Patent application number | Description | Published |
20120263731 | HIGH CONCENTRATION ANTI-TNFalpha ANTIBODY LIQUID FORMULATIONS - The invention provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, which reduces pain associated with injection in a subject by at least about 50% when compared to injecting an otherwise identical formulation comprising at least one salt and/or at least one buffer. The invention also provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, having increased bioavailability upon subcutaneous administration into a subject. The formulation may comprise a therapeutic protein, such as a human anti-TNF-alpha antibody, or an antigen-binding portion thereof, or a biosimilar thereof. | 10-18-2012 |
20140377275 | HIGH CONCENTRATION ANTI-TNFalpha ANTIBODY FORMULATIONS - The invention provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, which reduces pain associated with injection in a subject by at least about 50% when compared to injecting an otherwise identical formulation comprising at least one salt and/or at least one buffer. The invention also provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, having increased bioavailability upon subcutaneous administration into a subject. The formulation may comprise a therapeutic protein, such as a human anti-TNF-alpha antibody, or an antigen-binding portion thereof, or a biosimilar thereof. | 12-25-2014 |
Patent application number | Description | Published |
20130140632 | Lateral Transistor Component and Method for Producing Same - A transistor component includes an active transistor region arranged in the semiconductor body. And insulation region surrounds the active transistor region in the semiconductor body in a ring-shaped manner. A source zone, a drain zone, a body zone and a drift zone are disposed in the active transistor region. The source zone and the drain zone are spaced apart in a lateral direction of the semiconductor body and the body zone is arranged between the source zone and the drift zone and the drift zone is arranged between the body zone and the drain zone. A gate and field electrode is arranged over the active transistor region. The dielectric layer has a first thickness in in a region near the body zone and a second thickness in a region near the drift zone. | 06-06-2013 |
20140077066 | MANUFACTURING OF AN IMAGER DEVICE AND IMAGER DEVICE - Embodiments related to the manufacturing of an imager device and an imager device are disclosed. Embodiments associated with methods of an imager device are also disclosed. | 03-20-2014 |
20140145281 | CONTROLLING OF PHOTO-GENERATED CHARGE CARRIERS - Embodiments related to controlling of photo-generated charge carriers are described and depicted. At least one embodiment provides a semiconductor substrate comprising a photo-conversion region to convert light into photo-generated charge carriers; a region to accumulate the photo-generated charge carriers; a control electrode structure including a plurality of control electrodes to generate a potential distribution such that the photo-generated carriers are guided towards the region to accumulate the photo-generated charge carriers based on signals applied to the control electrode structure; a non-uniform doping profile in the semiconductor substrate to generate an electric field with vertical field vector components in at least a part of the photo-conversion region | 05-29-2014 |
20140231970 | METHOD FOR PROCESSING A CARRIER, A CARRIER, AN ELECTRONIC DEVICE AND A LITHOGRAPHIC MASK - Various embodiments provide a method for processing a carrier, the method including changing the three-dimensional structure of a mask layer arranged over the carrier so that at least two mask layer regions are formed having different mask layer thicknesses; and applying an ion implantation process to the at least two mask layer regions to form at least two implanted regions in the carrier having different implantation depth profiles. | 08-21-2014 |
20140339634 | Lateral Transistor Component and Method for Producing Same - A transistor component includes an active transistor region arranged in the semiconductor body. And insulation region surrounds the active transistor region in the semiconductor body in a ring-shaped manner. A source zone, a drain zone, a body zone and a drift zone are disposed in the active transistor region. The source zone and the drain zone are spaced apart in a lateral direction of the semiconductor body and the body zone is arranged between the source zone and the drift zone and the drift zone is arranged between the body zone and the drain zone. A gate and field electrode is arranged over the active transistor region. The dielectric layer has a first thickness in a region near the body zone and a second thickness in a region near the drift zone. | 11-20-2014 |
