Patent application number | Description | Published |
20080237135 | Pb- ion binding by polyacid- based nanoparticles - Methods are disclosed for preparing novel biodegradable nanoparticles based on complexation of poly-gamma-glutamic acid (γ-PGA) or its cross-linked derivatives with bivalent lead ions. The final products are stable in aqueous media at low pH, neutral and mild alkaline conditions. The size of the complexes depends on the pH, concentrations and the ratios of γ-PGA and lead ions | 10-02-2008 |
20090018266 | Preparation of hydrophilic nanoparticles by copolymerization of mono and divinyl monomers in micellar solution - The present invention relates to the preparation of hydrophilic nanoparticles and in particular hydrophilic nanoparticles that are biocompatible. Free radical monovinyl-divinyl monomer copolymerization/cross-linking reactions of water-soluble, monovinyl N-vinyl-2-pyrrolidone (NVP) with a bi-unsaturated divinyl, comonomer (poly{ethylene glycol}dimethacrylate) (PEGDMA), has been found to yield hydrophilic nanoparticles (NPs). These nanoparticles are built from three-dimensional nanopolymer networks. In the polymers' synthesis the composition of the monomers, and the total monomer concentration were varied. The characteristics of copolymers were determined by nuclear magnetic resonance spectroscopy (NMR), Fourier transform infrared (FTIR) and elemental analysis. Particle size and morphology of nanoparticles were confirmed by dynamic light scattering (DLS), transmission electron microscope (TEM) and scanning electron microscope (SEM) methods. In the present invention hydrophilic polymers can be used in micellar polymerization to create hydrophilic nanoparticles. | 01-15-2009 |
20090180966 | Cancer cell diagnosis by targeting delivery of nanodevices - Macromolecular contrast agents for magnetic resonance imaging are described. Biomolecules and their modified derivatives form stable complexes with paramagnetic ions thus increasing the molecular relaxivity of carriers. The synthesis of biomolecular based nanodevices for targeted delivery of MRI contrast agents are described. Nanoparticles (NP) have been constructed by self-assembling of chitosan (CHIT) as polycation and poly-gamma glutamic acids (PGA) as polyanion. NP's are capable of Gd-ion uptake forming a particle with suitable molecular relaxivity. Folic acid (FA) is linked to the NP's to produce NP-FA bioconjugates that can be used for targeted in vitro delivery to a human cancer cell line. | 07-16-2009 |
20100144919 | Reactive polymeric nanoparticles (RPNPS) for restoration materials in dentistry - A method is disclosed in which modified and generic dental resins are combined as mixtures with reactive polymeric nanoparticles (RPNPs). Nanoparticles as additives clearly demonstrate that the RPNPs significantly influence the mechanical and shrinkage properties of the matrix and composites. | 06-10-2010 |
20130302243 | RADIOLABELED NANOSYSTEM, PROCESS FOR THE PREPARATION THEREOF AND ITS USE - Disclosed are novel, targeted, self-assembled nanoparticles radiolabeled with technetium-99m (Tc-99m) as radiodiagnostic compositions, methods of using these compositions and methods for preparing such radiolabeled compositions. Specifically, the compositions of the nanoparticles are composed of self-assembled polyelectrolyte biopolymers having targeting moieties, which can be suitable for targeted delivery of radionuclide metal ions complexed to the nanoparticles. These radiolabeled nanoparticles can specifically bind and internalize into the targeted tumor cells to realize the receptor mediated uptake. Radiolabeled, targeted nanoparticulate composition, methods for making, radiolabeling and using such compositions in the field of diagnosis and therapy are also provided. | 11-14-2013 |
20130302255 | NOVEL TARGETED PARAMAGNETIC CONTRAST AGENT - Disclosed are novel, targeting, paramagnetic nanoparticles as contrast agent for magnetic resonance imaging. The compositions of the nanoparticles are composed of self-assembled polyelectrolyte biopolymers having targeting moieties, which can suitable for targeted delivery of paramagnetic ions complexed to the nanoparticles. The nanoparticulate contrast agent can internalize into the targeted tumor cells to realize the receptor mediated uptake, and therefore afford enhanced relaxivity and improved signal-to-noise effect on the examined tissue areas. Methods for making these targeting MRI contrast agents are also provided. | 11-14-2013 |
20140099266 | MAGNETIC FLUID NANOSYSTEM - Targeting contrast agent for magnetic resonance imaging (MRI). In preferred embodiments, self-assembled polyelectrolytes coated superparamagnetic iron oxide contrast agent particles are provided, which are labeled with targeting moieties, afforded enhanced relaxivity, improved signal-to-noise and targeting ability. Accordingly, the invention relates to a stable targeting contrast nanosystem applicable for magnetic resonance imaging (MRI) having at least one nanoparticle polyelectrolyte polyanion; a targeting agent conjugated to the biopolymer; and a superparamagnetic ligand. In another embodiment the nanosystem according to the invention has at least two biocompatible and biodegradable nanoparticle polyelectrolyte biopolymer. Particularly, the superparamagnetic iron oxide particles are coated by a polyelectrolyte biopolymer and this system self-assembles with the other biopolymer to produce stable nanosystem for magnetic resonance imaging. Targeting moieties are conjugated to a biopolymer or to the self-assembled biopolymers to realize a targeted delivery of contrast agent. Methods for making these targeting MRI contrast agents are also provided. | 04-10-2014 |
20140294966 | STABLE NANOCOMPOSITION COMPRISING DOCETAXEL, PROCESS FOR THE PREPARATION THEREOF, ITS USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT - A nanoparticulate composition is disclosed for the targeted therapeutic treatment of tumours. The stable self assembled nanocomposition according to the invention comprises (i) a carrier and targeting system comprising an optionally modified polyanion, and optionally a polycation, which may also be modified; at least one targeting agent which is linked to either the polycation/modified polycation or the polyanion/modified polyanion, or both or to the surface of the nanoparticle; (ii) an active compound selected from the group of docetaxel and its pharmaceutically acceptable salts and derivatives especially its hydrates, especially docetaxel trihydrate and docetaxel trihydrate monohydrochloride; and optionally (iii) at least one complexing agent, a metal ion and a stabilizer/formulating agent, or a PEGylating agent. The present invention furthermore relates to a process for the preparation of the above-mentioned composition, the therapeutic uses thereof, and pharmaceutical compositions containing the nanocomposition according to the invention. | 10-02-2014 |
