Patent application number | Description | Published |
20100311869 | POLYMERIC MATERIALS INCORPORATING CARBON NANOSTRUCTURES AND METHODS OF MAKING SAME - The present invention relates to novel composites that incorporate carbon nanospheres into a polymeric material. The polymeric material can be any polymer or polymerizable material compatible with graphitic materials. The carbon nanospheres are hollow, graphitic nanoparticles. The carbon nanospheres can be manufactured from a carbon precursor using templating catalytic nanoparticles. The unique size, shape, and electrical properties of the carbon nanospheres impart beneficial properties to the composites incorporating these nanomaterials. | 12-09-2010 |
20120020872 | HIGH TEMPERATURE REDUCTION OF HYDROGEN PEROXIDE CATALYST FOR IMPROVED SELECTIVITY - Method for making a direct synthesis hydrogen peroxide catalyst includes (i) mixing together a solvent, a plurality of noble metal catalyst atoms, and a plurality of organic dispersing agent molecules, the organic dispersing agent molecules each including at least one functional group capable of bonding with the noble metal catalyst atoms; (ii) reacting the organic dispersing agent with the catalyst atoms to form complexed catalyst atoms and forming a plurality of catalytic nanoparticles from the complexed catalyst atoms; (iii) supporting the catalytic nanoparticles on a support material; and (iv) reducing the catalyst atoms at a temperature of at least 351° C. to yield a supported and activated direct synthesis hydrogen peroxide catalyst. | 01-26-2012 |
20120286216 | METHODS FOR MITIGATING AGGLOMERATION OF CARBON NANOSPHERES USING A LONG CHAIN HYDROCARBON SURFACTANT - Novel methods for manufacturing carbon nanostructures (e.g., carbon nanospheres) that are highly dispersed include forming a precursor composition, polymerizing the precursor composition, applying a long chain hydrocarbon surfactant to the polymerized carbon material, and carbonizing the polymerized material (e.g., through pyrolysis) to form the carbon nanostructures. The long chain hydrocarbon surfactant facilitates the formation of dispersed carbon nanostructures during the carbonization step. | 11-15-2012 |
20120286217 | METHODS FOR MITIGATING AGGLOMERATION OF CARBON NANOSPHERES USING EXTRACTION - Novel methods for manufacturing carbon nanostructures (e.g., carbon nanospheres) that are highly dispersed include forming a precursor composition, polymerizing the precursor composition, extracting water from the polymerized carbon material using an organic solvent, and carbonizing the polymerized material (e.g., through pyrolysis) to form the carbon nanostructures. The extraction-treated polymerized carbon material forms carbon nanostructures that are less agglomerated than carbon nanostructures manufactured using a similar technique without solvent extraction of water. | 11-15-2012 |
Patent application number | Description | Published |
20080280873 | Biaryl Substituted Pyrazinones as Sodium Channel Blockers - Biaryl substituted pyrazinone compounds represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, itchiness, allergic dermatitis, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. | 11-13-2008 |
20090074890 | Substituted Triazoles as Sodium Channel Blockers - Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier (I), (II), (III). | 03-19-2009 |
20100087446 | 2-SUBSTITUTED INDOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS - 2-Substituted indole derivatives represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, calcium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, itchiness, allergic dermatitis, epilepsy, diabetic neuropathy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, bipolar disorder and stroke, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. | 04-08-2010 |
Patent application number | Description | Published |
20090312303 | Antidiabetic Bicyclic Compounds - Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia. | 12-17-2009 |
20100105725 | ANTIDIABETIC BICYCLIC COMPOUNDS - Diaryl ethers in which one of the aryl groups is a phenyl fused to a cycloalkyl or heterocyclic ring, to which is attached an acetic acid group, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that often accompany this disease, including insulin resistance, obesity and lipid disorders. | 04-29-2010 |
20140235583 | SUBSTITUTED PYRIMIDINES - The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions. | 08-21-2014 |
20140349972 | SUBSTITUTED PYRIMIDINES - The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions. | 11-27-2014 |
20150018356 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS - Provided are certain fused tetra or penta-cyclic compounds and salts thereof, compositions thereof, and methods of use thereof. | 01-15-2015 |
20150045355 | FUSED TRICYCLIC COMPOUNDS AS RAF KINASE INHIBITORS - Provided are certain fused tricyclic compounds and salts thereof, compositions thereof, and methods of use therefor. | 02-12-2015 |
Patent application number | Description | Published |
