Irena
Irena Antic, Chicago, IL US
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20160030531 | BACTERIAL TOXINS AND USES THEREOF AS RAS SPECIFIC PROTEASES - Disclosed are bacterial toxins and uses thereof as specific proteases for Ras sarcoma oncoproteins (Ras proteins). The bacterial toxins may be modified for use as pharmaceutical agents for treating Ras-dependent diseases and disorders including cell proliferation diseases and disorders such as cancer. | 02-04-2016 |
Irena Barbulovic-Nad, Toronto CA
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20090203063 | Droplet-based cell culture and cell assays using digital microfluidics - We introduce a new method for implementing cell-based assays and long-term cell culture. The method is based on digital microfluidics (DMF) which is used to actuate nanoliter droplets of reagents and cells on a planar array of electrodes. DMF method is sutable for assaying and culturing both cells in suspension and cells grown on surface (adherent cells). This method is advantageous for cell culture and assays due to the automated manipulation of multiple reagents in addition to reduced reagent use and analysis time. No adverse effects of actuation by DMF were observed in assays for cell viability, proliferation, and biochemistry. These results suggest that DMF has great potential as a simple yet versatile analytical tool for implementing cell-based assays and cell culture on the microscale. | 08-13-2009 |
20100081578 | Exchangeable sheets pre-loaded with reagent depots for digital microfluidics - The present invention provides an exchangeable, reagent pre-loaded sheets which can be temporarily applied to an electrode array on a digital microfluidic device (DMF). The substrate facilitates virtually un-limited re-use of the DMF devices avoiding cross-contamination on the electrode array itself, as well as enabling rapid exchange of pre-loaded reagents while bridging the world-to-chip interface of DMF devices. The present invention allows for the transformation of DMF into a versatile platform for lab-on-a-chip applications. | 04-01-2010 |
20110240471 | EXCHANGEABLE CARRIERS PRE-LOADED WITH REAGENT DEPOTS FOR DIGITAL MICROFLUIDICS - The present invention provides exchangeable, reagent pre-loaded carriers ( | 10-06-2011 |
20130143312 | DROPLET-BASED CELL CULTURE AND CELL ASSAYS USING DIGITAL MICROFLUIDICS - We introduce a new method for implementing cell-based assays and long-term cell culture. The method is based on digital microfluidics (DMF) which is used to actuate nanoliter droplets of reagents and cells on a planar array of electrodes. DMF method is suitable for assaying and culturing both cells in suspension and cells grown on surface (adherent cells). This method is advantageous for cell culture and assays due to the automated manipulation of multiple reagents in addition to reduced reagent use and analysis time. No adverse effects of actuation by DMF were observed in assays for cell viability, proliferation, and biochemistry. These results suggest that DMF has great potential as a simple yet versatile analytical tool for implementing cell-based assays and cell culture on the microscale. | 06-06-2013 |
20140199719 | Impedance-Based Sensing of Adherent Cells on A Digital Microfluidic Device - Devices and methods are provided for measuring, on a digital microfluidic platform, electrical signals associated with the impedance of adherent cells. In one embodiment, a sub-droplet of cell culture media containing adherent cells is passively dispensed at a pre-selected electrode location where a local hydrophilic surface region is provided, and adherent cells are attached to the local hydrophilic surface region. The cell culture media sub-droplet is replaced with a sub-droplet of a low-conductivity medium in a passive dispensing step, retaining the attached adherent cells. An AC voltage with a suitable frequency is applied between electrodes of the device and a signal associated with the impedance of the adherent cells is obtained. One of the electrodes to which the AC voltage is applied may be a dedicated sensing electrode. The local thickness of a dielectric layer coating the pre-selected electrode may be reduced to increase the detection sensitivity of the device. | 07-17-2014 |
Irena Beylis, Tel Aviv IL
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20080221303 | Method for the Preparation of Peptide-Oligonucleotide Conjugates - The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks. | 09-11-2008 |
Irena Borucki, Mount Prospect, IL US
