Patent application number | Description | Published |
20120033103 | Raw-Split Mode Image Capture - Systems, methods and a computer readable mediums for reducing run-time bandwidth requirements within digital image capture devices are disclosed herein. As the resolution of digital image capture devices increase, the bandwidth needed to support this increased resolution is becoming increasingly difficult to support. To reduce the problems associated with run-time bandwidth requirements, it may be beneficial to obtain full-resolution and display-resolution images at the same time from the image capture circuitry—writing both to memory at virtually the same time. The display resolution image may then be delivered to a display unit directly without the need for additional memory operations on the full-resolution image. Only when a user indicates they wish to capture an image need additional memory operations on the full-resolution image be performed. | 02-09-2012 |
20130044228 | Motion-Based Video Stabilization - Systems, methods, and computer readable media for stabilizing video frames based on information from a motion sensor are described. In general, digital video stabilization techniques are disclosed for generating and applying image-specific transformations to individual frames (images) in a video sequence after, rather than before, the image has been captured. The transformations may be used to counter-balance or compensate for unwanted jitter occurring during video capture due to, for example, a person's hand shaking. | 02-21-2013 |
20150350483 | Dynamic Compression Ratio Selection - An image is compressed according to a compression ratio selected based on a compression metric. In one embodiment, the compression metric is based on image characteristics indicative of the amount of image noise in an image, such as gain and lux. Greater compression ratios are used for image having compression metrics indicating a higher degree of noise. Because an image with higher image noise levels already has a reduced visual quality, the impact of higher compression is less significant as compared to the impact of compression on images having low image noise. In an embodiment, an image is divided into a number of regions, for each of which a compression metric and corresponding compression ratio is determined, so that regions of the image having high image noise may be compressed more than regions having low image noise. | 12-03-2015 |
Patent application number | Description | Published |
20120255392 | COMPLIANT CAM WITH FLEXURE CAM ARM - A compliant cam system includes a one-piece cam including: a cam body rotatable with respect to a cam rotational axis and a having a cam body center spaced from the cam rotational axis and an outer surface; and a deflecting arm freely extending from the cam body having a free end elastically deflected toward the cam body in an arm deflected condition. A follower has at least one follower surface in direct contact with the cam outer surface at the deflecting arm. An arm non-deflected condition is defined when the outer surface is in direct contact with the cam follower surface prior to deflection of the deflecting arm. The cam when thereafter rotated with respect to the cam rotational axis acts to move the cam body center toward the follower thereby deflecting the deflecting arm to the deflected condition creating a biasing force acting toward the follower. | 10-11-2012 |
20120255393 | COMPLIANT CAM OF COMPOSITE MATERIALS - A compliant cam system includes a cam having a cam body rotatable with respect to a cam rotational axis. The cam body has a cam body center spaced from the cam rotational axis. At least a portion of the cam is an elastically compressible material. A follower having at least one follower surface is in contact with the compressible material portion of the cam. A cam non-deflected condition is defined when an elastically compressible material portion outer surface is in contact with the cam follower surface prior to deflection of the elastically compressible material portion. The cam when thereafter rotated with respect to the cam rotational axis moves the cam body center toward the follower. The elastically compressible material portion deflects, defining a deflected condition, creating a biasing force acting toward the follower, and releasably frictionally engaging the elastically compressible material portion with the follower. | 10-11-2012 |
20120255510 | CAM SYSTEM HAVING COMPLIANT FOLLOWER - A compliant follower cam system includes a cam rotatable about a cam rotational axis continuously aligned with a cam displacement axis. The cam has a body center spaced from the rotational axis. A compliant follower has an elastically deformable first contact wall positioned proximate to a cavity. The first contact wall is directly contacted by the cam body outer surface. A compliant follower non-deflected condition occurs when a first contact wall outer surface directly contacts the cam body outer surface prior to deflection of the first contact wall, with the cam body center out of alignment with the displacement axis. Rotating the cam moves the body center toward the compliant follower into alignment with the displacement axis. The cam thereby deflects the first contact wall into the cavity defining a compliant follower deflected condition and creates a biasing force releasably frictionally engaging the first contact wall and cam. | 10-11-2012 |
