Zhou, PA
Aiguo Zhou, Philadelphia, PA US
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20090055106 | METHOD FOR STRUCTURAL HEALTH MONITORING USING A SMART SENSOR SYSTEM - The structural health monitoring method of the present invention utilizes a sensor system to determine information about deformation, stress and/or damage in structural elements. The sensor system and the method employ at least one sensor which comprises a material having fully-reversible nonlinear elasticity. The method comprises associating at least one sensor including a material having fully-reversible nonlinear elasticity with a structural element in a manner whereby stress is transferred from said structural element to said sensor, propagating ultrasound through a portion of the sensor, receiving the ultrasound which has been propagated through at least a portion of the sensor and determining information about the structural element from attenuation and/or time of flight of said received ultrasound. | 02-26-2009 |
20110154903 | METHOD FOR STRUCTURAL HEALTH MONITORING USING A SMART SENSOR SYSTEM - The structural health monitoring method of the present invention utilizes ultrasound to determine information about deformation, stress and/or damage in structural elements. The method propagates ultrasound through at least a portion of a material having fully-reversible nonlinear elasticity, receives the ultrasound which has been propagated through at least a portion of the material and determining information about the structural element from attenuation and/or time of flight of said received ultrasound. | 06-30-2011 |
Chao Zhou, Bethlehem, PA US
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20140160488 | APPARATUS AND METHOD FOR SPACE-DIVISION MULTIPLEXING OPTICAL COHERENCE TOMOGRAPHY - A space-division multiplexing optical coherence tomography apparatus and system is provided. In one embodiment, the system includes a light source, a reference arm, and a sample arm. The sample arm splits the sampling light into a plurality of sampling beams which may be scanned simultaneously onto a surface of a sample. An optical delay may be introduced into the sampling beams before scanning. A plurality of reflected light signals returned from the sample is collected. In one arrangement, the signals may be combined to produce a single reflected light signal. The reflected light signal(s) and a reference signal are combined to produce an interference signal comprising data representative of digitized images captured of the actual object. In one embodiment, a single sample arm may be used for scanning and collecting image data. A related method is also provided. | 06-12-2014 |
Chenming Zhou, Pittsburgh, PA US
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20140184447 | PHASE-BASED RANGING FOR BACKSCATTER RFID TAGS - A RF tag reader may use spatial averaging to compensate for the limitations of performing multi-frequency continuous-wave ranging (MFCW) in a bandwidth-limited environment. Although MFCW provides an estimate of the separation distance between a RF tag and the tag reader with errors that vary widely, the error values form a pattern based on the separation distance. That is, as the separation distance increases or decreases, the error values oscillate between maximum and minimum values centered on the correct separation distance. Accordingly, in one embodiment, the receiver uses spatial averaging to average out this oscillating error (e.g., the maximum errors are counter-balanced by the minimum errors). The more accurate, spatially-averaged MFCW estimate may then be used to resolve the cycle ambiguity in continuous-wave ranging to identify the separation distance between the RF tag and the tag reader. | 07-03-2014 |
Chenming Zhou, Pittsburg, PA US
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20130147609 | TRANSMIT DIVERSITY FOR PASSIVE BACKSCATTER RFID - Techniques are presented for adaptively increasing power delivered to an RF tag. In one embodiment, a tag reader uses multiple transmit antennas to increase the power delivered to an RF tag without increasing the transmission power. The tag reader may perform transmit diversity (or a related antenna diversity schema) to ensure that transmitted signals from the multiple transmit antennas constructively interfere at the location of the RF tag. The tag reader may transmit a pilot signal and measure a phase associated with a received signal from the RF tag. The tag reader may then use the phase to determine a phase shift for each of the plurality of antennas. The phase shift may then be applied to any subsequent signals transmitted by the antennas to ensure that the signals interfere at the RF tag's location. | 06-13-2013 |
Dongming Zhou, Philadelphia, PA US