20140294967 | STABLE NANOCOMPOSITION COMPRISING PACLITAXEL, PROCESS FOR THE PREPARATION THEREOF, ITS USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT - A nanoparticulate composition is disclosed for the targeted therapeutic treatment of tumours. The stable self assembled nanocomposition according to the invention comprises (i) a carrier and targeting system comprising an optionally modified polyanion, and optionally a polycation, which may also be modified; at least one targeting agent which is linked to either the polycation/modified polycation or the polyanion/modified polyanion, or both or to the surface of the nanoparticle; (ii) paclitaxel as active compound; and optionally (iii) at least one complexing agent, a metal ion and a stabilizer/formulating agent or a PEGylating agent. The invention furthermore relates to a process for the preparation of the above-mentioned composition, the therapeutic uses thereof, and pharmaceutical compositions containing the nanocomposition according to the invention. | 10-02-2014 |
20140294983 | STABLE NANOCOMPOSITION COMPRISING DOXORUBICIN, PROCESS FOR THE PREPARATION THEREOF, ITS USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT - A nanoparticulate composition for the targeted therapeutic treatment of tumours. The stable self assembled nanocomposition according to the invention comprises (i) a carrier and targeting system comprising an optionally modified polyanion, and optionally a polycation, which may also be modified; at least one targeting agent which is linked to either the polycation/modified polycation or the polyanion/modified polyanion, or both, or to the surface of the nanoparticle; (ii) an active compound selected from the group of doxorubicin and its pharmaceutically acceptable salts, especially hydrochloride; and optionally (iii) at least one complexing agent, a metal ion, a stabilizer/formulating agent, or a PEGylating agent. The present invention furthermore relates to a process for the preparation of the above-mentioned composition, the therapeutic uses thereof, and pharmaceutical compositions containing the nanocomposition according to the invention. | 10-02-2014 |
20140296173 | STABLE NANOCOMPOSITION COMPRISING EPIRUBICIN, PROCESS FOR THE PREPARATION THEREOF, ITS USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT - A nanoparticulate composition is disclosed for the targeted therapeutic treatment of tumours. The stable self assembled nanocomposition according to the invention comprises (i) a carrier and targeting system comprising an optionally modified polyanion, and optionally a polycation, which may also be modified; at least one targeting agent which is linked to either the polycation/modified polycation or the polyanion/modified polyanion, or both; (ii) an active compound selected from the group of epirubicin and its pharmaceutically acceptable salts, especially hydrochloride; and optionally (iii) at least one complexing agent, metal ion and stabilizer/formulating agent. The invention furthermore relates to a process for the preparation of the above-mentioned composition, the therapeutic uses thereof, and pharmaceutical compositions containing the nanocomposition according to the invention. | 10-02-2014 |
20150177199 | METHOD AND APPARATUS FOR CHARACTERIZING IMPURITY PROFILE OF ORGANIC MATERIALS - Method and apparatus for characterizing drug-modified polymers, macromolecules, proteins, antigens, antibodies or nanoparticles and quantitative determination of their impurity profile by two-dimensional liquid chromatography analysis. The first dimension is preferably size exclusion chromatography (SEC)—which is also known as gel permeation chromatography in case of non-aqueous samples (GPC)—for complete molecular weight analysis of nanoscale particles. It is not just included the application of separating small molecules from big molecules, but it is also the separation of different sorts of oligomers (e.g. monomers, dimers, trimers, tetramers). The second dimension is adapted for separating and characterizing small molecules which can be impurities or non-reacted modifiers with high-performance liquid chromatography (HPLC). Between the dimensions it is feasible to use solid phase extraction column(s) to collect small molecules, wash off or change solvent, or minimize broadening of their peaks. | 06-25-2015 |
Patent application number | Description | Published |
20130295726 | Integrated Memory Arrays, And Methods Of Forming Memory Arrays - Some embodiments include methods of forming memory arrays. A stack of semiconductor material plates may be patterned to subdivide the plates into pieces. Electrically conductive tiers may be formed along sidewall edges of the pieces. The pieces may then be patterned into an array of wires, with the array having vertical columns and horizontal rows. Individual wires may have first ends joining to the electrically conductive tiers, may have second ends in opposing relation to the first ends, and may have intermediate regions between the first and second ends. Gate material may be formed along the intermediate regions. Memory cell structures may be formed at the second ends of the wires. A plurality of vertically-extending electrical interconnects may be connected to the wires through the memory cell structures, with individual vertically-extending electrical interconnects being along individual columns of the array. Some embodiments include memory arrays incorporated into integrated circuitry. | 11-07-2013 |
20130302995 | Methods Of Treating Semiconductor Substrates, Methods Of Forming Openings During Semiconductor Fabrication, And Methods Of Removing Particles From Over Semiconductor Substrates - Some embodiments include methods of treating semiconductor substrates. The substrates may be exposed to one or more conditions that vary continuously. The conditions may include temperature gradients, concentration gradients of one or more compositions that quench etchant, pH gradients to assist in removing particles, and/or concentration gradients of one or more compositions that assist in removing particles. The continuously varying conditions may be imparted by placing the semiconductor substrates in a bath of flowing rinsing solution, with the bath having at least two feed lines that provide the rinsing solution therein. One of the feed lines may be at a first condition, and the other may be at a second condition that is different from the first condition. The relative amount of rinsing solution provided to the bath by each feed line may be varied to continuously vary the condition within the bath. | 11-14-2013 |
20140374833 | Memory Arrays - The invention includes semiconductor constructions having trenched isolation regions. The trenches of the trenched isolation regions can include narrow bottom portions and upper wide portions over the bottom portions. Electrically insulative material can fill the upper wide portions while leaving voids within the narrow bottom portions. The trenched isolation regions can be incorporated into a memory array, and/or can be incorporated into an electronic system. The invention also includes methods of forming semiconductor constructions. | 12-25-2014 |
Patent application number | Description | Published |
20090017596 | Methods Of Forming Oxides, Methods Of Forming Semiconductor Constructions, And Methods Of Forming Isolation Regions - Some embodiments include methods of forming isolation regions in which spin-on material (for example, polysilazane) is converted to a silicon dioxide-containing composition. The conversion may utilize one or more oxygen-containing species (such as ozone) and a temperature of less than or equal to 300° C. In some embodiments, the spin-on material is formed within an opening in a semiconductor material to form a trenched isolation region. Other dielectric materials may be formed within the opening in addition to the silicon dioxide-containing composition formed from the spin-on material. Such other dielectric materials may include silicon dioxide formed by chemical vapor deposition and/or silicon dioxide formed by high-density plasma chemical vapor deposition. | 01-15-2009 |
