Patent application number | Description | Published |
20090106004 | Systems and methods for evaluating interventions - A system and method for evaluating one or more interventions having a direct or indirect impact on a disease identification or a disease progression incorporating a causal framework to establish relationships among the disease, complications, and comorbidities. The system and method determines population groups and risk factors for the disease, complications, and comorbidities. The system and method structures and calibrates a simulation model of the relationships, population groups, and risk factors and characterizes interventions. The system and method analyzes the characterized interventions to determine the direct or indirect impact of the interventions on the disease identification or progression using the simulation model. An indication of the impact of the interventions is provided on an electronic display or to a memory device. | 04-23-2009 |
20140172678 | INSTITUTION SIMULATION - Among other things, a calibrated and tested dynamic simulation model of at least one municipality or institution or commercial entity is operated to generate information that enables the municipality or institution or commercial entity and suppliers of products for development projects of the municipality or institution or commercial entity to engage in execution of development projects that the model demonstrates will enhance the performance and sustainability of the municipality or institution or commercial entity. The simulation model of the municipality or institution or commercial entity is used to monitor and influence the execution of the development projects or ongoing operations and policies of the municipality or institution or commercial entity. Financers of the development projects are provided with information from operation of the dynamic simulation model that demonstrates the performance and sustainability of the municipality or institution or commercial entity and the acceptability of risks associated with the financing of the projects or operations. | 06-19-2014 |
20140278294 | MODELING AND SIMULATION - A method includes, based on information received from a user through a graphical user interface, forming and storing elements that define a model that can be run by a computer to simulate operation of a real-world system that includes real-world features. The method includes including in the elements that are formed and stored, collections of software entities that correspond to the real-world features, and running the model using the software entities. | 09-18-2014 |
Patent application number | Description | Published |
20120034847 | ABRASIVE TOOL AND A METHOD FOR FINISHING COMPLEX SHAPES IN WORKPIECES - An abrasive tool includes a bonded abrasive body having abrasive grains contained within a bonding material, wherein the bonded abrasive body comprises a complex shape having a form depth (FD) of at least about 0.3. The form depth is described by the equation [(Rl−Rs)/Rl], wherein Rs is a smallest radius (Rs) at a point along the longitudinal axis of the bonded abrasive body and Rl is a largest radius (Rl) at a point along the longitudinal axis of the bonded abrasive body. The abrasive tool can be used to finish complex shapes in workpieces. | 02-09-2012 |
20130157542 | Apparatuses Methods for Coolant Delivery - In various embodiments, a coolant delivery apparatus is presented. Namely, a coolant delivery apparatus comprises a plurality of internal channels configured to provide coolant to the work face of a grinding wheel. | 06-20-2013 |
20150017885 | METHOD FOR FORMING A WORKPIECE - A method of forming a workpiece having machinability rating not greater than a machinability rating of Inconel 718. The method may include removing material from the workpiece by moving at least one grinding tool relative to the workpiece and may be conducted at a specific grinding energy of not greater than about 7 Hp/in | 01-15-2015 |
20150079883 | Abrasive Tool and a Method for Finishing Complex Shapes in Workpieces - An abrasive tool includes a bonded abrasive body having abrasive grains contained within a bonding material, wherein the bonded abrasive body comprises a complex shape having a form depth (FD) of at least about 0.3. The form depth is described by the equation [(R1−Rs)/R1], wherein Rs is a smallest radius (Rs) at a point along the longitudinal axis of the bonded abrasive body and R1 is a largest radius (R1) at a point along the longitudinal axis of the bonded abrasive body. The abrasive tool can be used to finish complex shapes in workpieces. | 03-19-2015 |
Patent application number | Description | Published |
20090136507 | HBM variants that modulate bone mass and lipid levels - The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis. | 05-28-2009 |
20100331200 | POST TRANSLATIONAL MODIFICATION PATTERN ANALYSIS - This invention relates to methods and apparatus for detecting the pattern of post translational modification in a protein or in a plurality of proteins in a sample. One or more target proteins are subjected to predetermined proteolysis to yield plural peptide fragments comprising potential post translational modification sites. The fragments and the state of such sites are analyzed to yield a post translational pattern for the protein or proteins. | 12-30-2010 |
20110201513 | PROTEIN SPLICE VARIANT / ISOFORM DISCRIMINATION AND QUANTITATIVE MEASUREMENTS THEREOF - The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents, each combination being unique to the splicing variant to be detected/measured. | 08-18-2011 |
Patent application number | Description | Published |
20090259237 | Pyloric valve devices and methods - A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a plurality of disc-shaped flanges connected in series. The blocking portion may be disposed in a contracted position wherein the plurality of disc-shaped flanges is disposed in a stacked configuration and a resting position wherein the plurality of disc-shaped flanges is disposed in a linear configuration. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its resting and contracted positions. Insertion and removal systems are also provided for use with the pyloric valve. | 10-15-2009 |
20090259238 | Pyloric valve devices and methods - A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve. | 10-15-2009 |
20090259239 | Pyloric valve devices and methods - A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve. | 10-15-2009 |
20090259240 | PYLORIC VALVE - A pyloric valve for regulating the flow of fluids in the pyloric region a patient's gastrointestinal tract is disclosed herein. In one embodiment, a pyloric valve includes a plurality of axially connected blocking members located along a longitudinal axis of the valve in a proximal to distal direction. Each blocking member of the valve preferably includes at least one blocking portion defining at least one entryway adapted to receive fluids such as chyme therethrough. The at least one entryway of each blocking member is preferably not aligned with the at least one entryway of each blocking member adjacent thereto along the longitudinal axis. The non-alignment of the at least one entryways of the blocking members preferably creates a non-linear path for fluids such as chyme to travel through the pyloric region of the patient. | 10-15-2009 |