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20130209512 | UNIVERSAL INFLUENZA A VACCINES - Universal flu vaccines are disclosed. The vaccines induce broad and sustained protection against a wide range of influenza A viruses, reduce the need for annual vaccination campaigns with vaccines based upon viral strains predicted to be the predominant circulating strains, and ameliorate the threat of future pandemics that can potentially kill millions. | 08-15-2013 |
20140377295 | INFLUENZA VACCINES CONTAINING MODIFIED ADENOVIRUS VECTORS - This disclosure provides universal influenza vaccines which can provide extended protection for several years, provide improved protection to circulating influenza strains that were not predicted accurately for annual vaccine manufacturing, and provide protection against newly emerging strains of influenza virus which carry the potential for establishing global pandemics. | 12-25-2014 |
Fan Zhou, Bethlehem, PA US
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20080301522 | STRUCTURED DE-INTERLEAVING SCHEME FOR PRODUCT CODE DECODERS - A structured interleaving/de-interleaving scheme enables efficient implementation of encoding/decoding based on two-dimensional product codes (2D PC). An encoder has an integrated architecture that performs structured interleaving and PC coding in an integrated manner in which locations in the interleaved data stream are related to row and column indices for the 2D PC coding based on closed-form expressions. In one embodiment, a corresponding decoder implements two-stage low-density parity-check (LDPC) decoding based on the same relationships between locations in the interleaved data stream and row and column indices for the LDPC decoding. | 12-04-2008 |
Honglin Zhou, North Wales, PA US
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20110065087 | NOVEL HIV TARGETS - A set of cellular genes that were identified by siRNA screening as being essential for Human Immunodeficiency Virus (HIV) infection. These genes are host cellular factors involved in DNA repair, specifically in the base excision repair pathway. | 03-17-2011 |
Jianguo J. Zhou, Bethlehem, PA US
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20130029556 | Copolymers of E-Caprolactone and Glycolide for Melt Blown Nonwoven Applications - Copolymers exhibiting the following combinations of properties, including without limitation, ε-caprolactone in an amount ranging from about 12 to about 70 mole percent, glycolide in an amount ranging from about 30 to about 88 mole percent, crystallinity ranging from about 10 to about 50% as measured by WAXD or about 10 to about 50 J/g as measured by DSC, and an inherent viscosity ranging from about 0.5 to about 1.45 dL/g as measured in a 0.1 g/dl solution of HFIP at 25° C.; a method for melt blowing such copolymers and nonwoven constructs produced therefrom are described herein. | 01-31-2013 |
Jianguo Jack Zhou, Bethlehem, PA US
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20090104276 | ABSORBABLE COPOLYESTERS OF POLY(ETHOXYETHYLENE DIGLYCOLATE) AND GLYCOLIDE - A semi-crystalline, absorbable copolyester composition comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the reaction product of diglycolic acid and/or a derivative thereof and diethylene glycol; and the copolyester comprises about 30 to 60% by weight of the polycondensation polyester based on the total weight of the copolyester. Also medical devices such as absorbable sutures comprising such copolyesters and absorbable microspheres comprising such copolyesters and methods of making of such absorbable microspheres. Additionally, a method of melt blowing an absorbable copolyester composition and a nonwoven construct are disclosed. | 04-23-2009 |
20090118241 | BIOABSORBABLE POLYMER COMPOSITIONS EXHIBITING ENHANCED CRYSTALLIZATION AND HYDROLYSIS RATES - A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend. | 05-07-2009 |
20090264040 | Copolymers of Epsilon-Caprolactone and Glycolide for Melt Blown Nonwoven Applications - Copolymers exhibiting the following combinations of properties, including without limitation, ε-caprolactone in an amount ranging from about 12 to about 70 mole percent, glycolide in an amount ranging from about 30 to about 88 mole percent, crystallinity ranging from about 10 to about 50% as measured by WAXD or about 10 to about 50 J/g as measured by DSC, and an inherent viscosity ranging from about 0.5 to about 1.45 dL/g as measured in a 0.1 g/dl solution of HFIP at 25° C.; a method for melt blowing such copolymers and nonwoven constructs produced therefrom are described herein. | 10-22-2009 |
20120215307 | BIOABSORBABLE MULTILAYER NASAL VALVE SPREADER GRAFT - Novel bioabsorbable, nasal spreader graft implant devices are disclosed. The devices are useful in rhinoplasty and nasal reconstruction surgical procedures, as well as other surgical procedures. The devices have biodegradable core plates and biodegradable spreader plates or tissue ingrowth plates. The plates may have tissue ingrowth properties. | 08-23-2012 |
20120302528 | BIOABSORBABLE POLYMER COMPOSITIONS EXHIBITING ENHANCED CRYSTALLIZATION AND HYDROLYSIS RATES - A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend. | 11-29-2012 |
