Engelman
Alan Engelman, Brookline, MA US
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20110142854 | COMPOSITIONS AND METHODS FOR INHIBITION OF RETROVIRUSES - Described herein are methods and compositions for the inhibition of retroviral integration and replication. The methods and compositions inhibit the activity of one or more components of the SET complex or base excision repair enzymes and induce autointegration of retroviral double-stranded nucleic acid. | 06-16-2011 |
Bob Engelman, Katy, TX US
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20130067995 | APPARATUS AND METHODS OF DETERMINING FLUID VISCOSITY - Various embodiments include apparatus and methods of determining the viscosity of a fluid downhole in a well. A parameter of a response signal, obtained from driving a tube containing a fluid with an excitation signal for vibrating the tube, can be collected while maintaining the tube in a vibrating mode. The parameter can be evaluated to measure the viscosity of the fluid. In various embodiments, the fluid viscosity may be measured in-situ downhole in the well. | 03-21-2013 |
David William Engelman, Austin, TX US
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20150019415 | AUTOMATIC CONSUMER DEBIT AND PAYMENT SYSTEM - Customers provide payday and creditor/biller information to a payment service, which determines the customer's aggregated monthly payments on periodic accounts such as vehicle loans and mortgages and then on each payday deducts a fraction of the aggregated amount in a single transaction, resulting in only a single fee to the customer. The fraction depends on how many times per month the customer is paid. The customer's funds are held in a trust account and on days that payment for a respective creditor is due during the month, the respective creditor is automatically paid out of the trust account. | 01-15-2015 |
Donald Engelman, Guilford, CT US
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20090298761 | Methods of treating cartilage defects using a soluble morphogenic protein complex - The present invention provides methods of repairing and regenerating cartilage tissue using a soluble morphogenic protein complex comprising (a) a morphogenic protein; and (b) a morphogenic protein pro region isolated from a morphogenic protein, or a conservative substitution variant or a fragment of said pro region, wherein said pro region or variant or fragment is noncovalently linked to the morphogenic protein, and wherein said complex is more soluble in an aqueous solvent than said morphogenic protein alone. | 12-03-2009 |
20150057222 | METHODS OF TREATING CARTILAGE DEFECTS USING A SOLUBLE MORPHOGENIC PROTEIN COMPLEX - The present invention provides methods of repairing and regenerating cartilage tissue using a soluble morphogenic protein complex comprising (a) a morphogenic protein; and (b) a morphogenic protein pro region isolated from a morphogenic protein, or a conservative substitution variant or a fragment of said pro region, wherein said pro region or variant or fragment is noncovalently linked to the morphogenic protein, and wherein said complex is more soluble in an aqueous solvent than said morphogenic protein alone. | 02-26-2015 |
Donald M. Engelman, New Haven, CT US
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20120039990 | Liposome Compositions and Methods of Use Thereof - The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide. | 02-16-2012 |
20120065576 | DRUG DELIVERY SYSTEM - A drug delivery system including a chamber, which is configured for enclosing or covering at least a surface of a patient, a source of a drug and a pressure source, which selectively pressurizes the chamber. In addition, the system includes a controller for controlling the transfer of the drug to the chamber wherein the drug is administered to the surface of the patient under pressure. | 03-15-2012 |
20150051153 | Environmentally Sensitive Compositions - An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues. | 02-19-2015 |
20150086617 | Liposome Structures And Methods of Use Thereof - The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide. | 03-26-2015 |
20150191508 | Selective Delivery of Molecules into Cells or Marking of Cells in Diseased Tissue Regions Using Environmentally Sensitive Transmembrane Peptide - A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a membrane spontaneously in a pH-dependant fashion placing one terminus inside cell. The polypeptide conjugated with various functional moieties delivers and accumulates them at cell membrane with low extracellular pH. The functional moiety conjugated with polypeptide terminus placed inside cell are translocated through the cell membrane in cytosol. The peptide and its variants or non-peptide analogs can be used to deliver therapeutic, prophylactic, diagnostic, imaging, gene regulation, cell regulation, or immunologic agents to or inside of cells in vitro or in vivo in tissue at low extracellular pH. | 07-09-2015 |