20090269569 | Low Temperature Process for Polysilazane Oxidation/Densification - Semiconductor devices, structures and systems that utilize a polysilazane-based silicon oxide layer or fill, and methods of making the oxide layer are disclosed. In one embodiment, a polysilazane solution is deposited on a substrate and processed with ozone in a wet oxidation at low temperature to chemically modify the polysilazane material to a silicon oxide layer. | 10-29-2009 |
20090305511 | Methods of Treating Semiconductor Substrates, Methods Of Forming Openings During Semiconductor Fabrication, And Methods Of Removing Particles From Over Semiconductor Substrates - Some embodiments include methods of treating semiconductor substrates. The substrates may be exposed to one or more conditions that vary continuously. The conditions may include temperature gradients, concentration gradients of one or more compositions that quench etchant, pH gradients to assist in removing particles, and/or concentration gradients of one or more compositions that assist in removing particles. The continuously varying conditions may be imparted by placing the semiconductor substrates in a bath of flowing rinsing solution, with the bath having at least two feed lines that provide the rinsing solution therein. One of the feed lines may be at a first condition, and the other may be at a second condition that is different from the first condition. The relative amount of rinsing solution provided to the bath by each feed line may be varied to continuously vary the condition within the bath. | 12-10-2009 |
20100013061 | SEMICONDUCTOR STRUCTURES INCLUDING SQUARE CUTS IN SINGLE CRYSTAL SILICON - A single crystal silicon etching method includes providing a single crystal silicon substrate having at least one trench therein. The substrate is exposed to a buffered fluoride etch solution which undercuts the silicon to provide lateral shelves when patterned in the <100> direction. The resulting structure includes an undercut feature when patterned in the <100> direction. | 01-21-2010 |
20100109120 | SINGLE CRYSTAL SILICON STRUCTURES - A single crystal silicon etching method includes providing a single crystal silicon substrate having at least one trench therein. The single crystal silicon substrate is exposed to an anisotropic etchant that undercuts the single crystal silicon. By controlling the length of the etch, single crystal silicon islands or smooth vertical walls in the single crystal silicon may be created. | 05-06-2010 |
20100221916 | Methods of Etching Oxide, Reducing Roughness, and Forming Capacitor Constructions - The invention includes methods in which one or more components of a carboxylic acid having an aqueous acidic dissociation constant of at least 1×10 | 09-02-2010 |
20100276780 | Memory Arrays - The invention includes semiconductor constructions having trenched isolation regions. The trenches of the trenched isolation regions can include narrow bottom portions and upper wide portions over the bottom portions. Electrically insulative material can fill the upper wide portions while leaving voids within the narrow bottom portions. The trenched isolation regions can be incorporated into a memory array, and/or can be incorporated into an electronic system. The invention also includes methods of forming semiconductor constructions. | 11-04-2010 |
20110121255 | Integrated Memory Arrays, And Methods Of Forming Memory Arrays - Some embodiments include methods of forming memory arrays. A stack of semiconductor material plates may be patterned to subdivide the plates into pieces. Electrically conductive tiers may be formed along sidewall edges of the pieces. The pieces may then be patterned into an array of wires, with the array having vertical columns and horizontal rows. Individual wires may have first ends joining to the electrically conductive tiers, may have second ends in opposing relation to the first ends, and may have intermediate regions between the first and second ends. Gate material may be formed along the intermediate regions. Memory cell structures may be formed at the second ends of the wires. A plurality of vertically-extending electrical interconnects may be connected to the wires through the memory cell structures, with individual vertically-extending electrical interconnects being along individual columns of the array. Some embodiments include memory arrays incorporated into integrated circuitry. | 05-26-2011 |
20110183492 | Methods of forming oxides, methods of forming semiconductor constructions, and methods of forming isolation regions - Some embodiments include methods of forming isolation regions in which spin-on material (for example, polysilazane) is converted to a silicon dioxide-containing composition. The conversion may utilize one or more oxygen-containing species (such as ozone) and a temperature of less than or equal to 300° C. In some embodiments, the spin-on material is formed within an opening in a semiconductor material to form a trenched isolation region. Other dielectric materials may be formed within the opening in addition to the silicon dioxide-containing composition formed from the spin-on material. Such other dielectric materials may include silicon dioxide formed by chemical vapor deposition and/or silicon dioxide formed by high-density plasma chemical vapor deposition. | 07-28-2011 |
20110260298 | SEMICONDUCTOR STRUCTURES INCLUDING SQUARE CUTS IN SINGLE CRYSTAL SILICON AND METHOD OF FORMING SAME - A single crystal silicon etching method includes providing a single crystal silicon substrate having at least one trench therein. The substrate is exposed to a buffered fluoride etch solution which undercuts the silicon to provide lateral shelves when patterned in the <100> direction. The resulting structure includes an undercut feature when patterned in the <100> direction. | 10-27-2011 |
20120168898 | METHODS OF FORMING SINGLE CRYSTAL SILICON STRUCTURES AND SEMICONDUCTOR DEVICE STRUCTURES INCLUDING SINGLE CRYSTAL SILICON STRUCTURES - A single crystal silicon etching method includes providing a single crystal silicon substrate having at least one trench therein. The single crystal silicon substrate is exposed to an anisotropic etchant that undercuts the single crystal silicon. By controlling the length of the etch, single crystal silicon islands or smooth vertical walls in the single crystal silicon may be created. | 07-05-2012 |
20120178221 | Methods Of Forming Memory Arrays - Some embodiments include methods of forming memory arrays. A stack of semiconductor material plates may be patterned to subdivide the plates into pieces. Electrically conductive tiers may be formed along sidewall edges of the pieces. The pieces may then be patterned into an array of wires, with the array having vertical columns and horizontal rows. Individual wires may have first ends joining to the electrically conductive tiers, may have second ends in opposing relation to the first ends, and may have intermediate regions between the first and second ends. Gate material may be formed along the intermediate regions. Memory cell structures may be formed at the second ends of the wires. A plurality of vertically-extending electrical interconnects may be connected to the wires through the memory cell structures, with individual vertically-extending electrical interconnects being along individual columns of the array. Some embodiments include memory arrays incorporated into integrated circuitry. | 07-12-2012 |