20090170861 | Pyridazinone Derivatives Useful as Glucan Synthase Inhibitors - In its many embodiments, the present invention provides -substituted pyridazinone compounds as glucan synthase inhibitors, methods of preparing such compounds, pharmaceutical including one or more of such compounds, methods of preparing pharmaceutical formulations including one or more such compounds or one or more such compounds along with other antifungal agents, and methods of treatment, prevention, inhibition, or amelioration of one or more fungal infections associated with glucan synthase using such compounds or pharmaceutical compositions. | 07-02-2009 |
20110224136 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE - The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below. | 09-15-2011 |
20110319403 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE - The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below: formula (I). | 12-29-2011 |
20120022057 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE - The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below (I). | 01-26-2012 |
20140088124 | IMIDAZOLE DERIVATIVES - Described herein are compounds of formula (I), The compounds of formula I act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity. | 03-27-2014 |
Patent application number | Description | Published |
20090156586 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 06-18-2009 |
20100120838 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 05-13-2010 |
20100145048 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): | 06-10-2010 |
20110178007 | SPIRO-IMIDAZOLONE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS - The present invention relates to compounds of the general formula: (I) wherein ring A, ring B, R | 07-21-2011 |
20110288054 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I) as described herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof. | 11-24-2011 |
20110288077 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES - This invention relates to compounds of the Formula (I)-(IX):, as defined herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α combinations thereof. | 11-24-2011 |
20120010181 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof. | 01-12-2012 |
20120015926 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof. | 01-19-2012 |
20130012434 | NOVEL SPIRO IMIDAZOLONES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE - The present invention relates to compounds of the general formula: wherein ring A, ring B, R1, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto. | 01-10-2013 |
20130012493 | NOVEL SPIRO IMIDAZOLONE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE - The present invention relates to compounds of the general formula (I): wherein ring A, ring B, G, R | 01-10-2013 |
Patent application number | Description | Published |
20090054613 | FAST DRYING POLYURETHANE COMPOSITION - A fast drying polyurethane coating composition wherein the reactants comprise (a) a first component comprising one or more polyol compounds having a glass transition temperature of less than or equal to about 25° C., and preferably an Mw of 5000 or less, preferably acrylic or polyester polyols, and (b) a second component, comprising the reaction of a (poly)isocyanate oligomer having an average NCO functionality of greater than 2, for example a biuret with an NCO functionality of 3, with a compound X comprising a substrate portion comprising one or more cycloaliphatic rings, one or more heterocyclic rings, one or more aromatic rings, or a particle of a crosslinked polymer, and functional groups covalently bonded to such substrate portion, for example hydrogenated bisphenol A (HBPA). | 02-26-2009 |
20090194003 | EFFICIENT COALESCING AGENTS - A coalescent composition for coating compositions such as paints, adhesives, and coatings comprising a blend of diesters, the blend comprising adducts of alcohol and diacids, the alcohol selected from the group consisting of ethyl, propyl, isopropyl alcohol and mixtures thereof, and the diacids selected from the group consisting of a blend of adipic, glutaric and succinic diacids (“AGS”) and a blend of adipic, methylglutaric, and ethylsuccinic diacids (“MGA”), and paint, adhesive, and coating compositions comprising such coalescent compositions are disclosed. | 08-06-2009 |
20090198002 | Low VOC coalescing agents - A coalescent composition for coating compositions such as paints, adhesives, and coatings comprising a blend of dibasic esters, specifically (i) esters of adipic, glutaric, and/or succinic diacids and/or (ii) esters of isomers of adipic acid have advantages, including efficiency and low VOC. | 08-06-2009 |
20100064934 | EFFICIENT COALESCING AGENTS - A coalescent composition for coating compositions such as paints, adhesives, and coatings comprising a blend of diesters, the blend comprising adducts of alcohol and diacids, the alcohol selected from the group consisting of ethyl, propyl, isopropyl alcohol and mixtures thereof, and the diacids comprising a blend of adipic, glutaric and succinic diacids (“AGS”); and paint, adhesive, and coating compositions comprising such coalescent compositions are disclosed. | 03-18-2010 |
