Evans, MA
Brandon Adam Evans, Cambridge, MA US
Patent application number | Description | Published |
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20140114792 | ELECTRONIC COMMERCE SYSTEM - The exchange-driven electronic market system disclosed herein allows increasing volume and efficiency of transactions between buyers and sellers in a marketplace. An implementation of the electronic market system includes a method comprising receiving a plurality of sale offers, each sale offer including required revenue values required volume values for a product, determining an offered market price based on the plurality of sale offers, displaying the offered market price to a plurality of buyers, receiving from the plurality of buyers a plurality of conditional offers for purchases (COPs), and completing a plurality of sales transactions, if the combination of one or more of the plurality of COPs meets the combination of one or more of the required revenue values. | 04-24-2014 |
Brian Charles Evans, Marshfield, MA US
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20110278137 | SLOPE PLATE CARROUSEL CARRIAGE FRAME - The present disclosure is directed to a carriage frame that is used in a slope plate carriage carrousel system that may be found in airports for conveying luggage for passengers to claim. A slope plate carrousel carriage frame according to an embodiment of the present disclosure includes a slope plate support member. The slope plate support member is configured to support a slope plate of the carrousel system. A lower carriage is coupled to the slope plate support member. The carriage frame also includes at least one removable connecting link. | 11-17-2011 |
20140158653 | HINGED LOAD PANEL FOR PACKAGE DELIVERY VEHICLES - An exemplary system for use in a package delivery vehicle is provided that may include a hinge member that includes a first opening and a hinge body that includes a second opening that is pivotally coupled to the first opening so that the hinge body can pivot with respect to the hinge member. The hinge body also includes a first protrusion and a second protrusion that extends from the first protrusion. The first and second protrusions are slideable within a key structure that extends at least partway along a longitudinal axis of an edge railing of the package delivery vehicle. | 06-12-2014 |
20150225021 | STOWABLE FLOOR ASSEMBLY FOR PACKAGE DELIVERY VEHICLES - A stowable floor panel system includes a horizontal railing coupled to a sidewall of a package delivery vehicle where the horizontal railing includes an upper and a lower track that are spaced apart from each other. The upper track defines an upper channel, and the lower track defines a lower channel. A hinge assembly couples a stowable floor panel to the horizontal railing. A hinge body has a plurality of relief features and an upper projection extending from a rail receiving body portion and a lower projection extending from the rail receiving body portion opposite the upper projection. When the hinge body is inserted in the railing and rotated 90 degrees the upper projection seats in the upper channel, and the lower projection seats in the lower channel. A hook assembly maintains the stowable floor panel in a stowed position and includes a cam block with a cam surface that is configured to direct the hook to a rest position with the hook-shaped portion disposed generally parallel to the sidewall of the package delivery vehicle. | 08-13-2015 |
Catherine A. Evans, Someville, MA US
Patent application number | Description | Published |
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20120088738 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z | 04-12-2012 |
Catherine A. Evans, Somerville, MA US
Patent application number | Description | Published |
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20090099131 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). | 04-16-2009 |
20110028478 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-03-2011 |
20110028482 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-03-2011 |
20110034437 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 02-10-2011 |
20110172186 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides compounds, and pharmaceutically acceptable compositions thereof, encompassed by any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof. The present invention also provides methods for treating an FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof. | 07-14-2011 |
20110224171 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). | 09-15-2011 |
20110230440 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). | 09-22-2011 |
20120059000 | CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION - Chemical compounds that modulate kinase activity, including PI3 kinase activity, and chemical compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. | 03-08-2012 |
20120122838 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 05-17-2012 |
20130029982 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 01-31-2013 |
20130029984 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 01-31-2013 |
20130053362 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. | 02-28-2013 |
20130059819 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). | 03-07-2013 |
20130267521 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 10-10-2013 |
20130338107 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z | 12-19-2013 |
20140088099 | CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION - Chemical compounds that modulate kinase activity, including PI3 kinase activity, and chemical compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. | 03-27-2014 |
20140100214 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. | 04-10-2014 |
20140121183 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). | 05-01-2014 |
20140288048 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. | 09-25-2014 |
20150031672 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 01-29-2015 |
20150099738 | ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides isoxazoline FAAH inhibitors of the formula (I): | 04-09-2015 |
20150105385 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 04-16-2015 |
20150111874 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 04-23-2015 |
20150126506 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 05-07-2015 |
20150225410 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 08-13-2015 |
20150246932 | HETEROCYCLIC COMPOUNDS AND USES THEREOF - Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. | 09-03-2015 |
20150344503 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE, METHODS OF TREATMENT AND METHODS OF PREPARING SAME - The present invention provides compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). | 12-03-2015 |
20150368278 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE - The present invention provides compounds, and pharmaceutically acceptable compositions thereof, encompassed by any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof. The present invention also provides methods for treating an FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof. | 12-24-2015 |
