Patent application number | Description | Published |
20090170916 | Pyrrole and Pyrazole DAAO Inhibitors - Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof: | 07-02-2009 |
20100016397 | Pyrrole and Pyrazole DAAO Inhibitors - Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof: | 01-21-2010 |
20110092559 | PYRROLE AND PYRAZOLE DAAO INHIBITORS - Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof: | 04-21-2011 |
Patent application number | Description | Published |
20090099248 | INHIBITORS OF D-AMINO ACID OXIDASE - The present invention provides novel inhibitors of the enzyme D-amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/or condition, wherein modulation of D-serine levels, and/or its oxidative products, is effective in ameliorating symptoms. The invention further provides methods of enhancing learning, memory and/or cognition. For example, the invention provides methods for treating or preventing loss of memory and/or cognition associated with neurodegenerative diseases, such as Alzheimer's disease. The invention further provides methods for preventing loss of neuronal function characteristic of neurodegenerative diseases. In addition, methods are provided for the treatment or prevention of neuropsychiatric diseases (e.g., schizophrenia) and for the treatment or prevention of pain and ataxia. | 04-16-2009 |
20100022612 | FUSED HETEROCYCLES - This invention provides fused heterocycles having the formula: | 01-28-2010 |
20100029737 | INHIBITORS OF D-AMINO ACID OXIDASE - The present invention provides novel inhibitors of the enzyme D-amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/or condition, wherein modulation of D-serine levels, and/or its oxidative products, is effective in ameliorating symptoms. The invention further provides methods of enhancing learning, memory and/or cognition. For example, the invention provides methods for treating or preventing loss of memory and/or cognition associated with neurodegenerative diseases, such as Alzheimer's disease. The invention further provides methods for preventing loss of neuronal function characteristic of neurodegenerative diseases. In addition, methods are provided for the treatment or prevention of neuropsychiatric diseases (e.g., schizophrenia) and for the treatment or prevention of pain and ataxia. | 02-04-2010 |
20100029741 | FUSED HETEROCYCLES - This invention provides methods of improving cognitive function by administering to a subject a therapeutically effective amount of a fused heterocycle having the formula: | 02-04-2010 |
20100120740 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE - The invention relates to prodrugs of fused heterocyclic inhibitors of D-amino oxidase (DAAO) and methods of treating diseases and conditions, wherein modulation of D-amino acid oxidase activity, D-serine levels, D-serine oxidative products and NMDA receptor activity in the nervous system of a mammalian subject is effective. | 05-13-2010 |
20110034434 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE - The invention relates to prodrugs of fused heterocyclic inhibitors of D-amino oxidase (DAAO) and methods of treating diseases and conditions, wherein modulation of D-amino acid oxidase activity, D-serine levels, D-serine oxidative products and NMDA receptor activity in the nervous system of a mammalian subject is effective. | 02-10-2011 |
20110319380 | Compounds for Treating Disorders Mediated by Metabotropic Glutamate Receptor 5, and Methods of Use Thereof - Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein. | 12-29-2011 |
20140179682 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF - Compounds that modulate GluR5 activity and methods of using the same are disclosed. | 06-26-2014 |
20140221332 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF - Compounds that modulate GluR5 activity and methods of using the same are disclosed. | 08-07-2014 |
Patent application number | Description | Published |
20080254437 | Global Computer Network Tutoring System - A global computer network method and apparatus for creating and deploying many types of intelligent tutoring systems across many different platforms is disclosed. A run time engine supports state graph pseudo tutors and JESS model tracing cognitive tutors, in both a client and server context. An Assistment Builder enables development, testing and deployment of the pseudo tutors, generally the tutorials formed of teacher composed problems. The system simplifies the process of tutorial construction to allow educator users with little or no ITS experience to develop content of problems and teaching strategies (i.e., format of problems including hints, messages and sequencing of related problems). The system provides a Web these tutorials. A reporting component is Web based and allows for live database reporting to teachers, showing how their students are performing. Automated analysis and reporting of experimental tutorials developed by teachers is included. | 10-16-2008 |
20100279265 | Computer Method and System for Increasing the Quality of Student Learning - Today, students are underperforming on the standardized testing. In an effort to better performance on these tests, software systems allow a student to practice different topics. These software systems, however, do not perform a longitudinal analysis of a student allowing the creation of an adaptable learning environment for the system. In contrast, the present invention provides a system that enables a student to answer one or more questions of a problem set. Next, the system stores information for each answer of the one or more questions over a period of time, analyzes the information for each student answer in a longitudinal manner, and identifies one or more deficiencies in learning of the student based on the longitudinal analysis. In this way, the system uses longitudinal analysis to identify student deficiencies, which allows a teacher or parent, using the analysis, to increase the quality of learning for the student. | 11-04-2010 |