Donald M. Engelman, Guilford, CT US
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20090048555 | DRUG DELIVERY SYSTEM - A drug delivery system including a chamber, which is configured for enclosing or covering at least a surface of a patient, a source of a drug and a pressure source, which selectively pressurizes the chamber. In addition, the system includes a controller for controlling the transfer of the drug to the chamber wherein the drug is administered to the surface of the patient under pressure. | 02-19-2009 |
E. Eric Engelman, Doylestown, PA US
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20110243860 | ORAL CARE COMPOSITIONS - Oral care compositions that are stable, pourable and swishable suspension containing suspending polymer(s). Optional further components include abrasives, surfactants, flavorings, colorings, anti-plaque agents, anti-tartar agents, agents for sensitive teeth, fluoride ion sources and sweeteners. | 10-06-2011 |
20110243861 | ORAL CARE COMPOSITIONS - The present invention relates generally to oral care compositions, and more specifically to oral care compositions suitable for cleaning the oral cavity. Methods of use are also disclosed. | 10-06-2011 |
Gerald H. Engelman, Plymouth, MI US
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20150235557 | AUTONOMOUS VEHICLE HANDLING ANND PERFORMANCE ADJUSTMENT - A vehicle includes an autonomous driving sensor configured to detect a road condition and output at least one road condition signal representing the road condition, an autonomous mode controller configured to control the vehicle according to the at least one road condition signal, and a communication module configured to broadcast the road condition signal. | 08-20-2015 |
20150241226 | AUTONOMOUS DRIVING SENSING SYSTEM AND METHOD - First and second sets of data are collected in a vehicle from respective data sources. Each of the first and second sets of data are provided for determinations respectively selected from first and second categories of autonomous vehicle operations. A determination is made to take an autonomous action selected from the first category of autonomous vehicle operations. Data is used from each of the first and second data sets relating respectively to the first and second categories of autonomous vehicle operations to determine the autonomous action. | 08-27-2015 |
Jeffery A. Engelman, Mead, CO US
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20090015856 | METHODS AND STRUCTURE FOR MANAGING PRESENTATION OF MULTI-LANGUAGE FONTS - Methods and structures for improved font management providing for selection of one or more subsets of a selected typeface font in a font management program. A user is presented with information identifying one or more subsets of related code points in a selected typeface in a font management program. By selecting one or more subsets from the presented information, the user may reduce wasted presentation or management of code points in the typeface that are not presently of interest to the user. For example, when managing a Unicode typeface, a user may be prompted to select one or more language subsets prior to printing/displaying a matrix of the glyphs of the selected typeface. The presentation of glyphs or other code point information may then be limited to only the selected one or more subsets. | 01-15-2009 |
Jeffrey Engelman, Chestnut Hill, MA US
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20120225870 | METHODS FOR TREATING CANCER RESISTANT TO ERBB THERAPEUTICS - Provided herein are methods for treating cancer that is resistant to treatment with an anti-ErbB therapeutic agent and which is associated with an activating MET gene mutation or a MET gene amplification. The methods involve administering to a subject a combination of an anti-ErbB therapeutic and an anti-MET therapeutic. Also provided are methods for reducing ErbB mediated signaling or PI3 kinase mediated signaling in a cancer cell. | 09-06-2012 |