20120322263 | METHODS OF ETCHING SINGLE CRYSTAL SILICON - A single crystal silicon etching method includes providing a single crystal silicon substrate having at least one trench therein. The substrate is exposed to a buffered fluoride etch solution which undercuts the silicon to provide lateral shelves when patterned in the <100> direction. The resulting structure includes an undercut feature when patterned in the <100> direction. | 12-20-2012 |
20120329215 | Methods of Forming Memory Arrays - Some embodiments include methods of forming memory arrays. A stack of semiconductor material plates may be patterned to subdivide the plates into pieces. Electrically conductive tiers may be formed along sidewall edges of the pieces. The pieces may then be patterned into an array of wires, with the array having vertical columns and horizontal rows. Individual wires may have first ends joining to the electrically conductive tiers, may have second ends in opposing relation to the first ends, and may have intermediate regions between the first and second ends. Gate material may be formed along the intermediate regions. Memory cell structures may be formed at the second ends of the wires. A plurality of vertically-extending electrical interconnects may be connected to the wires through the memory cell structures, with individual vertically-extending electrical interconnects being along individual columns of the array. Some embodiments include memory arrays incorporated into integrated circuitry. | 12-27-2012 |
20130009310 | SEMICONDUCTOR DEVICE STRUCTURES AND COMPOSITIONS FOR FORMING SAME - A method of removing a metal nitride material is disclosed. The method comprises forming a semiconductor device structure comprising an exposed metal material and an exposed metal nitride material. The semiconductor device structure is subjected to a solution comprising water, ozone, and at least one additive to remove the exposed metal nitride material at a substantially greater rate than the exposed metal material. Resulting semiconductor device structures are also disclosed, as are compositions used to form the semiconductor device structures. | 01-10-2013 |
20150206761 | METHODS OF FORMING SINGLE CRYSTAL SILICON STRUCTURES - A single crystal silicon etching method includes providing a single crystal silicon substrate having at least one trench therein. The single crystal silicon substrate is exposed to an anisotropic etchant that undercuts the single crystal silicon. By controlling the length of the etch, single crystal silicon islands or smooth vertical walls in the single crystal silicon may be created. | 07-23-2015 |
Patent application number | Description | Published |
20090076663 | Method and Device for Assigning a Wheel of a Motor Vehicle - A method and device for assigning a vehicle wheel to axles having different wheel sizes. The method includes measuring the acceleration “a” sensed by an acceleration sensor of a wheel electronic system in a wheel. The measured acceleration value is transmitted to an evaluation unit, which compares the measured acceleration value “a” with a standard value stored in a memory for a standard wheel. The evaluation unit assigns the vehicle wheel to an axle as a function of the comparison result. The method and device are particularly suited to determining lift axles for trucks. | 03-19-2009 |
20090084174 | Method for Assigning a Tire Pressure Monitoring System After Driving Interruptions and Device and System for Measuring Air Pressure in a Vehicle Tire - A method for assigning a position of a tire, having a tire sensor, on a vehicle, includes transmitting, with the sensor, a signal including at least an identification number of the sensor following activation by a signal from an LF antenna connected to an evaluation unit. At a system start time, the evaluation unit first initiates an initialization including determination of the position of each tire having a sensor. The evaluation unit stores the identification number of each sensor together with the determined position of the tire having the sensor, before switching into a normal operating mode in which tire data, for example air pressure, is monitored by the sensors, with the position and preferably assignment of the sensor to a specific LF antenna, being stored in the sensor and kept available for retrieval. A device and a system for measuring air pressure in a vehicle tire are also provided. | 04-02-2009 |
20090085732 | Method, Tire Sensor Device, Central Control Unit and System for Anti-Theft Protection Through Tire Removal Recognition - A method for recognizing the removal of a tire provided with a tire sensor device, includes recognizing, with the tire sensor device, if a respective tire is mounted on the motor vehicle and storing an item of information relating to a mounting status in the tire sensor device. If a removal is determined, the tire sensor device sends an item of information characterizing the removal to a central control unit and the central control unit outputs a warning. A tire sensor device, a central control unit and a system for anti-theft protection through tire removal recognition, are also provided. | 04-02-2009 |
20090085734 | Device and Method for Distinguishing Positions of Tire Sensors of a Double Tire System - A device and a method for distinguishing positions of two tire sensors of a double tire include an LF antenna attached to a vehicle and connected to a central processing unit and one tire sensor each per tire. The tire sensors have a device for measuring field strength of a signal emitted by the LF antenna and the tire sensors report back information on the measured field strength through the LF antenna to the central processing unit. The central processing unit determines the position of the two tire sensors of the double tire from a distribution or course of a current flow during wheel rotation. | 04-02-2009 |
20090309780 | METHOD FOR DISTANCE MEASUREMENT AND DATA TRANSMISSION IN A CONTINUOUS WAVE RADAR SYSTEM - A method for distance measurement and data transmission in a continuous wave radar system is described. A continuous wave radar system has a transmit and receive module and at least one transponder device, a mobile control and monitoring device and an HMI system. Transponder devices are searched for with the aid of an unmodulated continuous wave signal as an interrogation signal, such that the transponder device can send a radio response signal to the transmit and receive module in response to the interrogation signal, as a result of which a data transmission takes place from the transponder device to the transmit and receive module. Upon completion of the data transmission a frequency-modulated continuous wave signal is generated in order to measure, on the basis thereof, a distance between the transponder device and the transmit and receive module. | 12-17-2009 |
Patent application number | Description | Published |