Chistopher H. Evans, Cohasset, MA US
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20120309817 | VIRAL AND NON-VIRAL VECTORS AS VEHICLES FOR DELIVERING TRANSGENES FOR TREATING BONE PATHOLOGIES - The present invention relates to a method for treating bone pathologies comprising delivering a viral or non-viral delivery vehicle comprising genetic information (e.g. a transgene) encoding a therapeutic osteoinductive factor to target cells in vivo enabling the cells to produce the osteoinductive factor at the site of the bone pathology. The delivery is achieved by a simplified method which does not require cumbersome ex vivo techniques or additional matrix or scaffolding agents. Such viral and non-viral delivery vehicles of the present invention are derived from the following nonlimiting examples: adenoviruses, adeno-associated viruses, retroviruses, herpes simplex viruses, liposomes, and plasmids. The osteoinductive factors include, but are not limited to, growth factors, cytokines, growth factor inhibitors and cytokine inhibitors. | 12-06-2012 |
Christopher C. Evans, Cambridge, MA US
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20120039560 | ALL-OPTICAL LOGIC GATES AND METHODS FOR THEIR FABRICATION - The present invention provides optical devices that employ nonlinear optical effects for processing optical signals. For example, such an optical device can include a nano-sized interferometric component that provides an optical output signal via interference of two input signals subsequent to their asymmetric nonlinear phase accumulation. The interferometric element can have a variety of configurations, such as Sagnac, Mach-Zehnder or Michelson configurations. | 02-16-2012 |
Christopher H. Evans, Cohasset, MA US
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20110280935 | VIRAL AND NON-VIRAL VECTORS AS VEHICLES FOR DELIVERING TRANSGENES FOR TREATING BONE PATHOLOGIES - The present invention relates to a method for treating bone pathologies comprising delivering a viral or non-viral delivery vehicle comprising genetic information (e.g. a transgene) encoding a therapeutic osteoinductive factor to target cells in vivo enabling the cells to produce the osteoinductive factor at the site of the bone pathology. The delivery is achieved by a simplified method which does not require cumbersome ex vivo techniques or additional matrix or scaffolding agents. Such viral and non-viral delivery vehicles of the present invention are derived from the following nonlimiting examples: adenoviruses, adeno-associated viruses, retroviruses, herpes simplex viruses, liposomes, and plasmids. The osteoinductive factors include, but are not limited to, growth factors, cytokines, growth factor inhibitors and cytokine inhibitors. | 11-17-2011 |
Conor L. Evans, Boston, MA US
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20090059360 | SYSTEM AND METHOD FOR SELF-INTERFERENCE FLUORESCENCE MICROSCOPY, AND COMPUTER-ACCESSIBLE MEDIUM ASSOCIATED THEREWITH - Exemplary apparatus and/or method can be provided using which, it is possible to provide information associated with at least one portion of a sample. For example, at least one electro-magnetic radiation received from the at least one portion of the sample can be separated into a plurality of first radiations, one of the first radiations having a phase delay that is different from a phase delay of another of the first radiations. In addition, at least one of the first radiations can be received and separated into second radiations according to wavelengths of the received at least one of the first radiations. Further, it is possible to detect the second radiations and generate information regarding a position of the at least one portion of the sample as a function of at least one characteristic of at least one interference of the first radiations. According to another exemplary embodiment, it is possible to provide system, method and computer accessible medium, in which data associated with first radiations can be obtained, and the information regarding a position of the at least one portion of the sample may be generated. Such information can be generated based on the data by separating second radiations associated with the portion(s) of the sample according to wavelengths of at least one of the second radiations. For example, one of the second radiations can have a phase delay that is different from a phase delay of another one of the second radiations, and the second radiations may be interfering. | 03-05-2009 |
20150182166 | SYSTEM AND METHOD FOR MONITORING AND TREATING A SURFACE OF A SUBJECT - A system and method are provided for the design and assembly of a device including a sensor capable and a compatible matrix material incorporated into a dressing. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions, and the matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. | 07-02-2015 |
David A. Evans, Seekonk, MA US
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20120127632 | EXTENDED LIFE CAPACITORS - Capacitors employing liquid or gel electrolytes have their useful lifetime significantly extended by including, in the electrolyte, a binary mixture of transition metal ion species. Each species has at least two distinct oxidation states when dissolved in the electrolyte. The interaction of the mixture of ion species reduces the potential of the cathode and maintains the potential of the cathode below the hydrogen potential to prevent the reduction of hydrogen ions and the formation of hydrogen. The binary mixture of transition metal species reduces the cathode potential by oxidation of the transition metal species at the anode and reduction of the transition metal species at the cathode. Thus, the rate of decrease in capacitance, increase in equivalent series resistance, and swelling of the capacitor are suppressed. In addition, the ratio of capacitor aging to the quantity of charge passed by the capacitor is decreased by at least a factor of two as compared to previous known extended life capacitors. | 05-24-2012 |
20130095299 | SINTERED ARTICLE AND SINTERING METHOD, PARTICULARLY FOR LOW ESR CAPACITOR ANODES - A method of making a sintered article in which a solid object is embedded includes forming a green body of compressed particles with the solid body is partially embedded. The green body includes an opening across which the solid body extends. The green body is sintered to form a sintered body and the opening permits deformation of the solid body in response to stress applied during the sintering process. A sintered article in which a solid body is at least partially embedded includes an opening. The solid body extends across the opening so that the solid body can deform within the opening. The opening in the solid body prevents distortion of the sintered body from a planar configuration during sintering, even when the green body is relatively thin. | 04-18-2013 |
20140218843 | SINTERED ARTICLE, PARTICULARLY FOR LOW ESR CAPACITOR ANODES - A sintered article in which a solid body is at least partially embedded includes an opening. The solid body extends across the opening so that the solid body can deform within the opening. The opening in the solid body prevents distortion of the sintered body from a planar configuration during sintering, even when the green body that is sintered is relatively thin. | 08-07-2014 |
