Willing
Alison Willing, Tampa, FL US
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20150051291 | N,N'-DI-1 NAPHTHYLGUANIDINE HCL (NAGH) AND N,N'-DI-P-NITROPHENYLGUANIDINE HCL (NAD) TREATMENT FOR STROKE AT DELAYED TIMEPOINTS - A composition and method of treating stroke by administration of a novel sigma agonist is presented. Twenty-four hours after MCAO, systemic administration of several novel sigma agonists including: Bromo-DTG; Chloro-DTG; N,N′-di-1-Naphthylguanidine hydrochloride (NAGH); N,N′-di-p-Nitrophenylguanidine HCL (NAD) or vehicle were injected subcutaneously daily for 3 days. Rats treated with Bromo-DTG and Chloro-DTG had no significant improvements in any of the motor or cognitive tests while NAGH treated rats showed improved vertical movement and had significantly less motor asymmetry and bias than vehicle treated rats. Sigma receptor agonist NAGH also was found to exert its long-term neuroprotective effects by preserving both gray matter and white matter tracts. Both NAD and NAGH, when administered 24 hours after experimental stroke, reduced neural damage and enhanced behavioral recovery thirty days later which suggests that NAGH and NAD potentially extend the therapeutic window of stroke several fold over the current treatments. | 02-19-2015 |
Alison E. Willing, Tampa, FL US
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20110274674 | ISCHEMIC TISSUE CELL THERAPY - The present invention is directed to compositions and methods for treatment of ischemic diseases and conditions, particularly myocardial, CNS/brain and limb ischemia. More particularly, the present invention provides methods of treating disorders by administering monocytes obtained from blood, including umbilical cord blood, peripheral blood, or bone marrow to an individual in need of treatment, wherein the drug is administered to the individual at a time point specifically determined to provide therapeutic efficacy. In one embodiment, the cells are for injection into ischemic myocardium for the treatment of angina. | 11-10-2011 |
20140369983 | ISCHEMIC TISSUE CELL THERAPY - The present invention is directed to compositions and methods for treatment of ischemic diseases and conditions, particularly myocardial, CNS/brain and limb ischemia. More particularly, the present invention provides methods of treating disorders by administering monocytes obtained from blood, including umbilical cord blood, peripheral blood, or bone marrow to an individual in need of treatment, wherein the drug is administered to the individual at a time point specifically determined to provide therapeutic efficacy. In one embodiment, the cells are for injection into ischemic myocardium for the treatment of angina. | 12-18-2014 |
Alison Elizabeth Willing, Tampa, FL US
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20130129673 | USE OF ENDOGENOUS ANTIOXIDANT PROTEINS IN THE TREATMENT OF STROKE - Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced OL dysfunction. Infusion of human umbilical cord blood (HUCB) cells protects striatal white matter tracts in vivo and directly protects mature primary OL cultures from oxygen glucose deprivation (OGD). Microarray studies of RNA prepared from OL cultures subjected to OGD and treated with HUCB cells showed an increase in the expression of 33 genes associated with OL proliferation, survival, and repair functions, such as myelination. Immunohistochemistry showed antioxidant protein expression was upregluated in the ipsilateral white matter tracts of rats infused with HUCB cells 48 hrs after middle cerebral artery occlusion (MCAO). These results show expression of genes induced by HUCB cell therapy that could confer oligoprotection from ischemia. | 05-23-2013 |
Benjamin Willing, Vancouver CA
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20120213772 | Metabolic biomarkers of Crohn's Disease - The invention provides for a method for identifying a biomarker in a fecal sample of a subject in need of such identification comprising: determining whether a fecal sample collected from a subject comprises a biomarker. | 08-23-2012 |
Bernhard Willing, Bonn DE
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20140167316 | METHOD AND DEVICE FOR THE PRODUCTION OF FORM PARTS - The invention relates to a method for the production of form parts from multi-component reactive plastic material, especially from polyurethane, wherein a plurality of moulds are moved by means of mould carriages ( | 06-19-2014 |
20140175701 | METHOD AND DEVICE FOR THE PRODUCTION OF FORM PARTS - The invention relates to a method for the production of form parts from multi-component reactive plastic material, especially from polyurethane, wherein a plurality of moulds are moved by means of mould carriages ( | 06-26-2014 |
Bert Willing, Blonay CH
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20080198364 | GAS SENSOR - A combined gas sensor device allowing the measuring of the concentration of a gas by tunable diode laser spectrometry as well as by resonant photo-acoustics within one housing. A laser beam used for laser spectrometry is sent across the openings of a measuring cell usually used for resonant photo-acoustic determination. Thus, both measuring principles use the same gas sensing module with a minimum of space consumption, so that the device can be produced with minimum dimensions. Further, a common opto-electronics and electronics platform can be used which reduces the overall costs of such a combined gas sensor. | 08-21-2008 |