20130006349 | TISSUE ENGINEERED BLOOD VESSELS - Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed. | 01-03-2013 |
20130210310 | BIOABSORBABLE POLYMER COMPOSITIONS EXHIBITING ENHANCED CRYSTALLIZATION AND HYDROLYSIS RATES - A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend. | 08-15-2013 |
Linqiu Zhou, Wynnewood, PA US
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20090299357 | CRYONEEDLE AND CRYOTHERAPHY SYSTEM - A device and system for cryogenically treating tissue having an external cryoneedle including an outer housing having a proximal end, a proximal portion, a distal portion and a distal end. The proximal portion of the outer housing is coated with a first material and the distal portion of the outer housing is coated with a second material. The distal end is sealed with a third material. The first material has different temperature conductive properties than the second and third materials. An internal cryoneedle having a first and second end is axially disposed within the external cryoneedle. The first end of the internal cryoneedle is in communication with the sealed distal end of the external cryoneedle and the second end of the internal cryoneedle being in fluid communication with a cryogen source. | 12-03-2009 |
Mingda Zhou, University Park, PA US
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20150369781 | MEMS FLOW CONTROL CHIP FOR GAS CHROMATOGRAPHY - A micro-electro-mechanical system (MEMS) flow control chip that can control the flow of gas and be configured to operate in a gas chromatography system are disclosed. The MEMS flow control chip can include at least one inlet port in the chip, at least one outlet port in the chip, at least one flow channel between the inlet and outlet ports, and at least one pneumatic valve in the chip for controlling a flow of gas through the flow channel and between the inlet port and outlet ports. Advantageously, the MEMS flow control chip can be positioned in an oven of the a gas chromatography system and have a temperature approximately the same as one or more chromatographic columns of the system. | 12-24-2015 |
Mingda Zhou, State College, PA US
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20130180909 | FLEXIBLE FILTER DEVICE FOR CAPTURING OF PARTICLES OR CELLS IN A FLUID - A filtering device includes a housing and one or more flexible filter arrays. The flexible filter arrays can be coupled to the housing. Each flexible filter array can include a plurality of members and one or more support members. The plurality of members each can have a proximal and a distal end, the plurality of members being spaced apart by a predetermined distance. The one or more support members can be coupled to one or more of the plurality of members. Each of the plurality of members can be configured to deflect relative to the one or more support members. | 07-18-2013 |
20140146159 | Z-MICROSCOPY - We present a method for parallel axial imaging, or z-microscopy, utilizing an array of tilted micro mirrors arranged along the axial direction. Image signals emitted from different axial positions can be orthogonally reflected by the corresponding micro mirrors and spatially separated for parallel detection, essentially converting the more challenging axial imaging to a lateral imaging problem. Each micro mirror also provides optical sectioning capability due to its finite dimension. | 05-29-2014 |
Q. Jean Zhou, Malvern, PA US
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20100168108 | PHENYL DERIVATIVES AND METHODS OF USE - Novel phenyl compounds, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the compounds are agonists and/or ligands of cannabinoid receptors and may be useful, inter alia, for treating and/or preventing pain, gastrointestinal disorders, genitourinary disorders, inflammation, glaucoma, auto-immune diseases, ischemic conditions, immune-related disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, and as an appetite stimulant. | 07-01-2010 |
Ruqian Zhou, Pittsburgh, PA US
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20100294590 | Method, Apparatus, and Arrangement for a Lifeline System - A shuttle member for a horizontal lifeline system having at least one elongate line attached between at least two anchorage points. The shuttle member includes: a body having: (i) an upper portion configured for attachment to the line by at least partially surrounding the line; (i) an intermediate portion that, together with the upper portion, defines at least one passage slit that is sized such that the elongate line cannot pass therethrough; and (iii) an attachment portion configured for attachment of at least a portion of a lanyard. A shuttle member arrangement and a passing method are also disclosed. | 11-25-2010 |
Sean Zhou, Collegeville, PA US