James Evans, Burlington, MA US
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20140157100 | PERSISTENT LAYER LABELS FOR A PIVOT TABLE OR CROSS-TABULAR REPORT - A system and method for facilitating displaying information, including layer labels, in a table or data grid, such as a pivot table or cross-tabular report. An example method includes rendering a first table that includes one or more column headers and one or more row headers, wherein the one or more column headers and the one or more row headers are associated with one or more layers; and persistently displaying one or more labels for the one or more layers. In a more specific embodiment, the first table includes a pivot table with one or more column layers and one or more row layers, which are each associated with the one or more column headers and the one or more row headers, respectively. The example method further includes employing an intersection cell to display layer labels for a row of column headers and for a column of row headers. | 06-05-2014 |
20140351746 | MULTIDIMENSIONAL SPLIT VIEW FOR A PIVOT TABLE OR OTHER GRID-BASED COMPONENT - A data view may be into multiple data panes. Splits between data panes may be horizontal or vertical, allowing data panes to be arranged horizontally and vertically. Scroll boundaries are set for each pair of adjacent data panes, such that each data pane may only scroll through a portion of the data on its side of the scroll boundary. Data panes may be scrolled independently in the direction of a split. Data panes may be scrolled together perpendicular to the direction of a split. | 11-27-2014 |
James A. Evans, Burlington, MA US
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20130103738 | EAGER BLOCK FETCHING FOR WEB-BASED DATA GRIDS - Techniques for improving scrolling performance in a web-based data grid. In one set of embodiments, when a user scrolls through a data grid rendered in a viewport of the user's web browser, client-side code executing in the web browser can detect whether a scroll event has occurred that requires a portion of the viewport to be filled/refreshed with data from a server. The client-side code can further determine whether the scroll event is a short scroll or a long scroll, and can send a request to the server that indicates the type of scroll event. If the scroll event is a short scroll, the server can determine a first amount of data to fetch based on one or more first parameters. If the scroll event is a long scroll, the server can determine a second amount of data to fetch based on one or more second parameters. | 04-25-2013 |
20140289673 | EAGER BLOCK FETCHING FOR WEB-BASED DATA GRIDS - Techniques for improving scrolling performance in a web-based data grid. In one set of embodiments, when a user scrolls through a data grid rendered in a viewport of the user's web browser, client-side code executing in the web browser can detect whether a scroll event has occurred that requires a portion of the viewport to be filled/refreshed with data from a server. The client-side code can further determine whether the scroll event is a short scroll or a long scroll, and can send a request to the server that indicates the type of scroll event. If the scroll event is a short scroll, the server can determine a first amount of data to fetch based on one or more first parameters. If the scroll event is a long scroll, the server can determine a second amount of data to fetch based on one or more second parameters. | 09-25-2014 |
James Mb Evans, Sudbury, MA US
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20120305174 | LAYER PROCESSING FOR PHARMACEUTICALS - Layer processing for pharmaceuticals, and related systems, methods, and articles are generally described. In some embodiments, ingestible pharmaceutical products (e.g., tablets) can be formed by processing one or more layers containing a pharmaceutically active composition. For example, at least one layer containing a pharmaceutically active composition can be manipulated (e.g., folded, rolled, stacked, etc.) such that the average thickness of the product formed by the manipulation is at least about two times the average thickness of the portions of the layer(s) used to form the product. In some embodiments, after the layer is manipulated, it can be processed (e.g., cut, coated, etc.) to form a final product such as, for example, a tablet. | 12-06-2012 |
Joseph Romney Evans, Newton, MA US
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20110099122 | SYSTEM AND METHOD FOR PROVIDING CUSTOMERS WITH PERSONALIZED INFORMATION ABOUT PRODUCTS - Embodiments of the invention may provide a personalized fit prediction to a particular consumer about a particular product. Personalization of the fit prediction may be accomplished by processing various types of data, including data about consumers, products, and previous purchases by consumers. For example, this data may be used to generate a model (e.g., set of rules), which can then be applied to predict whether and/or how well a particular product will suit a particular consumer. | 04-28-2011 |
20120030062 | ENABLING PROXY SHOPPING - Some embodiments of the invention enable a buyer to shop for and purchase items for a recipient with confidence. For example, some embodiments of the invention enable a recipient to create a profile that may be accessed to make recommendations to a buyer on items deemed likely to suit the recipient in any of numerous ways (e.g., those deemed likely to fit the recipient, be age-appropriate, reflect the recipient's style, suit the recipient's fit preferences, conform to the recipient's measurements, etc.). In some embodiments, a recipient may indicate that certain, or all, aspects of the profile be kept private, so that the buyer need not know information about the recipient such as his/her body measurements, fit preferences, style preferences, and/or other information to be able to shop confidently for the recipient. | 02-02-2012 |
20140244431 | SYSTEM AND METHOD FOR PROVIDING CUSTOMERS WITH PERSONALIZED INFORMATION ABOUT PRODUCTS - Embodiments of the invention may provide a personalized fit prediction to a particular consumer about a particular product. Personalization of the fit prediction may be accomplished by processing various types of data, including data about consumers, products, and previous purchases by consumers. For example, this data may be used to generate a model (e.g., set of rules), which can then be applied to predict whether and/or how well a particular product will suit a particular consumer. | 08-28-2014 |
Llewelyn John Evans, Wilbraham, MA US
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20090278843 | COMPUTER AIDED DESIGN OF THREE-DIMENSIONAL CARTONS WITH CURVED CREASES - A method, a computer readable medium with instructions to execute a method, and a carton designed using a method. The method includes accepting a specification of a carton made up of a substrate and having at least one curved crease. The method further includes for a curved crease, accepting a folding angle at any point of the crease; and automatically calculating at least one shape of the folded carton in order to determine a three-dimensional model of the folded carton. | 11-12-2009 |