20130333514 | COMPLIANT CAM OF COMPOSITE MATERIALS - A compliant cam system includes a cam having a cam body rotatable with respect to a cam rotational axis. The cam body has a cam body center spaced from the cam rotational axis. At least a portion of the cam is an elastically compressible material. A follower having at least one follower surface is in contact with the compressible material portion of the cam. A cam non-deflected condition is defined when an elastically compressible material portion outer surface is in contact with the cam follower surface prior to deflection of the elastically compressible material portion. The cam when thereafter rotated with respect to the cam rotational axis moves the cam body center toward the follower. The elastically compressible material portion deflects, defining a deflected condition, creating a biasing force acting toward the follower, and releasably frictionally engaging the elastically compressible material portion with the follower. | 12-19-2013 |
Patent application number | Description | Published |
20110180434 | DURABLE PACKAGING ASSEMBLY FOR MEDIA DEVICES - A secure carrier assembly for media devices. The assembly includes a carrier having a front panel, a rear panel, and an intermediate panel. At least one panel of the carrier comprises a durable polymeric material, such as a lens sheet assembly including a lens sheet, and an image layer. The carrier with lens sheet assembly provides enhanced security features, increased durability, and eye-catching features compared to traditional carrier or packaging assemblies. | 07-28-2011 |
20120140333 | LENS SHEET HAVING LENS ARRAY FORMED IN PRE-SELECTED AREAS AND ARTICLES FORMED THEREFROM - A lens sheet having one or more lens arrays positioned in selected discrete areas. Each lens array includes a plurality of lenses, each having a width, a height, and a lens peak. The lens array is set below the planar surface of the lens sheet, such that lens array does not extend above the lens sheet. Furthermore, the lens array is completely bordered by or contained within planar portions of the lens sheet. One or more dimensional images are printed below each of the lens arrays, and/or one or more static images can be printed on the planar portions of the lens sheet. | 06-07-2012 |
20130068642 | DURABLE PACKAGING ASSEMBLY FOR MEDIA DEVICES - A secure carrier assembly for media devices and media content. The assembly includes a carrier having a front panel, a rear panel, and an intermediate panel. At least one panel of the carrier comprises a durable polymeric material, such as a lens sheet assembly including a lens sheet, and an image layer. The carrier with lens sheet assembly provides enhanced security features, increased durability, and eye-catching features compared to traditional carrier or packaging assemblies. | 03-21-2013 |
20140118835 | LENS SHEET HAVING LENS ARRAY FORMED IN PRESELECTED AREAS AND ARTICLES FORMED THEREFROM - A lens sheet having one or more lens arrays positioned in selected discrete areas. Each lens array includes a plurality of lenses, each having a width, a height, and a lens peak. The lens array is set below the planar surface of the lens sheet, such that lens array does not extend above the lens sheet. Furthermore, the lens array is completely bordered by or contained within planar portions of the lens sheet. One or more dimensional images are printed below each of the lens arrays, and/or one or more static images can be printed on the planar portions of the lens sheet. | 05-01-2014 |
Patent application number | Description | Published |
20090092988 | Modulating Gene Expression with agRNA and Gapmers Targeting Antisense Transcripts - Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene. | 04-09-2009 |
20090099109 | INTERFERING RNAS AGAINST THE PROMOTER REGION OF P53 - The present invention relates to the inhibition of p53 transcription by interfering with the activity of a p53 promoter using inhibitory double-stranded RNAs. Use of these inhibitory RNAs in the treatment of cancers also is disclosed. | 04-16-2009 |
20090326051 | Modulation of gene expression through endogenous small RNA targeting of gene promoters - Gene expression can be selectively regulated by endogenous miRNAs that target promoters of genes. Altering of the activity of these promoter-targeting miRNAs with single-stranded complementary oligonucleotides that bind the miRNA causes modulation of expression of the target gene. Endogenous miRNAs that modulate expression of target genes can be identified by (a) evaluating an endogenous miRNA for complementarity to a target gene promoter; and (b) determining that the complementary miRNA modulates expression of the target gene. | 12-31-2009 |
20100273863 | Modulation of Gene Expression Using Oligomers That Target Gene Regions Downstream of 3' Untranslated Regions - Gene expression can be selectively modulated by contacting a cell with an oligomer that targets a gene region downstream of a ′3-UTR, thereby increasing or decreasing the expression of the target gene. | 10-28-2010 |
