Patent application number | Description | Published |
20100204328 | Solution and Method to Reduce, Treat and/or Prevent Oxidative Stress and Cell Activation - The present invention concerns a solution and methods to reduce, treat and/or prevent oxidative stress and cell activation. According to the invention the solution gives rise to the following concentrations of constituents within a blood flow of 0.1-18 mM N-acetyl-cysteine, optionally of 0.01-0.21 mM vitamin C, optionally of 2-26 mM gluconic acid and optionally of 0.01-5 mM glutathione. According to the invention the methods comprises adding a solution according to the invention in an extracorporeal setting through the membrane by adding the solution to the dialysis fluid, or by infusion of a solution according to the invention, either by bolus injection, continuous injection or a combination thereof. | 08-12-2010 |
20100320146 | HYDROPHILIC MEMBRANES WITH A NON-IONIC SURFACTANT - The invention relates to hydrophilic membranes which are supplemented or treated with a non-ionic surfactant and processes for preparing such membranes. The membranes are particularly suitable for plasma separation or for haemodialysis and haemodiafiltration, but can also advantageously be used in other applications. Accordingly, the invention is further directed to the use of such membranes for plasma separation, plasma filtration, micro filtration, plasma therapy, haemodialysis and haemodiafiltration or cell filtration applications, respectively. The treated hydrophilic membranes show excellent biocompatibility, such as reduced platelet drop and decreased TAT levels. | 12-23-2010 |
20110015720 | IMPLANTABLE ACCESS DEVICE AND METHOD FOR PREPARING THEREOF - The present invention concerns an implantable access device and a method for preparing the device. According to the invention the device comprises a shape memory base structure with a biological substructure suitable for cell adhesion, cell engraftment and proliferation for use in transferring and transporting fluid mixtures (blood, suspensions, drug formulations, emulsions, cell suspensions) in/into/out of a human or animal body. | 01-20-2011 |
20110263020 | MEMBRANE FOR CELL EXPANSION - A membrane which can be used for cultivating cells, in particular adherent cells. The membrane permits the adhesion and proliferation of the cells based on its specific composition comprising polyurethane. The resulting surface characteristics further permit the membrane to be used without any pre-treatment with surface modifying substances. A method for preparing a membrane which can be used for cultivating cells, in particular adherent cells. Methods of using the membrane for cultivating cells, in particular adherent cells. | 10-27-2011 |
20120067815 | HYBRID BIOARTIFICIAL KIDNEY - A bioartificial kidney equivalent and a process for producing the bioartificial kidney equivalent. The hybrid bioartificial kidney comprises human proximal and distal renal tubule cells grown on particular synthetic membranes. | 03-22-2012 |
20120145626 | DEVICE FOR RENAL CELL EXPANSION - A device for culturing, storing and expanding adherent renal cells. The device permits the adhesion and proliferation of the cells and the surface characteristics of the membrane material used in said device further permit the cellular matrix components (EMC). A method for expanding adherent renal cells and methods of using particular membranes for culturing, storing and expanding adherent renal cells. The membranes comprise a copolymer of acrylonitrile and sodium methallyl sulfonate as well as polyethylenimine. | 06-14-2012 |
Patent application number | Description | Published |
20080215247 | Machine and Procedure For Extracorporeal Treatment of Blood - A machine ( | 09-04-2008 |
20080268538 | Device and Method to Prevent Culture Media Degradation - The present invention provides a device for cell culture. The device comprises a culture zone, a selective sorption zone and culture media transfer means. Culture media is transferred or recirculated from the culture zone through the selective sorption zone which comprises at least one agent reactive with cytotoxic degradation products present in the culture media and back to the culture zone via the culture media transfer means. | 10-30-2008 |
20090047654 | Polymer affinity matrix, a method for the production and use thereof - A polymer affinity matrix for the binding of one or more substances in a fluid or removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid with a view to preventing, eliminating or reducing undesired activation of components in said fluid is described, as well as a method for removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid, a method for the production of said matrix, use of said matrix and a kit comprising said matrix. The polymer affinity matrix comprises a solid support, a spacer and a ligand, containing arginine as a binding unit. | 02-19-2009 |