Matthew John Evans, Cambridge, MA US
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20160116678 | SYSTEMS AND METHODS FOR LASER FREQUENCY STABILIZATION USING AN ARBITRARILY BIREFRINGENT RESONATOR - Systems and methods to stabilize a laser frequency include a birefringent resonator that introduces an arbitrary phase difference between two polarization components of the laser beam, a polarizing beam splitter to separate the two polarization components after the birefringent resonator, and a differential detector to monitor the separated two polarizations, based on which an error signal can be produced to control a servo to adjust the laser frequency or resonator resonance frequency accordingly. The birefringent resonator can comprise a fiber ring, a whispering gallery mode (WGM) resonator, or any other birefringent ring resonator. A servo can be included in the systems and methods to lock the laser frequency to the resonant frequency of the birefringent resonator or to lock the resonator resonant frequency to the laser frequency. One or more polarization controllers can also be employed to adjust the polarization state of the laser beam. | 04-28-2016 |
Morgan Evans, Manchester, MA US
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20090162953 | PREDICTING DOSE REPEATABILITY IN AN ION IMPLANTATION - An approach for predicting dose repeatability in an ion implantation is described. In one embodiment, an ion source is tuned to generate an ion beam with desired beam current. Beam current measurements are obtained from the tuned ion beam. The dose repeatability is predicted for the ion implantation as a function of the beam current measurements. | 06-25-2009 |
Morgan D. Evans, Manchester, MA US
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20090242808 | TECHNIQUES FOR IMPROVED UNIFORMITY TUNING IN AN ION IMPLANTER SYSTEM - Techniques for uniformity tuning in an ion implanter system are disclosed. In one particular exemplary embodiment, the techniques may be realized as a method for ion beam uniformity tuning. The method may comprise generating an ion beam in an ion implanter system. The method may also comprise measuring a first ion beam current density profile along an ion beam path. The method may further comprise measuring a second ion beam current density profile along the ion beam path. In addition, the method may comprise determining a third ion beam current density profile along the ion beam path based at least in part on the first ion beam current density profile and the second ion beam current density profile. | 10-01-2009 |
20120258583 | METHOD FOR EPITAXIAL LAYER OVERGROWTH - Oxygen, silicon, germanium, carbon, or nitrogen is selectively implanted into a workpiece. The workpiece is annealed to incorporate the ions into the workpiece. A compound semiconductor is then formed on the workpiece. For example, gallium nitride may be formed on a silicon, silicon carbide, or sapphire workpiece. The width of the implanted regions can be configured to compensate for any shrinkage during annealing. | 10-11-2012 |
20120276658 | METHOD OF ETCHING A WORKPIECE - A workpiece is implanted to a first depth to form a first amorphized region. This amorphized region is then etched to the first depth. After etching, the workpiece is implanted to a second depth to form a second amorphized region below a location of the first amorphized region. The second amorphized region is then etched to the second depth. The implant and etch steps may be repeated until structure is formed to the desired depth. The workpiece may be, for example, a compound semiconductor, such as GaN, a magnetic material, silicon, or other materials. | 11-01-2012 |
20120286285 | METHOD OF IMPLANTING A WORKPIECE TO IMPROVE GROWTH OF A COMPOUND SEMICONDUCTOR - A workpiece is implanted to improve growth of a compound semiconductor, such as GaN. This workpiece may be implanted such that the workpiece has a dose at a center different from a dose at a periphery. This workpiece also may be implanted one or more times to form a pattern of lines, which may be a grid, a series of circles, or other shapes. The distance between certain pairs of lines may be different across the workpiece. | 11-15-2012 |
20120289031 | COMPOUND SEMICONDUCTOR GROWTH USING ION IMPLANTATION - A workpiece is implanted to affect growth of a compound semiconductor, such as GaN. Implanted regions of a workpiece increase, reduce, or prevent growth of this compound semiconductor. Combinations of implants may be performed to cause increased growth in certain regions of the workpiece, such as between regions where growth is reduced. Growth also may be reduced or prevented at the periphery of the workpiece. | 11-15-2012 |
20130020580 | HETEROEPITAXIAL GROWTH USING ION IMPLANTATION - In one embodiment, a method of growing a heteroepitaxial layer comprises providing a patterned substrate containing patterned features having sidewalls. The method also includes directing ions toward the sidewalls in an exposure, wherein altered sidewall regions are formed, and depositing the heteroepitaxial layer under a set of deposition conditions effective to preferentially promote epitaxial growth on the sidewalls in comparison to other surfaces of the patterned features. | 01-24-2013 |
20160111254 | Workpiece Processing Method And Apparatus - A system and method for processing a workpiece is disclosed. A plasma chamber is used to create a ribbon ion beam, extracted through an extraction aperture. A workpiece is translated proximate the extraction aperture so as to expose different portions of the workpiece to the ribbon ion beam. As the workpiece is being exposed to the ribbon ion beam, at least one parameter associated with the plasma chamber is varied. The variable parameters include extraction voltage duty cycle, workpiece scan velocity and the shape of the ion beam. In some embodiments, after the entire workpiece has been exposed to the ribbon ion beam, the workpiece is rotated and exposed to the ribbon ion beam again, while the parameters are varied. This sequence may be repeated a plurality of times. | 04-21-2016 |
Neil D. Evans, North Chelmsford, MA US
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20100114850 | Event recording with local event record locking - Systems, methods, and other embodiments associated with event recording are described. One example method includes locally locking a record in an event data store corresponding to an event having a same event type as a given event when a prior occurrence of the given event has not yet been recorded. The event data store is updated to record the given event while the record is locked. One example system includes an event data store configured to store records corresponding to events, an event recorder configured to record event data in the event data store and a local lock actuable by the event recorder. The event recorder is configured to update the locked record to correspond to a received event. | 05-06-2010 |