20120029138 | Anti-settling composition and methods for use - An anti-settling additive, compositions containing anti-settling additives and methods for use, the additive containing a monomer or polymer compound that contains at least one polymerizable functional group per molecule, and at least one bicycloheptyl-, bicycloheptenyl-, or branched (C | 02-02-2012 |
20120095145 | LOW VOC COALESCING AGENTS - A coalescent composition for coating compositions such as paints, adhesives, and coatings comprising a blend of dibasic esters, specifically (i) esters of adipic, glutaric, and/or succinic diacids and/or (ii) esters of isomers of adipic acid have advantages, including efficiency and low VOC. | 04-19-2012 |
20150038635 | ANTI-SETTLING COMPOSITION AND METHODS FOR USE - An anti-settling additive, compositions containing anti-settling additives and methods for use, the additive containing a monomer or polymer compound that contains at least one polymerizable functional group per molecule, and at least one bicycloheptyl-, bicycloheptenyl-, or branched (C | 02-05-2015 |
Patent application number | Description | Published |
20100265043 | AMPLITUDE MODULATOR - A method for amplitude modulating a carrier signal according to one embodiment includes splitting the carrier signal into first and second paths; phase modulating the carrier signal on the first path; phase modulating the carrier signal on the second path; combining the phase modulated carrier signal on the first path with the phase modulated carrier signal on the second path for generating an amplitude modulated output signal; and wherein a first feedback loop couples the amplitude modulated output signal to circuitry for phase modulating the carrier signal on the second path but not to circuitry for phase modulating the carrier signal on the first path, the first feedback loop being for reducing a residual phase variation of the amplitude modulated output signal. Additional systems and methods are also presented. | 10-21-2010 |
20140248837 | ISOLATION TUNERS FOR DIRECTIONAL COUPLERS - A device according to one embodiment includes a variable-capacitor-tuned isolation tuning circuit having a directional coupler having an input port, an output port, an isolation port, and a coupling port. The variable-capacitor-tuned isolation tuning circuit also has and a tunable capacitor coupled in shunt to the coupling port of the directional coupler. | 09-04-2014 |
20140300387 | OVER-CURRENT AND/OR OVER-VOLTAGE PROTECTION CIRCUIT - A logic inverter with over-current protection according to one embodiment includes a transistor, an input signal line coupled to a gate terminal or base region of the transistor, an output signal line coupled to a drain terminal or collector region of the transistor, a power supply line coupled to the drain terminal or collector region of the transistor, and a feedback resistor between a source terminal or emitter region of the transistor and ground. | 10-09-2014 |
Patent application number | Description | Published |
20090307449 | SNAPSHOT STORAGE AND MANAGEMENT SYSTEM WITH INDEXING AND USER INTERFACE - A system and method of managing stored data in a storage management system. The storage management system includes a storage manager, a media agent connected to the storage manager, and a primary volume connected to the media agent. A plurality of snapshots are taken of the primary volume. The snapshots are indexed by associating respective information with the snapshot. The indexed snapshots are copied to a recovery volume. In this way, browsing features are enabled for the user. The user may view the snapshots in a hierarchical format, and may even view snapshot data in association with the corresponding application. The resultant recovery volume may be used to replace a primary volume. | 12-10-2009 |
20100114837 | REMOTE DISASTER DATA RECOVERY SYSTEM AND METHOD - The present invention provides computer systems, methods, and software products enabling the creation and maintenance of disaster recovery volumes having a reduced impact with regard to network traffic over a communications network. A disaster recovery volume is generally created at a local archival storage unit including therein at least one storage medium constituting the disaster recovery volume. The medium constituting the disaster recovery volume is associated with the primary volume thereby allowing the storage medium constituting the disaster recovery volume to be relocated to a remote archival storage unit at a remote location without compromising the association between the primary volume and the disaster recovery volume. Incremental changes to the primary volume may then be communicated and incorporated in to the disaster recovery relocated to the remote location. | 05-06-2010 |
20100287141 | SYSTEM AND METHOD FOR PERFORMING INTEGRATED STORAGE OPERATIONS - The present invention relates to a method for performing integrated storage operations on an information store. The present invention comprises identifying a plurality disparate types of storage operations stored in a policy option table. A first storage operation is performed according to a first set of storage criteria stored in the policy option table and a second operation, disparate from the first storage operation, is performed according to a second set of storage criteria stored in the policy option table. | 11-11-2010 |