20090027677 | METHOD AND GAS SENSOR FOR PERFORMING QUARTZ-ENHANCED PHOTOACOUSTIC SPECTROSCOPY - A method for performing quartz-enhanced photoacoustic spectroscopy of a gas, includes providing a light source configured to introduce a laser beam having at least one wavelength into the gas such said at least one molecule within in the gas is stimulated generating an acoustic signal, accumulating the acoustic signal in a resonant acoustic detector, generating a resonant absorption signal (S | 01-29-2009 |
20100002235 | LASER DIODE ARRANGEMENTS AND METHOD FOR GAS DETECTION - A gas detection laser diode device and gas detection unit including the gas detection laser diode device having a hermetically sealed housing with electrical connectors at the bottom and a window, and inside the housing a laser diode and thermistor mounted on one stage of a thermo element. The thermo element is connected with the other stage to the base of the housing. Collimating means are arranged in the laser beam between the laser diode and the window. The window is tilted in respect to the axis of the laser beam such, that the ordinary reflection of the laser beam is steered off the laser beam axis and at least does not impinge on the laser diode. Preferably the collimating means and the laser diode are mounted on a same surface for holding them on the same temperature. The new device allows the detection of toxic gases with reduced detection limits over the prior art. The arrangement further claims a method to achieve reduced detection limits for gases. | 01-07-2010 |
20110110390 | LASER DIODE STRUCTURE WITH INTEGRATED TEMPERATURE-CONTROLLED BEAM SHAPING ELEMENT AND METHOD FOR GAS DETECTION BY MEANS OF A LASER DIODE STRUCTURE - The invention relates to a laser diode structure, specifically for use in gas detection, with a hermetically sealed housing with electrical connections having a bottom and a window. A laser diode chip and a temperature control system for the laser diode chip are provided in the housing. A thermo element in the form of a Peltier element forms the temperature control system, and is connected via a lower flat surface to the bottom of the housing and via an upper flat surface to the laser diode chip, with a temperature-controlled beam shaping element as collimator provided between the laser diode chip and the window of the housing that acts on a laser beam emerging from a laser aperture of the laser diode chip before it passes through the window. The beam shaping element is in contact with the laser diode chip and is preferably connected via a boundary surface to the laser aperture with surface-to-surface contact or adhesively, or is made in one piece together with the laser aperture. | 05-12-2011 |
20110216793 | LASER DIODE STRUCTURE WITH REDUCED INTERFERENCE SIGNALS - A laser diode structure for generating a collimated or divergent laser beam, preferably for application in gas detection, with a laser diode arranged in a closed housing, with the housing comprising a housing bottom, an exit window, electrical connections, a temperature control device for the laser diode, and an optical element for influencing the laser beam. The temperature control device carrying the laser diode is arranged on the housing bottom and the optical element is positioned at a distance from the laser diode. The invention proposes an electrically controllable power device for the cyclic alteration of the position and/or alignment of the optical element in relation to the laser diode so that the optical path length for the laser beam in the housing changes periodically. The oscillating motion of the optical element has the effect of time-averaging the etalon and/or self-mixing effects caused by the back-reflections of the laser beam in the housing, thereby reducing the optical noise of the laser diode structure. | 09-08-2011 |
20110304844 | GAS SENSOR AND PROCESS FOR MEASURING MOISTURE AND CARBON DIOXIDE CONCENTRATION - An TDLS gas sensor with a measuring pick-up to be arranged outside of the interior chamber of an incubator or a climate chamber of similar design, and with an absorption pick-up to be arranged inside the interior chamber, and also with a window separating the measuring area and absorption area for the atmospheric separation of the laser diode from the interior chamber of the incubator, with the window being arranged at an angle to the axis of the laser beam emitted by a laser diode, and with the optronic components being arranged in a block of material in the measuring pick-up, said block being made of thermally well-conducting material and serving as heat sink, and with a heating system for the window in the measuring pick-up. The TDLS gas sensor is easy to install and remove and permits the measurement of moisture and of the carbon dioxide concentration in one measuring cycle. However, it does not need to be removed for the sterilization. By installing an additional laser diode for measuring oxygen, the TDLS gas sensor can be used to perform a wide bandwidth of measurements. In addition, the invention concerns a process for measuring the moisture and the carbon dioxide concentration. | 12-15-2011 |
20150030054 | WIDE-RANGE PRECISION CONSTANT VOLUME GAS THERMOMETER - A Constant Volume Gas Thermometer (CVTG) device for measuring the temperature with high precision over a wide temperature range comprises a pressure measurement device, which comprises a mechanical assembly forming a membrane. The capillary tube communicates with the bottom side of the membrane and a first pressure measurement element on the membrane generates a signal in dependence of a deformation of the membrane. Further, the CVTG comprises electronic means for reading and correlating the signal of said first pressure measurement element to the temperature of the gas cartridge. The gas volume inside the pressure measurement device is minimized by careful design and tight tolerances. To measure pressures below 0.1 MPa inside the CVGT with sufficient accuracy, the CVGT include a second pressure measurement device which is based on the Pirani measurement principle. A Pirani measurement device measures the thermal conductivity of the surrounding gas. To this end, a thermally insulated wire or surface is heated electrically to a defined temperature, while the surrounding gas is at ambient temperature. If the thermal conductivity of the surrounding gas changes, either the Pirani element's temperature changes, or the electrical heating power needs to be adapted in order to maintain the Pirani element's temperature. | 01-29-2015 |