Owen R. Evans, Chelmsford, MA US
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20130005842 | SULFUR-CONTAINING ORGANIC-INORGANIC HYBRID GEL COMPOSITIONS AND AEROGELS - Methods and materials are described for preparing organic-inorganic hybrid gel compositions where a sulfur-containing cross-linking agent covalently links the organic and inorganic components. The gel compositions are further dried to provide porous gel compositions and aerogels. The mechanical and thermal properties of the dried gel compositions are also disclosed. | 01-03-2013 |
20140044929 | SEGMENTED FLEXIBLE GEL COMPOSITES AND RIGID PANELS MANUFACTURED THEREFROM - The present invention describes various methods for manufacturing gel composite sheets using segmented fiber or foam reinforcements and gel precursors. Additionally, rigid panels manufactured from the resulting gel composites are also described. The gel composites are relatively flexible enough to be wound and when unwound, can be stretched flat and made into rigid panels using adhesives. | 02-13-2014 |
20150344663 | SULFUR-CONTAINING ORGANIC-INORGANIC HYBRID GEL COMPOSITIONS AND AEROGELS - Methods and materials are described for preparing organic-inorganic hybrid gel compositions where a sulfur-containing cross-linking agent covalently links the organic and inorganic components. The gel compositions are further dried to provide porous gel compositions and aerogels. The mechanical and thermal properties of the dried gel compositions are also disclosed. | 12-03-2015 |
20160046867 | AEROGEL COMPOSITIONS WITH ENHANCED PERFORMANCE - Aerogel materials, aerogel composites and the like may be improved by enhancing their smoke suppression, combustion reduction properties. It is additionally useful to provide aerogel based composites compatible with environments conducive to combustion. Such aerogel materials and methods of manufacturing the same are described. | 02-18-2016 |
Owen Richard Evans, Chelmsford, MA US
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20130196137 | Composite Aerogel Thermal Insulation System - The present invention provides methods and systems to effectively insulate hot or cold surfaces in industrial, domestic and building systems. It provides composite thermal insulation systems, which comprises an at least two-layer thermal insulation cladding, with at least two layers each containing from 25 to 95% by weight of aerogel and from 5 to 75% by weight of inorganic fibres, wherein the layers of the thermal insulation cladding are joined to one another by means of an inorganic binder. | 08-01-2013 |
20160096949 | HYDROPHOBIC AEROGEL MATERIALS - The present disclosure provides an aerogel composition which is durable and easy to handle, which has favorable performance in aqueous environments, and which also has favorable combustion and self-heating properties. Also provided is a method of preparing an aerogel composition which is durable and easy to handle, which has favorable performance in aqueous environments, and which has favorable combustion and self-heating properties. Further provided is a method of improving the hydrophobicity, the liquid water uptake, the heat of combustion, or the onset of thermal decomposition temperature of an aerogel composition. | 04-07-2016 |
Paul Evans, Allston, MA US
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20110104614 | Self-imageable film forming polymer, compositions thereof and devices and structures made therefrom - Embodiments in accordance with the present invention encompass self-imageable film forming compositions that comprise norbornene-type polymers and that can be formulated to be either positive tone imaging or negative tone. The films formed thereby are useful in the forming of microelectronic and optoelectronics devices. | 05-05-2011 |
Robert Evans, Worcester, MA US
Patent application number | Description | Published |
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20120061373 | AXIAL RESISTANCE SHEATHED HEATER - An axial resistance sheathed heater is presented. The axial resistance sheathed heater includes a retaining sheath having a first end and a second end and a resistance wire completely disposed within the retaining sheath. The heater further includes a first conductor rod partially disposed within the retaining sheath and extending beyond the first end of the retaining sheath, the first conductor rod in direct electrical communication and direct mechanical communication with the resistance wire; and a second conductor rod partially disposed within said retaining sheath and extending beyond the second end of the retaining sheath, the second conductor rod in direct electrical communication and direct mechanical communication with the resistance wire. The resistance wire, the first conductor rod and the second conductor rod comprise a circuit achieving a power to voltage rating of about 5000:24. | 03-15-2012 |
20130284717 | Axial Resistance Sheathed Heater - An axial resistance sheathed heater is presented. The axial resistance sheathed heater includes a retaining sheath having a first end and a second end and a resistance wire completely disposed within the retaining sheath. The heater further includes a first conductor rod partially disposed within the retaining sheath and extending beyond the first end of the retaining sheath, the first conductor rod in direct electrical communication and direct mechanical communication with the resistance wire; and a second conductor rod partially disposed within said retaining sheath and extending beyond the second end of the retaining sheath, the second conductor rod in direct electrical communication and direct mechanical communication with the resistance wire. The resistance wire, the first conductor rod and the second conductor rod comprise a circuit achieving a power to voltage rating of about 5000:24. | 10-31-2013 |
Robert Evans, Sturbridge, MA US
Patent application number | Description | Published |
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20090116826 | INTER-AXIAL INLINE FLUID HEATER - An inter-axial inline fluid heater is presented. The inter-axial inline fluid heater includes an outer retaining sheath defining a first area, and an interior flow tube disposed within the outer sheath and capable of having fluid flow therethrough. Further, the inter-axial inline fluid heater includes a resistance wire disposed between the interior flow tube and the outer retaining sheath, the resistance wire capable of producing heat for heating a fluid passing through the interior flow tube when power is applied to the resistance wire. Also includes is a dielectric heat transfer material disposed between the interior flow tube and the outer retaining sheath and surrounding at least a portion of the resistance wire. | 05-07-2009 |