20110110860 | MODULATION OF LDL RECEPTOR GENE EXPRESSION WITH DOUBLE-STRANDED RNAS TARGETING THE LDL RECEPTOR GENE PROMOTER - Gene expression can be selectively regulated by double-stranded “antigene” RNAs that target regions of the low density lipoprotein receptor (LDL-R) promoter, thereby permitting modulation of LDL levels in vivo and subsequent effects on circulating LDL levels. | 05-12-2011 |
20110190222 | Selective Inhibition of Polyglutamine Protein Expression - The present invention relates to the selective inhibition of protein expression of CAG repeat-related disease proteins such as Huntingtin using nucleic acid analogs. Peptide nucleic acids and locked nucleic acids are particularly useful analogs. | 08-04-2011 |
20120288869 | Modulating Gene Expression With agRNA and Gapmers Targeting Antisense Transcripts - Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene. | 11-15-2012 |
20130172399 | SELECTIVE INHIBITION OF POLYGLUTAMINE PROTEIN EXPRESSION - The present invention relates to the selective inhibition of protein expression of CAG repeat-related disease proteins such as Huntingtin Disease Protein and Ataxin-3 using double-stranded RNAs and nucleic acid analogs. Chemically-modified RNAs having at least one mismatch as compared to the target CAG repeat sequence are specifically contemplated. | 07-04-2013 |
20140128449 | OLIGONUCLEOTIDE MODULATION OF SPLICING - The present invention relates to the selective modulation of pre-mRNA splicing, in particular, for that involving alternative splicing in disease-related proteins such as those involved in Duschenne's Muscular Dystropy and Spinal Muscular Atrophy. | 05-08-2014 |
20150064709 | MODULATING GENE EXPRESSION WITH agRNA AND GAPMERS TARGETING ANTISENSE TRANSCRIPTS - Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene. | 03-05-2015 |
20150211007 | SELECTIVE INHIBITION OF POLYGLUTAMINE PROTEIN EXPRESSION - The present invention relates to the selective inhibition of protein expression of CAG repeat-related disease proteins such as Huntington using nucleic acid analogs. Peptide nucleic acids and locked nucleic acids are particularly useful analogs. | 07-30-2015 |
Patent application number | Description | Published |
20110263569 | RYANODINE CHANNEL BINDERS AND USES THEREOF - Increasing the affinity of calstabin-2 for the cardiac calcium channel RyR2 and thereby stabilizing the channel in the closed state has recently been identified as novel mechanism for treating heart failure, particularly ventricular arrhythmias. JTV-519, a 1,4-benzothiazepine derivative, has been shown to stabilize the calstabin2/RyR2 complex. Novel derivatives of JTV-519 that may be useful in treatment or prevention of heart failure, atrial fibrillation, or exercise-induced cardiac arrhythmias are provided. Synthetic methodology and intermediates in the synthesis of the inventive JTV-519 derivatives are also described. | 10-27-2011 |
20120190659 | ANGIOGENESIS INHIBITORS - Compounds of Structural Formula I or pharmaceutically acceptable salts thereof, are effective inhibitors of angiogenesis: | 07-26-2012 |
20160081915 | TRANSDERMAL FORMULATIONS OF FLUTICASONE - The present invention generally relates to the transdermal delivery of fluticasone and other glucocorticoids. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment, for example, a high ionic strength environment. One set of embodiments provides a composition for transdermal delivery comprising fluticasone and/or a salt thereof, and optionally, a nitric oxide donor. Other glucocorticoids can also be used in some cases. Such compositions may be used to facilitate the delivery of effective amounts of fluticasone or other glucocorticoids systemically or to deeper tissues, rather than only locally or superficially, and in some cases, the effects of fluticasone or other glucocorticoids may be prolonged for unexpectedly long periods of time, e.g., days or weeks. | 03-24-2016 |
Patent application number | Description | Published |
20140279929 | DATABASE SYSTEM WITH DATABASE ENGINE AND SEPARATE DISTRIBUTED STORAGE SERVICE - A database system may include a database service and a separate distributed storage service. The database service (or a database engine head node thereof) may be responsible for query parsing, optimization, and execution, transactionality, and consistency, while the storage service may be responsible for generating data pages from redo log records and for durability of those data pages. For example, in response to a write request directed to a particular data page, the database engine head node may generate a redo log record and send it, but not the data page, to a storage service node. The storage service node may store the redo log record and return a write acknowledgement to the database service prior to applying the redo log record. The server node may apply the redo log record and other redo log records to a previously stored version of the data page to create a current version. | 09-18-2014 |