Bruce Willing, Fairfield, CA US
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20090044838 | OZONATION FOR ELIMINATION OF BACTERIA FOR WET PROCESSING SYSTEMS - In a first aspect, an apparatus adapted to clean a semiconductor device manufacturing component is provided. The apparatus includes an ozone module adapted to (1) obtain Ozone; (2) combine the Ozone with a fluid to generate ozonated fluid; and (3) deliver the ozonated fluid to the semiconductor device manufacturing component so as to clean the semiconductor device manufacturing component. Numerous other aspects are provided. | 02-19-2009 |
Gerold A. Willing, Louisville, KY US
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20110209604 | COMPOSITE ARMOR PANEL - A composite armor panels is comprised of a first layer, composed of a matrix of an elastomeric material and a crushed aggregate material, and a second backing layer. One or more geogrids can be included in the first layer of the armor panel to prevent the aggregate material from moving within the first layer. A method of making a composite armor panel includes exposing a mixture of elastomeric material and crushed aggregate material to elevated temperatures and pressures for predetermined time periods, such that a matrix of elastomeric material and crushed aggregate material is formed. | 09-01-2011 |
James Willing, Victoria AU
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20150254090 | SYSTEM AND METHOD FOR MODIFYING ALLOCATED RESOURCES - Various embodiments illustrated and described herein include systems, methods, and computer program products to modify virtual machine resources. Some embodiments collect a wide variety of metrics and then analyze the metrics to determine whether a virtual machine is not being utilized. This determination may include an associated confidence level. When the confidence level reaches a designated threshold, action may be initiated. Such actions can include notifying users of the virtual machine and/or a user's supervisor that the virtual machine is not being utilized and that further action will be taken at a designated time. Further actions can include such thins as archiving the virtual machine, reducing the resources allocated to the virtual machine, archiving user data, and deleting the virtual machine. | 09-10-2015 |
James E. Willing, Davison, MI US
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20130129413 | LATCH MECHANISM FOR AUTOMOTIVE SEAT ASSEMBLY - A latch mechanism for a seat of a vehicle includes a side plate, a hook, a locking pawl, an anti-rattle cam and a transfer plate. The side plate includes a first and second mounting bushing and a first and second pivot bushing. The hook is pivotably supported on the second pivot bushing, and includes a receiving portion configured to accept a striker. The hook is further configured to rotate between an engaged position and a released position. The locking pawl and anti-rattle cam are pivotably supported on the first pivot bushing and configured to rotate between a locked and an unlocked state. The locking pawl is configured to prevent the hook from rotating toward the released position when in a locked state. The transfer plate is configured to selectively urge the hook to rotate toward a released position. | 05-23-2013 |
Nadine Willing, Emmerich DE
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20120292578 | METHOD FOR PRODUCING COMPOSITE MATERIALS BASED ON POLYMERS AND CARBON NANOTUBES (CNTs), COMPOSITE MATERIALS PRODUCED IN THIS WAY AND USE THEREOF - The invention relates to a method for producing composite materials based on at least one polymer and carbon nanotubes (CNTs), and to composite materials obtained in this manner and the use thereof. | 11-22-2012 |
Stefan Willing, Jena DE
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20130127337 | Flexible Impedance Matching for a Microwave Generator Supplied with Pulse Current - A method for operating an arrangement of equipment that include a pulse generator for generating electrical pulses, a microwave generator with a break-through voltage, and a transmission element is provided. For transmission of the pulses, the pulse generator is connected to the microwave generator via the transmission element, which in the arrangement of equipment, acts as an impedance varying over time. The voltage characteristic over time or the current characteristic over time of each pulse is defined such that in an operating mode, the impedance of the transmission element is matched to the impedance of the microwave generator when the break-through voltage is reached. | 05-23-2013 |
20130195252 | Radiation Unit with External Electron Accelerator - A radiation unit for generating bremsstrahlung includes an electron accelerator producing the bremsstrahlung, a supply unit disposed in a main unit, and at least one supply line connecting the supply unit and the electron accelerator. The at least one supply line is a waveguide. The at least one supply line has a first longitudinal section running from the supply unit to a terminal disposed on the main unit. The electron accelerator is disposed outside the main unit and is connected to the terminal via a second longitudinal section of the at least one supply line. | 08-01-2013 |
