Patent application number | Description | Published |
20090320577 | METHOD FOR DETECTING FAULTS IN THE AIR SYSTEM OF INTERNAL COMBUSTION ENGINES - A method for detecting faults in an air system of an internal combustion engine having an intake manifold and an exhaust manifold includes, but is not limited to the steps of measuring an oxygen concentration of the gas flowing in the exhaust manifold, estimating an intake oxygen control value in the intake manifold and estimating an intake oxygen reference value in the intake manifold based on said oxygen concentration of the gas flowing in the exhaust manifold. The method further includes, but is not limited to the steps of calculating an intake deviation value as a difference between the intake oxygen control value and the intake oxygen reference value and verifying if the intake deviation value is greater than a predetermined first threshold. Besides, the method includes, but is not limited to the steps of estimating an exhaust oxygen control value in the exhaust manifold, calculating an exhaust deviation value a difference between the exhaust oxygen control value and the oxygen concentration of the gas flowing in the exhaust manifold and verifying if the exhaust deviation value is greater than a predetermined second threshold. The method further includes, but is not limited to the steps of determining an exhaust oxygen concentration setpoint indicative of the oxygen concentration in the exhaust manifold, calculating a fresh airflow setpoint as a function of said exhaust oxygen concentration setpoint, measuring a fresh air mass flow value and calculating ( | 12-31-2009 |
20100005872 | METHOD FOR ESTIMATING THE OXYGEN CONCENTRATION IN INTERNAL COMBUSTION ENGINES - A method for estimating the oxygen concentration in an internal combustion engine that includes, but is not limited to an intake manifold, an exhaust manifold, an EGR system, a throttle valve, an air mass sensor for measuring a fresh air flow ({dot over (m)} | 01-14-2010 |
20100175674 | METHOD FOR CONTROLLING THE EGR AND THE THROTTLE VALVES IN AN INTERNAL COMBUSTION ENGINE - A method and system are provided for controlling a throttle valve and an EGR valve in internal combustion engine. The method includes, but is not limited to the steps of measuring an actual fresh mass air flow value entering the engine, determining an exhaust oxygen concentration set point ([O | 07-15-2010 |
20110195817 | POWER-BASED ENGINE SPEED CONTROL - A control system includes an engine speed control module, a fuel control module, and an air control module. The engine speed control module controls an actual speed of an engine based a desired power to be generated by combustion in the engine, wherein the desired power is a product of a desired speed of the engine and a desired torque output of the engine. When operating in a fuel lead mode, the fuel control module controls fuel flow in the engine by adjusting a desired fuel mass for each activated cylinder of the engine based on the desired power. The air control module controls air flow in the engine based on an actual air/fuel ratio of the engine resulting from the desired fuel mass. | 08-11-2011 |
Patent application number | Description | Published |
20080214596 | BIOMARKERS FOR SENSITIVITY OF PROLIFERATIVE DISEASES TO MTOR INHIBITORS - Disclosed is a method for determining the sensitivity of a proliferate disease in a subject to treatment with an mTOR inhibitor, comprising determining the level of expression and/or phosphorylation state of S6 in a sample derived from the subject, as well as related methods of treatment and uses. | 09-04-2008 |
20090069394 | CANCER TREATMENT WITH EPOTHILONES - The present invention relates to an in vivo regimen for the treatment of a proliferative disease, including non small cell lung carcinoma, where an epothilone, including epothiline B, is administered in a loading dose followed by at least one maintenance doses. | 03-12-2009 |
20100105696 | IMIDAZOQUINOLINES AS DUAL LIPID KINASE AND mTOR INHIBITORS - The invention relates to the use of compounds of formula (I) | 04-29-2010 |
20100196365 | USE OF IMIDAZOQUINOLINES FOR THE TREATMENT OF EGFR DEPENDENT DISEASES OR DISEASES THAT HAVE ACQUIRED RESISTANCE TO AGENTS THAT TARGET EGFR FAMILY MEMBERS - The present invention relates to the use of compounds of formula (I) | 08-05-2010 |
20110105521 | COMBINATION OF (A) A PHOSPHOINOSITIDE 3-KINASE INHIBITOR AND (B) A MODULATOR OF RAS/RAF/MEK PATHWAY - The invention relates to a pharmaceutical combination which comprises (a) a phosphoinositide 3-kinase inhibitor compound and (b) a compound which modulates the Ras/Raf/Mek pathway for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human. | 05-05-2011 |
20110195966 | COMBINATION OF A PHOSPHATIDYLINOSITOL-3-KINASE (PI3K) INHIBITOR AND A MTOR INHIBITOR - The invention relates to a pharmaceutical combination which comprises (a) a phosphoinositide 3-kinase inhibitor compound of formula (I) and (b) a mTOR inhibitor for the treatment of a target of rapamycin (mTOR) kinase dependent disease, especially a cancer disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human. | 08-11-2011 |
20120059005 | COMBINATION OF (A) A PHOSPHOINOSITIDE 3-KINASE INHIBITOR AND (B) AN ANTIDIABETIC COMPOUND FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES - The invention relates to a pharmaceutical combination which comprises (a) a phosphoinositide 3-kinase inhibitor compound and (b) an insulin sensitivity enhancer compound for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human. | 03-08-2012 |
20140057904 | Combination of (a) a phosphoinositide 3-kinase inhibitor and (b) a modulator of RAS/RAF/MEK pathway - The invention relates to a pharmaceutical combination which comprises (a) a phosphoinositide 3-kinase inhibitor compound and (b) a compound which modulates the Ras/Raf/Mek pathway for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human. | 02-27-2014 |
20140066474 | COMBINATION OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3K) INHIBITOR AND A MTOR INHIBITOR - The present invention relates to a pharmaceutical combination comprising a phosphatidylinositol-3-kinase (PI3K) inhibitor compound which is a 2-carboxamide cycloamino urea derivative or a pharmaceutically acceptable salt thereof and at least one mammalian target of rapamycin (mTOR) inhibitor or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising such a combination; and the uses of such a combination in the treatment proliferative diseases, more specifically of mammalian target of rapamycin (mTOR) kinase dependent diseases. | 03-06-2014 |