Patent application number | Description | Published |
20100170612 | PARTICLE LITHOGRAPHY METHOD AND ORDERED STRUCTURES PREPARED THEREBY - Particles having a non-uniform property, such as non-uniform charge, can be used to form complex yet controlled particle assemblies. In one method of fabrication, particles are located on a substrate, and a surface treatment applied to the exposed portion of the particle surface. The surface treatment modifies the particle properties within the exposed portion. One or more lithographed regions are not exposed to the surface treatment, providing spatial selectivity in inter-particle bonding after the particles are removed from the substrate. | 07-08-2010 |
20100289736 | ELECTROPHORETIC PARTICLES, AND PROCESSES FOR THE PRODUCTION THEREOF - An electrophoretic medium comprises at least one electrically charged particle dispersed posed in a fluid. The electrically charged particle comprises an inorganic black pigment having a surface area of at least about 7 m | 11-18-2010 |
20110012825 | ELECTROPHORETIC PARTICLES AND PROCESSES FOR THE PRODUCTION THEREOF - In electrophoretic media, it is advantageous to use pigment particles having a polymer chemically bonded to, or cross-linked around, the pigment particles, the polymer comprising repeating units derived from a fluorinated acrylate or fluorinated methacrylate monomer. The polymer desirably has a branched chain structure with side chains extending from a main chain. Desirably, the fluorinated acrylate or fluorinated methacrylate monomer comprises from 1 to 5 mole per cent of the polymer. | 01-20-2011 |
20140211296 | ELECTROPHORETIC PARTICLES AND PROCESSES FOR THE PRODUCTION THEREOF - In electrophoretic media, it is advantageous to use pigment particles having a polymer chemically bonded to, or cross-linked around, the pigment particles, the polymer comprising repeating units derived from a fluorinated acrylate or fluorinated methacrylate monomer. The polymer desirably has a branched chain structure with side chains extending from a main chain. Desirably, the fluorinated acrylate or fluorinated methacrylate monomer comprises from 1 to 5 mole percent of the polymer. | 07-31-2014 |
20140340430 | COLORED ELECTROPHORETIC DISPLAYS - An electrophoretic medium comprises a fluid and at least one species of particles disposed, When a first addressing impulse is applied to the medium, the first species of particles move in one direction relative to the electric field, but when a second addressing impulse, larger than the first addressing impulse, is applied to the medium, the first species of particles move in the opposed direction relative to the electric field. | 11-20-2014 |
Patent application number | Description | Published |
20090102099 | Injection Molding Apparatus Having Magnetic Valve Pin Coupling - A magnetic coupling for an injection molding apparatus, such as a hot half or hot runner, includes a first magnetic part for connection to an actuator, a valve pin plate, or the like and a movable second magnetic part for connection to a valve pin. The first magnetic part and the second magnetic part are coupled by a magnetic force. The first magnetic part can be part of the actuator. The second magnetic part can be part of the valve pin. A valve pin plate can be provided for a plurality of valve pins. | 04-23-2009 |
20090148551 | Injection Molding Apparatus With Plate Actuation of Valve Pins - An injection molding apparatus includes a back plate, a driven pulley connected to the back plate and rotatable with respect to the back plate, a screw connected to the driven pulley to rotate with the driven pulley, a motor having an attached drive pulley, a belt or chain coupling the driven pulley and the drive pulley, a valve pin plate, a nut connected to the valve pin plate and mated with the screw, at least one valve pin connected to the valve pin plate, a manifold fixed with respect to the back plate, and at least one nozzle connected to the manifold. The valve pin extends through the nozzle to control flow of molding material. The screw can be a ball screw and nut can be a ball nut. The screw can have one portion connected to the driven pulley and another portion connected to a mold plate in a rotatable manner. The valve pin plate may be an assembly with an upper plate, a lower plate, and at least one valve pin holder fixed between the upper plate and the lower plate, the valve pin being fastened to the valve pin plate assembly with the valve pin holder. The positions of the screw and nut can be reversed. | 06-11-2009 |
20100233310 | Thermal Shroud and Method of Making Same - An injection molding hot runner nozzle and a method of making such a nozzle are disclosed that improves heat transfer along the length of the nozzle. The nozzle includes a nozzle body and a heating element located on an outer surface of the nozzle body having a form-fitting thermally conductive shroud that conforms to a profile of the nozzle and the heating element. | 09-16-2010 |