20140296100 | METHODS FOR TREATING CANCER RESISTANT TO ERBB THERAPEUTICS - Provided herein are methods for treating cancer that is resistant to treatment with an anti-ErbB therapeutic agent and which is associated with an activating MET gene mutation or a MET gene amplification. The methods involve administering to a subject a combination of an anti-ErbB therapeutic and an anti-MET therapeutic. Also provided are methods for reducing ErbB mediated signaling or PI3 kinase mediated signaling in a cancer cell. | 10-02-2014 |
Jerry H. Engelman, Plymouth, MI US
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20140043152 | System and Method for Controlling Adaptive Cruise Control Based on Driver Status - A device for controlling an adaptive cruise control system based on driver status is provided. The device comprises a controller configured to receive at least one driver status signal indicative of the driver being either a primary driver or a secondary driver and to determine whether the driver of the vehicle is the one of the primary driver and the secondary driver based on the at least one driver status signal. The controller is further configured to allow control by a primary driver over operating parameters of an ACC system and to allow the primary driver to establish a restricted mode in which a secondary driver is prevented from making certain dis-allowed changes in the operating parameters. | 02-13-2014 |
20140052358 | TRAILBRAKING - A system for trailbraking includes a velocity sensor providing a velocity output signal, a second sensor providing a second output signal and a trailbraking controller for receiving the velocity output signal and the second output signal. The trailbraking controller will provide an output control signal conditioned by the velocity output signal and the second output signal when indicative of an emergency avoidance maneuver. A method for trailbraking is provided. | 02-20-2014 |
John Russell Engelman, Calgary CA
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20140262220 | Cellar Oil Recovery Techniques for In Situ Operations - Techniques for recovering hydrocarbons, such as heavy hydrocarbons or bitumen, from a cellar region below a horizontal production well can include providing a cellar well section that extends from the horizontal production well into the cellar region. The horizontal production well can be part of a Steam-Assisted Gravity Drainage (SAGD) in situ recovery system, which forms a hydrocarbon depleted region and a hydrocarbon bearing cellar region. The cellar region includes hydrocarbons that have been pre-heated by SAGD operations. One or more cellar well sections are provided from the SAGD production well to extend into the cellar region, in order to form a branched production well. A pressurizing gas can be injected into the hydrocarbon depleted region from a SAGD injection well, in order to provide sufficient pressure to promote production of pre-heated hydrocarbons from the cellar region through the cellar well section. A branch well section can also be provided from a horizontal production well into a pre-heated adjacent region. | 09-18-2014 |
Joshua Edward Engelman, Brooklyn, NY US
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20150066727 | Electronic Trading Exchange with User-Definable Order Execution Delay - Exemplary embodiments are related to processing electronic trading orders in an electronic trading exchange environment. Electronic trading orders can be accepted from market participant electronic devices. The electronic trading orders have execution speeds associated therewith that can be used by exemplary embodiments to determine when the electronic trading orders are executed by a matching engine. | 03-05-2015 |
Lawrence Engelman, Oxford, CT US
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20080215376 | LONG-TERM CARE INSURANCE - An insurance policy in which the initial maximum benefit payable under the policy is less than or equal to the premium. The policy protects an insured's assets under a Government benefit program that has an asset limit for applicants and that allows applicants to shelter assets by obtaining private insurance. Assets may be sheltered under such a Government program by providing such insurance, obtaining payment for a benefit under the insurance; and applying benefits under the Government program. Insurance can be sold to shelter assets under such a Government benefit program by setting the maximum payable benefit to less than or equal to the premium. Optionally, the initial maximum benefit payable under the policy is less than or equal to about 105% of the premium. The Government benefit program may be a Medicaid State Long-Term Care (LTC) Partnership Program and the insurance benefit may be a long-term health care benefit. | 09-04-2008 |
Robert E. Engelman, Katy, TX US
