Cybulski
Cezary Cybulski, Wolczkowo PL
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20110105342 | METHOD FOR DETERMINING REDUCED PREDISPOSITION TO CANCER BASED ON GENETIC PROFILE - The invention provide methods for early detection of a reduced risk of developing cancer, which comprises detecting the absence of a series of genetic polymorphisms associated with a predisposition of developing cancer, including the polymorphisms of the genes BRCA1, BRCA2, CARD15 (NOD2), CHEK2, CDKN2A (P16), CYP1B1, FGFR2 (KGFR2), MAP3K1 (MEKK1), p53 (TP53), TNRC9, XPD (ERCC2) and the genetic marker Rs6983267, in a biological sample from the analyzed subject, wherein the absence of the genetic polymorphisms is indicative of significantly decreased risk of developing, at least, breast cancer. | 05-05-2011 |
Cezary Cybulski, Przeclaw PL
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20090092984 | Determining a predisposition to cancer - The present invention relates to methods and kits for determining a predisposition and surveillance protocols for developing cancer of various sites due to specific mutation in at least one allele of CHEK2 gene and/or at least one allele of NOD2 gene and/or at least one allele of CDKN2A gene. | 04-09-2009 |
20090197255 | Determining a predisposition to cancer - The present invention relates to methods and kits for determining a predisposition for developing cancer, e.g., prostate and/or breast cancer, due to a germline mutation of a NBS1 gene. The present invention also relates to surveillance protocols for developing cancer, e.g., prostate and/or breast cancer, due to germline mutation of a NBS1 gene. | 08-06-2009 |
Eric Cybulski, St. Paul, MN US
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20100051502 | CARRIER HAVING INTEGRAL DETECTION AND MEASUREMENT OF ENVIRONMENTAL PARAMETERS - A carrier includes an enclosure for storing articles sensitive to electrostatic discharge (ESD) and a replacement component that is affixed to the enclosure as an integral component of the carrier. The replacement component includes a housing that provides an enclosure for a device having a sensor for sensing one or more environmental parameters. At least one of the sensed environmental parameters is an ESD parameter. | 03-04-2010 |
Eric R. Cybulski, Woodbury, MN US
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20090188061 | HEATED FOOD PREPARATION SURFACE CLEANING SYSTEM - A system for cleaning a hot food preparation surface is provided. According to an embodiment, the system includes a cleaning tool including a handle and a detachable base. In one embodiment the handle and detachable base comprise a polymeric material, where the melting point of the polymeric material in the handle is lower than the melting point of the polymeric material in the base. According to another embodiment, the system includes a scrubbing pad support member that is configured to engage and secure a scrubbing pad and connect the scrubbing pad to a handle or a base of a cleaning tool. In some embodiments, the handle of the tool is constructed to be reused numerous times whereas the detachable accessories, e.g., the scrubbing pad support member and/or a scrubbing pad, are constructed to be disposable. A method of molding the scrubbing pad support member is also provided. A method of cleaning is also provided wherein the cleaning tool is used with liquid or solid cleaners to clean a hot food preparation surface. | 07-30-2009 |
20090199868 | HEATED FOOD PREPARATION SURFACE CLEANING PAD - A heated surface cleaning pad that can be attached to a bottom portion of a hand tool configured to be used to scrub a heated food preparation surface. According to an embodiment, the cleaning pad is configured to clean a hot griddle surface that has a number of parallel raised ridges. According to another embodiment, the cleaning pad includes a non-woven construction that is impregnated with abrasive particles and/or a liquid cleaner or a dissolvable solid cleaner. In addition, a method of cleaning a hot food preparation surface is provided. According to one embodiment, the method includes the steps of attaching a scrubbing pad to a cleaning tool, contacting the openings in the cleaning surface of the scrubbing pad with the raised ridges of a griddle surface, and scrubbing the griddle surface with the pad until the surface is clean. Moreover, a method of constructing a cleaning pad for cleaning a hot griddle surface is also provided. According to one embodiment, the method includes binding pad elements together such that a cleaning end of the cleaning pad is comprised of end portions of adjacently arranged scrubbing elements. | 08-13-2009 |