20160110408 | OPTIMIZED LOG STORAGE FOR ASYNCHRONOUS LOG UPDATES - A log-structured data store may implement optimized log storage for asynchronous log updates. In some embodiments, log records may be received indicating updates to data stored for a storage client and indicating positions in a log record sequence. The log records themselves may not be guaranteed to be received according to the log record sequence. Received log records may be stored in a hot log portion of a block-based storage device according to an order in which they are received. Log records in the hot log portion may then be identified to be moved to a cold log portion of the block-based storage device in order to complete a next portion of the log record sequence. Log records may be modified, such as compressed, or coalesced, before being stored together in a data block of the cold log portion according to the log record sequence. | 04-21-2016 |
Patent application number | Description | Published |
20090148468 | RAPID, EFFICIENT PURIFICATION OF HSV-SPECIFIC T-LYMPHOCYTES AND HSV ANTIGENS IDENTIFIED VIA SAME - Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 06-11-2009 |
20100215693 | IMMUNOLOGICAL HERPES SIMPLEX VIRUS ANTIGENS AND METHODS FOR USE THEREOF - The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 08-26-2010 |
20110135687 | RAPID, EFFICIENT PURIFICATION OF HSV-SPECIFIC T-LYMPHOCYTES AND HSV ANTIGENS IDENTIFIED VIA SAME - Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigen or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 06-09-2011 |
20120027789 | ANTIGENIC PEPTIDE OF HSV-2 AND METHODS FOR USING SAME - The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV, The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 02-02-2012 |
20120027790 | IMMUNOLOGICAL HERPES SIMPLEX VIRUS ANTIGENS AND METHODS FOR USE THEREOF - The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 02-02-2012 |
20130011425 | RAPID, EFFICIENT PURIFICATION OF HSV-SPECIFIC T-LYMPHOCYTES AND HSV ANTIGENS IDENTIFIED VIA SAME - Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 01-10-2013 |
20130189294 | RAPID, EFFICIENT PURIFICATION OF HSV-SPECIFIC T-LYMPHOCYTES AND HSV ANTIGENS IDENTIFIED VIA SAME - Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 07-25-2013 |
20150335734 | ANTIGENIC PEPTIDE OF HSV-2 AND METHODS FOR USING SAME - The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection, including epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 11-26-2015 |
20160095918 | RAPID, EFFICIENT PURIFICATION OF HSV-SPECIFIC T-LYMPHOCYTES AND HSV ANTIGENS IDENTIFIED VIA SAME - A method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are specific to a virus that attacks skin. Also provided are HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection that have been identified via the methods of the invention. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection. | 04-07-2016 |
Patent application number | Description | Published |
20090288619 | ELECTROMAGNETIC VALVE ACTUATOR AND VALVE GUIDE HAVING REDUCED TEMPERATURE SENSITIVITY - An internal combustion engine includes an electromagnetic valve actuator having an armature between upper and lower electromagnets with a stem extending through one electromagnet and guided by a bushing with increased clearance about at least a portion of the inner circumference in at least a middle portion of the bushing to reduce oil shear length and associated viscous friction in the actuator. A two-piece intake/exhaust valve guide includes a lower half with a stepped outer diameter cooperating with a counter-bored hole in the cylinder head to provide a positive stop. The upper and lower halves of the valve guide have increased clearance relative to the valve stem around at least a portion of the inner circumference to reduce oil shear length and associated viscous friction. Reducing viscous friction of the actuator and associated valve guide improves system robustness by decreasing the system sensitivity to temperature. | 11-26-2009 |
20110162621 | Shallow Piston Bowl And Injector Spray Pattern For A Gasoline, Direct-Injection Engine - A combustion system for a direct-injection, spark-ignition engine is disclosed. A side-mounted fuel injector located outboard the intake valves directs multiple fuel jets into a shallow, spherical bowl formed in a domed piston. Both good mixing to facilitate good air utilization with early injection and an ignitable mixture at the spark plug with late injection to facilitate cold start are provided with such a combustion system. Because the bowl is smooth and shallow, the surface area of the combustion chamber is less than with a deeper bowl of complicated shape. Lowering surface area in the combustion chamber leads to improved fuel economy. | 07-07-2011 |
20140219849 | BRANCH COMMUNICATION VALVE FOR A TWIN SCROLL TURBOCHARGER - Methods and systems are provided for a branch communication valve in a twin turbocharger system. A branch communication valve may be positioned adjacent to a dividing wall separating a first scroll and a second scroll of the twin turbocharger. In an open position, the branch communication valve increases fluid communication between the first scroll and the second scroll and in a closed position, the branch communication valve decreases fluid communication between the first scroll and the second scroll. | 08-07-2014 |