20130001327 | HIGH-PRESSURE FUEL INJECTION VALVE FOR AN INTERNAL COMBUSTION ENGINE - A high-pressure fuel injection valve may include a control valve having an actuator, a high-pressure fuel connection and a low-pressure fuel connection. A control plunger and nozzle needle are aligned longitudinally in the valve stem and the valve tip. Together with the control plunger, the receiving chamber of the control plunger forms a closing control chamber delimited by the upper control plunger surface, and an opening control chamber delimited by the lower control plunger surface. Each control chamber is hydraulically connected via a feed throttle to the high-pressure fuel connection and via a return throttle to the low-pressure fuel connection. The control valve opens and closes the fuel return between the return throttles and the low-pressure fuel connection depending on the operation. The flow values of the feed throttles and of the return throttles are selected such that the high-pressure fuel injection valve opens and closes based on actuation of the control valve. | 01-03-2013 |
20130103287 | METHOD FOR REGULATING A FUEL INJECTION SYSTEM OF AN INTERNAL COMBUSTION ENGINE - A method for regulating a fuel injection system of an internal combustion engine includes outputting from a control unit an instruction to start an injection process of fuel through an injection valve, wherein during a determination of a time of the outputting of the instruction to start the injection process, the control unit takes into account delays caused by the mechanical system of the injection valve. Furthermore, during the determination of the time of the outputting of the instruction to start the injection process, the control unit also takes into account a correction value which describes the fuel pressure in the injector feed line. | 04-25-2013 |
20140039779 | Method For The Operation Of An Internal Combustion Engine, And Internal Combustion Engine - A method for operating an internal combustion engine and an internal combustion engine are described. In order to recognize and correct the drift in the amount of fuel injected over the service life of the injectors of the injection system of the internal combustion engine, multiple different corrective functions are used to establish corrected individual characteristics relative to nominal characteristics. Each offset of the corrected individual characteristic from the nominal characteristics is determined, offset curves are created, and the sections of the individual offset curves representing a minimal offset are used as control data for the amount of fuel to be injected, thus making it possible to always achieve overall optimal control with a minimal difference in the amount of injected fuel. | 02-06-2014 |
20150292462 | Piezo Injector - A piezo injector includes an actuator space in which a piezo actuator is arranged, a control piston bore in which a control piston with an end face is arranged, a leakage pin arranged between the piezo actuator and the end face to couple the piezo actuator with the control piston, and a union for fluidic communication with the control piston bore which union has a hydraulic throttle. | 10-15-2015 |
Patent application number | Description | Published |
20150092924 | STRUCTURED TARGETS FOR X-RAY GENERATION - We disclose targets for generating x-rays using electron beams, along with their method of fabrication. The targets comprise a number of microstructures fabricated from an x-ray target material arranged in close thermal contact with a substrate such that the heat is more efficiently drawn out of the x-ray target material. This in turn allows irradiation of the x-ray generating substance with higher electron density or higher energy electrons, which leads to greater x-ray brightness, without inducing damage or melting. | 04-02-2015 |
20150110252 | X-RAY SOURCES USING LINEAR ACCUMULATION - We disclose a compact source for high brightness x-ray generation. The higher brightness is achieved through electron beam bombardment of multiple regions aligned with each other to achieve a linear accumulation of x-rays. This may be achieved by aligning discrete x-ray sources, or through the use of novel x-ray targets that comprise a number of microstructures of x-ray generating materials fabricated in close thermal contact with a substrate with high thermal conductivity. This allows heat to be more efficiently drawn out of the x-ray generating material, and in turn allows bombardment of the x-ray generating material with higher electron density and/or higher energy electrons, leading to greater x-ray brightness. | 04-23-2015 |
20150117599 | X-RAY INTERFEROMETRIC IMAGING SYSTEM - We disclose an x-ray interferometric imaging system in which the x-ray source comprises a target having a plurality of structured coherent sub-sources of x-rays embedded in a thermally conducting substrate. The system additionally comprises a beam-splitting grating G | 04-30-2015 |
20150194287 | X-ray illuminators with high flux and high flux density - This disclosure presents systems for x-ray illumination that have an x-ray brightness several orders of magnitude greater than existing x-ray technologies. These may therefore useful for applications such as trace element detection or for micro-focus fluorescence analysis. | 07-09-2015 |
20150243397 | X-RAY INTERFEROMETRIC IMAGING SYSTEM - An x-ray interferometric imaging system in which the x-ray source comprises a target having a plurality of structured coherent sub-sources of x-rays embedded in a thermally conducting substrate. The system additionally comprises a beam-splitting grating G | 08-27-2015 |
20150247811 | X-RAY SURFACE ANALYSIS AND MEASUREMENT APPARATUS - This disclosure presents systems for total reflection x-ray fluorescence measurements that have x-ray flux and x-ray flux density several orders of magnitude greater than existing x-ray technologies. These may therefore useful for applications such as trace element detection and/or for total-reflection fluorescence analysis. | 09-03-2015 |
20150357069 | HIGH BRIGHTNESS X-RAY ABSORPTION SPECTROSCOPY SYSTEM - This disclosure presents systems for x-ray absorption fine structure (XAFS) measurements that have x-ray flux and flux density several orders of magnitude greater than existing compact systems. These are useful for laboratory or field applications of x-ray absorption near-edge spectroscopy (XANES) or extended x-ray fine absorption structure (EXFAS) spectroscopy. | 12-10-2015 |
20160064175 | STRUCTURED TARGETS FOR X-RAY GENERATION - Disclosed are targets for generating x-rays using electron beams and their method of fabrication. They comprise a number of microstructures fabricated from an x-ray target material arranged in close thermal contact with a substrate such that the heat is more efficiently drawn out of the x-ray target material. This allows irradiation of the x-ray generating substance with higher electron density or higher energy electrons, leading to greater x-ray brightness, without inducing damage or melting. The microstructures may comprise conventional x-ray target materials (such as tungsten) that are patterned at micron-scale dimensions on a thermally conducting substrate, such as diamond. The microstructures may have any number of geometric shapes to best generate x-rays of high brightness and efficiently disperse heat. In some embodiments, the target comprising microstructures may be incorporated into a rotating anode geometry, to enhance x-ray generation in such systems. | 03-03-2016 |