20110004228 | Systems and Methods for Treating Obesity and Type 2 Diabetes - The present invention provides systems and methods for treating and/or controlling obesity and type II diabetes. In one aspect of the invention, a device for treating obesity includes a flow restrictor and an anchor coupled to the flow restrictor. The flow restrictor is movable between a first or collapsed configuration sized and shaped for endoscopic advancement through the patient's esophagus and into a distal region of the stomach and a second or operative configuration sized and shaped for inhibiting a flow of chyme from the stomach to the pyloric sphincter. It is believed that this will cause the prolongation of satiety, and result in fewer meals being eaten and/or smaller meals being ingested. The anchor is movable between a first or collapsed configuration sized and shaped for advancement through the esophagus, stomach and pyloric sphincter and into the proximal region of the duodenum and a second or operative configuration sized and shaped to inhibit proximal movement of the anchor through the pyloric sphincter. | 01-06-2011 |
20120136457 | PYLORIC VALVE DEVICES AND METHODS - A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve. | 05-31-2012 |
20120259427 | Pyloric Valve - A pyloric valve for regulating the flow of fluids in the pyloric region a patient's gastrointestinal tract is disclosed herein. In one embodiment, a pyloric valve includes a plurality of axially connected blocking members located along a longitudinal axis of the valve in a proximal to distal direction. Each blocking member of the valve preferably includes at least one blocking portion defining at least one entryway adapted to receive fluids such as chyme therethrough. The at least one entryway of each blocking member is preferably not aligned with the at least one entryway of each blocking member adjacent thereto along the longitudinal axis. The non-alignment of the at least one entryways of the blocking members preferably creates a non-linear path for fluids such as chyme to travel through the pyloric region of the patient. | 10-11-2012 |
20130006381 | PYLORIC VALVE DEVICES AND METHODS - A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve. | 01-03-2013 |
20140088577 | DEVICES AND METHODS FOR LASER SURGERY - Small diameter tools are provided, and methods of use described, to facilitate less invasive surgical procedures employing laser beams. Such tools include distal tips that enhance the precise placement of optical waveguides, as well as enable cutting and dissecting procedures. A rotary coupler allows precise control of flexible conduits in which waveguides may be disposed. Waveguide tips with conical features protect waveguide ends and allow unobstructed propagation of the laser beam out of the waveguide. A preferentially bending jacket for waveguides may be used to control an orientation of a waveguide disposed therein. Surgical waveguide assemblies may include various combinations of these components. | 03-27-2014 |
20140316395 | Waveguide Locks and Counterbalances for Waveguide Conduits - An optical radiation delivery structure including a waveguide conduit having a surgical access portion and a handle portion. The handle portion includes a gripping portion and a waveguide lock, which is configured to have only a locked state and an unlocked state. In some embodiments, the handle portion includes a gripping portion and a counterbalance region, such that a center of mass of the waveguide conduit is disposed towards a proximal end of the waveguide conduit. | 10-23-2014 |
Patent application number | Description | Published |
20140057362 | LATERAL FLOW ASSAY ANALYSIS - Lateral flow assay analysis is shown and described. In one embodiment, the lateral flow assay comprises a surface having a reflectance profile that is adapted to enable monitoring of the assay continuously until the detection of an analyte. In other embodiments, a lateral flow assay system includes an incubator and a reader, wherein the incubator incubates the assay concurrently as the reader generates a test result. Further, an assay measurement apparatus may include an optical detector to perform continuous image detection of the assay to generate a diagnostic test result. | 02-27-2014 |
20140271362 | RECOGNITION TEST STRIPS - Test strips for the detection of at least one analyte in a sample are shown and described. In one embodiment, the test strip includes a test zone, a control zone and a surface reflectance profile to monitor the test strip continuously until the presence or absence of an analyte is detected. In other embodiments, a lateral flow assay includes a surface reflectance profile to monitor the test strip prior to the detection. The surface reflectance profile may include at least one flow reference area and/or at least one test result reference area. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample. | 09-18-2014 |
20140334980 | DETECTION SENSOR SYSTEMS AND METHODS - Analyte detection systems and devices are provided. In one embodiment, a sensor initially reviews an assay, for instance a test strip, to designate a particular testing sequence. The sensor may calibrate the unit and then identify the particular testing sequence by identifying a color indicator on the test strip. The result is systems and methods to improve the detection of the presence and/or absence of at least one analyte in a sample. | 11-13-2014 |
Patent application number | Description | Published |
20120143718 | OPTIMIZATION OF A WEB-BASED RECOMMENDATION SYSTEM - A method for determining product recommendations to be presented to users includes forming, by a formula generation module, a plurality of different recommendation formulas, including, for each recommendation formula, assigning a weight to at least some of a plurality of recommendation characteristics, wherein each recommendation characteristic is representative of at least one of a characteristic of a product, a characteristic of a method for presenting the product recommendations to the users, and a characteristic of a user. The method further includes iteratively performing the steps of: for each of the plurality of recommendation formulas, selecting, by a product recommendation module, at least one product for presentation to the users on the basis of the corresponding recommendation formula; sending, by a communications module, instructions to a server to present the selected product to the users; receiving, by a data evaluation module, data representative of user responses to each of the products presented to the users; evaluating, by the data evaluation module, the received data; and selecting, using the data evaluation module, a subset of the recommendation formulas included in the plurality of recommendation formulas on the basis of the evaluation of the collected data. | 06-07-2012 |