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20080266759 | HIGH DENSITY POWER DISTRIBUTION UNIT - A power distribution unit may include a power distribution unit frame, where the power distribution unit frame has a 2U form factor, and where the power distribution unit frame is coupled to mount in an embedded computer frame. A plurality of power ingress sites may be coupled to a rear portion of the power distribution unit frame, where each of the plurality of power ingress sites has a current capacity of at least 100 amperes, where each of the plurality of power ingress sites includes an ingress pin coupled to interface with an ingress in-line, hyperboloid radial socket, and where the power distribution unit has a current capacity density of the plurality of power ingress sites of at least 600 amperes per power distribution unit. | 10-30-2008 |
Irena Choroszy-Krol, Olesnica PL
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20100012588 | SYSTEM AND METHOD FOR THE EXTRA-CORPOREAL PURIFICATION OF BLOOD OF PATHOGENIC ENZYMES - The invention concerns an extra-corporeal system and method to purify blood of pathogenic enzymes which initiate tumoral processes as well as evoke dystrophic muscular lesion, including enzymes of the group of cysteine peptidases, in particular of cathepsins B and L and calpain, this system being intended for removing these proteins from the blood in order to eliminate the degradation of the body's cells caused by the presence of these proteins in the blood. | 01-21-2010 |
Irena Daberte, Riga LV
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20110280960 | THICK PINE NEEDLE EXTRACT COMPOSITION FOR CAPSULATION - The invention relates to pharmaceutics and to the pharmaceutical and food industries, in particular, to the production of compositions for stimulating the mucous membrane, ameliorating skin integument, and enhancing the organism's immunity. The aim of the invention is to develop a compound containing a thick pine needle extract with an improved quality composition in order to increase the biological activity of components and to preserve the processing characteristics and stability of the thick pine needle extract composition in capsular form. The aim is achieved by adding α-tocopherol (vitamin E), retinol (vitamin A), naphthoquinones (vitamin K), essential fatty acids (vitamin F) and microelements (zinc, selenium), with a specified component ratio, into the thick pine needle extract composition for capsulation. | 11-17-2011 |
Irena Ekiel, Pointe-Claire CA
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20090104215 | Methods and compositions for modulating tumor cell activity - Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding to clusterin. | 04-23-2009 |
Irena Fonda, Vrhnika SI
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20080293924 | Process For the Isolation and/or Purification of Proteins - The invention relates to the process for the isolation and/or purification of biologically active proteins, preferably TNF-alpha or TNF-alpha analogues. The process of the present invention results in the production of high yields of proteins, preferably TNF-alpha or TNF alpha analogues with a purity of greater than 98%. The described process is particularly suitable for the industrial production of proteins, preferably TNF-alpha or TNF-alpha analogues. | 11-27-2008 |
Irena Gokhman, Rehovot IL
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20090217411 | SALT RESPONSIVE GENES USEFUL FOR GENERATING SALT RESISTANT TRANSGENIC PLANTS - The present invention relates to a transgenic plant comprising one or more plant cells transformed with exogenous nucleic acid encoding a | 08-27-2009 |
Irena Ilcheva, Beaverton, OR US
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20090062892 | Article Of Apparel For Temperature Moderation - An article of apparel may include a polymer chamber element that defines an interior void for containing a substance in either a liquid or a solid state. Depending upon the substance located within the chamber element, the apparel may be utilized for increasing or decreasing the body temperature of the individual. The chamber element may have a plurality of subchambers, which may have a triangular shape and may be in fluid communication. In some configurations, the subchambers may have different sizes or volumes. | 03-05-2009 |
20140082815 | VARIABLE COMPRESSION GARMENT - Variable compression garments may use an elastomer such as silicone printed on a textile to create a varying amount of compressive force along a limb. Greater amounts of elastomer may be used to create greater amounts of compressive force. | 03-27-2014 |
Irena Irlik, Cracow PL
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20130235694 | GEOLOGICAL MEDIUM EXPLORATION - Systems and methods for geological medium exploration are provided herein. A method of geological medium exploration may include generating vibrations in a geological medium and recording wave-fields at a surface and in a borehole. Additionally, the method may include obtaining a wave field modification operator and applying the wave-field operator to a full range of seismic data to achieve a spectrally-modified wave field. | 09-12-2013 |
Irena Ivanovska, Seattle, WA US