20110131187 | SNAPSHOT STORAGE AND MANAGEMENT SYSTEM WITH INDEXING AND USER INTERFACE - A system and method of managing stored data in a storage management system. The storage management system includes a storage manager, a media agent connected to the storage manager, and a primary volume connected to the media agent. A plurality of snapshots are taken of the primary volume. The snapshots are indexed by associating respective information with the snapshot. The indexed snapshots are copied to a recovery volume. In this way, browsing features are enabled for the user. The user may view the snapshots in a hierarchical format, and may even view snapshot data in association with the corresponding application. The resultant recovery volume may be used to replace a primary volume. | 06-02-2011 |
20110264620 | SYSTEM AND METHOD FOR PERFORMING INTEGRATED STORAGE OPERATIONS - The present invention relates to a method for performing integrated storage operations on an information store. The present invention comprises identifying a plurality disparate types of storage operations stored in a policy option table. A first storage operation is performed according to a first set of storage criteria stored in the policy option table and a second operation, disparate from the first storage operation, is performed according to a second set of storage criteria stored in the policy option table. | 10-27-2011 |
20120179886 | SNAPSHOT STORAGE AND MANAGEMENT SYSTEM WITH INDEXING AND USER INTERFACE - A system and method of managing stored data in a storage management system. The storage management system includes a storage manager, a media agent connected to the storage manager, and a primary volume connected to the media agent. Multiple snapshots are taken of the primary volume. The snapshots are indexed by associating respective information with the snapshot. The indexed snapshots are copied to a recovery volume. In this way, browsing features are enabled for the user. The user may view the snapshots in a hierarchical format, and may even view snapshot data in association with the corresponding application. The resultant recovery volume may be used to replace a primary volume. | 07-12-2012 |
20130013563 | SYSTEM AND METHOD FOR PERFORMING INTEGRATED STORAGE OPERATIONS - The present invention relates to a method for performing integrated storage operations on an information store. The present invention comprises identifying a plurality disparate types of storage operations stored in a policy option table. A first storage operation is performed according to a first set of storage criteria stored in the policy option table and a second operation, disparate from the first storage operation, is performed according to a second set of storage criteria stored in the policy option table. | 01-10-2013 |
20130238872 | SNAPSHOT STORAGE AND MANAGEMENT SYSTEM WITH INDEXING AND USER INTERFACE - A system and method of managing stored data in a storage management system. The storage management system includes a storage manager, a media agent connected to the storage manager, and a primary volume connected to the media agent. Multiple snapshots are taken of the primary volume. The snapshots are indexed by associating respective information with the snapshot. The indexed snapshots are copied to a recovery volume. In this way, browsing features are enabled for the user. The user may view the snapshots in a hierarchical format, and may even view snapshot data in association with the corresponding application. The resultant recovery volume may be used to replace a primary volume. | 09-12-2013 |
Patent application number | Description | Published |
20090238935 | PRODUCTION OF STABILIZED WHOLE GRAIN FLOUR AND PRODUCTS THEREOF - A stabilized bran component and a stabilized whole grain flour containing the component are produced by subjecting a bran-enriched coarse fraction which contains bran, germ and starch to grinding or milling to reduce grittiness of the coarse fraction without substantially damaging the starch due to abrasion. The coarse fraction may be stabilized by heating to substantially reduce the lipase and lipoxygenase activity of the coarse fraction without substantial gelatinization of the starch. High levels of natural antioxidants and vitamins are retained while avoiding substantial acrylamide formation during the stabilization. The stabilized coarse fraction or stabilized bran component may be combined with a fine fraction which contains predominantly endosperm to obtain a stabilized whole grain flour. The stabilized whole grain flours and the stabilized bran component exhibit extended shelf life and may be used for making baked goods, such as cookies, with desirable oven spread, and a non-gritty mouthfeel. | 09-24-2009 |