20090163599 | Mif adsorbant - The present invention concerns an apheresis material or adsorbant and a method for removing, depleting or inactivating MIF (macrophage migration inhibitory factor) from blood, blood plasma, blood serum or other body fluids. The present invention is also concerned with the use of said apheresis material or adsorbant. In order to prepare a novel means and novel method, which can reduce the activity or amount of the mediator for sepsis and septic shock, MIF, in a patient's body fluid in a manner which is more pleasant and tolerable for the patient than prior art means and methods, the invention proposes that the apheresis material or adsorbant comprises a solid carrier material on the surface of which MIF-binding molecules or functional groups are immobilized. The method proposes that the apheresis material or adsorbant be brought into contact extracorporeally with the blood, blood plasma, blood serum or other body fluids. | 06-25-2009 |
20100204328 | Solution and Method to Reduce, Treat and/or Prevent Oxidative Stress and Cell Activation - The present invention concerns a solution and methods to reduce, treat and/or prevent oxidative stress and cell activation. According to the invention the solution gives rise to the following concentrations of constituents within a blood flow of 0.1-18 mM N-acetyl-cysteine, optionally of 0.01-0.21 mM vitamin C, optionally of 2-26 mM gluconic acid and optionally of 0.01-5 mM glutathione. According to the invention the methods comprises adding a solution according to the invention in an extracorporeal setting through the membrane by adding the solution to the dialysis fluid, or by infusion of a solution according to the invention, either by bolus injection, continuous injection or a combination thereof. | 08-12-2010 |
20100320146 | HYDROPHILIC MEMBRANES WITH A NON-IONIC SURFACTANT - The invention relates to hydrophilic membranes which are supplemented or treated with a non-ionic surfactant and processes for preparing such membranes. The membranes are particularly suitable for plasma separation or for haemodialysis and haemodiafiltration, but can also advantageously be used in other applications. Accordingly, the invention is further directed to the use of such membranes for plasma separation, plasma filtration, micro filtration, plasma therapy, haemodialysis and haemodiafiltration or cell filtration applications, respectively. The treated hydrophilic membranes show excellent biocompatibility, such as reduced platelet drop and decreased TAT levels. | 12-23-2010 |
20110015720 | IMPLANTABLE ACCESS DEVICE AND METHOD FOR PREPARING THEREOF - The present invention concerns an implantable access device and a method for preparing the device. According to the invention the device comprises a shape memory base structure with a biological substructure suitable for cell adhesion, cell engraftment and proliferation for use in transferring and transporting fluid mixtures (blood, suspensions, drug formulations, emulsions, cell suspensions) in/into/out of a human or animal body. | 01-20-2011 |
20110160664 | Applicator and method for applying lock solution in a catheter - A device for applying a lock solution in a catheter or other access system comprises a syringe ( | 06-30-2011 |
20110263020 | MEMBRANE FOR CELL EXPANSION - A membrane which can be used for cultivating cells, in particular adherent cells. The membrane permits the adhesion and proliferation of the cells based on its specific composition comprising polyurethane. The resulting surface characteristics further permit the membrane to be used without any pre-treatment with surface modifying substances. A method for preparing a membrane which can be used for cultivating cells, in particular adherent cells. Methods of using the membrane for cultivating cells, in particular adherent cells. | 10-27-2011 |
20120067815 | HYBRID BIOARTIFICIAL KIDNEY - A bioartificial kidney equivalent and a process for producing the bioartificial kidney equivalent. The hybrid bioartificial kidney comprises human proximal and distal renal tubule cells grown on particular synthetic membranes. | 03-22-2012 |
20120095381 | MACHINE FOR EXTRACORPOREAL TREATMENT OF BLOOD - A machine ( | 04-19-2012 |
20120145626 | DEVICE FOR RENAL CELL EXPANSION - A device for culturing, storing and expanding adherent renal cells. The device permits the adhesion and proliferation of the cells and the surface characteristics of the membrane material used in said device further permit the cellular matrix components (EMC). A method for expanding adherent renal cells and methods of using particular membranes for culturing, storing and expanding adherent renal cells. The membranes comprise a copolymer of acrylonitrile and sodium methallyl sulfonate as well as polyethylenimine. | 06-14-2012 |