20090229766 | ADHESIVE REMOVAL DEVICE - An adhesive removal system useful for removing a stretch release adhesive from a component includes a first member that engages with a component and an adhesive removal member that moves the adhesive and component relative to each other in order to stretch the adhesive and release the adhesive from a bond surface of the component. In some embodiments, the adhesive removal member applies a substantially uniform pulling force across the adhesive. The adhesive removal member may be manually actuated by a user or with the aid of an automated device. In some embodiments, the adhesive removal system comprises a rotatable portion that moves the adhesive relative to the component. In other embodiments, the adhesive removal system includes features that enable the first member and a second member, which is mechanically coupled to at least a portion of the adhesive extending from the component, to move relative to each other. | 09-17-2009 |
James S. Cybulski, Palo Alto, CA US
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20130296648 | MINIMALLY INVASIVE IMAGING SYSTEMS - Aspects of the invention include minimally invasive imaging system. Systems according to embodiments of the invention include: an access device having a proximal end and distal end and an internal passageway extending from the proximal to distal end; and an elongated member dimensioned to be slidably moved through the internal passageway of the access device and having a proximal and distal end. In the systems of the invention, at least one of multiple visualization elements and multiple illumination elements are positioned among the distal ends of the access device and the elongated member. Also provided are methods of using the systems in imaging applications, as well as kits for performing the methods. | 11-07-2013 |
James Stanley Cybulski, Palo Alto, CA US
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20140368816 | OPTICAL DEVICE - An optical device, such as a microscope, is disclosed that can be assembled from flat materials. The optical device can be assembled via a series of folds of a flat material. The optical microscope can include a stage for supporting a sample, an optic stage, and a light source. The optic stage can include one or more lenses. The optical microscope can be capable of obtaining simultaneous images from different forms of microscopy. The optical microscope may have bright field and filter field viewing capabilities wherein a user shifts from bright field to filter field by lateral movement of the stage containing a lens and a light source that cooperate to provide either the bright field or the filter field. | 12-18-2014 |
Marcin Cybulski, Warsaw PL
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20110160151 | Novel Acetates of 2-Deoxy Monosaccharides with Anticancer Activity - Novel compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are provided herein. | 06-30-2011 |
Marcin Cybulski, Warszawa PL
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20140031357 | ASYMMETRICALLY SUBSTITUTED ANTHRAPYRIDAZONE DERIVATIVES AS CYTOSTATICS - The invention relates to the new, asymmetrically substituted derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione and their use as cytostatics exhibiting activity against tumor cells, especially against cells with multidrug resistance (MDR). In particular, the invention concerns derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione represented by the general formula (I). | 01-30-2014 |
Ray Cybulski, San Diego, CA US
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20100098120 | VERY HIGH POWER LASER CHAMBER OPTICAL IMPROVEMENTS - An aspect of the disclosed subject matter includes a method of reducing the laser absorption of a beam reverser prism consisting of at least one of the following: increasing a first distance between a first incident point and a chamfered corner, wherein the first incident point is on a first reflective surface of the prism and the chamfered corner is formed between the first reflective surface and a second reflective surface of the prism, wherein the chamfered corner has a chamfered surface; increasing a second distance between a second incident point and the chamfered corner, wherein the second incident point is on the second reflective surface of the prism; and increasing a reflectivity of the chamfered surface of the chamfered corner of the prism. A method of determining a prime cut for an optical component is also disclosed. A laser including at least one prime cut optical component is also disclosed. | 04-22-2010 |
20120307858 | VERY HIGH POWER LASER CHAMBER OPTICAL IMPROVEMENTS - An aspect of the disclosed subject matter includes a method of reducing the laser absorption of a beam reverser prism consisting of at least one of the following: increasing a first distance between a first incident point and a chamfered corner, wherein the first incident point is on a first reflective surface of the prism and the chamfered corner is formed between the first reflective surface and a second reflective surface of the prism, wherein the chamfered corner has a chamfered surface; increasing a second distance between a second incident point and the chamfered corner, wherein the second incident point is on the second reflective surface of the prism; and increasing a reflectivity of the chamfered surface of the chamfered corner of the prism. A method of determining a prime cut for an optical component is also disclosed. A laser including at least one prime cut optical component is also disclosed. | 12-06-2012 |