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20090136957 | Methods and compositions for regulating cell cycle progression via the miR-106B family - In one aspect, a method is provided of inhibiting proliferation of a mammalian cell comprising introducing into said cell an effective amount of at least one microRNA-specific inhibitor of at least one miR-106b family member. In another aspect a method is provided for accelerating proliferation of a mammalian cell comprising introducing into said cell an effective amount of at least one miR-106b family member. | 05-28-2009 |
Irena Ivnitski-Steele, Coral Springs, FL US
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20150197526 | SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT - The present invention provides novel compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated disease by administering such compounds, and pharmaceutical compositions comprising such compounds. In one embodiment, the invention provides novel pyrazolo[1,5-a]pyrimidine efflux inhibitors that are selective toward ABCG2 over ABCB1. | 07-16-2015 |
Irena Izdebska-Szanda, Krakow PL
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20150246389 | COMPOSITION OF A CERAMIC LAYER FOR MANUFACTURING A CASTING MOULD AND OTHER PRODUCTS - A composition of a ceramic layer for manufacturing a casting mould and other products, in particular intended for making castings by investment casting, comprising a liquid ceramic mass consisting of in weight %, 50-75% of a ceramic material which is a mixture with particle-size distribution comprising minimum 90% of particles of size less than 0.04 mm, having the following phase composition: 30-90% of forsterite Mg | 09-03-2015 |
Irena Kemelmaher, Seattle, WA US
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20140177969 | FACE AND EXPRESSION ALIGNED MOVIES - Systems, methods and articles of manufacture for generating sequences of face and expression aligned images are presented. An embodiment includes determining a plurality of candidate images, computing a similarity distance between an input image and each of the candidate images based on facial features in the input image and the candidate images, comparing the computed similarity distances, selecting a candidate image based on the comparing, and adding the selected candidate image to an image sequence for real-time display. Embodiments select images from the image sequence as they are being added to the image sequence and scale, rotate and translate each image so that a face appearing in a selected image is aligned with a face appearing in a subsequently selected image from the image sequence. In this way, embodiments are able to render arbitrarily large image collections efficiently and in real time to display a face and expression aligned movie. | 06-26-2014 |
Irena Konstantinova, Dresden DE
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20100021950 | SCREENING METHOD FOR ANTI-DIABETIC COMPOUNDS - The present invention relates to a method of identifying a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of diabetes, the method comprising the steps of (a) contacting a test compound with a cell comprising a protein, wherein said protein (i) comprises or consists of the amino acid sequence of any one of SEQ ID NOs: 1 to 29; (ii) is encoded by a nucleic acid molecule comprising or consisting of the sequence of any one of SEQ ID NOs: 59 to 87; (iii) is a fragment of the protein according to (i) or (ii) and exhibits Eph-Receptor-Tyrosine-Kinase activity; or (iv) has a sequence at least 75% identical with the protein according to (i) or (ii) or with the fragment according to (iii) and exhibits Eph-Receptor-Tyrosine-Kinase activity; and (b) determining whether said test compound, upon contacting in step (a) inhibits the Eph receptor tyrosine kinase activity of said protein wherein said inhibition indicates a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of diabetes. | 01-28-2010 |
Irena Kostan, Hehaluz IL
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20130211810 | COUPLING ARCHITECTURAL AND IMPLEMENTATION/BEHAVIORAL MODELS OF A COMPUTER-BASED SYSTEM - Coupling architectural and implementation/behavioral models of a computer-based system by creating a bridge element, defining a port of the bridge element, associating the port of the bridge element with a port of an implementable element of an architectural model of a computer-based system and a port of an implementation element of an implementation/behavioral model of the computer-based system, mapping an interface member of the implementation element port to an interface member of the implementable element port, generating, from a template, skeleton source code applicable for the mapped interface member, generating a usage description element for the architectural model corresponding to the mapped interface member, generating an architectural description document from the architectural model, generating implementation code from the implementation/behavioral model and the generated skeleton source code, and generating a declaration file for an operating system service for use by the implementation code. | 08-15-2013 |