20160066870 | X-RAY INTERFEROMETRIC IMAGING SYSTEM - An x-ray interferometric imaging system in which the x-ray source comprises a target having a plurality of structured coherent sub-sources of x-rays embedded in a thermally conducting substrate. The structures may be microstructures with lateral dimensions measured on the order of microns, and in some embodiments, the structures are arranged in a regular array. | 03-10-2016 |
Patent application number | Description | Published |
20080311079 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease - The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds. | 12-18-2008 |
20090291902 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE - The present invention relates to compounds of formula I: | 11-26-2009 |
20100173851 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE - The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds. | 07-08-2010 |
20100330109 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE - The present invention relates to compounds of formula I: | 12-30-2010 |
20110104115 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE - The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds. | 05-05-2011 |
20130116169 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE - The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds. | 05-09-2013 |
20130316945 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE - The present invention relates to compounds of formula I: | 11-28-2013 |
20140010784 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE - The present invention relates to peptidomimetic compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. | 01-09-2014 |
20140031277 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE - The present invention relates to compounds of formula I: | 01-30-2014 |
Patent application number | Description | Published |
20100137622 | INDUSTRIAL METHOD FOR THE SYNTHESIS OF 17-ACETOXY-11beta-[4-(DIMETHYLAMINO)-PHENYL]-21-METHOXY-19-NORPREGNA-4,9-- DIEN-3,20-DIONE AND THE KEY INTERMEDIATES OF THE PROCESS - The present invention relates to a process for the synthesis of the known 17-acetoxy-11-β-[4-(dimethyl amino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione (further on CDB-4124) of formula (I) from 3,3-[1,2-ethandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II). Compound CDB-4124 belongs to the group of anti-hormones. The process has the following steps: i) formation of an epoxide; ii) addition of hydrogen cyanide; iii) silylation of a hydroxyl group; iv) reaction with 4-(dimethylamino)-phenyl magnesium bromide Grignard reagent in the presence of CuCl (Teutsch reaction); v) silylation of a hydroxyl group with trimethyl chlorosilane; vi) reaction with diisobutyl aluminum hydride and after addition of acid to the reaction mixture; vii) methoxy-methylation with methoxy-methyl Grignard reagent formed in situ, while hydrolyzing the trimethylsilyl protective groups; viii) oxidation of a hydroxyl group with dicyclohexyl carbodiimide in the presence of dimethyl sulfoxide and a strong organic acid (Swern oxidation), and in given case after purification by chromatography; ix) acetylation of a hydroxyl group with acetic anhydride in the presence of perchloric acid, and in given case, purification by chromatography. The invention also relates to new intermediates of the process. | 06-03-2010 |
20120142655 | NOVEL CRYSTAL FORM OF AN ORGANIC COMPOUND AND PROCESS FOR THE PREPARATION THEREOF - The present invention relates to novel crystalline Form II of 17α-acetoxy-21-methoxy-11β-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione, (also known as CDB-4124), processes for the preparation thereof and pharmaceutical compositions comprising it. Form II can be crystallized from different medium such as esters of C1-C4 alcohols and carboxylic acids, ketones, cyclohexane, acetonitrile, dimethylformamide, dimethyl sulfoxide, water and any mixture thereof. | 06-07-2012 |
Patent application number | Description | Published |
20100061231 | MULTI-DOMAIN NETWORK AND METHOD FOR MULTI-DOMAIN NETWORK - Each domain of a multi-domain network collects intra-domain routing information relating to that domain and makes a reduced view of that information available to other domains of the network, and in which each domain of the network uses its own intra-domain routing information together with the reduced-view routing information from the other domains to form a logical view of the network so as to enable that domain to make an end-to-end route selection decision. | 03-11-2010 |
20100110918 | Method and apparatus for performance monitoring in a communications network - A method and device for determining a packet drop indicator, for use in a communication system is described. The method comprises the following steps: A. determining the number of packets sent at a sending side within a first time period; B. determining the number of packets received at a receiving side within a second time period; and C. calculating a packet drop indicator on the basis of said number of sent packets and said number of received packets. | 05-06-2010 |
20100195492 | Controlling Traffic in a Packet Switched Communications Network - The present invention relates to a packet switched communications network especially to an Ethernet network in which User Network Interfaces (UNI) are standardized between client network ( | 08-05-2010 |
20100208614 | METHOD AND ARRANGEMENT FOR SCHEDULING DATA PACKETS IN A COMMUNICATION NETWORK SYSTEM - The present invention relates to a method and an arrangement for scheduling data packets each belonging to a particular traffic class associated with a certain quality of service (QoS) level and transmitted between a first communication network node and a second communication network node. Initially a token rate for assigning tokens to each traffic class is set and an incoming traffic rate of each traffic class is measured by counting a number of incoming data packets during a pre-determined period of time. Then, based on said measured incoming traffic rate said token rate is adjusted in order to obtain a fair scheduling of data packets belonging to different traffic classes. | 08-19-2010 |
20100309894 | Method and Apparatuses for Allowing a Nomadic Terminal to Access a Home Network on Layer 2 Level - A method of allowing a nomadic terminal to access a home network on the Layer 2 level. The method comprises connecting said terminal to a remote access network via an access point, the remote access network being connected to an operator's backbone network via a remote access router. Signalling is exchanged between the access point and an authentication server within the backbone network in order to authenticate the terminal to the authentication server and, following successful authentication, a Layer 2 tunnel extending across the backbone network is established for the purpose of connecting said nomadic terminal to the home network. | 12-09-2010 |
20110019654 | Method and Apparatus for Use in a Communications Network - A method is provided of enabling access for a terminal ( | 01-27-2011 |
20110026502 | Method and System for Simultaneous Local and EPC Connectivity - A system for providing simultaneous local and global connectivity for a 3 | 02-03-2011 |
20130142093 | Mobile Layer 2 Virtual Private Network Over Internet Protocol Networks - The present disclosure relates to a technique for maintaining communication established between a mobile node ( | 06-06-2013 |
