Park, MD
Adrian Park, Crownsville, MD US
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20120035507 | Device and method for measuring anatomic geometries - Provided herein is a device and system for measuring an object geometry. The device comprises a probe with contacting and tracking ends and a tracking means and actuation control unit positioned on the probe. The system further comprises a measurement and post processing unit in electronic communication with the tracking means and/or the actuation control unit. Also provided is a method for measuring a geometry of an anatomic object, for example, a hernia. One or more locations of interest on the object are touched directly with the contacting probe end and the location or motion data of the probe end and of the tracking means are tracked and transmitted to the measurement and post processing unit as the point(s) of interest are touched. The data is processed into the geometric measurement and a representative image may be displayed. | 02-09-2012 |
Adrian E. Park, Crownsville, MD US
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20090198107 | Adjustable Line and Net Retractors - Devices for use during surgical or non-surgical procedures can move items from the field of view or work space. Retraction of items during any surgical or non-surgical procedure moves the items from the field of view or work space. The flexibility and compactness of a retraction device can make it suitable for surgery, especially minimally invasive surgery (MIS). | 08-06-2009 |
20100209899 | Simulated Abdominal Wall - A physical model representing an anatomic model of the abdominal wall that provides for the option of: tactile feedback, the option for photo realism, the inclusion of various pathologies (including, but not limited to, abdominal wall defects such as hernia), and the customizability to mount the model to various training boxes or frames. This medical/anatomic simulation model is composed of various material layers including, but not limited to, non-elastomeric and elastomeric materials such as papers, fabrics, metallic sheets, metallic meshes, rubber-like foams, and other materials. This is a physical/mechanical model that simulates skin, tissue, and organs associated with abdominal wall morphology and pathology. | 08-19-2010 |
20120209254 | ADJUSTABLE LAPAROSCOPIC INSTRUMENT HANDLE - Instrument handles are adjustable relative to an end effector of the instrument. The handles may be releasably locked in selected positions and/or orientations relative to the end effector. When the lock is released, the handles may be moved to a different position and/or orientation relative to the end effector, and locked in place. The handles may pivot relative to the end effector around one or more joints. The handles may pivot about an axis of a hinge joint or a point of a ball and socket joint. The axis of the hinge joint may be aligned parallel or perpendicular to a center longitudinal axis of the end effector, or of a shaft between the handles and the end effector. | 08-16-2012 |
Adrian Edward Park, Crownsville, MD US
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20100174150 | Internal Retraction Systems and Devices - An internal retraction system for use in minimally-invasive surgical procedures includes, among other features, an elongated applicator that has proximal and distal ends. The distal end of the applicator includes a grasper and the proximal end includes a mechanism or actuator for moving the grasper from an open position to a closed position. A plurality of anchor clips are slidably mounted on the elongated applicator and are initially in a stored position. Each clip includes spring biased upper and lower jaws for grasping tissue. The internal retraction system also includes a structure associated with the applicator for deploying the anchor clips from the stored position to a deployed position at a desired location. Moreover, the internal retraction system includes a mechanism associated with the applicator for removing the anchor clips from the deployed position and returning the clips to the stored position. | 07-08-2010 |
20100249519 | Frame Device - The devices and methods described can be used to create and maintain a working space within the lumen of an organ or between or among organs or tissue structures during medical procedures in order to elicit a diagnosis, biopsy, surgery, or therapy. | 09-30-2010 |
Ben Ho Park, Baltimore, MD US