20120189757 | PRODUCTION OF STABILIZED WHOLE GRAIN FLOUR AND PRODUCTS THEREOF - A stabilized bran component and a stabilized whole grain flour containing the component are produced by subjecting a bran-enriched coarse fraction which contains bran, germ and starch to grinding or milling to reduce grittiness of the coarse fraction without substantially damaging the starch due to abrasion. The coarse fraction may be stabilized by heating to substantially reduce the lipase and lipoxygenase activity of the coarse fraction without substantial gelatinization of the starch. High levels of natural antioxidants and vitamins are retained while avoiding substantial acrylamide formation during the stabilization. The stabilized coarse fraction or stabilized bran component may be combined with a fine fraction which contains predominantly endosperm to obtain a stabilized whole grain flour. The stabilized whole grain flours and the stabilized bran component exhibit extended shelf life and may be used for making baked goods, such as cookies, with desirable oven spread, and a non-gritty mouthfeel. | 07-26-2012 |
20120196013 | PRODUCTION OF STABILIZED WHOLE GRAIN WHEAT FLOUR AND PRODUCTS THEREOF - A stabilized bran component and stabilized whole grain wheat flour containing the component are produced by subjecting a bran-enriched coarse fraction which contains bran, germ and starch to grinding or milling to reduce grittiness of the coarse fraction without substantially damaging the starch due to abrasion. The coarse fraction may be stabilized by heating to substantially reduce the lipase and lipoxygenase activity of the coarse fraction without substantial starch gelatinization. High levels of natural antioxidants and vitamins are retained while avoiding substantial acrylamide formation during the stabilization. The stabilized coarse fraction or stabilized bran component may be combined with a fine fraction which contains predominantly endosperm to obtain a stabilized whole grain wheat flour. The stabilized whole grain wheat flours and stabilized bran component exhibit extended shelf life and may be used for making baked goods, such as cookies, with desirable oven spread, and a non-gritty mouthfeel. | 08-02-2012 |
20140099421 | METHOD FOR PRODUCING STABILIZED WHOLE WHEAT FLOUR - A stabilized flour, such as stabilized whole grain wheat flour, exhibiting unexpectedly superior extended shelf life and superior biscuit baking functionality, may be produced with or without heating to inhibit lipase by subjecting whole grains or a bran and germ fraction or component to treatment with a lipase inhibitor, such as an acid or green tea extract. Treatment with the lipase inhibitor may be performed during tempering of the whole grains or berries or during hydration of the bran and germ fraction or component. | 04-10-2014 |
20140106052 | STABILIZED WHOLE GRAIN FLOUR AND METHOD OF MAKING - Stabilized whole grain flours having a fine particle size and which exhibit good baking functionality are produced with high throughput using two bran and germ fractions and an endosperm fraction. One bran and germ fraction is a coarse fraction which is subjected to two stage grinding, but the second bran and germ fraction is a low ash, fine bran and germ fraction which is sufficiently fine so that it does not need to be subjected to grinding thereby reducing starch damage and increasing production with reduced grinding equipment load. Portions of the coarse bran and germ fraction which are ground in the first grinding stage to a sufficient fineness are separated out and not subjected to additional grinding further reducing starch damage and increasing production. The bran and germ fractions may be combined, subjected to stabilization, and combined with the endosperm fraction to obtain a stabilized whole grain flour. | 04-17-2014 |
Patent application number | Description | Published |
20110044921 | SUBSTANCES AND COMPOSITIONS FOR ENHANCING DNA REPAIR AND METHODS OF USE - The invention provides methods of preventing or treating a condition associated with DNA damage in an animal comprising the administration of a substance that interferes with the activity of the CUL4A ubiquitin ligase. The invention also provides a substance that interferes with the activity of CUL4A, as well as compositions comprising the interfering substance and a carrier. The substance of the invention preferably enhances nucleotide excision repair activity in an animal. The invention further provides methods of identifying substances that negatively or positively modulate the expression and/or activity of CUL4A. | 02-24-2011 |
20130011920 | Methods for Reducing Protein Levels in a Cell - The present invention provides a method of reducing levels of at least one target protein in a cell. The cell is contacted with a first agent and a second agent. The first agent reduces synthesis of the target protein, e.g., by reducing levels of the mRNA of the target protein or inhibits translation of the mRNA. The second agent accelerates degradation of the target protein. The first agent may contact the cell before, after or simultaneously with the second agent. The first agent and the second agent may be in separate delivery vehicles, or in a single delivery vehicle. The first agent may be an RNAi (RNA interference) molecule, such as a small interfering RNA (siRNA), a small hairpin RNA (shRNA) or a microRNA (miRNA). The second agent may be a chimeric polypeptide containing a ubiquitin ligase polypeptide and a target protein interacting domain. The ubiquitin ligase polypeptide can be an E3 ubiquitin ligase, including, but not limited to, an SCF polypeptide, a HECT polypeptide and a UBR1 polypeptide. In one embodiment, the SCF polypeptide is an F-box polypeptide. | 01-10-2013 |