Irena Kostan, Hehaluz 4 IL
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20120072198 | COUPLING ARCHITECTURAL AND IMPLEMENTATION/BEHAVIORAL MODELS OF A COMPUTER-BASED SYSTEM - Coupling architectural and implementation/behavioral models of a computer-based system by creating a bridge element, defining a port of the bridge element, associating the port of the bridge element with a port of an implementable element of an architectural model of a computer-based system and a port of an implementation element of an implementation/behavioral model of the computer-based system, mapping an interface member of the implementation element port to an interface member of the implementable element port, generating, from a template, skeleton source code applicable for the mapped interface member, generating a usage description element for the architectural model corresponding to the mapped interface member, generating an architectural description document from the architectural model, generating implementation code from the implementation/behavioral model and the generated skeleton source code, and generating a declaration file for an operating system service for use by the implementation code. | 03-22-2012 |
Irena Krizmanic, Zagreb HR
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20090298879 | Impurities of Donepezil - The present invention relates to impurities of donepezil, or a pharmaceutically acceptable salt thereof, which may be produced during synthesis and storage of donepezil, or a pharmaceutically-acceptable salt thereof, and to methods of identifying such impurities. The invention also relates to the use of these impurities in analytical techniques and to product that contain certain low levels of these impurities in particular the following impurities are disclosed: formula (I) and formula (II). | 12-03-2009 |
Irena Krizmanic, Sisak HR
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20110275812 | PROCESS FOR THE PREPARATION AND PURIFICATION OF ETRAVIRINE AND INTERMEDIATES THEREOF - In one embodiment the present invention encompasses 4-(2,6-dichloropyrimidin-4-yloxy)-3,5-dimethylbenzonitrile (“ETHER”), 4-(4,6-dichloropyrimidin-2-yloxy)-3,5-dimethyl-benzonitrile (“ETHER C-2 isomer”), mixtures and salts thereof of. The present invention encompasses the use of ETHER and salts thereof to prepare Etravirine and Etravirine intermediates, and salts thereof. In another embodiment the present invention encompasses the use of ETHER and salts thereof to prepare debrometravirine (“DEBETV”) and salts thereof. In yet another embodiment the present invention encompasses the use of ETHER and salts thereof to prepare 4-(6-chloro-2-(4-cyanophenylamino)pyrimidin-4-yloxy)-3,5-dimethyl-benzonitrile (“ARCPBN”) and salts thereof. The compound, 4-(2,6-dichloropyrimidin-4-yloxy)-3,5-dimethylbenzonitrile “ETHER” of formula (A) wherein n is either 0 or 1 and HA is an acid. | 11-10-2011 |
20130035485 | PROCESS FOR THE PREPARATION AND PURIFICATION OF ETRAVIRINE AND INTERMEDIATES THEREOF - In one embodiment the present invention encompasses 4-(2,6-dichloropyrimidin-4-yloxy)-3,5-dimethylbenzonitrile (“ETHER”), 4-(4,6-dichloropyrimidin-2-yloxy)-3,5-dimethyl-benzonitrile (“ETHER C-2 isomer”), mixtures and salts thereof of. The present invention encompasses the use of ETHER and salts thereof to prepare Etravirine and Etravirine intermediates, and salts thereof. In another embodiment the present invention encompasses the use of ETHER and salts thereof to prepare debrometravirine (“DEBETV”) and salts thereof. In yet another embodiment the present invention encompasses the use of ETHER and salts thereof to prepare 4-(6-chloro-2-(4-cyanophenylamino)pyrimidin-4-yloxy)-3,5-dimethyl-benzonitrile (“ARCPBN”) and salts thereof. | 02-07-2013 |
20130123498 | PROCESS FOR THE PREPARATION OF ETRAVIRINE AND INTERMEDIATES IN THE SYNTHESIS THEREOF - The present invention includes compounds of Formula 1 of the following structure: | 05-16-2013 |
Irena Lovetinska-Slamborova, Praha 10 CZ
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20150064279 | ANTIBACTERIAL HYBRID LAYER OPERATING AGAINST PATHOGENIC BACTERIAL STRAINS, PARTICULARLY AGAINST THE BACTERIAL STRAIN MRSA, AND A METHOD OF ITS DEVELOPMENT - The invention hereunder concerns an antibacterial hybrid layer operating against pathogenic bacteria, particularly against the bacterial strain MRSA, made up of hybrid polymer resulting from the reaction of 3-(trialkoxysilyl) propyl methacrylate and/or 3-(trialkoxysilyl) propyl acrylate with 3-glycidoxy-propyltrialkoxy-silane, titanium alkoxide and silicon alkoxide with addition of soluble salts of silver, copper and zinc and potentially also with addition of titanium oxide nanoparticles. The hybrid polymer may further also contain addition of soluble salts of chromium (III) and/or vanadium or up to 90 mol. % of 3-(trialkoxysilyl) propyl methacrylate may be replaced with an equimolar mixture of methyl methacrylate and silicon alkoxide and, similarly, up to 90 mol. % of 3-(trialkoxysilyl) propyl acrylate may be replaced with an equimolar mixture of methyl acrylate and silicon alkoxide. | 03-05-2015 |