20120141100 | Inter-Axial Inline Fluid Heater - An inter-axial inline fluid heater is presented. The inter-axial inline fluid heater includes an outer retaining sheath defining a first area, and an interior flow tube disposed within the outer sheath and capable of having fluid flow therethrough. Further, the inter-axial inline fluid heater includes a resistance wire disposed between the interior flow tube and the outer retaining sheath, the resistance wire capable of producing heat for heating a fluid passing through the interior flow tube when power is applied to the resistance wire. Also includes is a dielectric heat transfer material disposed between the interior flow tube and the outer retaining sheath and surrounding at least a portion of the resistance wire. | 06-07-2012 |
Ruffin Eley Evans, Cambridge, MA US
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20150299894 | SYNTHETIC DIAMOND MATERIALS FOR QUANTUM AND OPTICAL APPLICATIONS AND METHODS OF MAKING THE SAME - A synthetic diamond material comprising one or more spin defects having a full width half maximum intrinsic inhomogeneous zero phonon line width of no more than 100 MHz. The method for obtain such a material involves a multi-stage annealing process. | 10-22-2015 |
Sean A. Evans, Acton, MA US
Patent application number | Description | Published |
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20140242182 | FORMULATIONS THAT STABILIZE PROTEINS - In one aspect, the disclosure provides formulations that stabilize proteins, wherein the formulations comprise a buffer. In some embodiments, the buffer comprises potassium mono-hydrogen-phosphate and potassium di-hydrogen-phosphate, or the buffer comprises sodium mono-hydrogen-phosphate and sodium di-hydrogen-phosphate. In some embodiments, the protein is a therapeutic protein. In some embodiments, the therapeutic protein is antithrombin. | 08-28-2014 |
Stephen Evans, Westford, MA US
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20140058194 | System and Mandrel for Creating Graft Devices - A system for applying a fiber matrix on a tubular member is provided. A mandrel, configured for atraumatic placement within the tubular member, is included. Methods for atraumatic placement of a mandrel into a tubular member are also provided. | 02-27-2014 |
20140221999 | ELECTROSURGICAL FORCEPS - An electrosurgical forceps is provided. The electrosurgical forceps includes a housing having a shaft extending distally therefrom. The shaft defines a longitudinal axis therethrough and a knife blade shaft is operably disposed within the shaft. An end effector is operably disposed at a distal end of the shaft. The end effector includes a pair of spaced-apart first and second jaw members that are movable from an open configuration to a clamping configuration. An electrode assembly includes first and second electrode housings and a knife blade. The first and second electrode housings are operably coupled to one another and are configured to selectively couple to respective first and second jaw members to electrosurgically treat tissue clamped between the first and second jaw members. The knife blade is configured to selectively couple to the knife blade shaft. | 08-07-2014 |
Stephen C. Evans, Westford, MA US
Patent application number | Description | Published |
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20090205644 | PNEUMOSTOMA MANAGEMENT SYSTEM FOR TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE - A pneumostoma management system for maintaining the patency of a pneumostoma while controlling the flow of material through the pneumostoma. The pneumostoma management system includes a two-part pneumostoma management device and associated insertion and removal tools. The pneumostoma management device includes a pneumostoma vent and a chest mount for positioning and securing the vent into a pneumostoma. The pneumostoma vent includes a hydrophobic filter and/or a one-way valve. | 08-20-2009 |
20090205645 | PNEUMOSTOMA MANAGEMENT METHOD FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE - A method for maintaining the patency of a pneumostoma while controlling the flow of material through the pneumostoma. A pneumostoma management system includes a two-part pneumostoma management device and associated insertion and removal tools. The pneumostoma management device includes a pneumostoma vent and a chest mount for positioning and securing the vent into a pneumostoma. To use the system, the chest is first cleaned and the chest mount secured to the chest adjacent the pneumostoma. The pneumostoma vent is then inserted into the pneumostoma through an aperture in the chest mount until it is engaged and secured by a coupling of the chest mount. The pneumostoma vent may be replaced periodically such as daily. The chest mount may be changed less frequently such as weekly. | 08-20-2009 |
20090205647 | PNEUMOSTOMA MANAGEMENT SYSTEM HAVING A COSMETIC AND/OR PROTECTIVE COVER - A pneumostoma management system which includes a pneumostoma management device and a cover. The pneumostoma management device maintains the patency of a pneumostoma while controlling the flow of material through the pneumostoma. The pneumostoma management device includes a hydrophobic filter and/or a one-way filter. The cover serves to protect the pneumostoma management device and/or provide a cosmetic skin to make the pneumostoma management device more acceptable to the patient and thereby encourage patient compliance with a pneumostoma treatment regimen. | 08-20-2009 |
20090205651 | ONE-PIECE PNEUMOSTOMA MANAGEMENT SYSTEM AND METHODS FOR TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE - A flexible pneumostoma management device maintains the patency of a pneumostoma while controlling the flow of material through the pneumostoma. The pneumostoma management device includes a pneumostoma vent having a tube which enters the pneumostoma to allow gases to escape the lung, a flange and a filter/valve to control flow of materials through the tube. The flange is a thin flexible patch which conforms and attaches to the chest of the patient. The flange secures the tube in position in the pneumostoma. The flange is formed in one piece with the tube. | 08-20-2009 |
20100174139 | Guide Wire Insertion and Re-Insertion Tools and Methods of Use - An insertion tool for use in inserting a guide wire into a guide wire lumen of a catheter for use in a lumen of an endoscope. The insertion tool includes a main body having a main lumen and a funnel-shaped extension connected to and disposed atop the main body. The funnel-shaped extension having a funnel lumen. The funnel lumen has a top opening and a bottom opening. The funnel lumen tapering from the top opening to the bottom opening. The bottom opening positioned and sized to communicate with the guide wire lumen of the catheter such that, when the catheter is disposed in the main lumen, the guide wire may be easily inserted into the top opening of the funnel lumen and into the guide wire lumen of the catheter. | 07-08-2010 |
20140249448 | Insertable Endoscopic Instrument For Tissue Removal - An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool. | 09-04-2014 |