20130236404 | SUBSTANCES AND COMPOSITIONS FOR ENHANCING DNA REPAIR AND METHODS OF USE - The invention provides methods of preventing or treating a condition associated with DNA damage in an animal comprising the administration of a substance that interferes with the activity of the CUL4A ubiquitin ligase. The invention also provides a substance that interferes with the activity of CUL4A, as well as compositions comprising the interfering substance and a carrier. The substance of the invention preferably enhances nucleotide excision repair activity in an animal. The invention further provides methods of identifying substances that negatively or positively modulate the expression and/or activity of CUL4A. | 09-12-2013 |
Patent application number | Description | Published |
20090220065 | Method and apparatus for active speaker selection using microphone arrays and speaker recognition - A method and apparatus for performing active speaker selection in teleconferencing applications illustratively comprises a microphone array module, a speaker recognition system, a user interface, and a speech signal selection module. The microphone array module separates the speech signal from each active speaker from those of other active speakers, providing a plurality of individual speaker's speech signals. The speaker recognition system identifies each currently active speaker using conventional speaker recognition/identification techniques. These identities are then transmitted to a remote teleconferencing location for display to remote participants via a user interface. The remote participants may then select one of the identified speakers, and the speech signal selection module then selects for transmission the speech signal associated with the selected identified speaker, thereby enabling the participants at the remote location to listen to the selected speaker and neglect the speech from other active speakers. | 09-03-2009 |
20110107238 | Network-Based Collaborated Telestration on Video, Images or Other Shared Visual Content - A telestration system comprises a telestration server configured to communicate with an arbitrary number of telestration clients over a network. The telestration server is further configured to receive telestration input signals from respective ones of the clients and to send telestration output signals to the respective clients, with the telestration output signal sent to a given one of the clients comprising telestration information derived from the telestration input signal received from at least one other one of the clients. Each of the clients with the support of the telestration server can generate a combined telestration overlay for presentation with associated visual content shared between the clients. | 05-05-2011 |
20120184209 | AREA TRACKING SYSTEMS AND METHODS OF TRACKING ELECTRONIC DEVICES - Area tracking systems including a plurality of short range sensors that are communicatively connected to a server and methods of tracking electronic devices. The electronic devices are tracked by polling for the electronic devices, the polling including transmission of electronic addresses corresponding to the electronic devices and determining whether a reply to the poling is received. The electronic addresses are each stored on one of a plurality of lists. Each of the lists may be polled at a different frequency and may include a different number of electronic device addresses. | 07-19-2012 |
Patent application number | Description | Published |
20090099788 | PROTEIN STRUCTURE ANALYSIS - Techniques for analyzing one or more protein structures. In one aspect of the invention, the technique comprises the following steps. A normalized second-order hydrophobic moment is determined for a protein structure. The normalized second-order hydrophobic moment is then used for analysis of the protein structure. A scoring function in accordance with the normalized second-order hydrophobic moment for the protein structure may be determined. A score for the protein structure may then be generated using the scoring function. The scoring function may represent an integral of the normalized second-order hydrophobic moment. The scores may be generated for a plurality of protein structures. The scores generated for the plurality of protein structures may then be compared. | 04-16-2009 |
20090299648 | Hydropathy Plots and Fourier Analysis with Ellipsoidal Distance Metric - Techniques for protein structure analysis are provided. In one aspect, an apparatus for characterizing at least a portion of a protein structure comprising amino acid residues is provided. A set of values characterizing the protein structure are determined, wherein each value represents a distance from a center of the protein structure to a center of a given one or more of the amino acid residues. One or more other sets of values characterizing the hydrophobicity of the protein structure are obtained. A Fourier transform is performed on each of the sets of values to obtain transformed values sets. The transformed value sets are compared to correlate the hydrophobicity with the protein structure. | 12-03-2009 |
