Patent application number | Description | Published |
20080286202 | Method of Diagnosing Prodromal Forms of Diseases Associated With Amyloid Deposition - A method of identifying a patient as prodromal to a disease associated with amyloid deposition by imaging techniques is provided. In addition, a method of identifying amyloid deposition diseases in patients who present with a dementing disorder of questionable etiology by imaging techniques is provided. The methods discloses substances which are used for imaging and generating data which can be used to determine progress of an asymptomatic patient to a disease associated with amyloid deposition, or to identify amyloid deposition diseases in patients who present with a dementing disorder of questionable etiology. | 11-20-2008 |
20090142269 | ISOTOYPICALLY-LABELED BENZOTHIAZOLE COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS - The present invention provides an isolated linezolid impurity, desfluoro linezolid, the preparation thereof and its use as a reference standard. | 06-04-2009 |
20100021388 | BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES - This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid deposit(s) and for diagnosing a disease, disorder or condition characterized by amyloid deposit(s). | 01-28-2010 |
20110257407 | THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION - This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele. | 10-20-2011 |
20120095235 | THIOFLAVIN DERIVATES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION - This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele. | 04-19-2012 |
20120148494 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS - Benzofuran compounds which contain at least one detectable label selected from the group consisting of | 06-14-2012 |
20120177572 | AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES - The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or formula (II) or structures 1-45 is administered to the patient and the patient is imaged again. Finally, baseline levels of amyloid deposition in the patient before treatment with the anti-amyloid agent are compared with levels of amyloid deposition in the patient following treatment with the anti-amyloid agent. | 07-12-2012 |
20120189545 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS - Benzofuran compounds which contain at least one detectable label selected from the group consisting of | 07-26-2012 |
20130004422 | BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES - This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid deposit(s) and for diagnosing a disease, disorder or condition characterized by amyloid deposit(s). | 01-03-2013 |
20130045164 | AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES - The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or Formula (II) or structures 1-45 is administered to the patient and the patient is imaged again. Finally, baseline levels of amyloid deposition in the patient before treatment with the anti-amyloid agent are compared with levels of amyloid deposition in the patient following treatment with the anti-amyloid agent. | 02-21-2013 |
20130236394 | THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER`S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION - This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele. | 09-12-2013 |
20140105820 | AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES - The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or Formula (II) or structures 1-45 is administered to the patient and the patient is imaged again. Finally, baseline levels of amyloid deposition in the patient before treatment with the anti-amyloid agent are compared with levels of amyloid deposition in the patient following treatment with the anti-amyloid agent. | 04-17-2014 |
20140220590 | METHODS OF USING BENZOTHIAZOLE DERIVATIVE COMPOUNDS AND COMPOSITIONS - This invention provides benzothiazole derivative compounds, compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for detecting amyloid deposit(s) and for diagnosing a disease, disorder or condition characterized by amyloid deposit(s). | 08-07-2014 |
Patent application number | Description | Published |
20090112045 | METHODS AND SYSTEMS FOR ASBESTOS TREATMENT - A vibratory system for asbestos treatment includes a trough with a heat-resistant liner, an opening, and a discharge end. The system also includes a transportation sub-system including a frame that may be coupled to the trough, as well as a vibration generator and resilient members coupled to the frame. Further, the system includes a heating sub-system including a furnace that may be disposed across the opening. A method for asbestos treatment includes disposing the asbestos in the trough, disposing the furnace across the opening, heating the asbestos in the trough to render the asbestos inert, vibrating the trough to move the inert asbestos along the trough to the discharge end, and collecting the inert asbestos from the trough. | 04-30-2009 |
20090272629 | CONVEYOR FOR AND METHOD OF CONVEYING HEATED MATERIAL - A conveyor for conveying hot ash may include a frame, a trough supported on the frame to receive a quantity of hot ash, the trough including a trough wall with a plurality of semi-circular steel plates that define a surface of the trough wall and a plenum disposed beneath the semi-circular steel plates, and a vibratory generator operatively coupled to the trough. The conveyor may also include a first plurality of apertures in the trough wall in fluid communication with the plenum, and a plurality of baffles spaced above the first plurality of apertures in the trough wall, the baffles defining a second plurality of apertures through which air exiting the first plurality of apertures may pass in a direction along the surface of the trough wall. | 11-05-2009 |
20100135103 | VIBRATORY APPARATUS WITH ANTI-STICK DECK SECTION - A vibratory apparatus includes a trough having side walls, and a deck section having a deck plate defining at least in part a deck and side walls, the side walls of the deck section resiliently coupled to the side walls of the trough. The apparatus also includes a primary vibratory generator coupled to the trough, the primary vibratory generator operating a first frequency and a first amplitude, and a secondary vibratory generator coupled to the deck section, the secondary vibratory generator operating at a second frequency and a second amplitude, the second frequency being higher than the first frequency and the second amplitude being smaller than the first amplitude. | 06-03-2010 |
20140208606 | Vibratory Dryer with Mixing Apparatus - A vibratory dryer includes a conveying surface over which a bed of materials to be dried is conveyed, the surface having an inlet end and an outlet end, and passages through which air passes through the conveying surface to pass through the bed of materials on the conveying surface, a source of heated air coupled to the passages to supply heated air to the bed through the passages, and a vibration generator coupled to the conveying surface. The dryer also includes at least one rotary mixer having an impeller spaced from the conveying surface at a distance so as to be disposed within the bed, the at least one rotary mixer disposed along the length of the conveying surface between the inlet end and the outlet end. The at least one rotary mixer is adapted to provide uplift within the bed without de-densification of the bed. | 07-31-2014 |