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20120157583 | Roofing Granules, Roofing Products Including Such Granules, and Process for Preparing Same - A coating composition including an inorganic sol material and an organic colorant is applied to mineral particles and cured at a temperature less than 200 degrees Celsius. | 06-21-2012 |
Sean X. Zhou, Collegeville, PA US
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20110159240 | COMPOSITE NANOPARTICLES FOR ROOFING GRANULES, ROOFING SHINGLES CONTAINING SUCH GRANULES, AND PROCESS FOR PRODUCING SAME - Roofing granules are prepared by coating granule cores with a coating material including composite nanoparticles and curing the coating layer to dissolve the aggregate binder and disperse the nanoparticles in the coating. | 06-30-2011 |
20130118545 | Photovoltaic Roofing Components And Systems - The present invention relates particularly to photovoltaic roofing systems in which photovoltaic elements are integrated on a roof deck with conventional roofing materials. In one aspect, a photovoltaic roofing system includes a two-part tee element disposed on a roof deck, the two-part tee element comprising a base piece including a central portion; two opposed horizontally-extending first and second flanges extending from the central portion, and a top piece attachment feature formed in the central portion, and a top piece including a base piece attachment feature mated with the top piece attachment feature of the base piece; and a vertically extending portion extending from the base piece attachment feature. A first photovoltaic element can be disposed on the roof adjacent the base piece with its edge disposed on the horizontally-extending first flange of the base piece of the two-part tee element. | 05-16-2013 |
20150027069 | Photovoltaic Roofing Components and Systems - The present invention relates particularly to photovoltaic roofing systems in which photovoltaic elements are integrated on a roof deck with conventional roofing materials. In one aspect, a photovoltaic roofing system includes a two-part tee element disposed on a roof deck, the two-part tee element comprising a base piece including a central portion; two opposed horizontally-extending first and second flanges extending from the central portion, and a top piece attachment feature formed in the central portion, and a top piece including a base piece attachment feature mated with the top piece attachment feature of the base piece; and a vertically extending portion extending from the base piece attachment feature. A first photovoltaic element can be disposed on the roof adjacent the base piece with its edge disposed on the horizontally-extending first flange of the base piece of the two-part tee element. | 01-29-2015 |
Shutong Zhou, Lansdale, PA US
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20080292315 | Anti Clipping Circuit For Laser Transmitters - This anti clipping circuit is for a laser transmitter used to transmit sub-carrier multiplexed signals for CATV applications. The circuit design is based on actual clipping measurements showing the specific time and duration of the clipping events is random. The individual clipping pulses interval is fixed, every 4 us. A PHEMT peak detection circuit is used in conjunction with a missing pulse detector/timer to catch all the clipping events. Thus the laser bias current is adjusted automatically at the specific time of the clipping event and for the duration of all the clipping pulses in the event. The controlled increase and decrease of the lasers bias current is DC coupled back into the normal DC bias path via a diode. This gives the anti clipping circuit noise isolation when there are no clipping events and avoids laser clipping during the laser current recovery time as when using an AC coupling scheme. | 11-27-2008 |
20090245309 | Dispersion Compensating Varactor Circuit - Improved dispersion compensating circuits for optical transmission systems are disclosed. According to the improved method, there is provided a compensation circuit comprising a varactor diode network. The network is preferably inserted between a source of laser modulating signal and the laser. A low-pass filter or all pass filter constructs the network. The network preferably includes an inductor or inductors and a combined circuit, which includes varactors. The network preferably provides an amplitude dependent delay of the modulating signal applied to the laser or to the optical receiver as post dispersion correction circuitry. In a first embodiment, a fixed capacitor is in series with a varactor and connected to a DC bias through inductor. Additional embodiments, using multiple varactors in different circuit configurations, with particular advantages for various applications identified. | 10-01-2009 |
Simon Zhou, Malvern, PA US
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20150328199 | METHODS AND COMPOSITIONS USING 4-AMINO-2-(2,6-DIOXO-PIPERIDINE-3-YL)-ISOINDOLINE-1,3-DIONE FOR TREATMENT OF CANCERS - Methods and compositions for treating, preventing or managing cancers are disclosed. The methods encompass the administration of 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione, also known as Pomalidomide. Furthermore, provided herein are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed. | 11-19-2015 |