20150018710 | ENDOSCOPE INCLUDING AN TORQUE GENERATION COMPONENT OR TORQUE DELIVERY COMPONENT DISPOSED WITHIN AN INSERTABLE PORTION OF THE ENDOSCOPE AND A SURGICAL CUTTING ASSEMBLY INSERTABLE WITHIN THE ENDOSCOPE - An endoscope for removing tissue at a surgical site includes an elongated tubular body insertable within a mammalian cavity of a patient. An instrument channel extends between a first opening at a distal end and a second opening at a proximal end of the tubular body and is sized and configured to receive a surgical cutting assembly that includes an aspiration channel configured to remove material entering the endoscope via a distal end of the surgical cutting assembly. A torque generation component configured to generate torque is positioned within the distal end and configured to provide the generated torque to a coupling component. The coupling component is positioned at the distal end of the elongated tubular member and configured to actuate a cutting component of the surgical cutting assembly responsive to actuation of the torque generation component. | 01-15-2015 |
20150018711 | ENDOSCOPE INCLUDING AN TORQUE GENERATION COMPONENT OR TORQUE DELIVERY COMPONENT DISPOSED WITHIN AN INSERTABLE PORTION OF THE ENDOSCOPE AND A SURGICAL CUTTING ASSEMBLY INSERTABLE WITHIN THE ENDOSCOPE - An endoscope for removing tissue at a surgical site includes an elongated tubular body insertable within a mammalian cavity of a patient. An instrument channel extends between a first opening at a distal end and a second opening at a proximal end of the tubular body and is sized and configured to receive a surgical cutting assembly that includes an aspiration channel configured to remove material entering the endoscope via a distal end of the surgical cutting assembly. A torque generation component configured to generate torque is positioned within the distal end and configured to provide the generated torque to a coupling component. The coupling component is positioned at the distal end of the elongated tubular member and configured to actuate a cutting component of the surgical cutting assembly responsive to actuation of the torque generation component. | 01-15-2015 |
20150025541 | INSERTABLE ENDOSCOPIC INSTRUMENT FOR TISSUE REMOVAL - An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool. | 01-22-2015 |
20150031951 | ENDOSCOPE INCLUDING AN TORQUE GENERATION COMPONENT OR TORQUE DELIVERY COMPONENT DISPOSED WITHIN AN INSERTABLE PORTION OF THE ENDOSCOPE AND A SURGICAL CUTTING ASSEMBLY INSERTABLE WITHIN THE ENDOSCOPE - An endoscope for removing tissue at a surgical site includes an elongated tubular body insertable within a mammalian cavity of a patient. An instrument channel extends between a first opening at a distal end and a second opening at a proximal end of the tubular body and is sized and configured to receive a surgical cutting assembly that includes an aspiration channel configured to remove material entering the endoscope via a distal end of the surgical cutting assembly. A torque generation component configured to generate torque is positioned within the distal end and configured to provide the generated torque to a coupling component. The coupling component is positioned at the distal end of the elongated tubular member and configured to actuate a cutting component of the surgical cutting assembly responsive to actuation of the torque generation component. | 01-29-2015 |
20150032024 | METHODS AND APPARATUS FOR REMOVING MATERIAL FROM WITHIN A MAMMALIAN CAVITY USING AN INSERTABLE ENDOSCOPIC INSTRUMENT - An endoscope for removing tissue at a surgical site includes an elongated tubular body insertable within a mammalian cavity of a patient. An instrument channel extends between a first opening at a distal end and a second opening at a proximal end of the tubular body and is sized and configured to receive a surgical cutting assembly that includes an aspiration channel configured to remove material entering the endoscope via a distal end of the surgical cutting assembly. A torque generation component configured to generate torque is positioned within the distal end and configured to provide the generated torque to a coupling component. The coupling component is positioned at the distal end of the elongated tubular member and configured to actuate a cutting component of the surgical cutting assembly responsive to actuation of the torque generation component. | 01-29-2015 |
20150065911 | INSERTABLE ENDOSCOPIC INSTRUMENT FOR TISSUE REMOVAL - An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool. | 03-05-2015 |
20150305726 | INSERTABLE ENDOSCOPIC INSTRUMENT FOR TISSUE REMOVAL - An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool. | 10-29-2015 |
20160081705 | METHODS AND APPARATUS FOR REMOVING MATERIAL FROM WITHIN A MAMMALIAN CAVITY USING AN INSERTABLE ENDOSCOPIC INSTRUMENT - An endoscope for removing tissue at a surgical site includes an elongated tubular body insertable within a mammalian cavity of a patient. An instrument channel extends between a first opening at a distal end and a second opening at a proximal end of the tubular body and is sized and configured to receive a surgical cutting assembly that includes an aspiration channel configured to remove material entering the endoscope via a distal end of the surgical cutting assembly. A torque generation component configured to generate torque is positioned within the distal end and configured to provide the generated torque to a coupling component. The coupling component is positioned at the distal end of the elongated tubular member and configured to actuate a cutting component of the surgical cutting assembly responsive to actuation of the torque generation component. | 03-24-2016 |
Steve Evans, Westford, MA US
Patent application number | Description | Published |
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20100030018 | ARTICULATING SURGICAL DEVICE - A surgical device for performing surgery generally includes a handle assembly, an elongate member extending from the handle assembly, an articulation mechanism operatively associated with the handle assembly, and an end effector. The elongate member has an articulating section and straight section. The articulating section is configured to articulate with respect to the straight section. The articulation mechanism is operatively associated with the handle assembly and the articulating section such that the articulating section articulates toward a first direction relative to the straight section upon movement of the handle assembly towards the first direction with respect to the straight section. The end effector is operatively coupled to the articulating section of the elongate member and includes first and second jaw members. The surgical device further includes a locking mechanism configured for fixing a relative position of first and second jaw members. | 02-04-2010 |
20110184459 | Articulating Surgical Device - An articulation mechanism for a surgical instrument includes an articulation assembly, a plurality of cables, and a trigger. The cables are coupled to the articulation assembly at a proximal end thereof and extend distally therefrom. The cables are configured to engage an end effector assembly of the surgical instrument at a distal end thereof. The trigger is coupled to the articulation assembly and is selectively moveable from a shipping position to a use position. In the shipping position, the cables are substantially un-tensioned. In the use position, the cables are disposed in an initial tensioned position. In the use position, the trigger is moveable between an unlocked position and a locked position. In the unlocked position, the cables are selectively tensionable to articulate the end effector assembly. In the locked position, the tensions on the cables are maintained to lock the end effector assembly in position. | 07-28-2011 |