20150260085 | BRANCH COMMUNICATION VALVE FOR A TWIN SCROLL TURBOCHARGER - Methods and systems are provided for a branch communication valve in a twin turbocharger system. A branch communication valve may be positioned adjacent to a dividing wall separating a first scroll and a second scroll of the twin turbocharger. In an open position, the branch communication valve increases fluid communication between the first scroll and the second scroll and in a closed position, the branch communication valve decreases fluid communication between the first scroll and the second scroll. | 09-17-2015 |
Patent application number | Description | Published |
20100076323 | METHOD AND APPARATUS FOR DETERMINING A RESPIRATION PARAMETER IN A MEDICAL DEVICE - An apparatus for determining a respiration parameter in a medical device in which a pressure sensor senses pressure signals, and a signal processor, coupled to the pressure sensor, receives the sensed pressure signals and generates corresponding sample points. A microprocessor continuously adjusts a breath detection threshold in response to the generated sample points to generate a current adjusted breath detection threshold, compares a current generated sample point to the current adjusted breath detection threshold, suspends the continuous adjusting of the breath detection threshold and sets the breath detection threshold equal to the most current adjusted breath detection threshold generated prior to the suspending, and determines the respiration parameter in response to a comparing of a next generated sample point to the set breath detection threshold | 03-25-2010 |
20100076324 | METHOD AND APPARATUS FOR DETECTING RESPIRATORY EFFORT IN A MEDICAL DEVICE - A medical device for determining a respiratory effort having a pressure sensor to sense pressure signals, a housing having system components positioned therein, and a microprocessor positioned within the housing, wherein the microprocessor detects an inspiration and an expiration in response to the pressure signals, detects a breath in response to the detected inspiration and the detected expiration, and determines the respiratory effort in response to the detected breath. | 03-25-2010 |
20100076325 | METHOD AND APPARATUS FOR DETERMINING RESPIRATORY EFFORT IN A MEDICAL DEVICE - A method of determining respiratory effort in a medical device in which pressure signals are sensed to generate corresponding sample points, an inspiration and an expiration are detected in response to the sensed pressure signals, a breath is detected in response to the detected inspiration and the detected expiration, and the respiratory effort is determined in response to the detected breath. | 03-25-2010 |
20100076514 | FILTERING OF A PHYSIOLOGIC SIGNAL IN A MEDICAL DEVICE - A system and method for filtering a pressure signal in a medical device in which a sensor terminal senses the pressure signal, an electrode terminal receives cardiac electrical signals, a signal filtering system filters the sensed pressure signal in response to a determined heart rate to generate a heart-rate dependent frequency response, and a microprocessor derives a respiration signal in response to the heart rate dependent frequency response, and determines metrics of hemodynamic function in response to the derived respiration signal. | 03-25-2010 |
Patent application number | Description | Published |
20110190850 | CLOCK SYNCHRONIZATION IN AN IMPLANTABLE MEDICAL DEVICE SYSTEM - This disclosure is directed to the synchronization of clocks of a secondary implantable medical device (IMD) to a clock of a primary IMD. The secondary IMD includes a communications clock. The communications clock may be synchronized based on at least one received communications pulse. The secondary IMD further includes a general purpose clock different than the communications clock. The general purpose clock may be synchronized based on at least one received power pulse. The communications clock may also be synchronized based on the at least one received power pulse. | 08-04-2011 |
20130138991 | CLOCK SYNCHRONIZATION IN AN IMPLANTABLE MEDICAL DEVICE SYSTEM - This disclosure is directed to the synchronization of clocks of a secondary implantable medical device (IMD) to a clock of a primary IMD. The secondary IMD includes a communications clock. The communications clock may be synchronized based on at least one received communications pulse. The secondary IMD further includes a general purpose clock different than the communications clock. The general purpose clock may be synchronized based on at least one received power pulse. The communications clock may also be synchronized based on the at least one received power pulse. | 05-30-2013 |
20130289635 | HANDLING RACE CONDITIONS DURING DATA TRANSFER BETWEEN MULTIPLE MODULES OF AN ELECTRONIC DEVICE - The accuracy of data processing operations in an electronic device is improved through reductions in errors associated with data acquisition, reading, and transmission. In one embodiment, two or more modules of an integrated circuit are operated at different clock speeds and a voting scheme is utilized to obtain a valid data value from one of the modules. The disclosure describes methods, devices and systems that utilize the voting schemes to eliminate errors induced by race conditions in obtaining valid data values during data transfer by obtaining a plurality of data samples while the communicating modules are operating at the different clock speeds and selecting from among the data samples the valid data value. | 10-31-2013 |