Suping Zhou, Philadelphia, PA US
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20140038916 | O-(SUBSTITUTED BENZYL) PHOSPHORAMIDATE COMPOUNDS AND THERAPEUTIC USE - This application discloses novel phosphoramidate and phosphonoamidate prodrugs of nucleosides, nucleotides, C-nucleosides, C-nucleotides, phosphonates, and other alcohol-containing drugs; use of these prodrugs for treatment of infectious diseases and cancers, in particular, liver infections and cancers; and methods of preparing these novel phosphoramidate and phosphonoamidate prodrugs. | 02-06-2014 |
20140315850 | 2',3'-Dideoxy-2'-alpha-Fluoro-2'-beta-C-Methylnucleosides and Prodrugs Thereof - The present invention is made to fulfill the foregoing need. Since most of antiHN nucleosides are 2′,3′-dideoxynucleosides that have been proved to be excellent substrates of kinases for the phosphorylations. 2′,3′-Dideoxy-2,-a-fluoro-2′-{3-C-methyl-nucleosides can be considered as one unique class of 2′,3′-dideoxynucleosides to be good substrate of kinases because fluorine mimics hydrogen. It also can be considered as ribo-nucleosides to incorporate into RNA of HCV because 2′-fluorine-a mimics 2′-a-OH group. | 10-23-2014 |
Wenchao Zhou, Philadelphia, PA US
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20130166712 | CLOUD-EDGE TOPOLOGIES - The description relates to cloud-edge topologies. Some aspects relate to cloud-edge applications and resource usage in various cloud-edge topologies. Another aspect of the present cloud-edge topologies can relate to the specification of cloud-edge applications using a temporal language. A further aspect can involve an architecture that runs data stream management systems (DSMSs) engines on the cloud and cloud-edge computers to run query parts. | 06-27-2013 |
20150296000 | CLOUD-EDGE TOPOLOGIES - The description relates to cloud-edge topologies. Some aspects relate to cloud-edge applications and resource usage in various cloud-edge topologies. Another aspect of the present cloud-edge topologies can relate to the specification of cloud-edge applications using a temporal language. A further aspect can involve an architecture that runs data stream management systems (DSMSs) engines on the cloud and cloud-edge computers to run query parts. | 10-15-2015 |
Xiang Yang Zhou, North Wales, PA US
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20140248305 | ADENOVIRAL VECTORS COMPRISING PARTIAL DELETIONS OF E3 - This disclosure provides replication-incompetent adenoviral vectors useful in vaccine development and gene therapy. The disclosed vectors comprise a selective deletion of E3 and are particularly useful for preparation of vaccines development and for gene therapy using toxic transgene products that result in vector instability that occurs when the entire E3 domain is deleted. | 09-04-2014 |
Xian Sean Zhou, Exton, PA US
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20150260819 | TRANSFER OF VALIDATED CAD TRAINING DATA TO AMENDED MR CONTRAST LEVELS - A method is disclosed for controlling an MR device. A control unit and an imaging device with a control unit are also disclosed. An embodiment of the method serves to transfer an interim result which is calculated by an automatic alignment algorithm which is provided in an image processing module, to a localizer image. An optimized result can then be converted into instructions which serve to control the MR device and are based on the localizer image which has been captured in a different recording technique than the images with which the automatic alignment algorithm has been trained. | 09-17-2015 |
Xixian Zhou, Collegeville, PA US
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20140300028 | METHOD OF MAKING CONTINUOUS FILAMENT REINFORCED STRUCTURAL PLASTIC PROFILES USING PULTRUSION/COEXTRUSION - A system and method are disclosed for producing a continuous filament reinforced thermoplastic profile having consistent cross section. A continuous reinforcing filament is pre-wetted with a first thermoplastic resin and introduced into a die, where it is contacted with a second thermoplastic resin extruded from an extruder at melt state. The temperature of the die is carefully controlled so that the pre-wetted filament and first resin do not cure or solidify until after they have contacted and mixed with the second thermoplastic resin. The mixture temperature is then controlled to make a substantially solidified profile pre-shape. A capping layer comprising a third thermoplastic resin is then co-extruded onto the outer surface of the pre-shape. A multistage die for bringing together the filament and thermoplastic resins and for maintaining appropriate temperatures at each stage of the profile-forming process is also disclosed. | 10-09-2014 |
