objective lens, so that the objective lens is not turned off during operation of the ion beam. An optional secondary particle detector and an optional charge neutralization flood gun are adapted to operate in the presence of the magnetic field. The magnetic objective lens is designed to have a constant heat signature, regardless of the strength of magnetic field being produced, so that the system does not need time to stabilize when the magnetic field is changed. | 12-22-2011 |
20120068068 | CHARGED PARTICLE DETECTORS - Disclosed are devices, systems, and methods are disclosed that include: (a) a first material layer positioned on a first surface of a support structure and configured to generate secondary electrons in response to incident charged particles that strike the first layer, the first layer including an aperture configured to permit a portion of the incident charged particles to pass through the aperture; and (b) a second material layer positioned on a second surface of the support structure and separated from the first layer by a distance of 0.5 cm or more, the second layer being configured to generate secondary electrons in response to charged particles that pass through the aperture and strike the second layer, where the device is a charged particle detector. | 03-22-2012 |
20120138815 | VARIABLE ENERGY CHARGED PARTICLE SYSTEMS - Charged particle system are disclosed and include a first voltage source, a second voltage source electrically isolated from the first voltage source, a charged particle source electrically connected to the first voltage source, and an extractor electrically connected to the second voltage source. Methods relating to the charged particle systems are also disclosed. | 06-07-2012 |
20120141693 | ION SOURCES, SYSTEMS AND METHODS - Ion sources, systems and methods are disclosed. | 06-07-2012 |
20140306121 | ION SOURCES, SYSTEMS AND METHODS - Ion sources, systems and methods are disclosed. | 10-16-2014 |
20150213997 | ION SOURCES, SYSTEMS AND METHODS - Ion sources, systems and methods are disclosed. | 07-30-2015 |
Richard F. Hill, Easthampton, MA US
Patent application number | Description | Published |
---|---|---|
20110001404 | APPARATUS INCLUDING LOCKING MEANS AND ENCLOSURE WITH LOCKING MEANS - An apparatus includes a swivel having a first flange with a first pivot on one side of a swivel pivot, and a second flange with a second pivot on an opposite side of the swivel pivot, and first, second, third and fourth rods. The first and second rods are each pivotally attached at a respective first end to the first pivot and extend outwardly therefrom. The third and fourth rods are each pivotally attached at a respective first end to the second pivot and extend outwardly therefrom. The first and third rods are respectively pivotable about the first and second pivots in a first plane, and the second and fourth rods are respectively pivotable about the first and second pivots in a second plane, wherein the first plane is parallel to the second plane. | 01-06-2011 |
Robert Hill, Bolton, MA US
Patent application number | Description | Published |
---|---|---|
20090007470 | Identification Tag and Releasable Attachment Clip - An identification tag that is adapted to be attached to a collar ring. The tag has a molded tag body that defines a pair of recesses, and a pliable clip having spaced arms that are adapted to be releasably received into the tag body recesses, the clip further adapted to be coupled to the collar ring, to releasably couple the tag body to the collar ring. | 01-08-2009 |
Robert P. Hill, Milford, MA US
Patent application number | Description | Published |
---|---|---|
20110120363 | APPARATUS FOR COUPLING A PUSHBOAT TO A BARGE - Apparatus for coupling a pushboat to a barge having a notch in its stern for receiving the bow of pushboat. The pushboat has three coupler units, two on the opposite sides and one at the bow end, each of which h an extensible and retractable connecting pin. The side connecting pin has hemi-spherical part at its outer end part which comes into tight contact with the similar hemi-spherical part of the holes in side socket on the side wall of the notch when it is extended out and inserted into the hole for connection. The bow connecting pin has wedge-shaped end which engages with the teeth of the center rack located in the barge's centerline at the deepest point of the notch when it is extended out for connection. The motions of connecting pins are remotely controlled from a control panel located in the navigation bridge. | 05-26-2011 |
Ryan Hill, Watertown, MA US
Patent application number | Description | Published |
---|---|---|
20150059864 | METHOD, SYSTEM AND APPARATUS FOR AUTOMATIC CALIBRATION OF A NEEDLE VALVE DEVICE IN A PRESSURIZED FLOW SYSTEM - Exemplary embodiments are directed to apparatus, systems and methods used in connection with a needle valve device operating in a pressurized flow system. The apparatus, systems and methods provide for automatic positioning of a needle relative to a seat in the needle valve device to provide consistent calibration with minimal user interaction after a maintenance event or upon a start-up of the pressurized flow system. The apparatus, systems and methods utilize a calibration collar secured to a shaft of an actuator within the needle valve device. The calibration collar includes one or more locking mechanism and a spring. | 03-05-2015 |
20150101419 | Phase Detection in Multi-Phase Fluids - The present disclosure relates to phase detection in multi-phase fluids where two fluid phases can be present in the fluid. Phase detection apparatus and methods are disclosed for determining the phase(s) (e.g., supercritical, liquid, and/or gas) of a fluid in a multi-phase fluid system, such as carbon dioxide based separation and chromatography system. | 04-16-2015 |
Ryan M. Hill, Watertown, MA US
Patent application number | Description | Published |
---|---|---|