20130290769 | SYSTEMS AND METHODS FOR HANDLING RACE CONDITIONS DURING DATA TRANSFER IN AN IMPLANTABLE MEDICAL DEVICE - The accuracy of data processing operations in implantable medical devices is improved through reductions in errors associated with data acquisition, reading, and transmission. In one embodiment, two or more circuit modules of the device are operated at different clock speeds and a voting scheme is utilized to obtain a valid data value from one of the modules. The disclosure describes methods, devices and systems that utilize the voting schemes to eliminate errors induced by race conditions in obtaining the valid data values by obtaining a plurality of data samples during operation of the circuit modules at the different clock speeds and selecting from among the data samples the valid data value. | 10-31-2013 |
Patent application number | Description | Published |
20110091877 | SYSTEMS AND METHODS FOR MINIMIZATION OR ELIMINATION OF DIFFUSION EFFECTS IN A MICROFLUIDIC SYSTEM - The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. | 04-21-2011 |
20120058460 | SLUG CONTROL DURING THERMAL CYCLING - The present invention, in one aspect, provides methods and systems for controlling slugs using temperature dependent fluorescent dyes. In some embodiments, the present invention uses one or more techniques to enhance the visibility of slugs, enhance a system's ability to differentiate between slugs, and enhance a system's ability to identify the positions of slugs. | 03-08-2012 |
20120058519 | METHOD, DEVICES, AND SYSTEMS FOR FLUID MIXING AND CHIP INTERFACE - In one aspect, the present invention provides methods, devices, and systems for ensuring that multiple components of a mixture are fully mixed in a continuous flow microfluidic system while ensuring that mixing between segments flowing through the chip is minimized. In some embodiments, the present invention includes mixing fluids in a droplet maintained at the tip of a pipette before the mixture is introduced to the microfluidic device. In another aspect, the present invention provides methods, devices, and systems for creating segments that move through a microfluidic chip with minimal mixing between segments. The microfluidic chip may have an interface chip and a reaction chip. In some embodiments, the present invention includes creating segments that flow through an interface chip and a reaction chip, wherein the interface chip and a reaction chip have separate flow control mechanisms and produce minimal mixing between segments. | 03-08-2012 |
20120058571 | METHODS, DEVICES, AND SYSTEMS FOR FLUID MIXING AND CHIP INTERFACE - In one aspect, the present invention provides methods, devices, and systems for ensuring that multiple components of a mixture are fully mixed in a continuous flow microfluidic system while ensuring that mixing between segments flowing through the chip is minimized. In some embodiments, the present invention includes mixing fluids in a droplet maintained at the tip of a pipette before the mixture is introduced to the microfluidic device. In another aspect, the present invention provides a pipette tip having a ratio of an outside diameter to an inside diameter that provides sufficient surface area for a droplet comprising up to the entire volume of the liquid to suspend from the pipette tip intact. In yet another aspect, the present invention provides methods, devices, and systems for delivering a reaction mixture to a microfluidic chip comprising a docking receptacle, an access tube and a reservoir. | 03-08-2012 |
20140220584 | SYSTEMS AND METHODS FOR MINIMIZATION OR ELIMINATION OF DIFFUSION EFFECTS IN A MICROFLUIDIC SYSTEM - The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. | 08-07-2014 |
20140272927 | METHODS, DEVICES, AND SYSTEMS FOR PROCESSING MULTIPLE ASSAYS BACKGROUND - Methods, devices, and systems for performing polymerase chain reaction (PCR) amplification and melt data acquisition according to a single slug approach in which a single slug in a microfluidic channel fills an entire thermal zone of the microfluidic channel, and the thermal zone used for both PCR temperature cycling and melt data acquisition. A detector may be configured to detect fluorescence from the thermal zone during the PCR temperature cycling for real-time PCR and/or during temperature ramping in the melt data acquisition. Slug position control may be achieved by detecting leading or trailing edges in a slug build target zone into which a slug passes after passing through the thermal zone. The single slug approach may break coupling between one or more events of the PCR amplification and melt data acquisition and enable events to be independently optimized. | 09-18-2014 |
20160051985 | SYSTEM AND METHOD FOR SERIAL PROCESSING OF MULTIPLE NUCLEIC ACID ASSAYS - The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions. | 02-25-2016 |