Irena Manov, Haifa IL
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20140248371 | SPALAX FIBROBLAST-DERIVED ANTI-CANCER AGENTS - A conditioned cell culture medium of cells derived from | 09-04-2014 |
Irena Meinikova, Jefferson, MA US
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20090023589 | METHODS FOR IDENTIFYING CONDITIONS AFFECTING A CELL STATE - The present invention is directed to methods for identifying agents which affect cell state. The instant invention provides rapid and efficient methods for identifying agents which affect cell state. Methods are directed toward the screening of complex combinations of agents for their ability to affect cell state. In one embodiment, cells are incubated under suitable conditions and subjected to different agents. After an appropriate amount of time, the cells are assayed to determine what, if any, characteristics they possess. Cell characteristics can be organized in a manner such that different and novel cell states can be identified. | 01-22-2009 |
Irena Moserova, Prague 9 CZ
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20150184130 | CRYOPRESERVATION OF APOPTOTIC CANCER CELLS FOR USE IN IMMUNOTHERAPY AGAINST CANCER - Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and using such cells to activate dendritic cells for use in immunotherapy. In a specific embodiment, the method comprises cryopreserving cancer cells undergoing cell death, which can be used to prepare a pharmaceutical composition for immunotherapy against cancer. | 07-02-2015 |
Irena Naguibneva, Villejuif FR
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20090053718 | NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF microRNAs AND THEIR TARGET mRNAs - The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNAs and their target mRNAs, as well as small interfering RNAs (siRNAs). The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g. alterations associated with human disease, such as cancer. | 02-26-2009 |
Irena Neverova, Kingston CA
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20100129851 | METHODS OF DIAGNOSING MUSCLE DAMAGE - A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage, and evaluating the sample for the presence or absence of a myofilament protein modification product. Preferably, the myofilament protein modification product is a chemical adduct of a myofilament protein. The method can also be used to assess the extent and/or type of muscle damage in a subject by studying the profile of myofilament protein modification products detected in the sample taken from the subject. The invention further provides a method for screening for an agent which modulates the level of a myofilament protein modification product present in a biological sample or for a calcium sensitizing agent. The invention is applicable to cardiac muscle and skeletal muscle. | 05-27-2010 |
Irena Oleinik, Ma'Alot IL
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20100092586 | Natural water soluble extracts for the inhibition of alpha-1-adrenergic receptors - The present invention discloses therapeutic natural products, in particular plant extracts effective in treating and preventing urinary tract disorders, and method for obtaining said extracts. In particular, the present invention discloses a water-soluble alcoholic extract of | 04-15-2010 |
20110229536 | COMPOSITIONS FOR TOPICAL APPLICATION COMPRISING MICROENCAPSULATED COLORANTS - Color-changing cosmetic or therapeutic compositions for topical application are provided, comprising one or more active substances and one or more microencapsulated colorants, which upon application on the skin provide a changing color effect that indicates the delivery of the active substances from said composition onto the skin and/or gives to the skin a visual esthetical effect. | 09-22-2011 |
Irena Oszczapowicz, Warszawa PL
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20090298786 | METHODS OF TREATING VIRAL INFECTIONS WITH ANTHRACYCLINE ANTIBIOTICS - A method of treating hepatitis C viral infection or viremia in a patient by administering to the patient an anti-hepatitis C virally effective amount of a compound of Formula 1 or Formula 2. A method for inhibiting the replication of hepatitis C virus by exposing the virus to a hepatitis C viral NS3 protease inhibiting amount of: a compound of Formula 1 or Formula 2. A pharmaceutical composition exhibiting an antihelicase activity containing at least a pharmaceutically-acceptable carrier, diluent or excipient, and a compound of Formula 1 or Formula 2. The pharmaceutical composition may additionally contain a second compound of Formula 1 or Formula 2; epidoxorubicin, doxorubicin, epidaunorubicin, or daunorubicin; and/or another antiviral agent. | 12-03-2009 |