20150129057 | STATIC BACK PRESSURE REGULATOR - The invention generally provides a static back pressure regulator. In exemplary embodiments, the static back pressure regulator includes a seat that defines part of a fluid pathway, a poppet, a spring arranged to bias the poppet toward the seat to restrict fluid flow through the fluid pathway, and a calibration element configured to adjust a force applied to the poppet by the spring. The calibration element can include a through hole that forms part of the fluid pathway. The poppet can include a first guiding portion that extends into the through hole of the calibration element and inhibits tipping of the poppet relative to the seat. | 05-14-2015 |
Samuel L. Hill, Somerville, MA US
Patent application number | Description | Published |
---|---|---|
20080266468 | OPTICALLY ENHANCED IMAGE SEQUENCES - Enhanced image sequences are provided by a high resolution imaging system (HRIS) for generating an enhanced image, where the system includes a device for outputting an image sequence including a plurality of K source images, each source image including a plurality of pixels; and a projector for projecting, within a period of integration, each of the source images to an optical filter, the filter adapted for providing pixels of each source image as sub-pixels of pixels in the enhanced image. The enhanced images may be two-dimensional or three-dimensional. A method and computer program product are provided for generating enhanced images, as well as techniques for fabrication of the HRIS. | 10-30-2008 |
20120303101 | CONTINUOUS LOW IRRADIANCE PHOTODYNAMIC THERAPY ILLUMINATION SYSTEM - A system for photodynamic therapy is provided that includes a light delivery device that delivers the illumination necessary to perform photodynamic therapy. The light delivery device includes one or more etched fibers arranged to illuminate a selective region of a body for photodynamic therapy. An illumination device is coupled to the light delivery device to provide the necessary illumination to the light delivery device. | 11-29-2012 |
20140128943 | IMPLANTABLE CLIPT ILLUMINATION SYSTEM - A light-based therapy device is provided that includes a controller mechanism that produces power and control signals to enable operation of one or more medical devices. An implantable light delivery device (IM-LDD) is coupled to the controller mechanism that receives the power and the control signals to enable a light source to emit sufficient illumination. The light source is implanted within body cavities enabling energy at one or more wavelengths to reach and provide therapy treatment to a selected region. | 05-08-2014 |
20150335911 | LIGHT EMITTING SYSTEM FOR WOUND CARE - A therapeutic light delivery system is provided that includes one or more fiber optic arrays that channels illumination from an illumination device. An optics module coupled to the one or more fiber optic arrays that provides the illumination to the one or more fiber optic arrays. A control module coupled to the optics module that controls the illumination to the one or more fibers. The illumination comprises a plurality of therapeutic illumination patterns and wavelengths. | 11-26-2015 |
Scott Frank Hill, Duxbury, MA US
Patent application number | Description | Published |
---|---|---|
20140138379 | Candle Cap - Often times friends would like to buy a special drink or an ice cream soda to celebrate a special occasion such as a birthday, anniversary or graduation event. A candle would be nice, but there is no easy way of mounting a small candle, sparkler or other illuminating device to the beverage glass or bottle along with a congratulatory message to mark the special occasion. This invention also provides a means to conveniently mount a candle or sparkler onto the top of a beverage while also providing restaurants, bars and other establishments and venues to offer a unique service for their customers while also creating a unique method to advertise the establishment, distributors, manufacturer with brand names and branding logos. | 05-22-2014 |
Stanley Hill, Holden, MA US
Patent application number | Description | Published |
---|---|---|
20090276385 | Artificial-Neural-Networks Training Artificial-Neural-Networks - A method of training an artificial-neural-network includes applying a training algorithm to a first artificial-neural-network using a first training set to generate a sequence of weight values associated with a connection in the first artificial-neural-network. The method also includes training a second artificial-neural-network to generate a weight value, where the training utilizes a second training set. The second training set includes the generated sequence of weight values associated with the connection in the first artificial-neural-network. A system includes a first artificial-neural-network including a plurality of connections, where each connection is associated with a weight value. The system also includes a second artificial-neural-network including a plurality of outputs, where each output generates the weight value associated with one connection of the plurality of connections in the first artificial-neural-network during a training of the first artificial-neural-network. | 11-05-2009 |
Westin Michael Hill, Cambridge, MA US
Patent application number | Description | Published |
---|---|---|
20150148602 | STEERING TECHNIQUES FOR SURGICAL INSTRUMENTS - A steerable endoscopic tool uses concentric sleeves of varying curvature to steer a tool tip toward or in the direction of a location of surgical interest. By rotating and/or axially displacing such sleeves relative to one another the tool tip may be maneuvered within a current field of view with several degrees of freedom without any physical movement of an endoscope, thus facilitating improved surgical access and control without complex mechanical systems in the endoscope or at the surgical site. | 05-28-2015 |