Thomas C. Evans, Topsfield, MA US
Patent application number | Description | Published |
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20090035814 | Method for producing circular or multimeric protein species in vivo or in vitro and related methods - A method is disclosed for forming multimeric proteins. The method relies on intermolecular trans-splicing of a split intein either in vivo or in vitro. | 02-05-2009 |
20110201056 | Repair of Nucleic Acids for Improved Amplification - Methods and compositions are provided for repairing a polynucleotide so that it can be synthesized efficiently with improved fidelity and yield in, for example, an amplification reaction. This involves the use of a reaction mixture that includes a ligase and a cofactor selected from NAD+ or ATP and incubating the polynucleotide with the reaction mixture in the absence of Endonuclease VI. | 08-18-2011 |
20130230887 | Synthetic Nucleic Acids for Polymerization Reactions - Compositions and methods are provided for inhibiting a polymerase from replicating non target DNA at a temperature below the amplification reaction temperature. The inhibitor is a synthetic nucleic acid which is single stranded but folds to form at least one double stranded region designed to melt at a temperature which is lower than the amplification reaction temperature, and at least one single stranded region where the single stranded region at the 5′ end contains at least one uracil or inosine and optionally a sequence at the 3′ end contains one or more derivative nucleotide or linkages. | 09-05-2013 |
20130260422 | Compositions and Methods Relating to Variant DNA Polymerases and Synthetic DNA Polymerases - Compositions of novel polymerase variants and methods of identifying, making and using these novel polymerases are described. The variants have been shown to have advantageous properties such as increased thermostability, deoxyuridine nucleoside triphosphate tolerance, salt tolerance, reaction speed and/or increased reverse transcriptase properties. Uses for these improved enzymes have been demonstrated in isothermal amplification such as LAMP. Enhanced performance resulting from the use of these variants in amplification has been demonstrated both in reaction vessels and in dedicated automated amplification platforms. | 10-03-2013 |
20130323738 | Detection of Amplification Products - Compositions and methods are provided for quantitative detection of amplification products, the methods being suitable for multiplexing. A first oligonucleotide that includes a primer sequence for priming an amplification reaction and also is labeled with a fluorescent label or quencher is mixed with a second oligonucleotide which has a sequence suitable for hybridizing to a portion of the first oligonucleotide and has a fluorescent label if the first oligonucleotide has a quencher or a quencher if the first oligonucleotide has a fluorescent label; and a third nucleotide which includes some or all the primer sequence contained in the first oligonucleotide but is not labeled, the first and third oligonucleotide being combined in a molar ratio of 2.8 to 8.2. | 12-05-2013 |
20130323793 | Compositions and Methods for Reducing Background DNA Amplification - Compositions are provided that include a plurality of small molecules selected from the group consisting of an amide, urea or acetone having a molecular weight less than 300 g/mol; and dNTPs and a polymerase in a buffer suitable for use as an amplification buffer. Methods of use of the compositions are also described for reducing non-template DNA amplification. | 12-05-2013 |
20140031248 | Detection of Amplification Products - Compositions and methods are provided for quantitative detection of amplification products, the methods being suitable for multiplexing. A first oligonucleotide that includes a primer sequence for priming an amplification reaction and also is labeled with a fluorescent label or quencher is mixed with a second oligonucleotide which has a sequence suitable for hybridizing to a portion of the first oligonucleotide and has a fluorescent label if the first oligonucleotide has a quencher or a quencher if the first oligonucleotide has a fluorescent label; and a third nucleotide which includes some or all the primer sequence contained in the first oligonucleotide but is not labeled, the first and third oligonucleotide being combined in a molar ratio of 2.8 to 8.2. | 01-30-2014 |
20140057268 | Detection of an Amplification Reaction Product Using pH-sensitive Dyes - Methods are provided for a rapid, low cost approach to monitoring an amplification reaction. This includes monitoring the progress of isothermal or PCR amplification reactions to completion using pH-sensitive dyes that are either colored or fluorescent. Compositions are described that include a mixture of a DNA polymerase, deoxyribonucleotide triphosphate and a weak buffer of less than 1 mM Tris or equivalent or no buffer. | 02-27-2014 |
20140179539 | Novel Ligase Activity - Compositions and methods are provided for ligating polynucleotides having a length that is greater than 8 nucleotides on an RNA splint. The ligation reaction provides consistent results in high or low ATP concentrations. The reaction can occur rapidly and is generally at least 10 fold more efficient than T4DNA ligase under optimal conditions for T4DNA ligase and the reaction time is less than 6 hours for example, less than 1 hour. | 06-26-2014 |
20150240293 | Detection of an Amplification Reaction Product Using pH-sensitive Dyes - Methods are provided for a rapid, low cost approach to monitoring an amplification reaction. This includes monitoring the progress of isothermal or PCR amplification reactions to completion using pH-sensitive dyes that are either colored or fluorescent. Compositions are described that include a mixture of a DNA polymerase, deoxyribonucleotide triphosphate and a weak buffer of less than 1 mM Tris or equivalent or no buffer. | 08-27-2015 |
Thomas John Evans, Brighton, MA US
Patent application number | Description | Published |
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20160052767 | Container Filling System and Valve for Same - A container filling valve may include a shuttle and a drive sleeve that are magnetically coupled. Movement of the drive sleeve may move the shuttle from a position in which the filling valve is closed to a position in which the filling valve is open. A container handling arm may include a distal end configured to hold a container and a proximal end that includes a load cell. A low flow setpoint system may be configured to arrest closing of a filling valve when that filling valve is partially closed. A pressure control system may be configured to maintain a desired pressure in a reservoir or in a flow path from that reservoir. A product recirculation system may be configured to adjust flow rate in the product recirculation system. | 02-25-2016 |