Charles Wilson
Charles Wilson, Palo Alto, CA US
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20100174623 | System and Method for Managing Items of Interest Selected from Online Merchants - A system for managing wish list items from a plurality of online merchants is provided. The system includes a memory, processor and item management module executed by the processor. The memory stores data regarding the wish list items that have been selected by a user while browsing online merchant websites. The item management module has a receive-advice feature that sends an electronic message to user-selected contacts. The electronic message contains a request for feedback on one or more selected items of interest. When the contacts submit feedbacks, they are stored in the memory for viewing by the user. | 07-08-2010 |
20110060663 | System and Method of Providing Customer Purchase Propensity Information to Online Merchants - A system for providing online merchants with purchase propensity information is provided. The system includes a processor and a purchase propensity module executable by the processor. The purchase propensity module receives, from an online merchant computer, a message containing a customer identifier that identifies a customer who has established an online browsing session with the online merchant. In response, the purchase propensity module transmits to the online merchant computer purchase propensity data associated with the identified customer while the browsing session is in progress. This allows the online merchant computer to determine a targeted offer for the user while the user is in the online browsing session. | 03-10-2011 |
Charles Wilson, Needham, MA US
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20100001012 | Container Wrap - A container wrap absorbs and/or collects condensation from the outside of a beverage container carrying a cold beverage, thereby reducing the inconvenience of the condensation. The wrap may include a sleeve and a base and may be foldable into a flat configuration such that it is easily stored yet easily opened for placement on a container. When opened, the base may be secured in a use configuration with an interference engagement between the base and an interior surface of the sleeve. The sleeve may have a frusto-conical shape so that a similarly shaped container is insertable into the wrap. An upper end of the sleeve may be configured to fit closely to the container around substantially the entire perimeter of the beverage container. A lower end of the sleeve may be configured to be separated from the perimeter of the beverage container. | 01-07-2010 |
Charles Wilson, Concord, MA US
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20080214489 | Aptamer-mediated intracellular delivery of oligonucleotides - Compositions and methods to mediate the intracellular and sub-cellular delivery of therapeutic, diagnostic and imaging agents, such as oligonucleotides. The compositions of the invention include nucleic acid conjugates comprising a delivery aptamer that is connected to an oligonucleotide. The delivery aptamer may be connected directly to the oligonucleotide, or may be connected indirectly to the oligonucleotide, such as through a linker. The oligonucleotide may be either a therapeutic, diagnostic or imaging oligonucleotide. The methods of the invention are used to increase potency, or alter distribution, half-life, metabolic fate, toxicity and other characteristics. | 09-04-2008 |
20090053138 | Stabilized Aptamers to Platelet Derived Growth Factor and their Use as Oncology Therapeutics - Materials and methods are provided for producing and using aptamers as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and/or VEGF receptor or any combination thereof with affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto. | 02-26-2009 |
20090075342 | Metabolic profile directed aptamer medicinal chemistry - The present invention provides materials and methods for enhancing aptamers. More specifically, the materials and methods of the present invention are directed toward the modification of aptamers by the identification of one or more cleavage sites, and introduction of a chemical substitution at a position proximal to the cleavage site(s). Such aptamers are useful for the treatment of disease, in diagnostic and detection applications, and/or research, e.g., target validation. | 03-19-2009 |
20090081679 | Compositions and methods for in vivo SELEX - The invention describes methods for the in vivo selection of oligonucleotides, preferably aptamers, that persist in biological compartments. In one embodiment, the biological compartment comprises at least one tissue which, in a preferred embodiment, is the blood within the circulatory system of a living mammal. The invention also contemplates oligonucleotides, preferably aptamers, selected through in vivo SELEX that may be linked to therapeutic or diagnostic compositions including other oligonucleotides. | 03-26-2009 |
20090105172 | Stabilized Aptamers to PSMA and Their Use as Prostate Cancer Therapeutics - The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands. | 04-23-2009 |
20120171304 | Stabilized Aptamers To Platelet Derived Growth Factor And Their Use As Oncology Therapeutics - Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto. | 07-05-2012 |
20120322860 | APTAMER THERAPEUTICS USEFUL IN THE TREATMENT OF COMPLEMENT-RELATED DISORDERS - The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders. | 12-20-2012 |
20130237589 | APTAMER THERAPEUTICS USEFUL IN THE TREATMENT OF COMPLEMENT-RELATED DISORDERS - The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders. | 09-12-2013 |
Charles Wilson, Turrella AU
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20130113259 | ADJUSTMENT MECHANISM - An adjustment mechanism ( | 05-09-2013 |
Charles Wilson, Frisco, TX US
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20130153396 | Purification of a fluid for example water after fracturing - An apparatus for treating frac water may include a vacuum container to support a vacuum, a heating device to heat the vacuum container, a spiral auger to rotate to separate the frac water being positioned within the vacuum container, a condenser to condense the water vapor to liquid water, a second vacuum chamber to receive the liquid water and a storage container to store the liquid water. | 06-20-2013 |
Charles Wilson, Vancouver CA
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20140117078 | SUBCRIPTION OF A USER - A machine may be configured to subscribe a user to a data feed that corresponds to an activity. The machine may generate an optically scannable code that encodes an activity identifier of the activity. The machine may cause a first device to access this optically scannable code, and the first device may present the optically scannable code to a second device. The second device may scan the optically scannable code, and the machine may detect that the optically scannable code has been scanned by the second device. In response to this detection, the machine may subscribe a user of the second device to a data feed that corresponds to the activity. Hence, a first user may present the optically scannable code using one device, and a second user can scan the optically scannable code using another device and be subscribed to the data feed for the activity. | 05-01-2014 |