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20100048523 | Compounds, Compositions and Methods for Treating Hormone-Dependent Maladies - A composition and method of using are provided, which composition includes: at least one compound selected from the group including a compound having formula (I), a salt thereof, a prodrug thereof, a compound having formula (II), a salt thereof, a prodrug thereof, and a combination thereof, the compounds being described herein, and a combination thereof, and at least one pharmaceutically acceptable carrier; wherein the composition is suitable for administration to a mammal. Methods of using the compound are also provided. | 02-25-2010 |
Chinsoo Park, Salisbury, MD US
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20100108622 | LOCKING ASSEMBLY - A locking assembly for securing and retaining a cage to a rack. The locking assembly is supported by a rack and includes a lock member. The lock member includes an obstruction member. The lock member is movable from an unlocked position to a locked position, wherein the default position of the lock member is the locked position. The lock member is designed and constructed such that the insertion of a person's hand into the hand space between the lock member and a cage is sufficient to cause the lock member to pivot into the unlocked position and move the obstruction member so that the cage can be removed from the rack. | 05-06-2010 |
20100132623 | Filter top assembly - A filter top assembly for a cage, wherein the assembly includes a bonnet having a perforated top wall to protect filter paper placed above the top wall. The perforations may be small enough to prevent an animal from getting a purchase position and spaced apart sufficiently to prevent the animal from biting the spacing between the perforations. The bonnet may also include one or more elevated ribs to retain the filter paper suspended above the bonnet. | 06-03-2010 |
20110132272 | DISPOSABLE CAGE - A disposable rodent cage used in both static and/or ventilated cage and rack systems, wherein the disposable cage includes a cage bottom. The cage may further be provided with a grommet disposed on the cage bottom and a bonnet constructed and arrange to fit over the cage bottom. The bonnet may further include a feeding and watering assembly. The cage may further include a filter cover that may be placed over an opening in the bonnet to cover the feeding and watering assembly. The bonnet may also include one or more elevated ribs disposed thereon to create an air seal when it is inserted into a canopy of a rack. | 06-09-2011 |
20110315087 | METHOD AND SYSTEM OF PROVIDING SEALED BAGS OF FLUID AT THE CLEAN SIDE OF A LABORATORY FACILITY - A method for facilitating the delivery of water to a plurality of cage level barrier-type cages, for housing animals for an animal study, the method including providing a plurality of cage level barrier-type cages for an animal study at a laboratory facility site, and disposing a bag forming apparatus at a clean side of a laboratory washroom at the laboratory facility site, wherein the bag forming apparatus is capable of providing sealed bags of water for use in the cage level barrier-type cages. The method can further include providing bag material to the laboratory facility site. | 12-29-2011 |
20140109838 | METHOD AND SYSTEM OF PROVIDING SEALED BAGS OF FLUID AT THE CLEAN SIDE OF A LABORATORY FACILITY - A method for facilitating the delivery of water to a plurality of cage level barrier-type cages, for housing animals for an animal study, the method including; providing a plurality of cage level barrier-type cages for an animal study at a laboratory facility site, and disposing a bag forming apparatus at a clean side of a laboratory washroom at the laboratory facility site, wherein the bag forming apparatus is capable of providing sealed bags of water for use in the cage level barrier-type cages. The method can further include providing bag material to the laboratory facility site. | 04-24-2014 |
20140158058 | FLUID DELIVERY SYSTEM - A fluid delivery system for delivering a fluid from a fluid bag to an animal caging system for housing an animal may comprise a fluid delivery valve assembly, wherein the fluid delivery valve assembly is adapted to be coupled to the fluid bag to facilitate the providing of the fluid to the caging system. The fluid delivery valve assembly may further comprise an upper member having a piercing member and a connecting member, the upper member having a fluid channel defined therethrough, a base having a flange member and a base fluid channel defined therethrough, wherein the base is designed to be matingly coupled to the upper member. The fluid delivery valve assembly may further comprise a spring element disposed within the base fluid channel and a stem member disposed in part within the base fluid channel, wherein a portion of the spring element abuts the stem member to apply a force. | 06-12-2014 |