20090299649 | Hydropathy Plots and Fourier Analysis with Ellipsoidal Distance Metric - Techniques for protein structure analysis are provided. In one aspect, an article of manufacture for characterizing at least a portion of a protein structure comprising amino acid residues is provided. A set of values characterizing the protein structure are determined, wherein each value represents a distance from a center of the protein structure to a center of a given one or more of the amino acid residues. One or more other sets of values characterizing the hydrophobicity of the protein structure are obtained. A Fourier transform is performed on each of the sets of values to obtain transformed values sets. The transformed value sets are compared to correlate the hydrophobicity with the protein structure. | 12-03-2009 |
20090306904 | Hydrophobic Moment of Multi-Domain Proteins - Techniques for protein structure analysis are provided. In one aspect, an apparatus for characterizing a multi-domain protein structure comprises the following steps. For at least one domain, a hydrophobic dipole, e.g., defined as a first-order hydrophobic moment of the domain, is calculated. A score representing the orientation of the hydrophobic dipole of the at least one domain relative to a hydrophobic dipole of one or more other domains of the multi-domain protein structure is then calculated. | 12-10-2009 |
20110231108 | PROTEIN STRUCTURE ANALYSIS - Techniques for analyzing one or more protein structures. In one aspect of the invention, the technique comprises the following steps. A normalized second-order hydrophobic moment is determined for a protein structure. The normalized second-order hydrophobic moment is then used for analysis of the protein structure. A scoring function in accordance with the normalized second-order hydrophobic moment for the protein structure may be determined. A score for the protein structure may then be generated using the scoring function. The scoring function may represent an integral of the normalized second-order hydrophobic moment. The scores may be generated for a plurality of protein structures. The scores generated for the plurality of protein structures may then be compared. | 09-22-2011 |
20140089328 | ASSOCIATION OF DATA TO A BIOLOGICAL SEQUENCE - A computer assembly includes a processor configured to access data on a network and to perform a method. The method includes identifying, in the network, one or more references having a relevance level greater than a predetermined threshold. The one or more references are associated to one or more probe sequences corresponding to one or more biological sequences. The one or more probe sequences are ranked based on one or more criteria corresponding to a target biological sequence. The one or more probe sequences are assigned with a level of affinity to one or more segments of the target biological sequence based at least on the ranking of each of the one or more probe sequences. | 03-27-2014 |
20140089329 | ASSOCIATION OF DATA TO A BIOLOGICAL SEQUENCE - A method for associating data with a target biological sequence includes identifying, in a network, one or more references to data, where the data has a relevance level greater than a predetermined threshold. The method includes associating the one or more references to one or more probe sequences corresponding to a segment of a biological sequence to which the data pertains The one or more probe sequences are ranked based on one or more criteria and the probe sequences are assigned a level of affinity to a segment of the target biological sequence based at least on the ranking of each reference. | 03-27-2014 |
Patent application number | Description | Published |
20100143383 | OXGR1 AGONISTS FOR USE IN THERAPIES FOR METABOLIC DISORDERS - Methods for identifying OXGR1 modulator useful for the treatment of diabetes and conditions associated with diabetes are provided. Further provided are methods for treating diabetes and conditions associated with diabetes with an OXGR1 agonist. | 06-10-2010 |
20100144617 | Oxyntomodulin Derivatives - Modified oxyntomodulin derivatives. Such derivatives can be used for the treatment of metabolic diseases such as diabetes and obesity. | 06-10-2010 |
20110123443 | PANCREATIC BETA-CELL MASS BIOMARKER - A biomarker for pancreatic beta-cell mass comprising measuring the levels of CFC1 in the serum of a subject is described. The biomarker provides a noninvasive means for measuring pancreatic beta cell mass that is particularly useful for monitoring the efficacy of treatments for metabolic disorders such as Type I or Type II diabetes, including pancreatic islet cell transplantations. | 05-26-2011 |