Yuhong Zhou, Phoenixville, PA US
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20080248034 | Methods For Inhibiting The Binding Of Endosialin To Ligands - The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands such as fibronectin and collagen. The invention provides methods for identifying inhibitors of the interaction of endosialin with endosialin ligands. Also provided are methods for inhibiting angiogenesis and neovascularization in vivo and in vitro. | 10-09-2008 |
20100008851 | ANTI-GD2 ANTIBODIES AND METHODS AND USES RELATED THERETO - Described herein are antibodies that specifically bind ganglioside GD2. Also described are nucleotides encoding such antibodies, cells expressing such antibodies, methods of use for such antibodies, and methods for using the antibodies to treat diseases associated with ganglioside GD2. In addition, tissue culture media supplements are described as are methods of use for the supplements. Described herein are albumin-ganglioside conjugates and corresponding methods for producing such conjugates. Methods of purifying or isolating antibodies are also described. | 01-14-2010 |
20110033455 | Methods For Inhibiting The Binding Of Endosialin To Ligands - The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands such as fibronectin and collagen. The invention provides methods for identifying inhibitors of the interaction of endosialin with endosialin ligands. Also provided are methods for inhibiting angiogenesis and neovascularization in vivo and in vitro. | 02-10-2011 |
20120328524 | ANTI-GD2 ANTIBODIES AND METHODS AND USES RELATED THERETO - Described herein are antibodies that specifically bind ganglioside GD2. Also described are nucleotides encoding such antibodies, cells expressing such antibodies, methods of use for such antibodies, and methods for using the antibodies to treat diseases associated with ganglioside GD2. In addition, tissue culture media supplements are described as are methods of use for the supplements. Described herein are albumin-ganglioside conjugates and corresponding methods for producing such conjugates. Methods of purifying or isolating antibodies are also described. | 12-27-2012 |
20130287691 | ANTI-GD2 ANTIBODIES AND METHODS AND USES RELATED THERETO - Described herein are antibodies that specifically bind ganglioside GD2. Also described are nucleotides encoding such antibodies, cells expressing such antibodies, methods of use for such antibodies, and methods for using the antibodies to treat diseases associated with ganglioside GD2. In addition, tissue culture media supplements are described as are methods of use for the supplements. Described herein are albumin-ganglioside conjugates and corresponding methods for producing such conjugates. Methods of purifying or isolating antibodies are also described. | 10-31-2013 |
20130305396 | ENGINEERED HUMAN ENDOSIALIN-EXPRESSING RODENTS - Provided herein are rodents that express the human endosialin gene. In preferred embodiments, the rodent is a mouse. Preferably, the human endosialin gene is integrated into the native or endogenous endosialin gene locus. More preferably, the host rodent is null for the endogenous endosialin gene product. The human endosialin gene is preferably expressed in a similar development and disease response pattern as that of the native endosialin gene product in parental or wild type rodents. This feature makes these rodents useful for studying the effects of test agents to positively or negatively affect endosialin biology for therapeutic use. Use of human endosialin expressing rodents lacking native endosialin gene product (HUE rodents) is proposed as a strategy for developing agents that can positively or negatively affect the endosialin pathway and also serve as a screening tool to identify those agents that may be useful as human therapies. | 11-14-2013 |
20150079104 | Methods For Inhibiting The Binding Of Endosialin To Ligands - The invention provides methods for inhibiting the interaction of endosialin with endosialin ligands. The inhibition is effectuated on the genetic level, by inhibiting endosialin gene expression, and on the protein level, by blocking the interaction of cell-surface expressed endosialin with ligands such as fibronectin and collagen. The invention provides methods for identifying inhibitors of the interaction of endosialin with endosialin ligands. Also provided are methods for inhibiting angiogenesis and neovascularization in vivo and in vitro. | 03-19-2015 |
Yuhong Zhou, Plymouth Meeting, PA US
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20090068185 | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders - A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders has also been discovered. The invention also includes a method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein. | 03-12-2009 |