20110008532 | METHOD OF MANUFACTURING HOT-RUNNER COMPONENT AND HOT-RUNNER COMPONENTS THEREOF - A method of manufacturing a hot-runner component includes providing a laser assembly, manufacturing a hot-runner component portion of a metallic material, introducing a property enhancing material to the hot-runner component portion, melting the property enhancing material onto the hot-runner component portion using a laser beam emitted from the laser assembly, and solidifying the melted property enhancing material on the hot-runner component portion. | 01-13-2011 |
20110304075 | Breakable Mechanical Connection Between Injection Molding Valve Pin Plate and Valve Pins - Breakable mechanical connections connect valve pins to an actuated valve pin plate of an injection molding apparatus. The valve pin plate can move the valve pins between opened positions and closed positions of associated mold gates. Each breakable mechanical connection can be independently or singularly destroyed or broken to free a respective valve pin from the valve pin plate. | 12-15-2011 |
20120227235 | Method of Taking a Nozzle of a Valve Gated Hot Runner Apparatus Out of Service - A method for taking a nozzle of a valve gated runner apparatus includes releasably attaching a valve pin to a movable part of an actuator for moving the valve pin between an open position and a closed position and detaching the valve pin from the actuator by moving the movable part of the actuator towards the open position when the valve pin is immobilized. The valve pin and the movable part valve pin may be releasably attached by a magnetic force. The step of detaching the valve pin from the actuator may be accomplished by overcoming the magnetic force. A valve pin plate can be provided for a plurality of valve pins to be releasably attached to the actuator. | 09-13-2012 |
Patent application number | Description | Published |
20080205974 | Locking Nut, Bolt and Clip Systems and Assemblies - The locking nut and bolt system utilizes a bolt with thread having a plurality of notches generally longitudinally spaced in a predetermined pattern. Each notch has a lock face and an opposing slope. The locking unit carries one or more tines. The tine has a distal tine end adapted to latch onto the lock face of the notch on the bolt and, when the distal tine end is not disposed in one or more notches, the tine end moves on the bolt thread crest. When the distal tine end is in the notch or notches, the lock face of the notch prevents counter-rotational movement of the bolt with respect to the nut when the distal tine end abuts the lock face. The locking unit supports the tine and may be cylindrical, rectangular or on a perpendicular support face normal to a radial plane through the axial centerline of the nut thread. The locking unit may be on a nut insert or may be carried on the leg of a U, J or S-shaped clip. The locking unit may be recessed as a blind hole. | 08-28-2008 |
20130200582 | Wheelbarrow Or Cart With Handles Which Can Be Extended In Step Less Increments - A wheelbarrow or cart with a forwardly located wheel and two rearwardly located stand guards having first and second tubular support legs adapted to be attached to the stand guards, and first and second tubular leg members having outside diameters slidably coupled in telescoping arrangement with the inside diameters of the first and second tubular support legs. A first twist clamp means is coupled to frictionally engage and selectively lock the first tubular support leg relative to the first tubular leg member to set the total length of the first telescoping tubes and a second twist clamp means coupled to frictionally engage and selectively lock the second tubular support leg relative to the second tubular leg member to set the total length of the second telescoping tubes. | 08-08-2013 |
20130328279 | Three-in-One Convertible Cart - An improved convertible cart can be converted from a hand truck to a platform by a simple pull of a spring loaded adjustment arm. The convertible cart has reversible wire retainers. When the edge of the wire retainer is facing upward, it prevents an object being carried from shifting sideways off of the rails. The wire retainers can also be flipped downwards to allow an oversized object to be carried flat and extend outside the retaining rails. The toe plate of the cart can be used as a seat with a pad that can be attached as a weeding pad either from the seated or kneeling position. The cart's handle frame can be sleeves into its base frame so that entire cart can be packed tightly within the tub to allow the tub to be the principal storage and delivery means for display, sale and shipment. | 12-12-2013 |