20110183902 | PHARMACEUTICAL COMPOSITION COMPRISING OXYNTOMODULIN DERIVATIVES AND A METHOD FOR REDUCING BODY WEIGHT USING THE COMPOSITION - Modified oxyntomodulin derivatives. Such derivatives can be used for the treatment of metabolic diseases such as diabetes and obesity. | 07-28-2011 |
20120034608 | MICRORNA AS A BIOMARKER OF PANCREATIC ISLET BETA-CELL ENGAGEMENT - MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression and which play important roles in many cell types, including as described herein, the pancreatic β-cell. Glucagon like peptide-1 (GLP-1), a hormone released from intestinal L-cells following meal intake, exerts pleiotropic effects on β-cell function including raising intracellular cAMP levels and now represents an important therapy for type 2 diabetes. Expression of miR-132 and miR212 is upregulated by CREB protein in response increased cAMP levels in the cell; therefore, methods for detecting and evaluating β-cell engagement by GLP-1 receptor agonists by monitoring miR-132 and miR-212 expression in a subject is described. The methods herein are particularly useful in the context of longitudinal clinical trials, such as those designed for testing the durability of any single or combination therapy in type 2 diabetes populations. Because the expression of these miRNAs is not affected by glucose, fatty acid, insulin, or β-cell function, monitoring miR-132 and miR-212 expression can be used to monitor the efficacy of any agent that effects an increase cAMP in β-cells. Such agents include for example, GLP-1, glucagon, GPR-119, and GIP receptor agonists; dipeptidyl peptidase IV (DPP IV) inhibitors; and phosphodiesterase inhibitors. | 02-09-2012 |
Patent application number | Description | Published |
20090173665 | CATALYST FOR HYDROCRACKING HYDROCARBONS CONTAINING POLYNUCLEAR AROMATIC COMPOUNDS - Oil soluble catalysts are used to convert polynuclear aromatic compounds in a hydrocarbon feedstock to higher value mono-aromatic compounds. The catalyst complex includes a catalytic metal center that is bonded to a plurality of organic ligands that make the catalyst complex oil-soluble. The ligands include an aromatic ring and a ligand spacer group. The ligand spacer group provides spacing of 2-6 atoms between the metal center and the aromatic ring. The spacing between the aromatic group and the catalytic metal center advantageously allows the catalyst to selectively crack polynuclear aromatic rings while preserving one of the aromatic rings, thereby increasing the content of mono-aromatic compounds in the hydrocarbon feedstock. | 07-09-2009 |
20090173666 | PROCESS FOR INCREASING THE MONO-AROMATIC CONTENT OF POLYNUCLEAR-AROMATIC-CONTAINING FEEDSTOCKS - Hydrocarbons containing polynuclear aromatics, such as cycle oil and pyrolysis fuel oil (PFO), are upgraded using an catalyst complex that selectively cracks the polynuclear aromatic compounds to form higher value mono-aromatic compounds, such as benzene toluene, xylenes and ethyl benzene (i.e., BTX). The catalyst complexes include a catalytic metal center and a plurality of organic ligands. During the hydrocracking procedure, the organic ligand preserves one of the aromatic rings of the polynuclear aromatic compounds while the catalytic metal breaks the other aromatic rings thereby yielding a monoaromatic compound. | 07-09-2009 |
20090308792 | CATALYST AND METHOD FOR HYDRODESULFURIZATION OF HYDROCARBONS - Oil soluble catalysts are used in a process to hydrodesulfurize petroleum feedstock having a high concentration of sulfur-containing compounds and convert the feedstock to a higher value product. The catalyst complex includes at least one attractor species and at least one catalytic metal that are bonded to a plurality of organic ligands that make the catalyst complex oil-soluble. The attractor species selectively attracts the catalyst to sulfur sites in sulfur-containing compounds in the feedstock where the catalytic metal can catalyze the removal of sulfur. Because the attractor species selectively attracts the catalysts to sulfur sites, non-productive, hydrogen consuming side reactions are reduced and greater rates of hydrodesulfurization are achieved while consuming less hydrogen per unit sulfur removed. | 12-17-2009 |
20100051507 | HYDROCARBON-SOLUBLE MOLYBDENUM CATALYST PRECURSORS AND METHODS FOR MAKING SAME - Hydrocarbon-soluble molybdenum catalyst precursors include a plurality of molybdenum cations that are each bonded with a plurality of organic anions to form an oil soluble molybdenum salt. A portion of the molybdenum atoms are in the 3+ oxidation state such that the plurality of molybdenum atoms has an average oxidation state of less than 4+, e.g., less than about 3.8+, especially less than about 3.5+. The catalyst precursors can form a hydroprocessing molybdenum sulfide catalyst in heavy oil feedstocks. The oil soluble molybdenum salts are manufactured in the presence of a reducing agent, such as hydrogen gas, to obtain the molybdenum in the desired oxidation state. Preferably the reaction is performed with hydrogen or an organic reducing agent and at a temperature such that the molybdenum atoms are reduced to eliminate substantially all molybdenum oxide species. | 03-04-2010 |