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20130340518 | DOWNHOLE FORMATION FLUID CONTAMINATION ASSESSMENT - The present invention relates to a method of detecting synthetic mud filtrate in a downhole fluid including placing a downhole tool into a wellbore, introducing a downhole fluid sample into the downhole tool, analyzing the downhole fluid sample in the downhole tool, producing at least two filtrate markers from the analyzing of the downhole fluid sample and converting the at least two filtrate markers by vector rotation to a sufficiently orthogonal signal. The first pumped fluid sample giving initial plateau readings can be a proxy for 100% drilling fluid having an initial orthogonal signal and subsequent samples can be converted to orthogonal signals that are referenced to the first pumped fluid signal to give a calculation of percent contamination of the formation fluid. | 12-26-2013 |
Robert E. Engelman, Houston, TX US
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20130312481 | FLUID PROPERTIES INCLUDING EQUATION OF STATE MODELING WITH OPTICAL CONSTRAINTS - The invention relates to a method of determining an unknown property or information of a reservoir fluid. The method includes measuring a set of responses of a measuring instrument to the fluid and measuring one or more physical or chemical properties of the fluid. The method further includes determining the unknown property or information of the fluid based on the relationship between the instrument responses and the measured properties of the fluid using equation-of-state (EOS) model. | 11-28-2013 |
Robert W. Engelman, Tampa, FL US
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20080280812 | HUMAN IMMUNOSUPPRESSIVE PROTEIN - A method for purifying an immunosuppressant protein (HISP) has the steps of obtaining supernatant from hNT cells; exposing the supernatant to preparative polyacrylamide gel electrophoresis to produce 20 isoelectric fractions, including active isoelectric fraction #10; placing the active isoelectric fraction on a Blue Sepharose column to bind albumin; and collecting the free fraction containing the concentrated, isolated HISP. Also disclosed is a method of treating inflammation, using an effective amount of an HISP. The HISP is anionic, has a molecular weight of 40-100 kDa, an isoelectric point of about 4.8 and is obtained from the supernatant of hNT cells, but not from NCCIT embryonal carcinoma cells. T98G glioblastoma cells or THP-1 monocytic leukemia cells. HISP can maintain T cells in a quiescent G.sub.0/G.sub.1 state without lowering their viability. HISP loses activity when treated with heat, pH2, pH11, or mixed with trypsin or carboxypeptidase, but not with neuraminidase. HISP can suppress proliferation of responder peripheral blood mononuclear cells in allogeneic mixed lymphocyte cultures; HISP can suppress T-cell proliferation and IL-2 production in response to phorbol 12-myristate 13-acetate (PMA), ionomycin and concanavalin-A. HISP does not bind to heparin-sepharose CL-B gel; or to albumin-binding resin Blue Sepharose, HISP is concentrated with YM10 ultrafiltration. HISP does not act through the T-cell receptor-CD3 complex or via altered accessory signal cells. A method of treating inflammation comprises administering an effective amount of hNT neuronal cells. | 11-13-2008 |
20140234401 | METHOD OF TREATING INFLAMMATION USING HUMAN IMMUNOSUPPRESSIVE PROTEIN - A method of treating inflammation by administering a therapeutically effective amount of a human immunosuppressant protein (HISP) to a subject is presented. The inventors have discovered a novel immunosuppressive protein purified from the supernatant of hNT cell culture. The immunosuppressant protein has a molecular weight of about 40-100 kDa, an isoelectric point of about 4.4, a net ionic charge and is capable of suppressing T-cell activation, T-cell proliferation and the production of IL-2. This protein can be used in treating inflammation, preventing graft rejection after transplantation, treating autoimmune diseases and suppressing allergic responses as well as other uses. | 08-21-2014 |
Russell Engelman, Calgary CA
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20140262241 | Systems and Methods for the Production of a Subterranean Reservoir Containing Viscous Hydrocarbons - A method for recovering viscous hydrocarbons from a reservoir in a subterranean formation includes (a) injecting steam into the reservoir. In addition, the method includes (b) injecting a surfactant into the reservoir with the steam during (a). Further, the method includes (c) decreasing the viscosity of the hydrocarbons in the reservoir with thermal energy from the steam. Still further, the method includes (d) emulsifying the hydrocarbons with the surfactant during (b) and (c). Moreover, the method includes (e) mobilizing at least some of the hydrocarbons in the reservoir. | 09-18-2014 |