Chin Soo Park, Salisbury, MD US
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20090095697 | VENTILATED RACK SYSTEM - A ventilated cage and rack system for assembly by a user using simple tools and a method for assembly is provided. A plurality of frames and vertical plenums can be connected to a base, and a retaining assembly can be used to connect a plurality of vertical beams and horizontal support beams. A plurality of canopies is preferably used to connect the plenums and the support beams to shroud cages beneath the canopies. The canopies preferably include removable side walls to adapt to the width of the cage being shrouded. A plenum clean out system preferably provides a relatively simple method of draining a cleaning fluid from a plenum by moving a lever between an open and closed position. A pressure based plenum system is also provided wherein a constant air pressure is maintained in the ventilated rack system and air is provided into a cage at a constant air pressure. | 04-16-2009 |
Hyung-Soon Park, Rockville, MD US
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20100016766 | ROBOTIC REHABILITATION APPARATUS AND METHOD - This patent describes an 8+2 degrees of freedom (DOF) intelligent rehabilitation robot capable of controlling the shoulder, elbow, wrist and fingers individually and allowing functional arm movements with accompanying trunk and scapular motions. The rehabilitation robot uses the following integrated rehabilitation approach: 1) it has unique diagnostic capabilities to determine patient-specific multiple joint and/or multiple DOF biomechanical and neuromuscular changes; 2) it stretches the stiff joints/DOFs under intelligent control to loosen up the specific stiff joints and to reduce excessive cross-coupling torques/movements between the specific joints/DOFs, which can be done based on the above diagnosis for subject-specific treatment; 3) the patients practice voluntary reaching and some functional tasks to regain/improve their motor control capability, which can be done after the stretching loosened up the stiff joints; and 4) the outcome will be evaluated quantitatively at the levels of individual joints, multiple joints/DOFs, and the whole arm. | 01-21-2010 |
20100106059 | SYSTEM AND METHOD FOR EVALUATING NEUROMUSCULAR AND JOINT PROPERTIES - A pocket neuromuscular evaluator delivers controlled tendon taps, makes quantitative measures of the taps and the reflex responses invoked, evaluates not only the neurological reflexes but also the muscle-joint properties, analyzes the data, displays the results, and records them to provide quantitative characterizations of the neuromuscular and joint properties. | 04-29-2010 |
20100145233 | SYSTEM AND METHOD FOR TRAINING HUMAN SUBJECTS TO IMPROVE OFF-AXIS NEUROMUSCULAR CONTROL OF THE LOWER LIMBS - Anterior cruciate ligament (ACL) is the most commonly injured knee ligament in sports-related activities, especially in pivoting sports. Considering that the knee is free to flex/extend but has much more limited motions about the off-axis (tibia rotation and valgus/varus), ACL injuries are often associated with excessive off-axis loadings. A pivoting/sliding mechanism combined with sagittal plane movement/exercise is described as a diagnostic tool to evaluate off-axis neuromechanical and anatomical risk factors of noncontact ACL injuries. The pivoting/sliding mechanism is also described as an intervention tool for off-axis training, possibly based on the diagnosis, to reduce the incidence of ACL injuries. Training outcome can also be evaluated using the pivoting/sliding mechanism. In general, the pivoting/sliding mechanism can be used with many sagittal plane exercise machines and used to improve off-axis control of the lower limbs and reduce lower limb injuries. | 06-10-2010 |
Jea Ho Park, Baltimore, MD US
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20140030193 | CUINSE/ZNS NIR-QUANTUM DOTS (QDS) FOR BIOMEDICAL IMAGIING - Applications in nanomedicine, such as diagnostics and targeted therapeutics, rely on the detection and targeting of membrane biomarkers. Disclosed herein are functionalized quantum dots exhibiting greater stability in water, methods of making the functionalized quantum dots and methods of in vivo imaging using the functionalized quantum dots. | 01-30-2014 |
Joseph Park, Pasadena, MD US