Irena Paluy, Upper Galilee IL
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20110229536 | COMPOSITIONS FOR TOPICAL APPLICATION COMPRISING MICROENCAPSULATED COLORANTS - Color-changing cosmetic or therapeutic compositions for topical application are provided, comprising one or more active substances and one or more microencapsulated colorants, which upon application on the skin provide a changing color effect that indicates the delivery of the active substances from said composition onto the skin and/or gives to the skin a visual esthetical effect. | 09-22-2011 |
Irena Paluy, Kibbutz Dafna IL
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20100092586 | Natural water soluble extracts for the inhibition of alpha-1-adrenergic receptors - The present invention discloses therapeutic natural products, in particular plant extracts effective in treating and preventing urinary tract disorders, and method for obtaining said extracts. In particular, the present invention discloses a water-soluble alcoholic extract of | 04-15-2010 |
Irena Pulte, Eschborn DE
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20110294890 | Neramexane for the treatment or prevention of inner ear disorders - The present invention relates to a method of treatment or prevention of an inner ear disorder in a female comprising administering a therapeutically effective amount of neramexane or a pharmaceutically acceptable salt thereof to a female. | 12-01-2011 |
Irena Riji, Mevaseret Zion IL
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20140201030 | DYNAMIC PAYMENT SERVICE - Systems and methods may provide for implementing a dynamic payment service. In one example, the method may generate a request communication including purchase detail information relating to an item to request credit from a vendor to conduct a transaction relating to the item, determine a scope of credit to be issued to conduct the transaction relating to the item based on the purchase detail information, and generate a payment communication including the transaction information to complete the transaction relating to the item. | 07-17-2014 |
Irena Rumenova Konstantinova, Horsham GB
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20150050240 | TREATMENT OF FIBROSIS - This invention is in the field of treatment of fibrosis. In particular, it relates to the treatment of IPF using N-Cadherin antibodies. The antibody may be any antagonising or neutralizing N-Cadherin antibody suitable for therapeutic use. | 02-19-2015 |
Irena Saltsman, Haifa IL
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20110098262 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE - Transition metal complexes of amphiphilic corroles, optical isomers and pharmaceutically acceptable salts thereof are useful for neuroprotection and neurorescue, particularly for treatment of diabetes and neurodegenerative diseases. The amphiphilic corrole is preferably a 5,10,15-tris-aryl- or 5,10,15-tris-CF | 04-28-2011 |
20140045809 | CORROLES FOR NEUROPROTECTION AND NEURORESCUE - Transition metal complexes of amphiphilic corroles, optical isomers and pharmaceutically acceptable salts thereof are useful for neuroprotection and neurorescue, particularly for treatment of diabetes and neurodegenerative diseases. The amphiphilic corrole is preferably a 5,10,15-tris-aryl- or 5,10,15-tris-CF | 02-13-2014 |
Irena Sikorska, Warszawa PL
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20150111267 | METHOD OF INITIATING ACETIC FERMENTATION UNDER INDUSTIRAL CONDITIONS - The subject of the present invention is a method of initiating acetic fermentation in a production fermenter using a starter culture cultured in a pilot fermenter which constitutes about 1-3% of the working volume of the production fermenter, and the production fermenter is inoculated in a continuous fashion with acetic fermentation bacteria cultured in the pilot fermenter. | 04-23-2015 |
Irena Skulj, Ljubljana SI
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20110298571 | RARE EARTH MAGNETIC MATERIALS COMPRISING GALLIUM AND METHODS OF MAKING THE SAME - Disclosed herein are rare earth permanent magnets comprising Ga, and a magnetic intermetallic compound. In one embodiment, the magnetic intermetallic compound comprises at least one rare earth element (R), at least three transition metal elements (T), with the balance comprising iron. Non-limiting examples of R include Y, Nd, Pr, and Dy; and non-limiting examples of T include Cu, AI, and Co. Methods of making the disclosed rare earth permanent magnets are also disclosed. | 12-08-2011 |
Irena Slamborova, Praha CZ