Steven Willing, Encinitas, CA US
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20130032395 | WIRE CONNECTOR ASSEMBLY INCLUDING SPLICE ELEMENTS FOR FLUID ENVIRONMENTS AND METHODS OF MAKING SAME - A wire connector assembly includes a connector body and at least one wire arrangement that communicates with the connector body. The wire arrangement includes at least one electrically-conductive element formed of a continuous solid mass of material throughout. The at least one solid mass element defines a plurality of bores in which at least a portion of the solid mass element separates at least one of the bores from the other bores in the plurality of bores. A plurality of wire cables is received in the plurality of bores and respectively electrically and mechanically connected to the solid mass element. The portion, grooves defined along the portion, and O-ring seals surroundingly disposed on the connector body combine to prevent fluid flow through the assembly when the assembly is disposed in a fluid environment. A pair of methods to construct the wire connector assembly are also presented. | 02-07-2013 |
20130140082 | WIRE CONNECTOR ASSEMBLY INCLUDING SPLICE ELEMENTS FOR FLUID ENVIRONMENTS AND METHOD OF MAKING SAME - A wire connector assembly configured to inhibit leakage of fluids between two distinct environments and a method of constructing same is presented. The assembly includes insulated wire cables having ends that are spaced apart and joined by a wire splice element within a connector body, thereby interrupting a fluid leak path through the strands of the wire cables. The connector body may be over-molded the wire splice elements and a portion of connector body may be disposed intermediate to the ends of the wire cables, providing an additional physical barrier to the fluid leak path. The wire splice element may include wire crimp wings that are crimped to the ends of the wire cable. The wire splice elements may also include insulation crimp wings that may be crimped to the insulation to prevent insulation on the wire cables from pulling back and exposing wire strands. | 06-06-2013 |
20140238741 | HERMETICALLY SEALED WIRE CONNECTOR ASSEMBLY AND METHOD OF MAKING SAME - A wire connector assembly configured to provide a hermetic seal between two distinct environments and a method of constructing same is presented. The assembly includes insulated wire cables having ends that are spaced apart and joined by a wire splice element within a connector body, thereby interrupting a fluid leak path through the strands of the wire cables. The connector body formed of a fiberglass filled epoxide epoxy material may be over-molded the wire splice elements having a matte tin plated finish. A portion of connector body or the wire splice element may be disposed intermediate to the ends of the wire cables, providing an additional physical barrier to the fluid leak path. The materials selected and the shape of the wire splice elements are selected to mitigate the formation of microcracks between the connector body and splice elements that could allow the infiltration of gases through the connector assembly. | 08-28-2014 |
Steven Lee Willing, Encinitas, CA US
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20090091897 | Power Conversion Device Frame Packaging Apparatus and Methods - The present invention relates, generally, to electrical power conversion devices and to the universal packaging of those devices for a wide range of applications yielding cost efficient inventory management of product lines consisting of a group of power conversion devices each with minor variations. More specifically, the present invention relates to a universal mounting frame for receiving a printed circuit board in a switch mode power supply. The universal frame is adapted for receiving an open frame or printed circuit board and securing the open frame within a plurality of known packaging configurations. To this end, only a single size printed circuit board is necessary for any type of switch mode power supply configurations, thereby, reducing costs associated with manufacture and testing. | 04-09-2009 |
20090181571 | SEALED CARTRIDGE ELECTRICAL INTERCONNECT - A sealed cover and plastic cartridge combination for electrical connections providing sealing, strain relief, mechanical retention, electrical insulation and flex relief similar to that achieved using an over-molded design includes a plastic cartridge of integral construction or composed of two or more parts, in either case housing one or more contacts of the connections. | 07-16-2009 |
Thomas Willing, Koln DE
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20130236242 | LOCKING DEVICE WITH SIGNAL STRUCTURE - A device in a vehicle for locking and unlocking a locking pin of a component includes using a locking hook that cooperates non-positively or positively with the locking pin to provide an unlocked position and a locked position. The locking hook is actuated between the unlocked position and the locked position by an actuating component. The device includes a signaling means for emitting a mechanical signal to at least one of another of the device and a display. The signaling means is connected to and cooperates with the actuating component to emit the mechanical signal. | 09-12-2013 |
20130248675 | LONGITUDINAL ADJUSTER FOR A VEHICLE SEAT - A longitudinal adjuster in the interior of a motor vehicle, has an upper and a lower rail, between which at least one rolling body is provided. A projection is provided on the upper and/or lower rail, the projection forming a local contact point between the two rails. | 09-26-2013 |