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20110062278 | CONTROLLABLE MINIATURE MONO-WING AIRCRAFT - Micro/nano mono-wing aircraft with the wing configured as a winged seed (Samara) is uniquely suited for autonomous or remotely controlled operation in confined environments for surrounding images acquisition. The aircraft is capable of effective autorotation and steady hovering. The wing is flexibly connected to a fuselage via a servo-mechanism which is controlled to change the wing's orientation to control the flight trajectory and characteristics. A propeller on the fuselage rotates about the axis oriented to oppose a torque created about the longitudinal axis of the fuselage and is controlled to contribute in the aircraft maneuvers. A controller, either ON-board or OFF-board, creates input command signals to control the operation of the aircraft based on a linear control model identified as a result of extensive experimentations with a number of models. | 03-17-2011 |
Ju-Hee Park, College Park, MD US
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20110165067 | CARBOHYDRATE FUNCTIONALIZED CATANIONIC SURFACTANT VESICLES FOR DRUG DELIVERY - Carbohydrate functionalized catanionic vesicles that include a glycoconjugate and/or peptidoconjugate for vaccination or drug delivery, methods for forming these, and methods of using these. | 07-07-2011 |
Jung Eun Park, Bethesda, MD US
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20110076693 | METHOD FOR DETECTION AND QUANTIFICATION OF PLK1 EXPRESSION AND ACTIVITY - Isolated peptide substrates of Plk1 and nucleic acids encoding these peptides are disclosed. The peptides include two to ten repeats of the amino acid sequence set forth as X | 03-31-2011 |
20120065146 | PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE - Found in various eukaryotic organisms, polo-like kinases (collectively, Plks) are a conserved subfamily of Ser/Thr protein kinases that play critical roles in cell proliferation. Provided herein are compounds that specifically inhibit the activity of Plks, specifically Plk1. Further provided herein are methods for use of the compounds for the treatment of hyperproliferative disorders, particularly cancer. Also provided are uses of the compounds for the preparation of a medicament. | 03-15-2012 |
20140142044 | PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE - Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds. The compounds of the invention have potential therapeutic activity in view of their binding and inhibitory activities towards Plk1. They are based on the amino acid sequence PLHSpT (phosphorylated Thr). The PEG moiety, when present, is covalently attached at the N-terminus. The invention also encompasses derivatives having substituents on the Pro and/or the His side chains, substituents on the phosphate group, the replacement of His with Gln, the replacement of Pro with a N-substituted Gly, the replacement of Ser with Ala, as well as HS-pT fragments with N-terminal alkoxycarbonyl group and PLHS fragments with a C-terminal glyco-imino-alkylxyalkylamide group. | 05-22-2014 |
Kye-Yoon Park, Rockville, MD US
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20130267029 | MANIPULATION OF STEM CELL FUNCTION BY P53 ISOFORMS - This invention provides methods and compositions for increasing the efficiency of obtaining pluripotent stem cells, the method comprising expressing a 133p53 in cells that are being re-programmed to obtain pluripotent cells. The invention also provides method of inhibiting the proliferation of cancer stem cells, the method comprising suppressing expression of 133p53 in the cells. | 10-10-2013 |
Kyong Park, Woodbine, MD US
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20130046990 | AUTHENTICATION AND BINDING OF MULTIPLE DEVICES - Systems and methods are described that relate to authentication and/or binding of multiple devices with varying security profiles. In one aspect, a first device with a higher security profile may vouch for the authenticity of a second device with a lower security profile when the second device requests access for content from a content provider. The vouching process may be implemented by allowing the first device to overlay its digital signature on a registration request that has been signed and transmitted by the second device. The second device with the lower security profile may access content from the content provider or source for a predetermined time period, even when the second device does not access content through the first device. | 02-21-2013 |
20130129095 | Key Delivery - A multi-hierarchical key system is provided such that users receive timely key renewals when required so that access to authorized content is not disrupted. Timely renewals of keys may occur continuously for various services while minimizing network traffic. The multi-hierarchical key system may be used in an adaptive streaming environment. | 05-23-2013 |