20130301416 | MULTI-LEVEL BEARER PROFILING IN TRANSPORT NETWORKS - A method is provided for transporting data packets over a telecommunications transport network. The data packets are carried by a plurality of bearers, the bearers each carrying data packets that relate to different ones of a plurality of services. In the method a multi-level bandwidth profiling scheme is applied to the data packets of each bearer. A series of information rates are assigned to a bearer, the profiling scheme identifying and marking each data packet of the bearer based on a desired resource sharing according to the minimum information rate with which the packet is conformant. The marked data packets are forwarded for transport through the transport network. If there is insufficient bandwidth available in the transport network to transport all data packets, data packets identified by the profiling and marked as only being conformant with a higher information rate are discarded before any data packets marked as being conformant with a lower information rate. | 11-14-2013 |
20140293793 | Service-Aware Profiling for Transport Networks - A method is provided of transporting data packets over a telecommunications transport network. The data packets are carried by a plurality of bearers, each carrying data packets that relate to different ones of a plurality of services. In the method bandwidth profiling is applied to the data packets of each bearer, independently of the other bearers, to identify and mark the data packets of each of the bearers that are conformant with a predetermined maximum information rate for the bearer. The data packets are forwarded for transport through the transport network, wherein, if there is insufficient bandwidth available in the transport network to transport all data packets, data packets not identified by the profiling as being conformant are discarded, so as not to be transported through the transport network. | 10-02-2014 |
20140321284 | Optimised Packet Delivery Across a Transport Network - A method of prioritising packets for delivery over a transport network interconnecting nodes of a mobile network, where a guaranteed minimum information rate over the transport network is specified for the mobile network. The method comprises, for each bearer to be injected into the transport network from the mobile network, specifying a bearer information rate and marking packets up to that rate as conformant with the bearer information rate and marking packets exceeding that rate as non-conformant with the bearer information rate. A plurality of traffic type streams from the mobile network are converged, each traffic type stream comprising a plurality of bearers. Packets of the converged traffic type streams are inspected to identify packets marked as conformant and non-conformant, and re-marking non-conformant packets, or at least a fraction of non-conformant packets, as conformant if the converged rate of conformant packets is less than said minimum information rate. The transport network prioritises the delivery of packets marked as conformant over those packets marked as non-conformant. | 10-30-2014 |
20140328170 | Enhanced Performance Service-Based Profiling for Transport Networks - A method is presented of transporting data packets over a telecommunications transport network. The data packets are carried by a plurality of bearers. For each of the bearers, independently of the other bearers, bandwidth profiling is applied to the data packets of the bearer to designate as ‘green’ data packets that are conformant with a predetermined maximum Information Rate for the bearer. One or more data packets is buffered for up to a predetermined maximum ‘green’ buffer time, during which if transporting the data packet would not cause the maximum information rate of the bearer to be exceeded, the data packet is designated as a ‘green’ data packet. The data packets are forwarded for transporting over the transport network. If there is insufficient bandwidth available in the transport network to transport all data packets, data packets that are not designated as ‘green’ data packets are discarded, so as not to be transported through the transport network. | 11-06-2014 |
20140341042 | Conditional Routing Technique - A technique for controlling network routing in a network ( | 11-20-2014 |
20150063121 | Load Balancing Among Alternative Paths - A method and a transmitting node for redirecting of a flow of data packets to a path of alternative paths, and a method and a receiving node for enabling redirection of a flow of data packets to a path of alternative paths, where data packets are marked with a value indicating the importance of the data packets. The method for directing directs one or more flows of data packets for the alternative paths, wherein data packets marked with a higher value are prioritized over data packets marked with a lower value. Based on feedback information, the transmitting node redirects a flow of data packets to a second path of the alternative paths, if the metric of congestion indicates a higher congestion on the first path than on the second path. | 03-05-2015 |
20150117218 | Feedback-based Profiling for Transport Networks - A method is provided of transporting data packets over a telecommunications transport network. The data packets are carried by a plurality of bearers, the bearers each carrying data packets that relate to different ones of a plurality of services. In the method, for each bearer independently of the other bearers, bandwidth profiling is applied to the data packets of the bearer to identify and mark the data packets of each of the bearers that are conformant with a determined maximum information rate for the bearer. The data packets are forwarded for transport through the transport network. If there is insufficient bandwidth available in the transport network to transport all data packets, data packets not identified by the profiling as being conformant are discarded, so as not to be transported through the transport network. The data packets of the bearer transported through the transport network are monitored to determine whether there has been any loss of data packets that should have been transported through the transport network, indicating congestion in the transport network. The maximum information rate of the bearer is adjusted based on the monitoring. | 04-30-2015 |
20150131442 | Dynamic Profiling for Transport Networks - A method is provided for transporting data packets over a telecommunications transport network. The data packets are carried by a plurality of bearers, and are sent over the transport network from a serving node. Information is received relating to a current capacity of the transport network. A current maximum total information rate for the serving node is dynamically adjusted based on information relating to a current capacity of the transport network. A current maximum information rate for each of the bearers is determined based on the current maximum total information rate. Bandwidth profiling is applied to the data packets of each of the bearers, independently of the other bearers, to identify the data packets of each of the bearers that are conformant with the determined current maximum information rate for the bearer. The data packets are forwarded for transport through the transport network. If there is insufficient bandwidth available in the transport network, data packets not identified by the profiling as being conformant are discarded. | 05-14-2015 |