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20150240411 | NANOFIBER STRUCTURE WITH IMMOBILIZED ORGANIC SUBSTANCE AND THE METHOD OF ITS PREPARATION - The invention concerns a nanofiber structure with immobilized organic agens that consists of silica nanofibers whose surface was modified with aminoaikyialkoxysilane and of subsequently immobilized organic agens. The invention also concerns a method of preparation of the nanofiber structure with immobilized organic agens, while silica nanofibers are prepared by electrostatic spinning from the initial sol synthesized by a sol-gel method from tetraalkoxysilane, heat-treated and their the surface modified by a solution of aminoaikyialkoxysilane and organic agens is then immobilized on the modified surface of the nanofibers. | 08-27-2015 |
Irena Sonnenfroh, Giengen DE
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20090038335 | Modular refrigeration device - A refrigeration device is provided with a housing having an interior and at least one housing part. The housing and the at least one housing part are interlinked to form a single unit. A sealing profile is arranged in the form of a frame-type structure between surfaces of the walls of the housing facing each other. The sealing profile consists of a compressible foam strand that is provided with a diffusion-inhibiting membrane extending between the surfaces. | 02-12-2009 |
Irena Szrek, East Greenwich, RI US
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20090131140 | MANAGEMENT OF OUTCOMES OF GAMES OF CHANCE - A method and system is provided for managing the outcomes of games of chance while maintaining the game's integrity. | 05-21-2009 |
20090150290 | PROTECTING LOTTERY RECEIPTS - A method and system for generation of ticket security codes is provided. The method includes generating, by a host computing system, a lottery transaction authentication code for each transaction, generating an additional security code for the transaction, and including the generated additional security code on a lottery receipt for the transaction. The additional security code includes information that cannot be reproduced in the host computing system without access to the lottery ticket receipt and allows verification of critical data for the transaction. | 06-11-2009 |
20100240440 | Secure Provisioning of Random Numbers to Remote Clients - The present disclosure provides a method for protecting the “identity” of random numbers used in multiplayer games, which prevents fraud related to access to random game elements by insiders. The method enables a distribution of random numbers by a game server in a way that the game server does not know the “identity” of random numbers but the game server may independently verify these random numbers. The method includes receiving transformation information, generating random numbers, transforming random numbers according to the transformation information, sending the transformed random numbers to a game server, securing, via the game server, the transformed random numbers, sending the transformed random numbers from the game server to a remote client, and transforming the transformed random numbers to recreate the generated random numbers. | 09-23-2010 |
20130151320 | PAYMENT METHOD AND SYSTEM - A payment system enables making purchases for a token fee. A customer is offered a choice of making a purchase at a regular price or taking a chance to make the purchase for an additional nominal fee. The nominal purchase or participation fee is determined based on the purchase price and a probability, which is calculated according to rules. The rules get established with a specific business and provide that the collected participation fees cover the cost of purchases. A random number generator system is programmed according to the rules of the method and system is used by the business. Based on the value of the random number, the system will determine if the customer was ‘lucky’ and needs to pay only the participation fee, nothing, or if the customer needs to pay the price of the goods plus the participation fee. | 06-13-2013 |
Irena Tsyrlova, Bethesda, MD US
Patent application number | Description | Published |
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20100041147 | HEMOGLOBIN ALPHA CHAIN PEPTIDE FRAGMENTS USEFUL FOR INHIBITING STEM CELL PROLIFERATION - Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation. | 02-18-2010 |
20140088006 | Stem Cell Mobilization and Tissue Repair and Regeneration - Stem cells are mobilized from bone marrow by administering an amount of Phe-Pro-His-Phe-Asp-Leu-Ser-His-Gly-Ser-Ala-Gin-Val (SEQ ID NO: 1) effective to mobilize the stem cells. This method is useful for promoting preservation, repair, or regeneration of bodily tissue, or revascularization, in a patient in need of such treatment. Alternatively, the mobilized stem cells can be collected for transplant. | 03-27-2014 |