20140304516 | Authentication and Binding of Multiple Devices - Systems and methods are described that relate to authentication and/or binding of multiple devices with varying security profiles. In one aspect, a first device with a higher security profile may vouch for the authenticity of a second device with a lower security profile when the second device requests access for content from a content provider. The vouching process may be implemented by allowing the first device to overlay its digital signature on a registration request that has been signed and transmitted by the second device. The second device with the lower security profile may access content from the content provider or source for a predetermined time period, even when the second device does not access content through the first device. | 10-09-2014 |
Kyoungsook Park, Severna Park, MD US
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20100330594 | Early Detection of Diabetes - The present invention is based on the discovery that hexosamine, and in particular the dynamic O-GlcNAcylation of proteins (modification of proteins by the sugar N-acetylglucosamine) both causes insulin-resistance (a hallmark of type II diabetes) and is responsible for glucose toxicity in the disease. Accordingly, the invention provides methods of diagnosing a subject as having or at risk of having pre-diabetes or diabetes. Also provided are methods of characterizing hyperglycemia in a subject, methods of identifying a protein as being associated with hyperglycemia, and kits for detecting pre-diabetes or diabetes. | 12-30-2010 |
Kyung Min Park, Baltimore, MD US
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20150196584 | OXYGEN-CONTROLLABLE AND HYPOXIA-INDUCIBLE HYDROGELS - Novel hydrogels that can serve as 3D hypoxic microenvironments are disclosed. Oxygen controllable, hypoxia-inducible hydrogels (HI hydrogels) are composed of a phenolic agent and polymer backbone, which can form hydrogel networks via oxygen consumption in an enzyme-mediated crosslinking reaction. The HI hydrogels are degradable, cytocompatible, and have tunable mechanical properties. Oxygen levels and gradients within the HI hydrogels are controlled and precisely predicted. As a result, the HI hydrogels induce prolonged hypoxic conditions. The HI hydrogels guide vascular morphogenesis in vitro by activating hypoxia-inducible factors and promote neovascularization from tissue, as well as stimulate tissue in dynamic in vivo environments. The HI hydrogels are a new class of biomaterials that are useful in many applications, ranging from the engineering of de novo tissues and disease models to the treatment of vascular disorders. | 07-16-2015 |
Michael Park, Rockville, MD US
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20090269814 | Method of Analyzing a BRCA2 Gene in a Human Subject - Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2 | 10-29-2009 |
20090325237 | Method of Analyzing a BRCA2 Gene in a Human Subject - Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2 | 12-31-2009 |
20090325238 | Method of Analyzing a BRCA2 Gene in a Human Subject - Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2 | 12-31-2009 |
20130280703 | METHOD OF ANALYZING A BRCA2 GENE IN A HUMAN SUBJECT - Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2 | 10-24-2013 |
20140302494 | METHOD OF ANALYZING A BRCA2 GENE IN A HUMAN SUBJECT - Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2 | 10-09-2014 |
Myung-Hee Park, Potomac, MD US
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20090253777 | Methods of diagnosing and treating hyperproliferative disorders - The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders. | 10-08-2009 |
20120095058 | Method of preventing survival of retrovirally cells and of inhibiting formation of infectious retroviruses - The present invention discloses compounds and pharmaceutical compositions which are highly effective at inhibiting the accumulation of spliced and unspliced viral transcripts and their utilization for viral protein synthesis at cellular ribosomes, and at inhibiting the formation of the hypusine residue in cellular eIF-5A precursor proteins, the cellular cofactors that render spliced and unspliced viral transcripts translatable at the ribosomes of infectled cells. The invention further relates to methods of using such compounds and pharmaceutical compositions therefrom for inhibiting or preventing viral protein synthesis. Such inhibition cause a dose-dependent release from the virally induced arrest of the otherwise genetically preprogrammed apoptosis of virally infected cells, and in consequence, triggers their apoptotic ablation and the eradication of the chronic infection-mediating provirus integrated into their genome. | 04-19-2012 |