20150131615 | DELAYED HANDOVER SIGNALLING IN A MOBILE NETWORK - In a mobile network comprising a plurality of base stations and a gateway, a user equipment may perform a handover from a source base station to a target base station. By control signalling, the handover may be notified from the target base station to a control node of the mobile network and then to the gateway so that the gateway may switch to a data path which connects the target base station and the gateway. The notification of the handover may be delayed at the target base station or at the control node, by starting a timer and sending the control signalling for initiating the path switching after expiry of the timer. | 05-14-2015 |
20150163148 | Packet Scheduling in a Communication Network - A method and apparatus for packet scheduling over a communication link in a communication network. A data packet scheduler accords scheduling weights to at least two sets of data packets to be transmitted, and the sending of the sets of data packets is scheduled in accordance with the scheduling weights. When it is determined that a change in available bandwidth over the communication link has occurred, the scheduler dynamically adjusts the scheduling weight for each set of data packets on the basis of the available bandwidth. This ensures more efficient resource sharing control and resource guarantees when the available bandwidth changes. | 06-11-2015 |
20150180766 | Technique for Network Routing - A technique for routing one or more service tunnels in a telecommunications backhaul network ( | 06-25-2015 |
20160105369 | TRANSMITTING NODE, RECEIVING NODE AND METHODS THEREIN - Embodiments herein relate to a method in a receiving node ( | 04-14-2016 |
Patent application number | Description | Published |
20080287404 | High Purity 17Alpha-Cyanomethyl-17Beta-Hydroxy-Estra-4,9-Diene-3- One and Process For the Syntheses Thereof - The invention relates to a new process for the synthesis of high purity 17α-cyanomethyl-17β-hydroxy-estra-4,9-diene-3-one (further on dienogest) of formula (I) from 3-methoxy-17-hydroxy-estra-2,5(10)-diene of formula (V). The invention relates also to the high purity 17α-cyanomethyl-17β-hydroxy-estra-4,9-diene-3-one and pharmaceutical compositions containing that as active ingredient. The pharmaceutical compositions according to this invention contain high purity dienogest of formula (I) in which the total amount of impurities is less than 0.1%, while the amount of 4-bromo-dienogest is under the detection limit (0.02%) as active ingredient or at least one of the active ingredients and auxiliary materials, which are commonly used in practice, such as carriers, excipients or diluents. According to our invention the dienogest of formula (I) is synthesized the following way: i) 3-methoxy-17-hydroxy-estra-2,5(10)-diene of formula (V) is reacted with aluminum isopropylate in the presence of cyclohexanone in an inert organic solvent under heating; ii) the so obtained 3-methoxy-estra-2,5(10)-diene-17-one of formula (IV) is reacted with cyanomethyl lithium at a temperature between 0 and −30° C.; iii) the obtained 3-methoxy-17α-cyanomethyl-17β-hydroxy-estra-2,5(10)-diene of formula (III) is reacted with a strong organic acid in tetrahydrofuran solution; iv) the obtained 17α-cyanomethyl-17β-hydroxy-estr-5(10)-ene-3-one of formula (II) is reacted with 1-1.5 equivalent of pyridinium tribromide in pyridine solution at a temperature between 0 and 60° C., then the obtained crude dienogest of formula (I) is purified by recrystallization and preparative HPLC. | 11-20-2008 |
20090312299 | Isolated Isomers of Norelgestromin and Methods of Making and Using the Same - The invention is directed to a process of preparing substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3E- and -3Z-oxime isomers, as well as a process for the synthesis of the mixture of isomers and the pure isomers. The invention also relates to substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime and substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer. Further aspects of the invention include a composition comprising substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene20-yn-3-one-3E-oxime or substantially pure d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-3Z-oxime isomer, and methods of treatment using said compositions. | 12-17-2009 |
Patent application number | Description | Published |
20090018149 | 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and methods for medical intervention against mycobacterial infections - Described are 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of mycobacteria-induced infections and opportunistic infections, as well as compositions containing at least one 4,5,6,7-tetrahydrobenzo[b]thiophene derivative and/or pharmaceutically acceptable salts thereof. Furthermore, the present application refers to the use of mycobacterial protein serine/threonine kinases for developing methods for detection and determination of these kinases for recognising and monitoring diseases and for controlling therapy of diseases. | 01-15-2009 |
20090298842 | Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor - Described herein is the discovery that certain mycobacterial serine/threonine protein kinases, particularly protein kinase G (PknG), are effective therapeutic targets for the treatment of mycobacterial infections. Furthermore, the present application refers to the use of mycobacterial serine/threonine protein kinases for developing methods for detection and determination of these kinases for recognizing and monitoring diseases and for controlling therapy of diseases. Additionally disclosed are novel 4,5,6,7-tetrahydrobenzo[b]thiophene compounds, benzo(g)quinoxaline compounds, and pharmaceutically acceptable salts thereof, and methods of using such compounds and salts thereof for the prophylaxis and/or treatment of virally and/or bacterially induced infections, particularly mycobacteria-induced infections, including opportunistic infections, as well as pharmaceutical compositions containing at least one 4,5,6,7-tetrahydrobenzo[b]thiophene compound and/or benzo(g)quinoxaline compound and/or pharmaceutically acceptable salts thereof in a pharmaceutically acceptable carrier. | 12-03-2009 |
20150368209 | 4-Pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (PLK1) for the treatment of cancer and their use for the treatment of bacterial infections - The present invention relates to 4-pyrimidinylamino-benzenesulfonamide derivatives of general formula (I) and pharmaceutically acceptable salts, solvates, hydrates, regioisomeric and polymorphic forms thereof, processes for manufacturing of them, the use of them, as well as pharmaceutical compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the inhibition of polo-like kinases (PLKs) and the treatment of cancer. Said 4-pyrimidinylamino-benzenesulfonamide compounds have been also identified as new drug candidates for the prevention and/or treatment of infectious diseases like bacterial diseases e.g. tuberculosis, including the currently multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) as well as for preventing tuberculosis. | 12-24-2015 |