20140262242 | Systems and Methods for the Production of a Subterranean Reservoir Containing Viscous Hydrocarbons - A method for recovering viscous hydrocarbons from a reservoir in a subterranean formation includes (a) injecting steam into the reservoir. In addition, the method includes (b) injecting a thermally activated chemical species into the reservoir with the steam during (a). The thermally activated chemical species decomposes at a temperature between 40° and 200° C. Further, the method includes (c) decreasing the viscosity of the hydrocarbons in the reservoir during (a) and (b). Still further, the method includes (d) mobilizing at least some of the hydrocarbons in the reservoir. | 09-18-2014 |
20140262243 | Systems and Methods for Accelerating Production of Viscous Hydrocarbons in a Subterranean Reservoir with Thermally Activated Chemical Agents - A method for mobilizing viscous hydrocarbons in a reservoir includes (a) injecting an aqueous solution into the reservoir with the reservoir at the reservoir ambient temperature. The aqueous solution includes water and a water-soluble chemical agent that is substantially non-decomposable and substantially non-reactive in the reservoir at the reservoir ambient temperature. In addition, the method includes (b) adding thermal energy to the reservoir at any time after (a) to increase the temperature of at least a portion of the reservoir to an elevated temperature greater than the ambient temperature of the reservoir. Further, the method includes (c) in response to the elevated temperature in (b), mobilizing at least a portion of the hydrocarbons in the reservoir by reducing the viscosity of the hydrocarbons and allowing the chemical agent to enhance mobilization of the hydrocarbons. | 09-18-2014 |
Travis Engelman, San Francisco, CA US
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20130147949 | AD HOC SECURITY DEVICE NETWORK - One example embodiment includes an ad hoc security device network. The ad hoc security device network includes a gateway, wherein the gateway is configured to connect to an external network. The ad hoc security device network also includes a security device. The security device is configured to connect to the external network through the gateway and monitor a desired condition in a particular area. | 06-13-2013 |
Zoar Jacob Engelman, Salt Lake City, UT US
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20130303876 | CAROTID BODY MODULATION PLANNING AND ASSESSMENT - Planning for and/or assessment of an ablation procedure on one or both carotid bodies or carotid body chemoreceptors or carotid body nerves to treat patients having a sympathetically mediated cardiac, metabolic, and pulmonary disease (e.g. hypertension, CHF, diabetes, sleep disordered breathing) resulting from peripheral chemoreceptor hypersensitivity, carotid body hyperactivity, high carotid body afferent nerve signaling or heightened sympathetic activation. | 11-14-2013 |
20130310823 | Endovascular Catheters and Methods for Carotid Body Ablation - Systems, devices, and methods for treating a patient having a sympathetically mediated disease associated at least in part with augmented peripheral chemoreflex or heightened sympathetic activation. The treatments include ablating one or more peripheral chemoreceptors or associated afferent nerves to reduce or remove afferent neural signals from the peripheral chemoreceptor. | 11-21-2013 |
20130324987 | Methods and Devices for Cryogenic Carotid Body Ablation - Methods and cryogenic devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation. | 12-05-2013 |
20130324989 | Percutaneous Methods and Devices for Carotid Body Ablation - Methods and percutaneous devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via percutaneous carotid body ablation. | 12-05-2013 |
20140018788 | Devices and Systems for Carotid Body Ablation - Methods and endovascular catheters for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via transmural carotid body ablation. | 01-16-2014 |
20140243809 | ENDOVASCULAR CATHETERS FOR TRANS-SUPERFICIAL TEMPORAL ARTERY TRANSMURAL CAROTID BODY MODULATION - Methods, devices, and systems for carotid body modulation via accessing a target site with an endovascular approach through a superficial temporal artery. | 08-28-2014 |