20120225093 | Abrogating HIV-1 Infection via Drug-Induced Reactivation of Apoptosis - The present invention relates to compositions and methods of treating, inhibiting, or controlling HIV infection. | 09-06-2012 |
Rudolph V. Park, Olney, MD US
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20100249886 | Systems and Methods for Communicating with an Implantable Stimulator - An exemplary system for communicating with an implantable stimulator includes a coil configured to transmit a signal modulated with either on-off keying (OOK) modulation or Frequency Shift Keying (FSK) modulation. The system further includes a first telemetry receiver in the implantable stimulator configured to receive the signal in accordance with the OOK modulation and a second telemetry receiver in the implantable stimulator configured to receive the signal in accordance with the FSK modulation. | 09-30-2010 |
Seungkyung Park, Pikesville, MD US
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20130096035 | SELF-SUSTAINED FLUIDIC DROPLET CASSETTE AND SYSTEM FOR BIOCHEMICAL ASSAYS - A fluidic cartridge for biochemical assays includes a cartridge body defining a first droplet region and a second droplet region with a droplet restraining barrier therebetween. The droplet restraining barrier has a gap between the first and the second droplet regions. The fluidic cartridge also includes a first droplet dispensed in the first droplet region. The first droplet includes a plurality of magnetic particles dispersed therein. The fluidic cartridge also includes a second droplet disposed in the second droplet region. The plurality of magnetic particles are sufficiently small to be drawn through the gap between the first and second droplet regions when compelled by an applied magnetic field, and the first droplet is restrained by the restraining barrier while the plurality of magnetic particles are drawn through the gap. A biochemical assay system includes a stage adapted to receive a fluidic cartridge, and a magnetic control assembly that includes a magnet. The magnet of the magnetic control assembly is movable to direct motion of magnetic particles contained within the fluidic cartridge. | 04-18-2013 |
Soon Sik Park, Clarksville, MD US
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20140378500 | METHODS FOR PREDICTING TUMOR REPONSE TO TARGETED THERAPIES - A method for identifying cancer patients that are likely to be responders or non-responders to a signal transduction pathway inhibitor is described. | 12-25-2014 |
Sukjoon Park, Germantown, MD US
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20100310593 | Vaccines Against Chlamydia Infection - The present invention is directed to providing a vaccine to enhance the immune response of an animal in need of protection against a | 12-09-2010 |
Sungjin Park, Baltimore, MD US
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20110183942 | Methods and Compositions for Treating Alzheimer's Disease - A method is disclosed for inhibiting the build-up of amyloid plaques in the brain of a patient with at least one risk factor for, or a diagnosis of, Alzheimer's Disease by administering to the patient an amount of one or more compounds effective to inhibit the phosphorylative activity of eEF2K, thereby inhibiting amyloid plaque deposition. | 07-28-2011 |
Sunho Park, Silver Spring, MD US
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20110117597 | Enhancement of in vitro translation by nanoparticle conjugates - Provided herein are kits and methods suitable for enhancing in vitro translation of a nuclei acid sequence of interest. | 05-19-2011 |
20140120575 | ENHANCEMENT OF IN VITRO TRANSLATION BY NANOPARTICLE CONJUGATES - Provided herein are kits and methods suitable for enhancing in vitro translation of a nuclei acid sequence of interest. | 05-01-2014 |
Tea Soon Park, Baltimore, MD US
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20130266541 | HUMAN INDUCED PLURIPOTENT STEM CELLS - The present invention relates generally to the field of stem cells and, more particularly, to reprogramming blood cells to pluripotent stem cells. In a specific embodiment, a method for producing an induced pluripotent stem cell from a human myeloid progenitor cell comprising the steps of (a) activating the human myeloid progenitor cell by incubation with hematopoietic growth factors; (b) transfecting the activated progenitor cells with a non-viral vector expressing one or more pluripotency factors; and (c) co-culturing the transfected cells with irradiated mesenchymal bone marrow stromal cells. | 10-10-2013 |