20090191191 | Methods for the Modulation of IL-13 - The present invention is drawn to methods for modulating IL-13 expression and/or activity in a mammal comprising administering an effective amount of an agent which modulates the expression and/or activity of IL-9. | 07-30-2009 |
Yunkai Zhou, Sewickley, PA US
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20090094175 | INTRUSIVE SOFTWARE MANAGEMENT - Intrusion features of a landing page associated with sponsored content are identified. A feature score for the landing page based on the identified intrusion features is generated, and if the feature score for the landing page exceeds a feature threshold, the landing page is classified as a candidate landing page. A sponsor account associated with the candidate landing page can be suspended, or sponsored content associated with the candidate landing page can be suspended. | 04-09-2009 |
20090094697 | INTRUSIVE SOFTWARE MANAGEMENT - Landing pages associated with advertisements are partitioned into training landing pages and testing landing pages. Iterative training and testing of a classification mode on intrusion features of the partitioned landing pages is conducted until the occurrence of a cessation event. Feature weights are derived from the iterative training and testing, and are associated with the intrusion features. The associated feature weights and intrusion features can be used to classify other landing pages. | 04-09-2009 |
20120005753 | INTRUSIVE SOFTWARE MANAGEMENT - Intrusion features of a landing page associated with sponsored content are identified. A feature score for the landing page based on the identified intrusion features is generated, and if the feature score for the landing page exceeds a feature threshold, the landing page is classified as a candidate landing page. A sponsor account associated with the candidate landing page can be suspended, or sponsored content associated with the candidate landing page can be suspended. | 01-05-2012 |
20120311707 | INTRUSIVE SOFTWARE MANAGEMENT - Intrusion features of a landing page associated with sponsored content are identified. A feature score for the landing page based on the identified intrusion features is generated, and if the feature score for the landing page exceeds a feature threshold, the landing page is classified as a candidate landing page. A sponsor account associated with the candidate landing page can be suspended, or sponsored content associated with the candidate landing page can be suspended. | 12-06-2012 |
20140258013 | ENTITY-BASED SEARCHING WITH CONTENT SELECTION - Systems and methods for entity-based searching with content selection include receiving a search query and determining that the search query corresponds to a search entity. The search entity may be associated with an online action, thereby forming an entity-action pair. Auction parameters that specify the entity-action pair may be used to select third-party content. A visual layout for the third-party content may be generated based on the relationship between a search query and the entity-action pair and used as part of the presentation of the third-party content on a search result screen. | 09-11-2014 |
20140258014 | ENTITY-BASED SEARCHING WITH CONTENT SELECTION - Systems and methods for entity-based searching with content selection include receiving a search query and determining that the search query corresponds to a search entity. The search entity may be associated with an online action, thereby forming an entity-action pair. Auction parameters that specify the entity-action pair may be used to select third-party content. Search results based on the search query, the search entity, and the selected third-party content may be provided for presentation as part of a search result screen. | 09-11-2014 |
Zhilian Zhou, Pittsburgh, PA US
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20120206805 | NANOWIRE GRID POLARIZERS AND METHODS FOR FABRICATING THE SAME - A polarizer including a substrate sheet configured with grid elements on at least a first surface, wherein the grid elements have a height to width aspect ratio of at least 1.5:1, and metal coupled with the grid elements, wherein the metal comprises a height to width aspect ratio greater than the aspect ratio of the grid elements of the substrate. | 08-16-2012 |
Zihan Zhou, State College, PA US
Patent application number | Description | Published |
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20150332117 | COMPOSITION MODELING FOR PHOTO RETRIEVAL THROUGH GEOMETRIC IMAGE SEGMENTATION - A composition model is developed based on the image segmentation and the vanishing point of the scene. By integrating both photometric and geometric cues, better segmentation is provided. These cues are directly used to detect the dominant vanishing point in an image without extracting any line segments. Based on the composition model, a novel image retrieval system is developed which can retrieve images with similar compositions as the query image from a collection of images and provide feedback to photographers. | 11-19-2015 |